更新于：2024-12-06
Garenoxacin Mesilate Hydrate
甲磺酸加诺沙星
更新于：2024-12-06
概要
基本信息
药物类型 小分子化药 |
别名 Des-F(6)-quinolone、Desquinolone、Garenoxacin + [13] |
作用机制 细菌DNA旋转酶复合体抑制剂、拓扑异构酶 IV抑制剂 |
非在研适应症 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C24H26F2N2O8S |
InChIKeyIGTHEWGRXUAFKF-NVJADKKVSA-N |
CAS号223652-90-2 |
关联
16
项与 甲磺酸加诺沙星 相关的临床试验甲磺酸加诺沙星片在中国健康受试者中空腹/餐后口服给药的单中心、开放、随机、两序列、两周期交叉生物等效性试验
Clinical efficacy of garenoxacin for treatment of bacterial respiratory infection secondary to chronic respiratory disease - GARIREO study
Specific post-marketing surveillance of garenoxacin (Geninax) Clinical efficacy and safety of garenoxacin in the treatment of legionella pneumonia
100 项与 甲磺酸加诺沙星 相关的临床结果
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100 项与 甲磺酸加诺沙星 相关的转化医学
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100 项与 甲磺酸加诺沙星 相关的专利（医药）
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308
项与 甲磺酸加诺沙星 相关的文献（医药）2024-08-06ENVIRONMENTAL SCIENCE & TECHNOLOGY
Solar Photodegradation of a Novel des-F(6)-Fluoroquinolone, Garenoxacin, and Ecotoxicity of Its Phototransformation Products
Article
作者: Huang, Shengnan ; Lin, Chunye ; Cheng, Hefa ; Zhang, Zhaobin
Garenoxacin (GRNX) is a novel des-F(6)-fluoroquinolone on the horizon; thus, its fate and risk in the aquatic environment deserve attention. This study systematically investigated, for the first time, the phototransformation of GRNX under simulated and natural sunlight and assessed the ecotoxicity of its photodegradation products. Phototransformation of GRNX was observed to depend strongly on its ionization state, with direct photolysis and self-sensitized photolysis having comparable contributions for the cationic and zwitterionic species, while the latter dominated for the anionic species. Singlet oxygen generated via the self-sensitized photolysis of GRNX was the major reactive oxygen species in its photodegradation. Phototransformation of GRNX in different ionization states followed distinct pathways, with defluorination of the difluoromethyl group occurring only for the zwitterionic and anionic species. GRNX photodegradation in natural water could be described by a simple kinetic model based on the measured steady-state concentrations of 1O2 and ·OH. Toxicity tests with Vibrio fischeri and Chlorella vulgaris consistently indicate that the generation of hydroxylation and decarboxylation products during photodegradation of GRNX increased the acute toxicity. These findings not only provide insights into the fate of GRNX in sunlit surface water but also reveal the potentially significant risk of its photodegradation products to the aquatic ecosystem.
2024-02-01European journal of dermatology : EJD
Fixed drug eruption due to tipepidine hibenzate and garenoxacin mesylate hydrate: an unusual case of polysensitivity
Article
作者: Fukuda, Hidetsugu ; Harada, Yuya
2023-11-10Cureus
Fixed Drug Eruption Caused by Garenoxacin: A Case Report and Literature Review
作者: Sawada, Yu ; Hara, Natsumi ; Saito-Sasaki, Natsuko
A new quinolone antibiotic called garenoxacin was developed in Japan. Garenoxacin is known to produce cutaneous adverse effects, particularly fixed drug eruption in Japan, despite several reports of cutaneous adverse events in English-language literature. However, English-language literature has not yet reported that fixed drug eruption is a common clinical manifestation of garenoxacin-induced drug eruption. In this article, we present a case of multiple fixed drug eruptions and review the literature on case reports of drug eruptions caused by garenoxacin.
100 项与 甲磺酸加诺沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 大肠杆菌感染 | 日本 | 2023-07-31 | |
| 大肠杆菌感染 | 日本 | 2023-07-31 | |
| 克雷伯菌感染 | 日本 | 2023-07-31 | |
| 克雷伯菌感染 | 日本 | 2023-07-31 | |
| 支原体感染 | 日本 | 2023-07-31 | |
| 支原体感染 | 日本 | 2023-07-31 | |
| 中耳炎 | 日本 | 2023-07-31 | |
| 中耳炎 | 日本 | 2023-07-31 | |
| 咽喉炎 | 日本 | 2023-07-31 | |
| 咽喉炎 | 日本 | 2023-07-31 | |
| 肺炎球菌感染 | 日本 | 2023-07-31 | |
| 肺炎球菌感染 | 日本 | 2023-07-31 | |
| 细菌性肺炎 | 中国 | 2019-07-25 | |
| 呼吸道感染 | 中国 | 2019-07-12 | |
| 细菌感染 | 韩国 | 2009-09-01 | |
| 急性支气管炎 | 日本 | 2007-07-31 | |
| 喉炎 | 日本 | 2007-07-31 | |
| 咽炎 | 日本 | 2007-07-31 | |
| 肺炎 | 日本 | 2007-07-31 | |
| 慢性呼吸道感染 | 日本 | 2007-07-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性支气管炎 | 申请上市 | 欧盟 | - | |
| 社区获得性肺炎 | 申请上市 | 欧盟 | - | |
| 复杂的皮肤和软组织感染 | 申请上市 | 欧盟 | - | |
| 腹腔感染 | 申请上市 | 欧盟 | - |
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