丹酚酸A(Salvianolic acid A) - 药物靶点：STING x miR-204-5p_在研适应症：急性胸部综合征，糖尿病肾病，周围神经系统疾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

丹参酚酸A

靶点

STING x miR-204-5p

作用方式

抑制剂

作用机制

STING 抑制剂(干扰素基因刺激蛋白抑制剂)、miR-204-5p 抑制剂(MiR-204 的 5' 端链抑制剂)、表观遗传学药物

治疗领域

神经系统疾病遗传病与畸形内分泌与代谢疾病+ [8]

在研适应症

急性胸部综合征糖尿病肾病周围神经系统疾病+ [6]

非在研适应症

原研机构

在研机构

+ [4]

非在研机构

中国医学科学院药物研究所Chia Tai Qingchunbao Pharmaceutical Co., Ltd.

北京本草天源药物研究院

权益机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)临床1期

特殊审评-

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结构/序列

分子式C26H22O10

InChIKeyYMGFTDKNIWPMGF-UCPJVGPRSA-N

CAS号96574-01-5

关联

10

项与丹酚酸A 相关的临床试验

ChiCTR2500103456

/ Not yet recruitingN/AIIT

Salvianolic acid A for cerebral small vessel disease cognitive impairment —— A Single-center, Prospective, Single-arm, Clinical Trial

开始日期2025-03-01

申办/合作机构

首都医科大学宣武医院

[+2]

ITMCTR2024000668

/ CompletedN/AIIT

Salvianolic acid A inhibits the activation and aggregation of platelets in patients with acute coronary syndrome

开始日期2022-10-01

申办/合作机构-

CTR20213269

/ Completed临床2期

评估注射用丹酚酸A钠用于急性心肌梗死患者PCI术后心肌保护的有效性和安全性的随机、双盲、安慰剂对照、多中心的IIa期临床研究

评价注射用丹酚酸A钠用于急性心肌梗死患者PCI术后心肌保护的有效性与安全性

开始日期2022-05-04

申办/合作机构

Chia Tai Qingchunbao Pharmaceutical Co., Ltd.

[+1]

100 项与丹酚酸A 相关的临床结果

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100 项与丹酚酸A 相关的转化医学

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100 项与丹酚酸A 相关的专利（医药）

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1,230

项与丹酚酸A 相关的文献（医药）

2026-02-01·JOURNAL OF COLLOID AND INTERFACE SCIENCE

Adsorption behavior and mechanism of salvianolic acid A on surface molecularly imprinted nonwoven fabrics

Article

作者: Zeng, Weihuan ; Kai, Guoyin ; Jia, Xu ; Qian, Jun ; Wang, Yue ; Zou, Liang ; Chen, Yupeng ; Shi, Mengli ; Gu, Jianxing

Salvianolic acid A (SAA) is a water-soluble phenolic acid compound with high biological activity, which is widely used in the treatment of cardiovascular diseases. In this paper, we report a strategy for synthesizing surface molecularly imprinted nonwoven fabrics (SMI-PP) for the adsorption of SAA from aqueous solution using 3-acryloylaminophenylboronic acid, 1-vinylimidazole, and methacrylamido propyl trimethyl ammonium chloride as functional monomers. The adsorption kinetics conformed to a pseudo-second-order kinetic model, and the adsorption equilibrium could be reached within 24 h at 298.15 K with high adsorption selectivity. The maximum adsorption amount was found to be 89.847 mg/g calculated by Langmuir adsorption model. The adsorption mechanism was investigated in-depth via molecular orbital theory (MOT), electrostatic potential (ESP), independent gradient modeling (IGM), density functional theory (DFT), molecular dynamics (MD)，spectral analysis as well as adsorption model fitting, which can be inferred to involve covalent bond, electrostatic interaction and hydrogen bond. It is shown that SMI-PP is an efficient, highly selective, low-cost and easy-to-operate adsorbent for the effective adsorption and separation of SAA from aqueous solution.

2025-12-31·ANNALS OF MEDICINE

Propofol in combination with salvianolic acid A protect against lipopolysaccharide-induced cardiac dysfunction and ferroptosis through activating the SIRT1/FoxO1 signaling under diabetic condition

Article

作者: Zhang, Liangqing ; Han, Hong ; Xia, Zhengyuan ; Yi, Bin ; Zhu, Jianyu ; Chu, Qinjun ; Liu, Xin ; Zhou, Jiaqi ; Huang, Hemeng ; Mo, Guixi ; Han, Kaijia ; Han, Ronghui ; Tang, Jing ; Zhang, Anyuan ; Shao, Yiming ; Ma, Xiwen

BACKGROUND:

This study aimed to investigate the therapeutic potential of a combined low-dose propofol (PPF) and salvianolic acid A (SAA) regimen in mitigating lipopolysaccharide (LPS)-induced cardiac dysfunction and ferroptosis in diabetic contexts, and to explore the role of the sirtuin 1 (SIRT1)/forkhead box O1 (FoxO1) signaling pathway.

METHODS:

Type 2 diabetes (DM) was induced in mice, followed by LPS administration to induce cardiac injury. The mice were randomly assigned to six groups: control, DM, control + LPS, DM + LPS, DM + LPS + high-dose PPF, and DM + LPS + low-dose PPF + SAA. Cardiac function was assessed via echocardiography, while ferroptosis was evaluated with BODIPY staining and transmission electron microscopy. In vitro, H9c2 cardiomyocytes were treated with high glucose and LPS. Ferroptosis was assessed with FerroOrange and JC-1 staining. Oxidative stress and inflammatory cytokines were measured using ELISA or flow cytometry, and protein expression of key markers was analyzed.

RESULTS:

Diabetes aggravated LPS-induced cardiac injury in mice evidenced as impaired myocardial function, which was concomitant with decreased cardiac expression of SIRT1, FoxO1, and GPX4 proteins; increased production of oxidative stress, pro-inflammatory cytokines, oxidized lipids, and damaged mitochondrial cristae as compared to NC + LPS group. The combined use of PPF and SAA enhanced cardiac SIRT1 and FoxO1 and ameliorated LPS-mediated cardiac dysfunction in diabetic mice, but these beneficial effects were abolished by inhibition of SIRT1 or FoxO1. In vitro, hyperglycemia and LPS-induced cellular injuries were ameliorated by PPF and SAA, respectively. Low dose of PPF in combination with SAA reduced the production of ROS and ferroptosis that were concomitant with increased SIRT1 and FoxO1 expression, effects that were either comparable or superior to those achieved with high-dose PPF alone, but these protective effects were reversed by silencing SIRT1 or FoxO1.

CONCLUSION:

The combination of low-dose PPF and SAA effectively protects against LPS-induced cardiac dysfunction and ferroptosis in diabetic conditions by activating the SIRT1/FoxO1 pathway.

2025-12-01·Regenerative Therapy

Corrigendum to “Salvianolic acid A facilitates cartilage repair in knee osteoarthritis model rats by promoting WDR5 expression” [Regen Therapy 29C (2025) 77–90/880]

作者: Dong, Dali ; He, Hua

[This corrects the article DOI: 10.1016/j.reth.2025.02.010.].

100 项与丹酚酸A 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB15246

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病周围神经病变	临床2期	中国	中国医学科学院药物研究所	2021-05-11
糖尿病周围神经病变	临床2期	中国	中国医学科学院	2021-05-11
急性胸部综合征	临床1期	中国	上海医药集团股份有限公司	2022-07-21
心绞痛	临床1期	中国	上海医药集团股份有限公司	2018-11-29
心绞痛	临床1期	中国	Chia Tai Qingchunbao Pharmaceutical Co., Ltd.	2018-11-29
心绞痛	临床1期	中国	北京本草天源药物研究院	2018-11-29
糖尿病肾病	临床1期	-	中国医学科学院	-
周围神经系统疾病	临床1期	-	中国医学科学院	-
脓毒症	临床前	中国	中国药科大学	2025-09-01
坐骨神经病	临床前	中国	烟台市烟台山医院	2025-04-25