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更新于：2025-07-20
Imexon
更新于：2025-07-20
概要
基本信息
原研机构 |
在研机构- |
非在研机构 |
权益机构- |
最高研发阶段终止临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C4H5N3O |
InChIKeyBIXBBIPTYBJTRY-UHFFFAOYSA-N |
CAS号59643-91-3 |
关联
8
项与 Imexon 相关的临床试验NCT01314014
A Phase II Study of Amplimexon® (Imexon for Injection) for the Treatment of Previously Treated Follicular and Aggressive Lymphoma in Adults
NCT00697060
A Multicenter, Phase II Trial of the Safety and Efficacy of Amplimexon® (Imexon for Injection) in Combination With Taxotere® (Docetaxel) for Previously Treated Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00637247
A Phase 2 Randomized, Double-Blind, Multicenter Trial of Amplimexon® Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy Naïve Pancreatic Adenocarcinoma (Stage IV)
100 项与 Imexon 相关的临床结果
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100 项与 Imexon 相关的转化医学
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100 项与 Imexon 相关的专利（医药）
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110
项与 Imexon 相关的文献（医药）2024-11-01Translational Oncology
Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance
Article
作者: Zhang, Kangnan ; Zhou, Jingyi ; Zhu, Zhenhua ; Wang, Na ; Xu, Ling ; Yu, Fudong ; Shi, Min
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin contraction. Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. This study sourced pan-cancer mRNA expression data from Xena to thoroughly evaluate the molecular and clinical characteristics of disulfidptosis-related genes. Through unsupervised clustering, mRNA expression data identified the expression levels of disulfidptosis-related genes and potential clusters related to this form of cell death. Kaplan-Meier survival curves illustrated the correlation between different clusters and overall survival. The findings reveal that high expression of disulfidptosis-related genes is linked to poor survival in liver cancer. The GDSC database was utilized to analyze the relationship between disulfidptosis-related genes and the AUC of 198 drugs. The results demonstrate that 12 disulfidptosis-related genes influence sorafenib resistance, as revealed by the intersection of differential genes related to sorafenib resistance from the GSE109211 dataset. Among them, the MYH9 gene was found to play a crucial role in both. Finally, experimental evidence confirmed that MYH9 mitigates sorafenib resistance in hepatocellular carcinoma through disulfidptosis-like changes. This study identifies disulfidptosis as a promising avenue for enhancing the sensitivity of tumor cells to drugs, offering new therapeutic perspectives for future research on disulfidptosis and drug resistance in cancer patients.
2024-08-01CELL BIOLOGY INTERNATIONAL
Single‐cell and bulk RNA‐sequencing reveals mitosis‐involved gene HAUS1 is a promising indicator for predicting prognosis and immune responses in prostate adenocarcinoma (PRAD)
Article
作者: Yu, Yang ; Xu, Jie ; Wang, Yi ; Li, Deng ; Liu, Shiwei
Abstract:
It was imperative to identify latent biomarkers pertinent to malignancies, given the pivotal role targeted molecular therapies play in tumor treatment investigations. This study aimed to assess the validity of HAUS1 as an indicator for survival prognosis and immune responses in prostate adenocarcinoma (PRAD) via single‐cell and bulk RNA‐sequencing. Related data on HAUS1 expression in PRAD were obtained from online databases, followed by comprehensive analyses to delineate its associations with survival prognosis, implicated pathways, and immune responses. Besides, the expression pattern of HAUS1 in PRAD was also verified in vitro, by using qRT‐PCR, Western blot analysis, and immunohistochemistry. We found HAUS1 was downregulated in PRAD compared with normal tissues, as verified in vitro by qRT‐PCR, Western blot, and immunohistochemistry (p < 0.05). Single‐cell RNA‐sequencing analysis indicated that HAUS1 had relatively higher expressions in B cells, Mono/Macro cells, and Endothelial cells compared with other cell types. Cox regression analysis revealed HAUS1 could serve as an independent indicator for the overall survival prognosis of PRAD (p < 0.05). Spearman correlation analyses revealed HAUS1 was closely related to the tumor microenvironment, immune cell infiltration levels, immune checkpoints, and immune cell pathways (p < 0.05). Furthermore, HAUS1 expression was found to be closely related to the immunotherapeutic response of patients receiving clinical intervention (p < 0.05). Collectively, our findings underscored the significant role of HAUS1 in PRAD prognosis and immune response, thereby presenting a novel and promising avenue for investigating the clinical utility of immunotherapy in PRAD.
2023-05-01JOURNAL OF MOLECULAR LIQUIDS
Adsorption of 40 low molecular weight drugs on pristine and fluorinated C60 fullerenes: Ab initio, statistical and neural networks analysis
作者: Kochaev, Alexey I. ; Grekova, Anastasiya A. ; Maslov, Mikhail M. ; Katin, Konstantin P. ; Bondarev, Nikolay V. ; Kaya, Savas ; Bauetdinov, Yusupbek A. ; Kalika, Elizaveta B.
Loading of 40 small drugs mols. with mol. weights in 47-210 g/mol range consisted of H, C, N, O, F, S elements on C60, C60F2 and C60F48 fullerenes are studied with the d. functional theory.Adsorption energies as well as deformation energies of fullerenes and drugs are calculatedThe C60F2 is recognized as the most active drugs adsorbent.Mean adsorption energies averaged over all considered drugs are 0.41, 0.59 and 0.54 eV with standard deviations of 0.10, 0.09 and 0.14 eV for C60, C60F2 and C60F48 fullerenes, resp.Mean energies of drug-induced deformations of C60, C60F2 and C60F48 are 8.6, 12.0 and 16.6 meV, resp.Multilinear regressions and neural networks were proposed for prediction of adsorption energies based on dipole moments and frontier MOs of the drugs.Achievable accuracy of such predictions is about 0.1 eV.Altretamine antibiotic is recognized as the notable drug possessing extremely high binding energies about 1 eV with fullerenes.IR spectral shifts due to its loading on fullerene carriers are calculated
100 项与 Imexon 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 转移性非小细胞肺癌 | 临床2期 | 美国 | 2010-08-01 | |
| 转移性胰腺腺癌 | 临床2期 | 美国 | 2008-04-01 | |
| 多发性骨髓瘤 | 临床2期 | 美国 | 2005-10-01 | |
| 不可切除的黑色素瘤 | 临床2期 | 美国 | 2005-07-01 | |
| 乳腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 去势抵抗性前列腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 晚期胰腺腺癌 | 临床1期 | 美国 | 2004-02-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | B细胞淋巴瘤 CD68 | GPX1 | SOD2 | - | Imexon 1000 mg/m(2) | 構鹽膚鏇製顧壓糧顧餘(遞範壓製壓積顧鹹選壓) = 鏇構遞蓋選鏇鹹襯網鹹 壓顧鏇顧築鬱醖選艱簾 (蓋願憲鹽遞膚膚構鹽鹽 ) | - | 2014-08-21 | |
临床2期 | 22 | 選願餘構願蓋衊願願襯 = 獵襯壓糧襯獵糧繭糧艱 積糧衊簾選遞醖鑰窪壓 (窪醖糧簾繭壓壓淵築鑰, 衊艱餘糧壓築構廠簾觸 ~ 齋憲夢獵醖壓簾鏇蓋鏇) 更多 | - | 2014-07-01 | |||
临床2期 | 142 | (Imexon + Gemcitabine) | 衊膚範淵獵襯製壓獵繭 = 繭艱窪鑰鏇窪糧衊壓憲 構觸蓋壓鏇築製鏇製積 (網鏇網遞遞網構衊範齋, 膚築蓋蓋簾衊網構膚糧 ~ 窪網廠願築膚蓋顧構夢) | - | 2010-11-30 | ||
imexon placebo + gemcitabine (Placebo + Gemcitabine) | 衊膚範淵獵襯製壓獵繭 = 鹽壓構膚鏇選鑰鬱廠簾 構觸蓋壓鏇築製鏇製積 (網鏇網遞遞網構衊範齋, 夢窪艱醖觸遞衊窪襯壓 ~ 齋獵選積鏇廠觸齋糧觸) | ||||||
临床1期 | 34 | 廠淵齋觸襯窪餘鹹壓範(襯遞構鑰構淵餘膚襯繭) = 餘鏇齋鑰壓艱遞蓋齋網 範淵襯積積窪網醖憲廠 (憲壓糧繭醖繭憲蓋願鹽 ) | - | 2010-10-01 | |||
临床1/2期 | 68 | 顧構繭夢糧憲襯簾襯鹹(醖積鏇膚糧衊範夢簾窪) = 顧齋襯簾簾願齋願衊鏇 艱窪淵獵淵獵憲艱廠糧 (鬱選範鏇簾簾淵網夢淵 ) 更多 | - | 2010-08-01 | |||
临床1期 | 胰腺癌 一线 | 105 | 鏇簾網壓鑰選襯衊構願(壓構衊構顧繭壓觸遞遞) = 顧選構遞積鹽鑰艱網齋 膚蓋醖鑰艱簾積鹽獵鬱 (衊製艱繭鏇鹽餘選顧鏇 ) | - | 2010-07-01 | ||
临床1期 | 29 | 網鹹壓齋膚窪簾鏇遞網(鬱鬱鬱遞簾顧構蓋鹹獵) = transient, grade 3–4 non cardiac chest pain (w/o enzyme elevations or EKG changes) in 3/3 pts with pulmonary metastases 觸醖鬱糧壓鏇廠襯襯蓋 (築壓鏇遞鹽鬱選餘鹹鬱 ) 更多 | - | 2008-05-20 | |||
临床1/2期 | 68 | 顧觸顧網膚繭網淵鹹蓋(壓製鏇餘構膚遞積壓鏇) = Seven Pts had SAEs that were possibly or definitely related to treatment 鏇襯糧觸製廠膚鏇夢顧 (網遞夢糧鏇鏇願淵膚壓 ) 更多 | - | 2008-05-20 | |||
临床1期 | 30 | 選網夢構製鑰夢遞遞鏇(獵觸願鹹憲繭鏇簾鹽顧) = 窪選窪壓構淵簾積窪夢 鹽窪範窪醖醖鏇襯構淵 (廠襯鹽糧鑰餘糧鬱糧襯 ) | - | 2005-06-01 |
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