预约演示
更新于：2026-10-27
Fluocinolone Acetonide/Hydroquinone/Tretinoin
氟轻松丙酮酯/氢醌/维A酸
更新于：2026-10-27
概要
基本信息
药物类型 小分子化药 |
别名 Hydroquinone/tretinoin/fluocinolone-acetonide、Tri-Luma、孚立美 |
作用方式 激动剂、抑制剂 |
作用机制 GR激动剂(糖皮质激素受体激动剂)、RARα激动剂(维甲酸受体α激动剂)、RARβ2激动剂(维甲酸受体β激动剂) |
在研适应症 |
非在研适应症 |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2002-01-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C24H30F2O6 |
InChIKeyFEBLZLNTKCEFIT-VSXGLTOVSA-N |
CAS号67-73-2 |
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关联
10
项与 氟轻松丙酮酯/氢醌/维A酸 相关的临床试验IRCT20220919055994N3
Evaluating the Effectiveness of Cispersa Cream Compared to Tri-luma Formulation in the Treatment of Melasma
CTR20244786
评价氟轻松氢醌维A酸乳膏治疗中、重度黄褐斑的疗效和安全性的多中心、随机、双盲、三臂、平行、安慰剂对照临床试验
CTRI/2024/10/075324
A split face study to compare efficacy and safety of Modified Kligman Formula (Hydroquinone 2% + Tretinoin 0.05% + Flucinolone Acetonide 0.01%) with Topical Metformin 30% in the patients with Melasma - A Prospective Comparative Study in Tertiary Care Hospital - NIL
100 项与 氟轻松丙酮酯/氢醌/维A酸 相关的临床结果
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100 项与 氟轻松丙酮酯/氢醌/维A酸 相关的转化医学
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100 项与 氟轻松丙酮酯/氢醌/维A酸 相关的专利（医药）
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5
项与 氟轻松丙酮酯/氢醌/维A酸 相关的文献（医药）2026-05-01JAAD case reports
Near-complete clinical improvement of an extensive congenital acantholytic epidermal nevus treated with topical fluocinolone acetonide/hydroquinone/tretinoin (Tri-luma): A case report
Article
作者: Rivera Ocampo, Stefania
2025-05-01Journal of Cosmetic Dermatology
Efficacy and Safety of Generic Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream Compared With TRI‐LUMA for the Treatment of Moderate‐To‐Severe Melasma in Chinese Patients: A Randomized, Single‐Center, Placebo‐Controlled Trial
Article
作者: Lunfei Liu ; Chengyao Zhu ; Honghua Hu ; Pengfei Zhou ; Hongliang Yao ; Bo Shen ; Xiangke Yu ; Bo Feng
ABSTRACT:
Background:
Treatment with fluocinolone acetonide, hydroquinone, and tretinoin cream is the gold standard for melasma; however, the effects of this treatment in the Chinese population remain unclear. Due to the differences between Chinese and Caucasian subjects, further clinical trials in Chinese patients with melasma are needed.
Aim:
To evaluate the efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin creams in Chinese patients with moderate‐to‐severe melasma.
Methods:
We recruited 53 patients who received a generic formulation (triple combination cream, TCC), brand formulation (TRI‐LUMA), or placebo once daily for 8 weeks. In weeks 4 and 8, efficacy was evaluated based on the Melasma Severity Scale and Melasma Area and Severity Index. In addition, safety was assessed based on the incidence and severity of treatment‐emergent adverse events.
Results:
The generic TCC group achieved 52.2% efficacy compared to 57.1% in the TRI‐LUMA group. There was no significant difference in the incidence of adverse effects between the TCC and TRI‐LUMA groups (69.6% and 90.5%, respectively; p > 0.05). The incidence of adverse events in the placebo group was 0%.
Conclusion:
Generic TCC was as effective as TRI‐LUMA and had a similar safety profile in this study of Chinese subjects with moderate‐to‐severe melasma.
2016-11-01Journal of drugs in dermatology : JDD4区 · 医学
The Efficacy of Q-Switched ND:YAG 1064 nm Laser in Recalcitrant Macular Amyloidosis: A Case Report.
4区 · 医学
Article
作者: Khurana, Nevil ; Urman, Christine
Macular amyloidosis typically presents as small, dusky-brown or greyish pigmented macules, the result of altered keratin deposition. Treatment of these hyperpigmented regions with topical and systemic therapies remains challenging, however Q-Switched neodymi- um-doped yttrium aluminum garnet (ND:YAG) laser has proven to be an effective treatment modality to reduce hyperpigmentation. In this case report we investigated the ef cacy of Q-Switched Nd:YAG laser treatment on a 34-year old woman with recalcitrant macular amyloidosis who failed to respond to over-the-counter bleaching creams. The patient was treated with 7 treatment sessions of Q- Switched Nd:YAG laser at one month intervals. According to our photographic analysis and patient self-assessment, the patient ap- peared to improve with each treatment session. Post-recurrence of the lesion after reaction to Triluma ( uocoinolone actetonide 0.01%, hydroquinone 4%, tretinoin 0.05%), the patient has been continuing to respond well to a second round of treatment with Q-switched Nd:YAG laser at 1064 nm. J Drugs Dermatol. 2016;15(11):1456-1458..
100 项与 氟轻松丙酮酯/氢醌/维A酸 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黄褐斑 | 美国 | 2002-01-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 雀斑样痣 | 临床2期 | 智利 | - | 2008-08-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 50 | Cryotherapy (CRY-AC3® device)+Tri-luma (Group 1) | 積鹹餘願網艱膚獵鏇夢(鏇獵範蓋築齋顧遞簾廠) = 蓋憲齋餘糧鬱齋鏇製繭 鑰艱餘鬱觸壓餘鬱醖選 (積淵築範鑰繭選構廠窪, 7.0) 更多 | - | 2020-09-17 | ||
Cryotherapy (CRY-AC3® device) (Group 2) | 積鹹餘願網艱膚獵鏇夢(鏇獵範蓋築齋顧遞簾廠) = 鏇繭觸廠憲齋遞襯齋窪 鑰艱餘鬱觸壓餘鬱醖選 (積淵築範鑰繭選構廠窪, 11.0) 更多 | ||||||
临床4期 | 56 | (Intense Pulsed Light (IPL) / Tri-Luma® Cream) | 製鬱艱齋鬱範鹽鏇獵淵 = 衊蓋窪積製鹹艱艱鏇鑰 構築積鹽遞糧範遞積網 (餘選齋鹹齋製願壓範簾, 範鹽積夢獵網選蓋網築 ~ 壓範積艱壓網遞獵積憲) 更多 | - | 2010-01-11 | ||
Cetaphil (Intense Pulsed Light (IPL) / Inactive Control Cream) | 製鬱艱齋鬱範鹽鏇獵淵 = 鏇遞蓋襯窪簾廠網獵齋 構築積鹽遞糧範遞積網 (餘選齋鹹齋製願壓範簾, 鑰願襯觸鏇網淵艱觸鑰 ~ 淵顧製餘餘選鹽獵鹽範) 更多 |
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