According to Boehringer, the development of a new schizophrenia treatment targeting GPR52 has the potential to address all three aspects of schizophrenia — ‘positive’ symptoms (psychosis, delusions and hallucinations), ‘negative’ symptoms (social withdrawal and apathy) and cognitive symptoms (attention, planning and memory deficits).
In the deal, Sosei will receive an upfront payment of $27.3 million (€25 million) from Boehringer, and is eligible for an option exercise payment of $65.6 million (€60 million) and further development, regulatory and commercialization milestone payments totaling up to $732.7 million (€670 million).