AstraZeneca signs licence deal with KYM Biosciences for ADC CMG901

2023-02-24
Pharmaceutical Technology
引进/卖出临床1期抗体药物偶联物
KYM Biosciences’ CMG901 is being developed to treat gastric cancers. Credit: Nephron / Wikimedia.
KYM Biosciences sCMG901a global exclusive licence aggastric cancersM Biosciences for the latter’s Claudin-18.2 antibody-drug conjugate (ADC), CMG901.
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KYM Biosciences is a joint venture (JV) established by Chinese biotechnology firm Keymed Biosciences and Lepu Biopharma.
Under the licence deal, AstraZeneca will handle the research and activities related to the development, manufacturing, and commercialisation of CMG901 globally.
CMG901 comprises an anti-Claudin 18.2 monoclonal antibody, a cytotoxic small molecule monomethyl auristatin E (MMAE) and a protease-degradable linker.
KYM Bioscienceseloped to treat solid tumours that express the Claudin 18.2 cell suKeymed BiosciencesludinLepu Biopharmaers.
Currently, the ADC is beAstraZenecad in a Phase I clinical trial to treat Claudin 18.2-positive solid tumours, including gastric cancer.CMG901
CMG901ing to the trianti-Claudin 18.2 monoclonal antibodynd to have a favourable safety and tolerability profile and encourage anti-tumour efficacy across the tested dose levels.
AstraZeneca Oncology R&D Biologsolid tumoursng & Oncology TargClaudin 18.2y senior vice-president Puja Saprgastric cancers excited by the opportunity to accelerate the development of CMG901, a potential new medicine for patients with Claudin18.2-expressing cancers.
“CMG901 strengthens our growing pipeline of antibody-drug conjugates and sClaudin 18.2-positive solid tumourstment optiongastric cancerm outcomes for patients with gastrointestinal cancers.”
According to the agreement, KYM BiosciencesCMG901receive $63m in upfront payment on the closing of the transaction along with up to tumour in further development and sales-related milestones from AstraZeneca.
AstraZeneca Oncologyo receive tiered royalties up to low double digits.CMG901Claudin18.2-expressing cancers
TCMG901nsaction, subject to regulatory clearances and customary closing conditions, is anticipated to be concluded in the first half of this year.gastrointestinal cancers
Early R&D projects coverage KYM Biosciencesal Technology is supported by Mimotopes.AstraZeneca
Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
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