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China Pharmaceutical Research & Development Center Co., Ltd.
更新于：2025-12-21
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CTR20222817
评估CRB4101片在健康成人受试者中单次给药的安全性、耐受性、药代动力学和药效动力学的Ⅰ期临床试验
CTR20220597
评价NIP142胶囊在EGFR突变阳性的局部晚期/转移性非小细胞肺癌患者中的安全性、耐受性、药代动力学特征和有效性的单臂、开放、多中心的Ia/Ib期临床试验
CTR20220772
一项随机、双盲、安慰剂对照、多次给药、剂量递增的Ib期临床研究评价NIP046在健康受试者中的安全性、耐受性以及药代动力学特征
100 项与 中国医药研究开发中心有限公司 相关的临床结果
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2021-12-23Anti-Cancer Agents in Medicinal Chemistry4区 · 医学
Lophira alata Suppresses Phorbol Ester-Mediated Increase in Cell Growth via Inhibition of Protein Kinase C-α/Akt in Glioblastoma Cells
4区 · 医学
Article
作者: Ezenyi, Ifeoma ; Amos, Samson ; Okhale, Samuel ; Lin, Stacy ; Emeje, Martins ; Jean-Louis, Denise
Background::
Medicinal plants serve as sources of compounds used to treat other types of cancers. The root of the plant Lophira alata (Ochnaceae) has been used as a component of traditional herbal decoctions administered to cancer patients in southwestern Nigeria. However, the mechanism of the cytotoxic effects of Lophira alata alone or in the presence of phorbol ester has not been investigated in brain tumor cells.
Objective::
This study was aimed at examining the cytotoxic potential of the methanolic fraction of Lophira alata root on malignant glioma invasive cellular growth and survival.
Method::
The methanolic fraction of Lophira alata (LAM) was subjected to high-performance liquid chromatography to determine the fingerprints of the active molecules. The antiproliferative effects of Lophira alata were assessed using the MTT and LDH assays. Protein immunoblots were carried out to test the effects of Lophira alata, alone or in the presence of phorbol ester, on survival signaling pathways such as Akt, mTOR, and apoptotic markers such as PARP and caspases.
Results::
The methanolic fraction of Lophira alata (LAM) induced a concentration-dependent and time-dependent
decrease in glioma cell proliferation. In addition, LAM attenuated phorbol ester-mediated signaling of
downstream targets such as Akt/mTOR. Gene silencing using siRNA targeting PKC-alpha attenuated LAM-mediated
downregulation of Akt. In addition, LAM induced both PARP and caspase cleavages. The HPLC fingerprint
of the fraction indicates the presence of flavonoids.
Conclusion::
LAM decreases cell proliferation and induces apoptosis in glioma cell lines and thus could serve as a therapeutic molecule in the management of gliomas.
2014-01-01JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Formulation and in vitro evaluation of pH-responsive ethosomes for vaginal delivery of metronidazole
作者: Adikwu, M. ; Attama, A. ; Kunle, O. ; Builders, P. ; Nzekwe, I. ; Mbah, C.
PH-responsive metronidazole ethosomes (ME) were formulated by solvent evaporation method using Phospholipon 90 H (P90H) and evaluated for vaginal delivery.Differential scanning calorimetry showed no interaction between metronidazole and P90H.SEM (SEM) showed formation of spherically-shaped vesicles.The average vesicle size was 179.9 nm with PDI of 0.338.The entrapment efficiency (EE) and loading capacity (LC) were 50.31 ± 3.38 % and 39.89 ± 0.02 %, resp.Over pH of 6.5-5.0, the permeation and flux were of the order: ME 5.6 > ME 5.0 > ME 6.5, resp., with ME 5.6 showing, significantly (P < 0.05) the highest release profile.Ethosome vesicles were formed which entrapped the metronidazole mols.The optimized ethosome gel (ME 5.6) exhibited pseudo-plastic flow behavior typical of non-Newtonian fluids and showed potentials for sustained delivery compared to the aqueous dispersion.This may be replicated in the vagina to cause increased local and systemic bioavailability of metronidazole.
Journal of medicinal plant research
Phytochemicaland proximate analyses and thin layer chromatography fingerprinting of the aerial part of Chenopodium ambrosioides Linn. (Chenopodiaceae)
作者: Kunle, Oluyemisi Folashade ; Ona, Eneyi Comfort ; Okhale, Samuel Ehiabhi ; Egharevba, Henry Omoregie
The aerial part of Chenopodium ambrosioides L., reputable for the treatment of malaria and diabetes in Nigeria, was qual. screened for the presence of secondary metabolites using standard methods.Some proximate parameters were also determinedThe result of the phytochem. screening revealed the presence of alkaloids, tannins, saponins, flavonoids, terpenes, sterols, cardenolide aglycon, volatile oils and carbohydrates.The proximate anal. revealed moisture content of 10.90%, total ash value of 14.65%, acid-insoluble ash value of 3.05%, water-soluble ash of 6.25%, water-soluble extractive value of 3.18% and alc.-soluble extractive value of 13.20%.The thin layer chromatog. fingerprinting and phytochem. screening revealed several chem. components, which could be isolated from the plant.Thus, C. ambrosioides is a potential drug plant considering the rich phytochem. and proximate pharmacognostic profile of the aerial part, hence its folkloric uses.The result of this study is the first of its kind on the Nigerian species of this plant drug and is informative for standardization and monograph development of this herbal plant.
100 项与 中国医药研究开发中心有限公司 相关的药物交易
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100 项与 中国医药研究开发中心有限公司 相关的转化医学
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