预约演示
更新于：2025-08-29
CNBG-Virogin Biotech (Shanghai) Ltd.
中生复诺健生物科技（上海）有限公司|合资公司 | 子公司|2019|中国上海市
中生复诺健生物科技（上海）有限公司|合资公司 | 子公司|2019|中国上海市
更新于：2025-08-29
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肿瘤
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溶瘤病毒
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NCT06124001
An Open-label Phase Ib/IIa Clinical Trial of VG161 Combined With Camrelizumab in the Treatment of Advanced Primary Hepatocellular Carcinoma
NCT06126510
A Single-arm, Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of VG161 in the Treatment of Advanced Bone and Soft Tissue Sarcoma
NCT06113731
A Randomized, Blinded, Controlled Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of a COVID-19 mRNA Vaccine (ZSVG-02-O) in a Healthy Population 18 Years of Age and Older
100 项与 中生复诺健生物科技（上海）有限公司 相关的临床结果
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2025-07-02ACS Applied Materials & Interfaces
Lipid Nanoparticles Consisting of Sterol-Conjugated Ionizable Lipids Enable Prolonged and Safe mRNA Delivery
Article
作者: Wu, Tengjie ; Zhou, Yiming ; Zhang, Yuntao ; Gao, Yanxia ; Wang, Chenglong ; Jia, William ; Pan, Xinping
mRNA offers a promising therapeutic approach for gene therapy, cancer treatment, and vaccine development. Lipid nanoparticles (LNPs) have emerged as a primary delivery system for mRNA. Ionizable lipids are key components of LNPs. Given the current limitations of LNPs regarding efficacy, safety, and stability, we undertook this research. We synthesized 11 asymmetric sterol-conjugated ionizable lipids. These lipids and their resulting LNP formulations were screened. Five of these ionizable lipids were selected, and a 40-50% molar ratio was determined to be optimal for the LNP formulation. Luciferase mRNA-loaded LNPs formulated with sterol-conjugated ionizable lipids demonstrated luminescence comparable to that of commercial LNPs composed of ALC-0315 and prolonged protein expression in mice. Furthermore, accelerated stability studies demonstrated that LNPs exhibited good stability. Additionally, LNPs loaded with varicella-zoster virus (VZV) gE mRNA successfully induced both humoral- and T-cell-mediated immune responses. Finally, in vivo safety studies revealed that LNPs based on these ionizable lipids exhibited improved safety profiles compared with commercially available LNPs. In conclusion, these sterol-conjugated ionizable lipid nanoparticles enable prolonged and safe mRNA delivery, representing a significant advance in mRNA delivery technology.
2023-05-01Journal of medical virology
Combination of novel oncolytic herpesvirus with paclitaxel as an efficient strategy for breast cancer therapy
Article
作者: Deng, Xinyue ; Shen, Yinan ; Jia, Weiguo ; Zhao, Bin ; Zhang, Chaomei ; Ding, Jun ; Dai, Zhijun ; Leng, Qi ; WeiyangLou ; Xue, Dixuan ; Zhao, Ronghua ; Yi, Ming ; Dong, Chenfang ; Zhong, Guansheng
Abstract:
Background:
New strategies are needed to improve the treatment of patients with breast cancer (BC). Oncolytic virotherapy is a promising new tool for cancer treatment but still has a limited overall durable antitumor response. A novel replicable recombinant oncolytic herpes simplex virus type 1 called VG161 has been developed and has demonstrated antitumor effects in several cancers. Here, we explored the efficacy and the antitumor immune response of VG161 cotreatment with paclitaxel (PTX) which as a novel oncolytic viral immunotherapy for BC.
Methods:
The antitumor effect of VG161 and PTX was confirmed in a BC xenograft mouse model. The immunostimulatory pathways were tested by RNA‐seq and the remodeling of tumor microenvironment was detected by Flow cytometry analysis or Immunohistochemistry. Pulmonary lesions were analyzed by the EMT6‐Luc BC model.
Results:
In this report, we demonstrate that VG161 can significantly represses BC growth and elicit a robust antitumor immune response in a mouse model. The effect is amplified when combined with PTX treatment. The antitumor effect is associated with the infiltration of lymphoid cells, including CD4+ T cells, CD8+ T cells, and NK cells (expressing TNF and IFN‐γ), and myeloid cells, including macrophages, myeloid‐derived suppressor cells, and dendritic cell cells. Additionally, VG161 cotreatment with PTX showed a significant reduction in BC lung metastasis, which may result from the enhanced CD4+ and CD8+ T cell‐mediated responses.
Conclusions:
The combination of PTX and VG161 is effective for repressing BC growth by inducing proinflammatory changes in the tumor microenvironment and reducing BC pulmonary metastasis. These data will provide a new strategy and valuable insight for oncolytic virus therapy applications in primary solid or metastatic BC tumors.
Nature communications1区 · 综合性期刊
mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge
1区 · 综合性期刊
ArticleOA
作者: Yu, Zhibin ; Liu, Xiaohu ; Yang, Xiaoming ; Hua, Xianwu ; Jia, William ; Huang, Hongwei ; Zhang, Yuntao ; Xu, Jiang ; Ding, Jun ; Zhao, Ronghua ; Hou, Fujun ; Murad, Yanal M ; Song, Yingying
Abstract:
The recent outbreaks of mpox have raised concerns over the need for effective vaccines. However, the current approved vaccines have either been associated with safety concerns or are in limited supply. mRNA vaccines, which have shown high efficacy and safety against SARS-CoV-2 infection, are a promising alternative. In this study, three mRNA vaccines are developed that encode monkeypox virus (MPXV) proteins A35R and M1R, including A35R extracellular domain -M1R fusions (VGPox 1 and VGPox 2) and a mixture of encapsulated full-length mRNAs for A35R and M1R (VGPox 3). All three vaccines induce early anti-A35R antibodies in female Balb/c mice, but only VGPox 1 and 2 generate detectable levels of anti-M1R antibodies at day 7 after vaccination. However, all three mRNA vaccine groups completely protect mice from a lethal dose of vaccinia virus (VACV) challenge. A single dose of VGPox 1, 2, and 3 provide protection against the lethal viral challenge within 7 days post-vaccination. Long-term immunity and protection were also observed in all three candidates. Additionally, VGPox 2 provided better passive protection. These results suggest that the VGPox series vaccines enhance immunogenicity and can be a viable alternative to current whole-virus vaccines to defend against mpox.
100 项与 中生复诺健生物科技（上海）有限公司 相关的药物交易
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100 项与 中生复诺健生物科技（上海）有限公司 相关的转化医学
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