Guizhou Medical University

贵医科研团队新发现 近日，贵州医科大学青年教师雷莉主导完成的研究论文“Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy”，发表于材料学国际顶级期刊Advanced Materials（IF:27.4）。该研究设计构建去铁胺（DFO）纳米药物，通过靶向细胞质和线粒体的不稳定铁池(LIP)，减少铁聚集、清除ROS过载，进而抑制多巴胺能神经元铁死亡，改善帕金森病的作用机制研究。 工程化纳米药物BDPR NSs在细胞、线虫和小鼠帕金森病模型中的神经保护作用及机制示意图。 帕金森病（Parkinson disease，PD）是仅次于阿尔茨海默病第二常见的老年性多因素疾病，其核心病理特征是中脑黑质多巴胺能神经元进行性的丢失（死亡），常伴有中脑黑质的铁聚集（Fe离子浓度异常增高）的现象。 LIP主要位于细胞质、细胞器的微环境，由与低亲和力配体结合的Fe离子组成，允许铁的摄取、利用、分布和输出。LIP中过度的游离Fe2+通过Fenton反应加剧活性氧（ROS）的形成，导致ROS过载和铁稳态失衡，进而诱导铁死亡。铁死亡是近年来发现并深入研究的铁依赖调节性细胞死亡，被认为是引起PD多巴胺能神经元不可逆退行性丢失的重要途径之一。因此，通过靶向调控LIP稳态是抑制PD多巴胺能神经元铁死亡的重要策略。 基于此，该团队利用黑磷纳米片作为抗氧化剂和载体负载“临床老药”去铁胺（DFO），并共价耦联脑靶向肽RVG29，构建多功能DFO纳米药物（BDPR NSs）。该纳米药物能够螯合游离Fe并抑制铁聚集，从而改善细胞LIP的超负荷、调控铁代谢稳态，并减少ROS产生。 此外，BDPR NSs可以聚积在线粒体中，抑制线粒体ROS生成和减少线粒体铁聚集，进而改善线粒体功能障碍。基于受体介导的靶向，BDPR NSs能够有效透过血脑屏障、靶向多巴胺能神经元，在PD病灶区特异性清除ROS和铁聚集，调节铁稳态和降低脂质过氧化，进而抑制铁死亡缓解多巴胺能神经元丢失和运动功能障碍，在PD细胞、线虫及小鼠模型中表现出良好的神经保护作用。该研究表明BDPR NSs具有作为PD临床治疗的新型纳米药物的潜力。 团队介绍 INTRODUCTION 贵州医科大学张春林教授和汤磊教授为该文章的共同通讯作者，基础医学院雷莉副教授、2024届毕业研究生袁佳丽、代志军副教授为文章的并列第一作者，基础医学院多名师生参与该研究。贵州省医学分子生物学重点实验室、贵州医科大学分子医学工程研究中心和基础医学科学研究中心提供了仪器和技术支持。该研究受多项国家自然科学基金资助，也是学校近年来围绕“双一流”内涵建设，持续完善创新团队和优秀青年科技人才政策体系的成果之一。 雷莉博士是贵州医科大学引进的博士青年人才，主要从事靶向递药系统和生物活性载体材料相关科研工作：研究设计构建系列智能纳米递送体系应用于帕金森病、阿尔兹海默症及恶性肿瘤等疾病诊治的研究；先后承担国家自然科学基金、省科技厅项目及省卫生健康委项目等；曾在多家学术期刊上发表7篇研究论文。近3年入职以来，以贵州医科大学为第一单位在Advanced Materials（1篇）；Chemical Engineering Journal（2篇）；Nano Convergence（1篇）；RSC Advances（1篇）以及中国生物化学与分子生物学报（1篇）等期刊发表多篇文章。 来源：天眼新闻 排版：杨茜 编辑：李菡逸 一审：李牧 二审：钱禾 三审：陈颖  往期回顾 RECENTLY RELEASED 再创佳绩！贵州医科大学国家自然科学基金立项120项 (⁎⁍̴̛ᴗ⁍̴̛⁎) 给你一节课的时间沉浸式阅读 打开！2024级新生与贵医的第一张照片 贵州医科大学版权所有 期待投稿合作 邮箱：gmctougao@163.com

BEIJING, Sept. 18, 2023 /PRNewswire/ -- "For this surgery, we have prepared for more than half a year," Xiao Yuehai told the Global Times when talking about the first laparoscopic surgery carried out in Solomon Islands. Xiao is an urologist from the Affiliated Hospital of Guizhou Medical University (AHGMU) and a member of the second group of Chinese medical workers dispatched to the Solomon Islands. "We reused the laparoscope machines and organized a new one. This helped us save at least 4 million yuan ($548,320)," Xiao said proudly. The first laparoscopic surgery was conducted by Solomon Islands doctors under the guidance of Chinese medical staff. As of August 22, two such surgeries had been conducted. "In the past, local doctors had to make an opening of 15-20 centimeters on the patient's torso when they conducted the surgery. The patient would lose a large amount of blood and have to be hospitalized for about one week before leaving the hospital. But now, they can leave the hospital two days after the surgery is completed," Xiao said. Meaningful exchanges This is not just happening in the Solomon Islands, but the whole South Pacific Islands region. According to a fact sheet on cooperation between China and Pacific Island Countries (PICs) the Chinese Foreign Ministry released in May 2022, China has sent a total of 600 medical workers to PICs, who have treated 260,000 local patients, provided free medical services on over 100 occasions, and donated a significant amount of both medical machines and medicines. They have helped improve local residents' health and local medical service capacity. In 2014, the China-assisted Navua Hospital opened to the public in Fiji, bringing benefits to over 30,000 local residents, according to the sheet. In January 2016, the China-Australia-PNG Malaria Prevention Program was officially launched in Papua New Guinea (PNG), effectively enhancing the ability of malaria prevention and treatment. In October 2017, the Shenzhen municipal government helped launch malaria elimination program in the Kirivina Islands of PNG, reducing the local community's vulnerability to malaria, the sheet noted. After the start of COVID-19, the two sides have been helping each other combat the disease. China has held more than 10 bilateral or multilateral public health expert meetings via video link with PICs, which have established diplomatic relations with China, to share experience covering disease prevention, control, treatment and diagnosis. China has actively provided vaccines, supplies and financial assistance to PICs, helping the latter build quarantine cubicles and other facilities. As of May 2022, China had provided PICs with 590,000 doses of vaccines and over 100 tons of supplies, according to the sheet. Restricted by their geographic location, medical standards across Pacific Islands Countries and the connectivity between the countries remains low, meaning local residents have difficulty in accessing treatment when faced with serious health issues. China's medical support not only brings medicines and equipment to the region, but also advanced technologies, which have helped improve the development of local medical care and bolster the development of the friendship between China and the entire region. The Chinese medical team also helps the Solomon Islands to organize an emergency medical team for the upcoming 2023 Pacific Games that is scheduled to be held in Honiara, Solomon Islands, between November 19 and December 2. Chinese doctors' selfless contribution has won respect and recognition of local governments and residents. In July, as Vanuatu celebrated the 43rd anniversary of its independence, Vanuatu President Nikenike Vurobaravu awarded nine members of the first Chinese medical team with state medals in recognition of their significant contribution to improving local medical standards and consolidating the China-Vanuatu cooperation in medical treatment and public health. Teaching a man to fish Apart from providing medical services directly to local residents, Chinese medical teams also train local medical staff "how to fish" through lectures, clinical practice and training sessions, which serve to enhance local medical capacity. According to the Xinhua News Agency, from 2002 to July 2023, Chinese medical teams to Papua New Guinea held more than 11,000 training courses and held at least 70 lectures to local medical workers. They also provided training for the use of 240 technologies that had never been available in the country. Medical teams in the Solomon Islands are delivering similar outcomes, despite only being active in the country for two years. On August 14, AHGMU and the Ministry of Health and Medical Services of the Solomon Islands signed an MOU on medical cooperation. The two sides agreed on support and assistance in upgrading tertiary hospital care at the National Referral Hospital (NRH) in the Solomon Islands as the center of teaching, treatment of complicated cases and major referral center. According to the MOU, the AHGMU will select senior doctors to be part of the China Medical Team in Solomon Islands, providing medical services to local communities. The Traditional Chinese Medicine and Acupuncture Center and Minimally Invasive Urological Surgery Center will be established at NRH in the near future, in which both sides will work closely on medical equipment and instruments donated to NRH. Doctors, nurses, and administrative personnel will have opportunities to receive training and postgraduate education at AHGMU and related medical technology supports will be provided to the centers to assist NRH medical staff master specialized skills. Growth in TCM The arrival of Chinese medical teams also generated new awareness over traditional Chinese medicine in the South Pacific region. "Thank you, China Medical Team, especially Doctor Jack Lei for giving much of your time with your experiences and techniques in delivering acupuncture treatment to me as one of your patients," commented a local resident on the Facebook page of the Chinese medical team. In less than half a year, Lei, an expert in traditional Chinese medicine and acupuncture from the medical team, has changed the local people's attitude toward acupuncture from "never heard of" to "pure magic." Now the Chinese medial team is also teaching acupuncture and other TCM knowledge to local doctors and nurses and the team also hopes to send some local doctors to China to study acupuncture in the future. Chinese naval hospital ship Peace Ark also visited the Solomon Islands in August during its "Harmonious Mission 2023." During its visit to the Solomon Islands, Peace Ark provided free medical service to local people and overseas Chinese. It also dispatched multiple medical teams to deliver medical care, critical disease consultation and academic exchange. In addition to the TCM consultation room's seven beds, some patients were seen with "cups" on their backs, or needles inserted in various acupuncture points on their legs, while other received moxibustion treatment on their feet. A local woman told the Global Times that she came to the hospital ship for treatment because she heard that Chinese medicine is famous and effective for foot pain. "I feel very good. Chinese doctors are very good!" she said. SOURCE Global Times