This study was based on the 2015-2018 National Health and Nutrition Examination Survey database.The relationship between the concentration of 10 distinct metals and metalloids (cadmium, total mercury, lead, selenium, manganese, chromium, cobalt, inorganic mercury, Et mercury, and Me mercury) and dyslipidemia (assessed by serum lipid markers) was examined through multivariate adjusted modeling and restricted cubic spline (RCS) modeling.The study demonstrated that selenium was the only element with a statistically significant association with dyslipidemia.The RCS anal. showed a notable elevation in the likelihood of dyslipidemia when selenium levels surpassed 164μg/L.This studys findings indicate a pos. correlation between blood selenium levels and dyslipidemia, underscoring the necessity of incorporating environmental factors into cardiovascular disease prevention strategies.