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关联

1

项与 Tokyo Dental College 相关的药物

CHX-3107

靶点

ACE

作用机制

ACE抑制剂 [+2]

在研机构-

原研机构

Senju Pharmaceutical Co., Ltd.

在研适应症-

非在研适应症

过敏 [+2]

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

18

项与 Tokyo Dental College 相关的临床试验

JPRN-UMIN000051907

/ RecruitingN/AIIT

Visual function of eyes implanted with non-diffractive extended depth of focus intraocular lens - Visual function of non-diffractive EDOF IOL

开始日期2023-07-25

申办/合作机构

Tokyo Dental College

JPRN-UMIN000051512

/ RecruitingN/AIIT

Comparison of the preventive effect of ondansetron and dexamethasone on nausea and vomiting after orthognathic surgery between remimazolam and propofol anesthesia. - Comparison of the preventive effect of ondansetron and dexamethasone on nausea and vomiting after orthognathic surgery between remimazolam and propofol anesthesia.

开始日期2023-07-04

申办/合作机构

Tokyo Dental College

JPRN-UMIN000051727

/ RecruitingN/AIIT

Elucidation of gene polymorphisms that contribute to nausea and vomiting after administration of ondansetron - Elucidation of gene polymorphisms that contribute to nausea and vomiting after administration of ondansetron

开始日期2023-05-03

申办/合作机构

Tokyo Dental College

100 项与 Tokyo Dental College 相关的临床结果

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0 项与 Tokyo Dental College 相关的专利（医药）

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6,253

项与 Tokyo Dental College 相关的文献（医药）

2025-06-01·MethodsX

Osteoclast visualization: Tartrate-resistant acid phosphatase activity staining using NewFuchsin compatible with non-aqueous mounting and tissue clearing

Article

作者: Kawaai, Katsuhiro ; Kuroda, Yukiko ; Nakamura, Takashi ; Matsuo, Koichi

Tartrate-resistant acid phosphatase (TRAP) staining is widely used to stain osteoclasts in histological bone sections. The red dye formed by the conventional TRAP enzymatic reaction using naphthol AS-MX (or AS-BI) phosphate and fast red-violet (or garnet) chromogens is readily soluble in alcohol or xylene and requires air-drying prior to cover slipping or the use of an aqueous mounting medium. However, the use of an aqueous mounting medium makes it difficult to store stained specimens for a long time. In this modified method, a new fuchsin (NewFuchsin) was used as a chromogen, which enabled dehydration and clearing after staining and the use of a non-aqueous organic solvent-based mounting medium. Samples prepared using this modified TRAP activity staining method (NewFuchsin TRAP staining) have the following advantages over conventional TRAP staining:•The staining of sections provides a clear histological image and allows for long-term preservation.•The red dye formed by NewFuchsin TRAP staining can be detected not only in the bright field, but also in the fluorescent field.•Combined with tissue clearing using ethyl cinnamate, osteoclasts are observed using three-dimensional imaging.

2025-05-01·The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D receptor in osteoblast lineage cells mediates increased sclerostin circulation and decreased bone formation in hypervitaminosis D

Article

作者: Tamamura, Yoshihiro ; Mori, Tomoki ; Nakamichi, Yuko ; Udagawa, Nobuyuki ; Liu, Ziyang ; Shi, Linan ; He, Zhifeng

Hypervitaminosis D is induced iatrogenically or endogenously. We previously reported that the vitamin D receptor (VDR) in osteoblast lineage cells mediates bone resorption and soft-tissue calcification in hypervitaminosis D. However, bone formation in hypervitaminosis D remains understudied. Here, we show that abundant 1α,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] suppresses bone formation through VDR in osteoblast lineage cells. High-dose 1,25(OH)₂D₃ suppressed bone formation and increased serum sclerostin, a bone formation inhibitor, in Control but not osteoblast lineage-specific VDR-cKO [Osterix (Osx)-VDR-cKO] mice. However, Sost mRNA expression in bone was downregulated by 1,25(OH)₂D₃ in Control but not Osx-VDR-cKO mice. Meanwhile, mRNA expression of β-1,4-N-acetyl-galactosaminyltransferase 3 (B4GALNT3), whose function is reported to decrease circulating sclerostin, was suppressed by 1,25(OH)₂D₃ in bone in Control but not Osx-VDR-cKO mice. Overexpressed B4galnt3 in rodent osteoblast-lineage cell lines increased GalNAcβ1→4GlcNAc- (LDN-) glycosylated sclerostin, suggesting that this modification can explain the discordance between serum sclerostin levels and mRNA in bone. Although excessive 1,25(OH)₂D₃ increased mRNA levels of Fibroblast growth factor 23 (Fgf23), another osteotropic factor, by 10-fold through VDR in osteoblast lineage cells, it was previously shown to increase serum FGF23 levels by several hundred-fold. 1,25(OH)₂D₃-induced changes of FGF23-degradation regulators, such as furin, polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), and family with sequence similarity member 20 C (FAM20C), did not match the markedly high FGF23 levels, suggesting the existence of other regulators of FGF23. These findings suggest that VDR plays pivotal roles in the suppression of bone formation in hypervitaminosis D, possibly by increasing circulations of sclerostin and FGF23 through post-translational or post-transcriptional mechanisms.

2025-05-01·International Journal of Oral and Maxillofacial Surgery

Japanese clinical practice guidelines for oral cancer, 2023

Review

作者: Miyabe, S ; Suzuki, T ; Hasegawa, T ; Yamada, S ; Yanamoto, S ; Danjo, A ; Kitamura, N ; Ohyama, Y ; Kurita, H ; Ohta, Y ; Abé, T ; Ueda, N ; Ibaraki, S ; Hasegawa, O ; Tanaka, T ; Asoda, S ; Katsuta, H ; Kaida, A ; Uchida, K ; Takeda, D ; Kakimoto, N ; Sato, H ; Uzawa, N ; Sugiura, T ; Nakayama, H ; Kirita, T ; Abe, T ; Kioi, M

The Japanese Society of Oral Oncology and Japanese Society of Oral and Maxillofacial Surgeons have jointly developed clinical practice guidelines for oral cancer (oral squamous cell carcinoma) to improve and standardize the quality of oral cancer treatment in Japan. The first, second, and third editions were published in 2009, 2013, and 2019, respectively, and the 2023 edition was recently developed. In the development of the 2023 edition, 60 clinical questions (CQs) were listed. Systematic reviews following the GRADE approach were performed for 11 of these CQs. This article outlines the 2023 edition and describes the most relevant guidelines and CQs for the diagnosis, treatment, follow-up, and supportive care of oral cancer patients in Japan.

100 项与 Tokyo Dental College 相关的药物交易

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100 项与 Tokyo Dental College 相关的转化医学

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