TC Biopharm Ltd.

TC BioPharm remains compliant with all Nasdaq listing requirements and will continue trading on the exchange EDINBURGH, Scotland, Oct. 25, 2024 /PRNewswire/ -- TC BioPharm (Holdings) PLC ("TC BioPharm" or the "Company") (NASDAQ: TCBP), a clinical-stage biotechnology company developing platform allogeneic gamma-delta T cell therapies for cancer and other indications, today refuted a false claim made earlier this week on social media, stating there is absolutely no way the company is in any danger of being delisted from the Nasdaq stock exchange. The since deleted rumor stated that the company had filed an 8-K Notice to "Delist" from the Nasdaq and would transfer trading to a different exchange. TC BioPharm reiterated that there is no truth to this remark and that TC BioPharm remains in compliance with all Nasdaq listing requirements. The Company will look to take action to defend itself from these types of these attacks which are perpetrated in an effort to create negative market dynamics. If you have any additional questions, please reach out to the company directly at [email protected]. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this Current Report on Form 8-K that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding the Company's intent or ability to affect any budget savings or execute on any M&A or capital raising strategy. These statements are based on management's current assumptions and are neither promises nor guarantees, but involve known and unknown risks, uncertainties, and other important factors that may cause the Company's actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. For other important factors that could cause actual results to differ materially from the forward-looking statements in this Current Report on Form 8-K, please see the risks and uncertainties identified under the heading "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2023, and our other reports filed with the SEC, all of which is available on the Company's Investor Relations website at and on the SEC website at . All forward-looking statements reflect the Company's beliefs and assumptions only as of the date of this Current Report on Form 8-K. The Company undertakes no obligation to update forward-looking statements to reflect future events or circumstances. About TC BioPharm (Holdings) PLC TC BioPharm is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of gamma-delta T cell therapies for the treatment of cancer with human efficacy data in acute myeloid leukemia. Gamma-delta T cells are naturally occurring immune cells that embody properties of both the innate and adaptive immune systems and can intrinsically differentiate between healthy and diseased tissue. TC BioPharm is the leader in developing gamma-delta T cell therapies, and the first company to conduct phase II/pivotal clinical studies in oncology. The Company is conducting two investigator-initiated clinical trials for its unmodified gamma-delta T cell product line - Phase 2b/3 pivotal trial in treatment of acute myeloid leukemia using the Company's proprietary allogeneic CryoTC technology to provide frozen product to clinics worldwide. SOURCE TC BioPharm WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

没钱，往往能遏住绝大多数Biotech脖子。正在渡劫进行时的蓝鸟生物，为续命，连连“挥刀”自救。 撰文| Qsher 一则裁员重组消息，再次将明星Biotech蓝鸟生物推至聚光灯下。进入2024年，它情况似乎越来越糟糕。 近日，蓝鸟生物宣布，将裁员25%，以求节约20%的现金消耗，帮助公司在2025年下半年达到现金流平衡。截至6月底，蓝鸟生物拥有375名全职员工，此次裁员意味着将有近百名员工离开。 早在年初JPM大会上，蓝鸟生物已预警手头现金或仅能维持到2025年Q1。截至今年6月底，蓝鸟生物仅有约1.93亿美元的现金余额，其中包括4900万美元的限制性现金。此番，通过裁员重组，通过“续命丹丸”将延长至2025下半年。 围绕着这家明星药企，太多的故事可讲，它几乎遭遇了Biotech所有可能遇到的难题：研发受阻、产品上市屡遇波折、商业化困境及内部管理动荡，多重因素交织，最终导致市值缩水99%。其兴衰历程令人唏嘘，也让人警醒。 从籍籍无名走至高台 花了近30年，这家明星Biotech从籍籍无名走向高台；可仅仅四年，又再次进入漫长的黑暗期。 回顾蓝鸟生物的历史，最早由两位麻省理工学院教授创办，自1992年成立后，与大多数靠着技术起家的Biotech一样，沉寂多年，埋头研发。2001年，在首席执行官Walter Ogier的带领下，蓝鸟生物开始专注研发名为Lentiglobin的基因疗法，治疗领域为镰状细胞疾病和β地中海贫血症这两种全球最普遍的严重人类遗传病。 十年间，凭借这款基因疗法，蓝鸟生物一战成名。2010年，《nature》发布了一项临床试验结果，在蓝鸟生物Lentiglobin基因疗法的临床试验中，一位患有重型β地中海贫血的患者成功摆脱输血治疗，蓝鸟生物自此声名鹊起。 也是在2010年，蓝鸟生物最大股东Third Rock Ventures投资公司的合伙人Nick Leschly出任CEO，该公司一路高歌猛进，此后三年连年获得资本青睐。 一时间，站在潮头上的蓝鸟生物风光无两，并于2013年顺利登陆纳斯达克。与此同时，在研发及合作上，蓝鸟生物也频频获得青睐，与新基、Lonza Houston、TC Biopharma、GSK、诺华等企业展开合作，还收购了基因编辑技术公司Pregenen。 步入2018-2019年，蓝鸟生物直接迎来了前所未有的高光年份。2019年，蓝鸟生物首个产品Zynteglo获得欧盟有条件上市许可，用于治疗β地中海贫血症，成为首个遗传性血液病的基因治疗产品，并以177万美元的售价，成为“全世界第二昂贵的药品”。业界对于该产品的商业化也抱以厚望，并被Evaluate Pharma列为该年度最有价值的药物之一。同年，蓝鸟生物也被Fierce Pharma评选为“最有可能被收购的十大并购标的之一”。 这就是蓝鸟生物从籍籍无名走向高光的20多年。凭借着自身积累，蓝鸟生物成为“提到基因疗法”就绕不开的一大存在，被视为基因疗法先驱。 回看蓝鸟生物的成长历程，这典型反映了Biotech最为普遍的发展路径：先是科学家创业，再是投资人加入，不断吸引融资；在钱、人到位后，后又在优势领域推动产品上市，逐渐崭露头角。 然而，转折点发生在2020年，不少难题一一摆在了蓝鸟生物面前：商业化产品销售迟迟难达预期、在研产品轮番受阻、高管频频变动、企业现金流持续紧张，股价和市值跌跌不休。 明星Biotech的陨落与自救 伴随着产品上市，在商业化上逐渐凸显的困境，让蓝鸟生物看见了市场的残酷性。 先看首款商业化产品Zynteglo，进程便频频遇阻。一开始，由于生产规格及生产规范问题，蓝鸟生物将产品上市时间推迟至2020年上半年。但新冠疫情的爆发，再次打乱了蓝鸟生物的商业化计划，该产品上市预期再次改变。此后又几经变更，直到2020年7月该产品才重新开始推广。 更致命的是，产品的市场销售情况远不及预期。背后主要原因在于，由于基因疗法的特殊性，德国政府能接受的最高价格仅为蓝鸟预期一半左右，双方价格无法达成统一，因此蓝鸟生物于2021年选择停止在德国销售Zynteglo。 难以攻克的支付问题，让这款备受期待的产品几乎惨淡收场。刚上市之际，Zynteglo被Evaluate Pharma评为年度最具价值的药物之一，预估2024年的销售额将达18.7亿美元。然而到了2023年，Zynteglo才卖了1670万美元，距离预期时间仅剩一年，这一高预期几乎难以达成。 继首款产品商业化遇阻后，蓝鸟生物第二款基因疗法Skysona仍延续了头款产品的“惨淡”，2023年销售额仅为1240万美元。要知道，诺华的基因疗法Zolgensma也在2019年同期首次获批上市，到2022年，销售额就已经突破10亿美元大关。 再看于2023年底推出的第三款基因疗法Lyfgenia，同样遭遇了商业化难题。一面是，这款用于治疗镰状细胞病（SCD）的产品，以310万美元再次刷新了最昂贵药物定价，再加上镰状细胞病市场规模本身就极为有限，市场预期并不高，在该产品上市当日股价便大跌40%。根据GlobalData数据显示，美国的镰状细胞病市场仅有不到10亿美元。 随着上市产品商业化接连遇阻，蓝鸟生物的商业化能力难免受到了质疑。除了已上市产品，还有多款在研产品临床同样面临诸多不顺，不少管线只得夭折。 除此之外，伴随着蓝鸟生物成长的一批老臣也接连出走，“没钱没人”的局面使该公司步履更为蹒跚。据不完全统计，原首席执行官Nick Leschly，首席科学官Philip Gregory、首席财务官Chip Baird、首席运营官兼肿瘤学业务部门负责人Joanne Smith-Farrell、首席医疗官David Davidson医学博士先后离开了蓝鸟生物。 进入2024年，蓝鸟生物所面临的现实情况越来越糟糕，市值不足1亿美元，股价也再创新低，跌破1美元/股，退市风险逼近。 成立30多年来，蓝鸟生物始终未走上凭借自身造血，实现可持续创新之路，不免让人唏嘘。为了自救，如大多数Biotech一般，蓝鸟生物选择不断挥下“拆分剥离、裁员”的大斧头，以降本保现金流。 站在当前，从备受投资者追捧，到被投资者统一抛弃，又留给了Biotech哪些警醒与启示？或可从以下几点来看。 一是，更好的管理资金储备及流动性。回想蓝鸟生物在股价巅峰时期，叠加此前融资情况，资金储备看似无忧，却未能预见并有效应对随后而来的多重危机。更为关键的是，蓝鸟生物在股价反弹的宝贵时机，未能把握融资窗口，缺乏足够的未雨绸缪。 二是，专注于细胞基因治疗领域的蓝鸟生物，成为了该领域的个中翘楚，但也应该知道，这一细分市场本就狭小，目标患者群体有限，高昂的定价策略，完全可能会限制产品的市场渗透率。另外选择自主商业化的它，并未在海外市场更好地拓展。特别是在德国市场的定价失误，不仅未能成功打入医保体系，反而引发了负面反响，最终不得不退出德国市场，甚至影响了整个欧盟市场的布局。 而今，面对现金流愈发紧绷的现实困境，蓝鸟生物虽然通过裁员试图延长企业现金流周期，但蓝鸟生物最终能否脱困、何以脱困，仍有待观察。 一审| 黄佳 二审| 李芳晨 三审| 李静芝 精彩推荐 CM10 | 集采 | 国谈 | 医保动态 | 药审 | 人才 | 薪资 | 榜单 | CAR-T | PD-1 | mRNA | 单抗 | 商业化 | 国际化 ｜ 猎药人系列专题 | 出海 启思会 | 声音·责任 | 创百汇 | E药经理人理事会 | 微解药直播 | 大国新药 | 营销硬观点 | 投资人去哪儿 | 分析师看赛道 | 药事每周谈 | 医药界·E药经理人 | 中国医药手册 创新100强榜单 | 恒瑞 | 中国生物制药 | 百济 | 石药 | 信达 | 君实 | 复宏汉霖 ｜翰森 | 康方生物 | 上海医药 | 和黄医药 | 东阳光药 |  荣昌 | 亚盛医药 | 齐鲁制药 | 康宁杰瑞 | 贝达药业 | 微芯生物 | 复星医药 ｜再鼎医药｜亚虹医药 跨国药企50强榜单 | 辉瑞 | 艾伯维 | 诺华 | 强生 | 罗氏 | BMS | 默克 | 赛诺菲 | AZ | GSK | 武田 | 吉利德科学 | 礼来 | 安进 | 诺和诺德 | 拜耳 | 莫德纳 | BI | 晖致 | 再生元

DUBLIN--( BUSINESS WIRE )--The "Cancer Immunotherapy Markets. The Race for the Cures. Market Forecasts for Immuno-Oncology Therapeutics by Therapy, by Cancer and by Customer including Executive and Consultant Guides. 2023 to 2027" report has been added to ResearchAndMarkets.com's offering. A revolution in cancer therapy is underway. New therapy based on using the body's natural immune defenses is having unprecedented success. CAR-T Cells? Checkpoint Inhibitors? Cytokines? Find out about the technology in readily understood terms that explain the jargon. Already worth billions the global market is poised for dramatic growth. The impact on the health care industry is enormous. The report forecasts the market size out to 2027. Find the opportunities and the pitfalls. Understand growth expectations and the ultimate potential market size. Make investment decisions and valuations with confidence using the latest data. This report explores the opportunity in this market and what companies are poised to benefit. Key Topics Covered: 1 Market Guides 1.1 Situation Analysis 1.2 Guide for Executives and Marketing Staff 1.3 Guide for Investment Analysts and Management Consultants 2 Introduction and Market Definition 2.1 What is Cancer Immunotherapy? 2.2 Immunotherapy - the looming cures 2.3 Market Definition 2.4 Methodology 2.5 U.S. Medical Market and Pharmaceutical Spending - Perspective 2.5.1 Global Expenditures for Medicines 3 Immunotherapy - Guide to Immune Technologies 3.1 The Immune System 3.1.1 Innate immune system 3.1.2 Adaptive immune system 3.1.3 Tumor immunology - the immune surveillance system 3.2 Immuno Oncology Technologies 3.2.1 Monoclonal Antibodies 3.2.2 Cancer vaccines 3.2.3 Cytokines 3.2.4 Cell Based Therapies 3.2.5 Inhibitors/Agonists 3.2.6 Antibody Drug Conjugates 3.2.7 Others 4 Industry Overview 4.1 Market Players - Roles & Impacts 4.1.1 Drug manufacturers - Larger/pharmaceutical 4.1.2 Drug manufacturers - Generic 4.1.3 Contract Research and Manufacturing 4.1.4 In Vitro Diagnostics Industry 4.1.5 Drug Marketing Companies 4.1.6 Biotechnology Companies 4.1.7 Regulatory Bodies 5 Market Trends 5.1 Factors Driving Growth 5.1.1 Outcome potential 5.1.2 Fast tracking 5.1.3 Funding 5.1.4 Technology Environment 5.1.5 Target Solutions 5.2 Factors Limiting Growth 5.2.1 Cost of Treatment 5.2.2 Clinical Trials Role 5.2.3 Combinations 5.2.4 Protocols 5.3 Therapeutic Technology Development 5.3.1 Combinations - Issues and Complexity 5.3.2 Preference for a drug 5.3.3 Problems of Immunity Engineering 5.3.4 The Role of Cost 5.3.5 The Disruption Dynamic 5.3.6 CAR-T Cell Therapy 5.3.7 The Next Five Years 6 Cancer Immunotherapy Recent Developments 6.1 Recent Developments - Importance and How to Use This Section 6.2 Continued Success with Immunotherapy in Melanoma 6.3 AC Immune Receives FDA Fast Track Designation 6.4 LTZ Announces Financing 6.5 Immunotherapy for Cancer Overview 6.6 Implantable device shrinks pancreatic tumors 6.7 mRNA Vaccine And Immunotherapy Reduce Melanoma Recurrence 6.8 Towards a Universal Cancer Immunotherapy 6.9 New Strategy May Improve T-Cell Therapy in Solid Tumors 6.10 Immunotherapy linked to increase in Medicare spending 6.11 Immunotherapy Effective with Ovarian Cancer 6.12 Cancer Immunotherapy Granted Fast Track 7 Profiles of Key Immunotherapy Companies AbbVie Achilles Therapeutics Acumen Pharmaceuticals Adagene Adaptimmune Therapeutics Adicet Bio ALX Oncology Holdings Ambrx Biopharma Amgen Apexigen Arcus Biosciences argenx AstraZeneca Atreca Avalo Therapeutics Avid Bioservices Bavarian Nordic BioAtla Biogen Inc. BioNTech Bolt Biotherapeutics Bristol-Myers Squibb Candel Therapeutics Caribou Biosciences Celldex Therapeutics Checkpoint Therapeutics Chinook Therapeutics Corvus Pharmaceuticals Cullinan Oncology Eli Lilly EOM Pharmaceuticals Evaxion Biotech Genenta Science Gilead Sciences Gracell Biotechnologies Greenwich LifeSciences Gritstone bio Harpoon Therapeutics ImmunityBio Immunocore Holdings Immunome IMV Inc Incyte Indaptus Therapeutics Instil Bio Iovance Biotherapeutics Johnson & Johnson Marker Therapeutics Medicenna Therapeutics Merck & Co. Merus Moderna Mustang Bio Nanobiotix Neoleukin Therapeutics Novartis Novavax Oncorus PDS Biotechnology Pfizer Regeneron Pharmaceuticals Roche Sanofi Sensei Biotherapeutics Senti Biosciences Surface Oncology Takeda Pharmaceutical TC Biopharm ThermoGenesis Holdings UroGen Pharma Werewolf Therapeutics Xilio Therapeutics Zymeworks 8 The Global Market for Immuno-Oncology Therapeutics 8.1 Global Market Overview by Country 8.2 Global Market by Therapy 8.3 Global Market by Cancer 8.4 Global Market by Customer 9 Global Immuno-Oncology Therapy Markets - By Therapy 9.1 MAB 9.2 Cytokine 9.3 Vaccine 9.4 Cell Based 9.5 Inhibitor/Agonist 9.6 Other IO Therapy 10 Global Immuno-Oncology Therapeutic Markets - By Cancer 10.1 Breast 10.2 ColoRectal 10.3 Cervical 10.4 Lung 10.5 Precancer 10.6 Prostate 10.7 Melanoma 10.8 Blood 10.9 Other Cancer 11 Global Immuno-Oncology Therapeutic Markets - By Customer 11.1 Pharma 11.2 Clinic 11.3 Other Customer For more information about this report visit https://www.researchandmarkets.com/r/8355qg About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.