Delving into the Latest Updates on 新疆维吾尔自治区药物研究所 with Synapse

Based on the standard big data cloud computing platform of lumbar degenerative diseases, the key technology application of AI intelligent assisted diagnosis and treatment system of TCM external treatment was developed and the individualized TCM external treatment and treatment system was established

开始日期2024-04-26

申办/合作机构

新疆维吾尔自治区药物研究所

CTR20234195 / Recruiting临床2期IIT

景红颗粒治疗冠心病心绞痛（气虚血瘀证）的随机、双盲、安慰剂平行对照、剂量探索、多中心、Ⅱa期临床试验景红颗粒Ⅱa期临床试验方案

以安慰剂为对照，初步探索景红颗粒治疗冠心病心绞痛（气虚血瘀证）的有效性及安全性，并探索最佳剂量。

开始日期2024-01-17

申办/合作机构

新疆维吾尔自治区药物研究所

ChiCTR2300074972 / Suspended早期临床1期IIT

A real world study on the construction of a big data diagnosis and treatment platform for lumbar degenerative diseases and the application of intelligent decision system to optimize the diagnosis and treatment plan of TCM external treatment

开始日期2023-10-01

申办/合作机构

新疆维吾尔自治区药物研究所

100 项与新疆维吾尔自治区药物研究所相关的临床结果

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0 项与新疆维吾尔自治区药物研究所相关的专利（医药）

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2

项与新疆维吾尔自治区药物研究所相关的文献（医药）

2024-06-01·Journal of Applied Toxicology

The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder

Article

作者: Zhao, Jingcheng ; Xu, Qian ; Li, Zhijian ; Xing, Jianguo ; Zheng, Ruifang ; Zhang, Yun ; Zhang, Huiwen ; Zhu, Chengyue

AbstractIsobavachalcone (IBC) is a flavonoid component derived from Psoraleae Fructus that can increase skin pigmentation and treat vitiligo. However, IBC has been reported to be hepatotoxic. Current studies on IBC hepatotoxicity are mostly on normal organisms but lack studies on hepatotoxicity in patients. This study established the depigmented zebrafish model by using phenylthiourea (PTU) and investigated the difference in hepatotoxicity between normal and depigmented zebrafish caused by IBC and the underlying mechanism. Morphological, histological, and ultrastructural examination and RT–qPCR verification were used to evaluate the effects of IBC on the livers of zebrafish larvae. IBC significantly decreased liver volume, altered lipid metabolism, and induced pathological and ultrastructural changes in the livers of zebrafish with depigmentation compared with normal zebrafish. The RNA‐sequencing and RT–qPCR results showed that the difference in hepatotoxicity between normal and depigmented zebrafish caused by IBC was closely related to the calcium signaling pathway, lipid decomposition and metabolism, and oxidative stress. This work delved into the mechanism of the enhanced IBC‐induced hepatotoxicity in depigmented zebrafish and provided a new insight into the hepatotoxicity of IBC.

Xinjiang Yike Daxue Xuebao

The mechanism of tilianin in the treatment of coronary heart disease based on network pharmacology and molecular docking

作者: Du Yanwen ; Su Wenling ; Zheng Ruifang ; Yang Jie ; Liu Guihua

Objective To explore the mechanism of tilianin in the treatment of coronary heart disease using network pharmacol. methods and mol. docking technol.Methods TCMSP database was used to obtain the biol. information of tilianin, and the Swiss target prediction website was established to predict the active mol. targets of tilianin, and the relationship network between tilianin and targets was constructed.Go(gene ontol.) anal. and KEEG pathway annotation anal. were performed by DAVID database.Used the drug bank database to search known targets of coronary heart disease with the key words of coronary heart disease, and using Venny 2.1.0(csic.es)website constructed the Venn map to screen the potential target and common target of tilianin.Autodock Vina 1.1.2 was used for mol. docking. and the conformation with the lowest binding energy of each docking result was used as the stable conformation.Through the establishment of a rat cardiomyocyte H9 c2 hypoxia-reoxygenation injury model, the efficacy of tilianin was exptl. verified.Results A total of 34 potential targets were predicted by Swiss target prediction website.Enrichment anal. showed that tilianin could inhibit cell apoptosis, inhibit calcium overload, activate vascular endothelial growth factor and promote cell proliferation.A total of 61 coronary heart disease targets were found through the database of drugbank, and 9 potential targets and coronary heart disease common targets were screened by constructing wenntu.Mol. docking showed tilianin has good binding ability to key targets such as CD38, NOX4, ADORA3, MMP1, ALDH2, AKR1 B1.CCK-8 results showed that tilianin could significantly promote the proliferation of H9 c2 injured by hypoxia reoxygenation.Conclusion Tilianin play a role in the treatment of coronary heart disease through multiple ways and targets.

100 项与新疆维吾尔自治区药物研究所相关的药物交易

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100 项与新疆维吾尔自治区药物研究所相关的转化医学

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