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更新于：2026-01-29
North Sichuan Medical College
更新于：2026-01-29
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ChiCTR2500108130
Comparisonofanestheticeffectofpropofol disodium and propofol in elderly patients undergoing laparoscopic radical resection of colorectal cancer: a single-center, randomized, double-blind, non-inferiority study
ChiCTR2500104449
The Effects of Dignity Therapy on Dignity, Hope, Depression, and Treatment Adherence in Patients with End-Stage Renal Disease
NCT06909604
Al18F-HER2-BCH PET/CT to Predict Response in Breast Patients Treated With Neoadjuvant Therapy
100 项与 川北医学院 相关的临床结果
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2026-05-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Controllable fabrication of bioinspired pollen-like microparticles via solvent evaporation of polyvinyl alcohol (PVA)-stabilized microfluidic polymer microdroplets
Article
作者: Wang, Chun-Chun ; Hu, Bai-Ren ; Pang, Tao ; Zhang, Hong-Lu ; Chen, Xin-Tong ; Yu, Yan-Ling ; Wang, Tian-Liang ; Peng, Hong ; Meng, Zhi-Jun ; He, Jian
Shaping the polymeric materials into pollen-inspired microparticles with unique structural properties represent a promising area in drug delivery, environmental sensing, and biomaterials. This work reports a robust droplet microfluidic method for fabricating bioinspired pollen-like microparticles from polyvinyl alcohol (PVA) stabilized polymer-contained chloroform microdroplets followed by a solvent evaporation induced consolidation process. Monodisperse oil in water droplets containing dissolved polymer(s) in chloroform are initially generated in a glass capillary microfluidic device using an aqueous continuous phase containing PVA. The PVA provides robust droplet stability during the incubation/evaporation process by suppressing droplet coalescence and enabling reproducible interfacial conditions for morphology development. By systematically varying polymer type (homopolymer or copolymer), polymer concentration, PVA concentration (0.5% to 5.0% (w/v)), incubation temperature (5 °C to 30 °C), and the number of polymer components (one to four), we achieved precise control over particle morphology without requiring elaborately synthesized block copolymer or conjugate polymers. By leveraging these variables, comprehensive characterization through optical microimaging and scanning electron microscopy (SEM) are used to reveal distinct structural outcomes: single-component polymer droplets evolved into spherical microparticles with smooth, porous, or concave surfaces, whereas multi-component droplets yielded complex non-spherical and multi-compartment structures mimicking Bougainvillea, Canna, and Pinus pollen. This study elucidates the interplay between fabrication parameters and microparticle morphology properties, providing a versatile, synthesis-light strategy for innovatively designing functional microparticles with tunable bioinspired features from common polymers.
2026-02-01NEUROPHARMACOLOGY
Gut microbiota-mediated amino acid reprogramming in ketamine-induced neurotoxicity: A novel microbiota-amino acid-mitochondrial axis associated with cognitive deficits
Article
作者: Liu, Xiang ; Zhan, Xinyi ; Song, Xiaojing ; Liao, Linchuan ; Jia, Zhiwei ; Mei, Xue ; Chen, Xiaoqin ; Wei, Ying
Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, is associated with chronic abuse leading to schizophrenia-like cognitive deficits. The gut-brain axis may play a role in mediating substance-induced neurotoxicity; however, its involvement in ketamine-induced cognitive impairment remains poorly understood. Here, chronic ketamine exposure was administered intraperitoneally to C57BL/6N mice to examine its effects on gut microbiota homeostasis and associated amino acid metabolism. Cognitive deficits were evaluated using the Y-maze and novel object recognition (NOR) tests. Hippocampal ultrastructure was assessed by transmission electron microscopy (TEM). Multi-omics integration included 16S rRNA sequencing, untargeted and targeted plasma metabolomics, and Spearman correlation analysis. The results showed that ketamine-exposed mice exhibited significant cognitive impairments, including impaired spontaneous alternation in the Y-maze (P < 0.05) and a reduced discrimination index in the NOR test (P < 0.01). TEM analysis revealed hippocampal mitochondrial damage, accompanied by chromatin condensation. Gut microbiota analysis indicated dysbiosis, with a notable increase in Lachnospiraceae, Bacteroidaceae, Helicobacteraceae, and Rikenellaceae and a decrease in Verrucomicrobiaceae and Prevotellaceae at the family level. Plasma amino acid levels were also disrupted, with a significant decrease in L-glutamine, L-lysine, L-threonine and an increase in L-cysteic acid. Furthermore, strong correlations were observed between the abundance of Bacteroides, branched-chain amino acids (BCAAs), and cognitive scores (|ρ| > 0.6, P < 0.05). This study identifies the microbiota-amino acid-mitochondrial axis as the underlying mechanism driving ketamine-induced neurotoxicity. It highlights the correlation between gut microbiota-associated amino acid reprogramming and this process, offering potential targets for microbiome-based interventions to combat substance-related cognitive impairments.
2026-02-01ENVIRONMENTAL RESEARCH
Regulating carrier pathways from type-II to S-scheme in g-C3N4-based heterojunctions for synchronous tetracycline degradation and hydrogen evolution
Article
作者: Fu, Min ; Liu, Xingyan ; Zhou, Lijie ; Sun, Lang ; Wu, Jianhui ; Wei, Siping ; Liang, Jiaxing ; Zhang, Chenghua ; Wu, Hong ; He, Youzhou
Simultaneously achieving pollutant degradation and hydrogen production from wastewater via photocatalysis is challenging. S-scheme heterojunctions, which maintain strong redox ability and promote charge carrier separation, are a research hotspot. We demonstrate that trace ordered Pd nanochannels can reconfigure a type-II (g-C3N4/TCPP-1 %) into an S-scheme heterojunction (g-C3N4/PdTCPP-1 %), thereby achieving synchronous tetracycline degradation and hydrogen evolution with remarkable efficiency. The ordered Pd nanochannel within the self-assembled PdTCPP nanotube acted as a directional electron channel to precisely convert the heterojunction from type-II to an S-scheme configuration, with in-situ XPS and photodeposition experiments confirming spatially separated charge accumulation and directional transfer pathways. The results showed that g-C3N4/TCPP-1 % and g-C3N4/PdTCPP-1 % could achieve 76.07 % and 84.66 % degradation efficiency for TC within 120 min under visible light irradiation. Notably, replacing deionized water with TC wastewater enhanced the photocatalytic hydrogen evolution rate of g-C3N4/PdTCPP-1 % by 2.2-fold that from 517.7 to 1138.2 μmol g-1·h-1, whereas g-C3N4/TCPP-1 % exhibited only a marginal increase from 181.1 to 211.3 μmol g-1·h-1 under identical conditions. We report a pioneering strategy for synchronous environmental and energy challenges by the direct conversion of a type-II to an S-scheme heterojunction through engineered Pd nanochannels, paving the way for efficient pollutant degradation and renewable H2 production.
100 项与 川北医学院 相关的药物交易
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