Delving into the Latest Updates on Inflamed Pharma GmbH with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

Bacterial DNA gyrase x Topoisomerase IV	1

关联

2

项与 Inflamed Pharma GmbH 相关的药物

threo-austrobailignan-6

靶点-

作用机制-

在研机构

Inflamed Pharma GmbH

原研机构

Mahidol University

在研适应症

诊断试剂

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

CUO246

靶点

Bacterial DNA gyrase x Topoisomerase IV

作用机制

细菌DNA旋转酶复合体调节剂 [+1]

在研机构

陕西盘龙药业集团股份有限公司 [+2]

原研机构

Novartis AG

在研适应症

新型冠状病毒感染 [+2]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Inflamed Pharma GmbH 相关的临床结果

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0 项与 Inflamed Pharma GmbH 相关的专利（医药）

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1

项与 Inflamed Pharma GmbH 相关的文献（医药）

Frontiers in Microbiology

ProcCluster® and procaine hydrochloride inhibit the replication of influenza A virus in vitro

Article

作者: Häring, Clio ; Schroeder, Josefine ; Henke, Andreas ; Engert, Beatrice ; Ehrhardt, Christina ; Löffler, Bettina ; Jungwirth, Johannes

IntroductionTreatment of influenza A virus infections is currently limited to few direct acting antiviral substances. Repurposing other established pharmaceuticals as antivirals could aid in improving treatment options.MethodsThis study investigates the antiviral properties of ProcCluster® and procaine hydrochloride, two derivatives of the local anesthetic procaine, in influenza A virus infection of A549, Calu-3 and MDCK cells.ResultsBoth substances inhibit replication in all three of these cell lines in multi-cycle experiments. However, cell line-dependent differences in the effects of the substances on viral RNA replication and subsequent protein synthesis, as well as release of progeny viruses in single-cycle experiments can be observed. Both ProcCluster® and procaine hydrochloride delay endosome fusion of the virus early in the replication cycle, possibly due to the alkaline nature of the active component procaine. In A549 and Calu-3 cells an additional effect of the substances can be observed at late stages in the first replication cycle. Interestingly, this effect is absent in MDCK cells. We demonstrate that ProcCluster® and procaine hydrochloride inhibit phospholipase A2 (PLA2) enzymes from A549 but not MDCK cells and confirm that specific inhibition of calcium independent PLA2 but not cytosolic PLA2 has antiviral effects.DiscussionWe show that ProcCluster® and procaine hydrochloride inhibit influenza A virus infection at several stages of the replication cycle and have potential as antiviral substances.

100 项与 Inflamed Pharma GmbH 相关的药物交易

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100 项与 Inflamed Pharma GmbH 相关的转化医学

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