A randomized controlled study of risk factors associated with residual numbness after lumbar disc herniation and the therapeutic effect of umbilical acupuncture combined with warm acupuncture

开始日期2025-01-01

申办/合作机构

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

NCT06649422 / Not yet recruitingN/AIIT

Clinical Study on the Efficacy and Safety of Reduced-Dose Chemotherapy Followed by 14 Days of Blinatumomab in Adult Patients with Newly Diagnosed Ph-Negative B-ALL: a Prospective, Multicenter, Observational Study.

This is a prospective, multicenter, observational study aimed at exploring the efficacy and safety of reduced-dose chemotherapy followed by frontline therapy with blinatumomab in patients aged 15-65 with newly diagnosed Ph-negative B-ALL.

开始日期2024-11-01

申办/合作机构

山东大学

[+12]

ITMCTR2024000429 / Suspended

A study of the seven-seven theory based on the expression of biological clock genes in granulosa cells of IVF-ET patients of different age groups

开始日期2024-10-01

申办/合作机构

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

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项与 The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine 相关的文献（医药）

2024-10-01·Biomedicine & Pharmacotherapy

Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis

Article

作者: Zhang, Fengyi ; Yu, Xiaoying ; Zhang, Jiayi ; Zhang, Yufeng ; Wang, Wenbo ; Tong, Xiaolin ; Li, Yujie ; Liu, Xuemei ; Zhao, Yifeng ; Su, Jie ; Zhang, Lili ; Zhao, Linhua

BACKGROUNDIn the early stages of diabetic kidney disease (DKD), the pathogenesis involves abnormal angiogenesis in the glomerulus. Hirudin, as a natural specific inhibitor of thrombin, has been shown in previous studies to inhibit the migration of various tumor endothelial cells and abnormal angiogenesis. However, its role in DKD remains unclear.METHODSThe effects of hirudin in DKD were studied using spontaneous type 2 diabetic db/db mice (which develop kidney damage at 8 weeks). Network pharmacology was utilized to identify relevant targets. An in vitro high glucose model was established using mouse glomerular endothelial cells (MGECs) to investigate the effects of hirudin on the migration and angiogenic capacity of MGECs.RESULTSHirudin can ameliorate kidney damage in db/db mice. Network pharmacology suggests its potential association with the VEGFA/VEGFR2 pathway. Western blot and immunohistochemistry demonstrated elevated protein expression levels of VEGFA, VEGFR2, AQP1, and CD31 in db/db mice, while hirudin treatment reduced their expression. In the MGECs high glucose model, hirudin may reverse the enhanced migration and angiogenic capacity of MGECs in a high glucose environment by altering the expression of VEGFA, VEGFR2, AQP1, and CD31. Moreover, the drug effect gradually increases with higher concentrations of hirudin.CONCLUSIONSThis study suggests that hirudin can improve early-stage diabetic kidney disease kidney damage by inhibiting the migration and angiogenesis of glomerular endothelial cells, thereby further expanding the application scope of hirudin. Additionally, the study found increased expression of AQP1 in DKD, providing a new perspective for further research on the potential pathogenesis of DKD.

2024-03-28·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

肠道菌群代谢产物氧化三甲胺与缺血性脑卒中关系的研究进展.

Review

作者: Fu, Yu ; Li, Li ; Hou, Xiaoqian ; Feng, Huiyue ; Feng, Ziyun

缺血性脑卒中(ischemic stroke，IS)是一类严重危害人类健康的脑血管疾病。肠道菌群作为中间介质在大脑与肠道之间起到双向调节的关键作用。近年来，氧化三甲胺(trimethylamine N-oxide，TMAO)作为肠道菌群代谢产物在心血管疾病中受到广泛关注。高TMAO水平可能通过影响IS的危险因素如动脉粥样硬化、心房颤动、高血压和2型糖尿病增加IS发生风险。TMAO加剧IS患者神经功能的损伤，增加IS复发风险，而且是患者卒中后认知障碍(post-stroke cognitive impairment，PSCI)的独立预测因素。目前的研究认为，TMAO的作用机制包括损伤血管内皮功能、促进泡沫细胞形成、影响胆固醇代谢和增强血小板反应性等。通过中药、饮食管理、维生素和益生菌的合理应用等治疗方式降低血浆TMAO水平，可预防和治疗IS。.

2024-03-28·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

中青年健康体检人群肥胖与早发血管老化的相关性.

Article

作者: Cui, Man ; Li, Ying ; Miao, Rujia ; Zhou, Hui ; Li, Yapei ; Wang, Jiangang ; Zhao, Linlin

目的: 中国中青年肥胖率逐年升高，心血管疾病的发生呈年轻化趋势。然而，肥胖是否与早发血管老化(early vascular aging，EVA)相关目前尚未见报道。本研究旨在分析中青年健康体检人群肥胖与EVA的相关性，为心血管疾病的预防提供参考。方法: 纳入2020年1至12月在中南大学湘雅三医院完成臂踝脉搏波传导速度(brachial-ankle pulse wave velocity，baPWV)测量的15 464名18~59岁中青年健康体检者，并选择其中血压正常且无心血管风险因素的1 965名受检者作为健康人群。根据健康人群各年龄段男性和女性的baPWV值，计算得到用于判断各年龄段男性和女性EVA的baPWV界值。按照年龄和性别进行分组，统计中青年健康体检人群中符合EVA标准的人数，并计算所占百分比。分别比较男性/女性EVA组和非EVA组之间肥胖指标[内脏脂肪指数(visceral adiposity index，VAI)、体重指数(body mass index，BMI)、腰围(waist circumference，WC)]的差异。以EVA作为因变量，分别将VAI、BMI、WC作为自变量纳入Logistic模型，分别分析校正其他影响因素前后各肥胖指标与EVA的相关性；并进一步分析各年龄段各肥胖指标与EVA的相关性。结果: 在健康体检人群中，不同年龄组男性EVA检出率1.65%~10.92%，女性EVA检出率1.16%~10.50%；随年龄增加，男性、女性EVA检出率均呈上升趋势；且除40~<50岁年龄组，其他年龄组男性EVA检出率均高于女性。不管是男性或女性，EVA组肥胖指标VAI、BMI、WC均明显高于非EVA组(均P<0.01)。在对其他影响因素进行校正前后，VAI、WC均与EVA相关(均P<0.05)。在未校正其他影响因素时，BMI为EVA的危险因素(P<0.01)，而在校正其他影响因素后，BMI与EVA的相关性不具有统计学意义(P=0.05)。校正其他影响因素后，18~<40岁、50~<60岁年龄组VAI与EVA的相关性均具有统计学意义(均P<0.05)，BMI、WC与EVA的相关性均无统计学意义(均P>0.05)；而在40~<50岁年龄组，VAI、BMI与EVA的相关性均无统计学意义(均P>0.05)，WC与EVA的相关性有统计学意义(P<0.01)。结论: 18~<40岁、50~<60岁中青年人群VAI与EVA的发生密切相关，40~<50岁中青年人群WC与EVA的发生密切相关。.

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