Alterations in skin hydration, moisture and genomic in adult patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIATM) supplementation

开始日期2024-11-04

申办/合作机构

Monash University Malaysia Sdn. Bhd.

[+1]

ISRCTN70382365 / RecruitingN/AIIT

The effects of transcranial direct current stimulation on EEG changes in nicotine use disorder patients: an exploratory study

开始日期2024-10-01

申办/合作机构

Monash University Malaysia Sdn. Bhd.

NCT06408493 / RecruitingN/AIIT

Peer-led Digital Health Lifestyle Intervention for a Low Income Community at Risk for Cardiovascular Diseases (MYCardio-PEER)

The goal of this interventional study is to develop and assess the effectiveness of a peer-led digital health program (MYCardio-PEER) for primary prevention of cardiovascular disease (CVD) in a low-income community at-risk of CVD.
The main questions it aims to answer are:
* Is MYCardio-PEER effective in improving knowledge, lifestyle behaviors and CVD biomarkers of a low-income community at-risk for CVD?
* Is there an association between MYCardio-PEER participants' adherence and satisfaction, with effectiveness and sustainability of the program?
Participants will attend the 8-weeks MYCardio-PEER program with their peer leaders, supplemented with face-to-face components. Participants will then be followed up for another 12 weeks, during which peer leaders and researchers will have minimal contact with the participants. Participants who have been allocated into the control group will receive printed documents with standard tips on dietary and lifestyle management for CVD, where they will be encouraged to maintain regular calorie intake and expenditure and perform regular exercise.

开始日期2024-03-01

申办/合作机构

Monash University Malaysia Sdn. Bhd.

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项与 Monash University Malaysia Sdn. Bhd. 相关的文献（医药）

2025-01-01·Journal of Affective Disorders

Recurrent depression predicts high leptin concentrations in patients with coronary artery disease over an 18-months follow-up period

Article

作者: Ronel, Joram ; Deter, Hans Christian ; DeZwaan, Martina ; Holdenrieder, Stefan ; Michal, Matthias ; Petrowski, Katja ; Jünger, Jana ; Söllner, Wolfgang ; Herrmann-Lingen, Christoph ; Weber, Cora S. ; Olliges, Elisabeth ; Atasoy, Seryan ; Ladwig, Karl-Heinz ; Weber, Cora S ; Johar, Hamima ; Albus, Christian ; Fritzsche, Kurt ; Marten-Mittag, Birgitt

BACKGROUNDLeptin, an adipokine suspected to play a role in coronary artery disease (CAD), may also be associated with deteriorated mental health. We investigated the prospective impact of recurrent depressed mood (RDM) on heightened plasma leptin levels in CAD patients.METHODSDerived from the randomized SPIRR-CAD trial, plasma leptin were measured by the Human Leptin DuoSet ELISA at baseline in 539 patients (including 115 (21.3 %) women and 424 (78.7 %) men) and in 373 participants after 18-months follow up (T₃). RDM was based on the clinical course from baseline to follow-up assessed by the Hamilton Depression Rating Scale (HAMD). Multivariate binary logistic regression models identified predictors for heightened leptin at T₃.RESULTSAt baseline, highest leptin level (3rd tertile) was associated with type 2 diabetes (p = 0.009), heart failure symptoms (NYHA III) (p < 0.001), female sex and BMI ≥30 (p < 0.001) but not with age and depression. At study endpoint (T3), RDM was associated with a substantially increased risk of experiencing the highest plasma leptin level (OR 2.92 (95 % CI 1.27-6.75)) followed by increased NT-proBNP (the most prominent indicator of CHF) with an OR of 2.73 (1.22-6.11) - both after adjustment for concurrent factors including weight gain (diff BMI T₃-T₁) over the study period - the latter accounting for an OR of 1.41 (1.17-1.70).LIMITATIONSFindings are limited to people of Caucasian ancestry which prevents being generalized to other ethnicities. Although relying upon a prospective design, reverse causality cannot be excluded but is unlikely.CONCLUSIONSIn CAD patients, RDM is a significant predictor of heightened leptin -a finding opening room for a new pathway of the psychobiological underpinning of depression on CAD risk.

2025-01-01·Food Chemistry

Unveiling fucoxanthin's fate: In vitro gastrointestinal digestion effects on bioaccessibility, antioxidant potential, colour changes, and metabolite profiles

Article

作者: Khong, Nicholas M.H. ; Choo, Wee Sim ; Lim, Vuanghao ; Khong, Nicholas M H ; Foo, Su Chern ; Yusof, Zuhaili

Limited knowledge of fucoxanthin's changes during digestion necessitates comprehensive investigation to ensure its efficacy as a functional ingredient. This study assessed the effects of digestion on fucoxanthin's bioaccessibility, antioxidant activity, colour changes, and metabolite formation through in vitro gastrointestinal digestion. Results indicated the highest bioaccessibility during gastric digestion (0.03 ± 0.00 mg/mL), followed by intestinal and mouth with 0.012 ± 0.00 and 0.011 ± 0.13 mg/mL, respectively. Antioxidant activity was the highest at the gastric stage, with significant activity persisting post-digestion (P < 0.05). Colour changes were significant, with total colour differences (∆E*) of 2.40, 2.86, and 2.76 at the mouth, gastric, and intestinal stages, respectively. LC-MS/MS-based metabolomics analysis revealed 15 key metabolites, with carboxylic acids as major metabolites during gastric and intestinal stages. Pearson correlation analysis demonstrated a significant correlation between identified metabolites with bioaccessibility, antioxidant activity, and colour changes, underscoring fucoxanthin's potential as a promising functional food ingredient.

2024-12-31·Journal of Medical Economics

Validity and measurement equivalence of EQ-5D-5L questionnaire among heart failure patients in Malaysia: a cohort study

Article

作者: Chee, Kok Han ; Kasim, Sazzli ; Kuan, Wai Chee ; Lim, Ka Keat ; Teoh, Siew Li ; Dujaili, Juman Abdulelah ; Lee, Kenneth Kwing-Chin

AIMThis study aimed to examine the validity of EQ-5D-5L among HFrEF patients in Malaysia, and to explore the measurement equivalence of three main language versions.METHODSWe surveyed HFrEF patients from two hospitals in Malaysia, using Malay, English or Chinese versions of EQ-5D-5L. EQ-5D-5L dimensional scores were converted to utility scores using the Malaysian value set. A confirmatory factor analysis longitudinal model was constructed. The utility and visual analog scale (VAS) scores were evaluated for validity (convergent, known-group, responsiveness), and measurement equivalence of the three language versions.RESULTS200 HFrEF patients (mean age = 61 years), predominantly male (74%) of Malay ethnicity (55%), completed the admission and discharge EQ-5D-5L questionnaire in Malay (49%), English (26%) or Chinese (25%) languages. 173 patients (86.5%) were followed up at 1-month post-discharge (1MPD). The standardized factor loadings and average variance extracted were ≥ 0.5 while composite reliability was ≥ 0.7, suggesting convergent validity. Patients with older age and higher New York Heart Association (NYHA) class reported significantly lower utility and VAS scores. The change in utility and VAS scores between admission and discharge was large, while the change between discharge and 1MPD was minimal. The minimal clinically important difference for utility and VAS scores was ±0.19 and ±11.01, respectively. Malay and English questionnaire were equivalent while the equivalence of Malay and Chinese questionnaire was inconclusive.LIMITATIONThis study only sampled HFrEF patients from two teaching hospitals, thus limiting the generalizability of results to the entire heart failure population.CONCLUSIONEQ-5D-5L is a valid questionnaire to measure health-related quality of life and estimate utility values among HFrEF patients in Malaysia. The Malay and English versions of EQ-5D-5L appear equivalent for clinical and economic assessments.

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