Arno Therapeutics, Inc.

Ad hoc announcement pursuant to Art. 53 LR Jean-Paul Clozel to retire as CEO and stand for election as Chairman of the Board of DirectorsMathieu Simon to stand for re-election to the Board – taking on the role of Vice-Chairman and Lead Independent DirectorAndré C. Muller, current CFO of Idorsia, to take over the role of CEO as of June 13, 2024 Allschwil, Switzerland – May 21, 2024Idorsia Ltd (SIX: IDIA) today announced changes to the Idorsia Executive Committee (IEC) and will propose changes in membership of the Board of Directors at the upcoming Annual General Meeting of shareholders (AGM), to be held on June 13, 2024. Jean-Paul Clozel, 69, has decided to retire from his role as Chief Executive Officer (CEO) of Idorsia and stand for election as Chairman of the Board of Directors at this year’s AGM. Jean-Paul has served as CEO of Idorsia since its foundation – the result of demerging the drug discovery and early clinical pipeline of Actelion, as part of the USD 30 billion acquisition. Jean-Paul had previously co-founded Actelion in 1997 and went on to lead the company as CEO in 2000 when the company became publicly traded. Jean-Paul Clozel, MD and CEO of Idorsia, commented: “It has been an absolute privilege to serve as CEO of Actelion and Idorsia for the past 24 years. I can think of no greater endeavor than discovering new medicines that help patients lead better lives. I’ve been very fortunate to work alongside some amazing people from all disciplines and together, we have achieved more than I could have ever imagined when I started out in my research career. The time is right for me to retire from the day-to-day running of Idorsia and hand the reins over to a younger generation to lead the company through the next phase of growth. Having devoted so much energy to Idorsia, I want to stay engaged and support the company to realize its potential, hence me standing for election as Chairman. I’m confident that Mathieu and I will form a strong partnership in leading the Board. I will also be able to devote more time to science which has always been my passion.” From June 13, 2024, André C. Muller will take on the position of CEO. André has served as the Chief Financial Officer (CFO) of Idorsia since its foundation and has taken the lead in the company’s Business Development initiatives in recent years. Before establishing Idorsia, André served as CFO of Actelion from 2013, leading the company through its acquisition and playing a crucial role in the demerger process. Jean-Paul Clozel, commented: “André has played a critical role in advancing Idorsia, particularly regarding our fund-raising and business development activities. He has shown the perfect qualities of a biotech leader; creativity, solution-oriented, resilient, a team-player and pragmatic – all qualities that we need to successfully discover and develop innovative drugs. Having worked with André for more than 10 years, I have observed that, despite not being a scientist by training, he has a keen understanding of innovative drug discovery and development. I have absolute confidence that he is the right person to prepare the company for an exciting future.” As a result of André becoming CEO, the role of CFO will remain an IEC member and be taken by Arno Groenewoud, the current Head of Finance and Procurement. In addition, Julien Gander, Group General Counsel, will become a member of the IEC. André C. Muller, Chief Financial Officer, commented: “I am very honored that the Board, its current Chairman, Mathieu Simon, and Jean-Paul have put this trust in me, particularly following such a long and successful tenure for Jean-Paul as CEO. I look forward to the challenge of delivering on the high expectations we have for Idorsia and will work closely with all colleagues around the globe who never fail to impress with their commitment and expertise. I welcome Arno and Julien to the executive team. Having worked closely with both Arno and Julien, I am convinced that their skills and strategic thinking will be vital as the company moves towards financial sustainability while managing multiple partnerships.” As of June 13, 2024, the IEC will consist of 5 members: André Muller, CEO; Martine Clozel, Chief Scientific Officer; Alberto Gimona, Head of Global Clinical Development; Arno Groenewoud, CFO; and Julien Gander, Group General Counsel. At this year’s Annual General Meeting, the Board will propose a reduced number of Board members for the time being. Three of the current Board members – Jörn Aldag, Felix Ehrat, Peter Kellogg – will not stand for re-election, with only one new member, Bart Filius, being proposed to the Board. The following Board members will stand for re-election: Jean-Paul Clozel (proposed Chairman), Mathieu Simon (Vice-Chairman and Lead Independent Director), Srishti Gupta, Sophie Kornowski, and Sandy Mahatme. Mathieu Simon, Chairman of the Board of Idorsia commented:“This year, the Board has held numerous additional meetings to discuss and review the various strategic initiatives. I’m very grateful for each member contributing generously with their expertise and experience. To those not standing for re-election, I say thank you for serving the company with professionalism and dedication. Bart’s very extensive financing, business development, and commercial experience in the biotechnology and pharmaceutical industry would be invaluable to Idorsia. I am completely behind the new management team, and proposing Jean-Paul to the Chairmanship, and I look forward to serving as Vice-Chairman and Lead Independent Director with the other members of the Board focused on guiding Idorsia as we execute our strategy.” Following a competitive selection process, the company considers it appropriate to invite a fresh perspective by proposing the election of Deloitte AG, Basel as a new statutory auditor. Notes to the editor About Jean-Paul ClozelJean-Paul Clozel, 69, is a cardiologist educated in France. He furthered his training in pharmacology and physiology at the University of Montreal, Canada, University of California, and San Francisco. After eleven years as a clinician, he decided to move to applied research and joined the Roche Cardiovascular Drug Discovery group. During his 12 years at F. Hoffmann-La Roche Ltd, Jean-Paul was responsible for the selection of the first calcium T-channel blocker and contributed to several key research programs, such as the selection of the first orally active renin inhibitor and the characterization of several anti-thrombotic agents. During his 25-year-career in cardiovascular research, Jean-Paul has published widely in peer-reviewed medical and scientific journals. At the same time, his passion has remained unchanged: being involved as closely as possible in bringing innovative medicine to "his" patients. He has developed various novel experimental models allowing for the differentiation of these drugs, work honored with the 1997 Hoffmann-La Roche Research Prize. In 2007, he was nominated for a professorship at the Collège de France in Paris, France (Chair of Technical Innovation). At the end of 1997, Jean-Paul co-founded Actelion to continue his work in cardiovascular research and development. In April 2000, he assumed the role of CEO when Actelion became a publicly traded company and subsequently launched three blockbuster drugs. With the acquisition of Actelion by Johnson & Johnson in June 2017, Jean-Paul co-founded Idorsia, a new biopharmaceutical company that was established by demerging the drug discovery and early clinical pipeline business from Actelion. Idorsia is specialized in the discovery and development of small molecules to provide innovative medicines in areas of unmet patient need. In the first 7 years of Idorsia’s existence, the company launched two innovative drugs, one for the treatment of insomnia disorder and one for the prevention of cerebral vasospasm following subarachnoid hemorrhage, with a third medicine on the verge of being launch for the treatment of uncontrolled blood pressure. Idorsia continues to perform innovative research across multiple therapeutic areas to feed its broad and diversified drug development pipeline. As a result of the establishment of Actelion and Idorsia, several hundred new jobs have been created in Switzerland as well as in other European countries, the US and Japan. About André C. MullerAndré C. Muller joined Idorsia at the time of its creation in June 2017 as Chief Financial Officer from Actelion, where he held the same position since 2013. Prior to joining Actelion he held various financial positions at Pierre Fabre SA, an international pharmaceutical and dermo-cosmetic company, serving as CFO from 2002. André, a French citizen, has a master’s degree in Business Administration from EMLYON Business School, Lyon, France. André also serves as a member of the Board of Directors of the listed company Carmat SA and the unlisted company Chiron Investments AG. About Bart FiliusMr. Filius is the former President of Galapagos, a position he held from 2021 to June 2023. He joined Galapagos in 2014 as Chief Financial Officer and added the role of Chief Operating Officer in 2017. During his tenure at Galapagos, Bart managed the substantial growth and financing of the company, including the IPO on Nasdaq in 2015 and subsequent follow-on financing transactions. He led the negotiations of the R&D collaboration with Gilead in 2019 and was instrumental in the build-out of the European commercial organization. Bart is also a member of the Board and Chairman of the Audit Committee of ProQR Therapeutics since 2019. Prior to joining Galapagos, Mr. Filius held a variety of executive positions at Sanofi between 2001 and 2014, including the role of Vice President, Head of Mergers & Acquisitions, Country manager for The Netherlands and Vice President, Chief Financial Officer for Europe. Prior to joining Sanofi, Mr. Filius was a strategy consultant at Arthur D. Little. Mr. Filius has an MBA degree from INSEAD, France and a bachelor’s degree in business from Nyenrode University, the Netherlands About IdorsiaIdorsia Ltd is reaching out for more – We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into a leading biopharmaceutical company, with a strong scientific core. Headquartered near Basel, Switzerland – a European biotech-hub – Idorsia is specialized in the discovery, development and commercialization of small molecules to transform the horizon of therapeutic options. Idorsia has a 25-year heritage of drug discovery, a broad portfolio of innovative drugs in the pipeline, an experienced team of professionals covering all disciplines from bench to bedside, and commercial operations in Europe and North America – the ideal constellation for bringing innovative medicines to patients. Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 750 highly qualified specialists dedicated to realizing our ambitious targets. For further information, please contactAndrew C. WeissSenior Vice President, Head of Investor Relations & Corporate CommunicationsIdorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil+41 58 844 10 10investor.relations@idorsia.com media.relations@idorsia.com www.idorsia.com The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as "estimates", "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks", "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company's investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected. Attachment Press Release PDF

SAB and MAG comprise global key opinion leaders in translationaltumor immunology and immunotherapy Paris, France – May9, 2023 Enterome, a clinical-stage company developing first-in-class immunomodulatory drugs for cancer and inflammatory diseases based on its unique Mimicry platform, announces the creation of its international Scientific Advisory Board (SAB) and Medical Advisory Group (MAG) comprising highly respected and influential scientific and clinical leaders in oncology and immunotherapy. The newly formed SAB and MAG will provide strategic, scientific, and clinical guidance to Enterome as it progresses its pipeline of innovative OncoMimics™ immunotherapies targeting solid and liquid tumors. Enterome’s Scientific Advisory Board comprises (biographies below): David Klatzmann, MD, PhD - Professor of Immunology at the Sorbonne University (Paris, France) Pedro Romero, MD, PhD - Director of Scientific and Medical Affairs, Novigenix, Professor Emeritus at University of Lausanne (Lausanne, Switzerland) Justin Eyquem, PhD - Assistant Professor in Microbiology and Immunology at the University of California (San Francisco, CA, US) Enterome’s Medical Advisory Group comprises (biographies below): Zuzana Jirakova, MD, PhD - Chief Medical Officer at Highlight Therapeutics (Madrid, ES) Peter Kiener, PhD - Venture Partner at ICG Life Sciences (Portland, OR, US) Alexander Zukiwski, MD - Chief Medical Officer at CASI Pharmaceuticals (Rockville, MD, US) “We are very pleased to announce the creation of our Scientific Advisory Board and Medical Advisory Group,” commented Pierre Belichard, CEO at Enterome. “Their combined knowledge and experience in immune-oncology will be fundamental as we look to advance and expand our pipeline of OncoMimics immunotherapies into and through clinical development targeting solid and liquid cancers. Their insights and expertise will be crucial to Enterome as we approach important near-term clinical readouts from the ROSALIE trial with EO2401 in recurrent glioblastoma and from the SIDNEY trial with EO2463 in Non-Hodgkin Lymphoma and as we consider the design and strategy for potentially pivotal clinical trials with these candidates. In addition, we look forward to their input to the development strategies around our other OncoMimics candidates, which are planned to enter clinical trials in 2023, including EO2040 in colorectal cancer with ctDNA-defined, minimal residual disease, and EO4010 for third-line colorectal cancer.” Biographies Scientific Advisory Board David Klatzmann, MD, PhD is a world-renowned immunologist who contributed to the discovery of HIV (human immunodeficiency virus), revealing its preferential tropism and cytopathic effect- the first indication that HIV is the cause of AIDS. David is Professor of Immunology at the Sorbonne University. He also holds several roles at both the Pierre and Marie Curie Medical School and Pitié-Salpêtrière Hospital in Paris, including as Chief of Biotherapy, Coordinator of the Clinical Investigation Center for Biotherapy and Immunology. With a current focus on translational system immunology, David brings a wealth of expertise and knowledge on T cell-based therapies in cancer and auto-immune diseases. Pedro Romero, MD, PhD is a specialist in translational tumor immunology and immunotherapy of cancer as well as immune and tumoral responses. He currently serves as Deputy Scientific Director of the Lausanne branch of the Ludwig Institute for Cancer Research in Switzerland and in 2021 was made Honorary Professor of the University of Lausanne. He joined Novigenix, Lausanne, as Director of Scientific and Medical Affairs in April 2023. Pedro was a postdoctoral fellow at the Institute of Immunology, the National University of Colombia and New York University School of Medicine. Pedro’s research which has been published in leading scientific journals has been instrumental to tumor immunology and clinical cancer immunotherapy developments. Justin Eyquem, PhD is an Assistant Professor in the department of Medicine at the University of California, San Francisco (UCSF), Investigator at the Gladstone-UCSF Institute for Genomic Immunology and co-founder and scientific advisor for Mnemo Therapeutics. Justin brings with him a unique understanding of the engineering of T lymphocytes to enhance CAR T and natural killer (NK) cell functions in hematological and solid tumors. Justin earned his PhD from the University of Paris-Diderot (France) in collaboration with the biotech company Cellectis and trained as a postdoctoral fellow at the Memorial Sloan-Kettering Cancer Center in New York, US. Medical Advisory Group Zuzana Jirakova Trnkova, MD, PhD has over 20 years of pharmaceutical industry and leading biotech experience in global drug development. Zuzana serves as a Chief Medical Officer at Highlight Therapeutics. Previously, she was Vice President of Clinical Development and Medical Affairs Radiology at Bayer Pharmaceuticals. Before this, she served as Vice President of Clinical Research and Development at BioNTech in Germany. Zuzana earned her MD and PhD in immunology and molecular biology at Charles University in Prague, Czech Republic. Zuzana brings cross-disciplinary experience in early to late-stage oncology drug development of small molecules and biologics in various indications, translational research and clinical pharmacology. Peter Kiener, PhD has extensive experience in research and development in biologics, immunotherapy and biopharmaceuticals and a brings a wealth of knowledge in drug development from discovery through to approval. He is a Venture Partner at ICG Life Sciences and the former Chief Scientific Officer at Sucampo. Prior to this, he was President and co-founder of Zyngenia and has held R&D leadership roles at Ambrx, MedImmune/AstraZeneca and Bristol-Myers Squibb. Peter earned his PhD in biochemistry at the University of Oxford. Alexander Zukiwski, MD, has 25+ years of experience in global oncology drug development and serves as Chief Medical Officer at CASI Pharmaceuticals. He has held several leadership roles in the pharmaceutical industry, including in global drug development, clinical evaluation and registration of many successful oncology treatments at leading companies such as Hoffmann-LaRoche, Glaxo Wellcome, Johnson & Johnson, MedImmune, and Arno Therapeutics. Alexander received his MD from the University of Calgary and conducted his post-graduate training at St. Thomas Hospital Medical Center in Akron, Ohio, and the University of Texas MD Anderson Cancer Center. Contacts ENTEROME MEDIA RELATIONS Guillaume Bayre Head of External Communications Tel; +33 (0)1 76 21 58 15 communication@enterome.com Sylvie Berrebi / Mark Swallow / David Dible MEDiSTRAVA Consulting Tel. +44 (0) 203 928 6900 enterome@medistrava.com About Enterome Enterome is a clinical-stage biopharmaceutical company developing breakthrough immunomodulatory drugs for the treatment of cancer and immune diseases. Enterome’s pioneering approach to drug discovery is based on its unique and powerful bacterial Mimicry drug discovery platform, allowing it to analyze and uncover new biological insights from the millions of gut bacterial proteins in constant cross-talk with the human body. Its first-in-class small protein and peptide drug candidates modulate the immune system by closely mimicking the structure, effect or actions of specific antigens, hormones, or cytokines. The company’s two pipelines of drug candidates include: OncoMimics™ peptides, a pipeline of peptide-based immunotherapies. Lead candidate, EO2401, is in Phase 2 clinical trials in patients with glioblastoma and adrenal tumors and has demonstrated clinical proof of concept. EO2463 is in a Phase 1/2 clinical trial for indolent non-Hodgkin lymphomas, with clinical data expected in H1 2023. EO2040, a new immune therapy, is expected to start a Phase 2 trial in 2023 in patients suffering from colorectal cancer with ctDNA-defined, minimal residual disease. EO4010 is in development for third-line colorectal cancer and targeted to enter clinical trials in 2023. EndoMimics™ peptides, a pipeline of next generation bioactives acting like human hormones or cytokines, are being developed in collaboration with Nestlé Health Science, for food allergies and inflammatory bowel disease (IBD). Lead candidate, EB1010, expected to enter the clinic in 2024, is a potent local inducer of IL-10, designed to improve therapeutic outcomes for patients with IBD. Enterome employs 73 people and is headquartered in Paris, France. Since its inception, the company has raised a total of €116 million from Europe- and US-based life science investors and more than €100 million from pharmaceutical partnerships. For more information, please visit the company’s website at:

Chronic lymphocytic leukemia is a common type of leukemia found in adults. In this type of cancer, lymphocytes, i.e., white blood cells develop in the bone marrow and travel through the blood. The lymphocytic leukemia cells are majorly found in the lymph nodes and other tissues. There are two types of chronic lymphocytic leukemia, one of which grows slowly, while the other type is fatal. Generally, chronic lymphocytic leukemia do not cause any symptom for a long time. Symptoms generally observed are swollen lymph nodes, fatigue, and easy bruising. Usually, the preferred treatment for chronic lymphocytic leukemia is chemotherapy. Stem-cell transplant is used in rare cases. According to an article published by Apollo Hospitals, an estimated one million cases of chronic lymphocytic leukemia are diagnosed in India every year. Cancer statistics states that, in England, 1 in every 155 men and 1 in every 260 women are affected with chronic lymphocytic leukemia in their lifetime. Read Report Overview - Increasing incidence of cancer across the globe, innovative drug therapy, fast regulatory approval process, and aggressive pipeline for chronic lymphocytic leukemia treatment drugs are the factors driving the growth of the global chronic lymphocytic leukemia market. However, lack of awareness regarding symptoms at an early stage, low accessibility of treatment options in under-developed countries, increasing use of generic products across countries hampering the demand for branded drugs, and adverse events occurring during the treatment, such as side effects of chemotherapy, are restraining the growth of the global market. Request Brochure of Report – The global chronic lymphocytic leukemia market can be segmented according to type of cancer, type of therapy, route of administration, end-user, and geography. In terms of type of cancer, the market can be classified into B-cell chronic lymphocytic leukemia, T-cell chronic lymphocytic leukemia, and natural chronic lymphocytic leukemia. On the basis of type of therapy, the market can be divided into targeted therapy or chemotherapy. In terms of route of administration, the market can be segmented into intravenous, subcutaneous, intrathecal route, intramuscular, and oral. According to end-user, the global chronic lymphocytic leukemia market can be classified into hospitals, ambulatory surgical centers, cancer institutes, and research & academic institutes. Request for Analysis of COVID-19 Impact on Chronic Lymphocytic Leukemia Market- In terms of region, the global chronic lymphocytic leukemia market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the global market, followed by Europe. According to the World Health Organization, cancer is the leading cause of death across countries. According to the National Cancer Institute, it is estimated that in 2018, in the U.S., about 1,735,350 new cases of cancer will be diagnosed and an approximate number of 609,640 number of patients will die due to cancer. Asia Pacific holds significant potential for growth for the market. Investment in the field of research and development for new drugs and in pharmaceutical and biotechnology companies in India, China, and Japan are the key factors driving the growth of the market in Asia Pacific. Rise in disposable income in the countries of Latin America, such as, Mexico and Brazil, is expected to boost the growth of the chronic lymphocytic leukemia market in the region. Developing health care infrastructure in the Middle East countries is projected to accelerate the growth of the chronic lymphocytic leukemia market in the region. Furthermore, increasing government investment in health care and growing presence of key players in Africa are anticipated to boost the market in Middle East & Africa. Request for Custom Research - Prominent players of the global chronic lymphocytic leukemia market are AbbVie, Inc., Arno Therapeutics, Genzyme Corporation, Gilead Sciences, Johnson &Johnson, Novartis AG, Ono pharmaceuticals Co. Ltd., F. Hoffmann-La Roche Ltd., Teva Pharmaceutical Industries Ltd., TG Therapeutics, Xeme Biopharma Ziopharma Oncology, Inc., among others. Pre Book Chronic Lymphocytic Leukemia Market Report - About Us Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals. Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. 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