This study aims to find out:
The tolerability of Cabotamig (ARB202) in adults with advanced solid gastrointestinal tumors who failed the standard treatment. People can participate if their tumor has the CDH17 marker.
To find out how study drug is broken down in the body
To know the effects of the study drug on the tumor.

开始日期2022-05-30

申办/合作机构

Arbele Corp.

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0 项与 Arbele Corp. 相关的专利（医药）

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项与 Arbele Corp. 相关的文献（医药）

2025-04-21·Cancer Research

Abstract 7068: Diagnostic and prognostic application of blood and tissue cadherin-17 biomarker in pancreatic cancer

作者: Wong, Dennis Anthony ; Cho, William C. ; Hon, Tsz Chun ; Zhang, Qi-Hua ; Luo, Hui-Yan ; Yu, Wing Shan ; Cheuck, Wah ; Luk, John M. ; Wang, Xiao Qi ; Cheung, Elaine T.Y.

AbstractBackground:Pancreatic cancer (PC) is one of the most lethal cancers, with a 5-year overall survival (OS) rate of ∼10%. CA19.9 remains the gold standard biomarker for detecting PC, but its performance is poor, necessitating the exploration of better alternatives. Cadherin-17 (CA17) is overexpressed in several gastrointestinal cancers but shows limited expression in normal tissues, indicating potential diagnostic and prognostic applications in PC. This study aimed to evaluate the diagnostic and prognostic value of CA17 in PC.Methods:We have newly developed an immunohistochemistry (IHC) platform to compare CA17 expression in PC tissues (n = 127), tumor-adjacent tissues (n = 86), and normal pancreatic tissues (n = 22) obtained from 50 retrospective PC cases, alongside a commercial tissue microarray of PC and normal samples. Digital imaging analysis was performed to quantify CA17 expression with an IHC scoring algorithm that combines the percentage of positive cells and staining intensity (M score). Additionally, 86 retrospective plasma samples were collected from asymptomatic donors and 49 patients with paired pre- and post-treatment plasma. CA17 and CA19.9 levels in plasma were measured using our newly developed highly sensitive and specific CA17 immunoassay and a commercial CA19.9 ELISA kit, respectively.Results:Normal pancreatic tissues showed negative CA17 IHC results. A significantly higher CA17 M score was observed in PC compared to both normal and cancer-adjacent tissues (median M score: 5.83, 0.38, 0.85, respectively; p < 0.001). We observed a significant elevation in blood CA17 levels from asymptomatic donors to pre-treatment stage I/II PC patients, with a decrease in CA17 expression in stage III/IV patients (median in ng/mL: 1.45, 7.14, 2.58, respectively; p < 0.0001). Compared to pre-treatment plasma, CA17 levels decreased in post-treatment samples from stages I/II patients, while remaining stable in stages III/IV patients (median in ng/mL: 4.02, 2.42, respectively). Similarly, CA19.9 expression increased progressively from normal donors to stages I/II and stages III/IV patients (median in U/mL: 43, 56, 1446, respectively, p < 0.0001). The ROC curve of the CA17 assay showed an AUC of > 0.92, with both sensitivity and specificity of 86% in detecting stages I/II PC, surpassing CA19.9 (55% and 90%, respectively). Stage III/IV PC patients were stratified based on median-high and low CA17 and CA19.9 levels for a 2-year OS analysis, indicating that combining CA17 and CA19.9 in predicting prognosis outperforms each biomarker individually. Patients with both median-high CA17 and CA19.9 levels had a significantly worse OS than those with median-low CA19.9 (median OS: 7 vs 13 months, p = 0.04).Conclusion:CA17 shows promise as a biomarker for early PC detection and prognosis prediction, potentially improving the screening of high-risk individuals for PC and aiding in disease management.Citation Format:William C. Cho, Wing Shan Yu, Tsz Chun Hon, Elaine T.Y. Cheung, Xiao Qi Wang, Qi-Hua Zhang, Hui-Yan Luo, Dennis Anthony Wong, Wah Cheuck, John M. Luk. Diagnostic and prognostic application of blood and tissue cadherin-17 biomarker in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7068.

2024-03-22·Cancer Research

Abstract 3212: Development of a Trop2/CD3 bispecific antibody with modulated Trop2 binding affinity as a novel immunotherapy for advanced gastrointestinal cancer treatment

作者: Wong, Po Yee ; Wong, Kwan Wa ; Luk, John Moon ; Chow, Kronos ; Wong, Kwong Fai ; O, Chui Yee ; Wong, Dennis

AbstractTrophoblast cell surface antigen 2 (Trop2) is considered as a potential therapeutic target because its over-expression in tumors is found to be associated with poor prognosis of patients with different cancers. Trop2-directed antibody-drug conjugates have been approved for the treatment of solid tumors, however, the expression of Trop2 in a broad range of epithelial tissues, even in low expression, would limit their clinical benefits. The present work generated a novel Trop2/CD3 bispecific antibody with its binding affinity towards Trop2 being well-modulated to mitigate the chance of on-target off-tumor effect. By linking a humanized anti-Trop2 monoclonal antibody with a CD3-binding scFv, a Trop2/CD3 bispecific antibody was produced. In order to adjust the bispecific antibody's affinity to the tumor target, ProABC-2 was used for in-silico paratope prediction (Ambrosetti F et al., 2020). A complementarity-determining residue (CDR) variant was produced and its binding to Trop2 antigen was analyzed using biolayer interferometry. The binding of both wild type (WT) and variant antibodies to Trop2-positive cancer cells, the activation of T cells upon target engagement and the redirection of T cell-mediated killing on cancer cells expressing high level of Trop2 were examined. The binding affinity of CDR variant to Trop2-expressing tumor cells was significantly reduced, which led to a slower induction of cytokines and T-cell proliferation, less acute T-cell activation, and a milder cytotoxic effect. This allowed the bispecific antibody to have a higher level of safety by restricting the cytotoxicity only to cancer cells that expressed high level of Trop2. Our novel Trop2/CD3 bispecific antibody not only showed potent anti-tumor activity, but also demonstrated a lower risk of on-target off-tumor toxicity. Monkey toxicity and other IND-enabling studies are beginning to further bring the drug candidate into clinical trial.Table showing EC50 values of Trop2/CD3 bispecific WT and CDR variant antibodies in different assays WT CDR variant Binding affinity (M) Trop2 4.62E-11 2.14E-10 Cytotoxicity (M) AsPC1 (low Trop2 level) 1.24E-11 No killing effect SW480 (medium Trop2 level) 1.25E-12 2.25E-11 NCI-H596 (high Trop2 level) 5.65E-12 5.89E-10 Receptor occupancy (%) Trop2 0.65 2.75 CD3 0.08 5.83 Cytokine induction (M) IL-2 4.82E-11 5.42E-11 IFNγ 6.46E-13 2.59E-11 T cell activation (M) CD25+ marker 2.02E-12 2.39E-10 CD69+ marker 3.81E-13 7.40E-11 T cell proliferation (M) Ki-67 marker 3.54E-12 8.80E-11Citation Format: Chui Yee O, Po Yee Wong, Kronos Chow, Kwan Wa Wong, Dennis Wong, John Moon Luk, Kwong Fai Wong. Development of a Trop2/CD3 bispecific antibody with modulated Trop2 binding affinity as a novel immunotherapy for advanced gastrointestinal cancer treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3212.

2024-03-22·Cancer Research

Abstract 3213: A novel CDH17/PD-1 bispecific antibody for treatment of advanced gastrointestinal cancers

作者: Wong, Po Yee ; Luk, John Moon ; Chow, Kronos ; Wong, Kwong Fai ; Wong, Kwan Wa ; O, Chui Yee ; Wong, Dennis

AbstractTargeting immune checkpoints like programmed death receptor 1 (PD-1) with monoclonal antibodies has achieved durable responses in a range of cancers, however, immune-related adverse events may occur in a subset of patients. As such, we developed a bispecific antibody targeting cadherin-17 (CDH17) and PD-1 with a hope to rejuvenate specifically the exhausted T cells within tumor microenvironment. In healthy individuals, CDH17 is expressed at a restricted level in intestinal epithelial junction that is not accessible to biologics, however, in gastrointestinal cancers, CDH17 is overexpressed and can be targeted by antibodies. Our new CDH17/PD-1 bispecific antibody would reactivate anti-tumor immunity with reduced risk of on-target off-tumor toxicity. Different bispecific antibody formats were designed, cloned, and expressed. Strong binders were first identified using CDH17 and PD-1 ELISA. The binding affinities to CDH17 and PD-1 of the selected candidate were examined using biolayer interferometry. The effect of these bispecific antibodies on blocking PD-1/PD-L1 axis in T cells was demonstrated in a cell-based reporter assay. T-cell mediated killing on CDH17-positive GI cancer cells and induction of T cell activation markers upon antibody treatment were also studied. A total of 7 CDH17/PD-1 bispecific antibodies of different formats were screened. Of these candidates, one, named ARB204, was selected because of its potent binding to both antigens in ELISA (i.e., EC50 values: CDH17, 1.6nM; PD-1, 0.4nM) and biolayer interferometry (i.e., KD values: CDH17, 2.4E-09M; PD-1, 6.02E-11M). ARB204 blocked PD-1/PD-L1 axis in the reporter assay with EC50 value 4.4nM. Notably, ARB204 redirected T cells to eradicate CDH17-positive pancreatic AsPC1 cells with an EC50 value of 3.5nM. No cytotoxicity against CDH17-negative cancer cells were seen. ARB204 effectively bound CDH17 on GI cancer cells and PD-1 on T cells. This bispecific design allowed selective T-cell mediated killing on cancer cells expressing CDH17, mitigating the risk of off-tumor toxicity. ARB204 warrants further studies on its immune checkpoint inhibition in animal models.Citation Format: Kwan Wa Wong, Po Yee Wong, Kronos Chow, Chui Yee O, Dennis Wong, John Moon Luk, Kwong Fai Wong. A novel CDH17/PD-1 bispecific antibody for treatment of advanced gastrointestinal cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3213.

项与 Arbele Corp. 相关的新闻（医药）

2025-01-06

·药研网

CDH17：消化道肿瘤新星冉冉升起

导语 2024年8月23日，普众发现1类新药注射用AMT-676在国内获得临床试验默示许可，用于治疗晚期实体瘤。据公开资料，AMT-676是普众发现研发的一款CDH17靶向抗体偶联药物（ADC），其针对晚期实体瘤的1期临床研究已在澳大利亚启动。在肿瘤组织中，CDH17在胃、胰腺、肝、食道、胆管癌和结直肠癌中过表达，被认为是消化道肿瘤药物研发的潜力靶点。关于CDH17 钙粘素（cadherin，钙粘蛋白，钙粘合素）是一类依赖于Ca2+的细胞粘附分子的超家族，它在维持组织结构和形态中发挥着关键作用。 Cadherin的表达失调往往与疾病有关，包括组织发育不良、肿瘤形成和转移。典型Cadherin胞外域由5个重复序列构成；胞内域由150-160个氨基酸组成，高度保守。 CDH17（Cadherin 17，LI-cadherin），也称为肝肠钙粘蛋白，是钙依赖性蛋白质CDH超家族的非经典成员。CDH17序列由七个细胞外钙粘蛋白结构域和一个非常短的细胞质结构域形成。与其他经典的钙粘蛋白不同，CDH17是一种钙依赖性跨膜糖蛋白，可介导细胞在肠上皮中的细胞粘附。图1.钙粘蛋白-17 (CDH17) 的结构特征 (即在细胞外氨基末端 (NH2) 具有 7 个钙粘蛋白重复序列(EC1-EC7)，随后是跨膜区和羧基处的短胞质结构域-终点（COOH）。钙离子（用红点表示）位于哺乳动物 CDH17 的钙粘蛋白重复序列之间) CDH17的生物学功能与表达 CDH17主要在肠上皮细胞及部分胰腺导管上皮细胞中表达，健康成人的肝细胞、食管和胃黏膜中几乎不表达。其主要功能是通过介导钙依赖性粘附在细胞间保持结构和形态的完整性。研究表明，CDH17在胃癌、结直肠癌、肝癌、胰腺癌和胆管癌等多种肿瘤中均有高表达，且其表达水平与患者的预后和治疗反应密切相关。 CDH17与肿瘤发展的关系 CDH17的功能紊乱与肿瘤细胞的浸润和转移密切相关。在胃癌中，CDH17的上调可通过激活NF-κB和促进MAPK信号通路来促进癌细胞的增殖和侵袭。同时，其在肝癌中的expression与Wnt/β-catenin信号通路的激活相联系，提示其可能在肝细胞癌的进展中发挥作用。此外，CDH17也被证明能与α2β1整合素相互作用，并且是α2β1整合素活性调控细胞粘附和增殖的关键决定因素，以及能促进结肠直肠癌细胞获得肝转移的能力。 CDH17在肿瘤中的作用机制以及在癌症治疗中的具体作用虽然尚未清楚，但已经有新型靶向治疗药物（如BI 905711和ARB102等）处于临床研究阶段，用于治疗胃癌、胰腺癌、食管癌、胆管癌等胃肠道癌。这些药物可同时结合肿瘤细胞表面的CDH17和死亡受体TRAILR2，诱导肿瘤细胞凋亡，对表达CDH17的正常细胞无损伤。吉满生物根据市场需求和研究现状，推出CDH17稳定表达细胞系/抗体/蛋白相关产品及服务（详细数据见文末），可用于抗体筛选、表征、一致性评价, 充分满足药物研发的需求，助力抗体药物临床申报。（咨询吉满客服联系同微信：18916119826）目前在研格局相较于其他靶点，CDH17靶点进展较慢，在研药物大多处于临床早期阶段，但CDH17靶向药类型比较丰富，涵盖单抗/双抗、ADC、细胞疗法等，尚未有相关产品获批。 1 ARB202 ARB202是利用TriAx技术构建的一种人源化抗CDH17xCD3的IgG4双抗，是一款潜在“同类首创”药物，其具备独特亲和力抗 CDH17 和抗 CD3 差异化的结构，在保证高特异性和高杀伤活性的同时，避免过度激活T细胞所引起的全身免疫反应风险。 Arbele的TriAx抗体设计是为了通过结合多种抗肿瘤机制在消化道癌症治疗中获得更大的疗效，具有低抗原性、稳定性、理想的生物分布和药代动力学特性。纳入TriAx抗体的抗肿瘤机制包括重新引导T/NK细胞的细胞毒性，抑制免疫检查点，吞噬作用和增强适应性免疫反应。临床前数据显示：ARB202能有效增强T细胞与表达CDH17的胃肠道肿瘤细胞系之间的相互作用，从而导致T细胞的活化并释放IL-2，有效的产生肿瘤细胞杀伤，通过体内注射低剂量ARB202 抗体可以有效地抑制肿瘤的生长。1a期研究的初步数据显示：ARB 202在血液循环中的耐受性Cmax高达150ng/ml，这表明在这些浓度下没有临床显著的脱靶T细胞活化。 2 BI-905711 BI905711是勃林格殷格翰公司首创的双特异性、四价治疗性抗体，靶向TRAILR2和CDH17的四价双抗，TRAILR2与CDH17交联诱导CDH17依赖性TRAILR2聚集，在共表达TRAILR2和CDH17的肿瘤细胞中诱导选择性凋亡。 BI 905711已推进至首次人体临床试验。在一项针对晚期胃肠道癌症患者的Ia/b 期研究中，48 名患者接受了BI 905711治疗，13 名患者病情稳定 (SD)，8 名患者无进展生存期≥4 个月 (PFS4)。CRC 患者中，6 名患者病情稳定，3 名患者无进展生存期为 4 个月；非CRC 患者中，7 名患者病情稳定 (PDAC：n = 6)，5 名患者无进展生存期为4 个月 (PDAC：n = 4)。未观察到 DLT 且未达到 MTD。 3 CHM-2101 CHM 2101 （CDH17 CAR T）是世界知名的宾夕法尼亚大学细胞治疗中心发明的同类首创第三代 CDH17 CAR T，具有CD28和4-1BB共刺激结构域。CHM 2101的临床前证据于2022年3月发表在《Nature Cancer》杂志上，证明在7种癌症中完全根除肿瘤。 CDH17 CAR-T细胞仅浸润肿瘤细胞，尽管正常细胞表达CDH17也不受影响。在正常细胞中，CDH17隐藏在正常细胞屏障的紧密连接之下；而在癌症中，CDH17上调导致其暴露在癌细胞膜上，允许CAR-T检测并结合它。目前针对晚期结直肠癌、胃癌和神经内分泌肿瘤患者正在开展一项多中心、开放标签1A/B期临床试验。临床前证据表明，CHM-2101具有完全根除肿瘤细胞而不复发的实体肿瘤的独特效力，并对正常组织没有毒性。 4 AMT-676 2024年8月23日，普众发现1类新药注射用AMT-676在国内获得临床试验默示许可，用于治疗晚期实体瘤。据公开资料，AMT-676是普众发现研发的一款CDH17靶向抗体偶联药物（ADC），其针对晚期实体瘤的1期临床研究已在澳大利亚启动。总结 CDH17作为一个新兴的肿瘤靶点，具有良好的肿瘤特异性及较低的毒性风险，其药物市场未来展望相当广阔，有望在不久的将来为癌症患者带来新的治疗选择和希望。对此，吉满生物自主设计并开发了一系列稳定表达CDH17细胞系以及一系列高特异性、高灵敏性CDH17（Cadherin 17）单克隆抗体，可用于ELISA，WB，IP，IF，IHC，FCM。除此之外，吉满生物还可提供高活性CDH17重组蛋白，涵盖多种不同的功能Domain以及多个种属的蛋白产品，可满足客户在动物免疫、抗体筛选以及表位鉴定等不同场景中的需求，所有产品均已通过严格的质量监测。产品列表数据展示 GM-C25980 H_CDH17 CHO-K1 Cell Line使用Anti-CDH17 hIgG1 Antibody流式验证结果 GM-C25981 H_CDH17 HEK-293 Cell Line使用Anti-CDH17 hIgG1 Antibody流式验证结果 GM-C25982 Cynomolgus_CDH17 HEK-293 Cell Line使用Anti-CDH17 hIgG1 Antibody流式验证结果 GM-C26466 Mouse_CDH17 HEK-293 Cell Line使用Anti-CDH17 hIgG1 Antibody(VHHl-28BB)流式验证结果 GM-C26465 Rat_CDH17 HEK-293 Cell Line使用Anti-CDH17 hIgG1 Antibody (VHHl-28BB)流式验证结果联系我们吉满生物助力药物研发，紧随前沿靶点资讯，储备几百株现货细胞，覆盖GPCR、细胞因子、免疫检查点、TAA等多领域，截止当前已布局近300个热门靶向药靶点，1000余株细胞系，旨在助力、加速大分子早期研发，做到进口细胞的国产替代。同时可根据客户需求提供细胞系服务。扫码咨询扫码找现货

抗体药物偶联物临床1期

2024-10-09

·PRNewswire

Arbele Announces Strategic Collaborations on AI Precision Oncology and Manufacturing to Advance CDH17-Targeted Immunotherapeutics

SEATTLE, Oct. 9, 2024 /PRNewswire/ -- Arbele, a leading innovator in biopharmaceutical & biotechnology focused on targeting cadherin-17 (CDH17), is pleased to announce strategic collaborations in precision oncology using artificial intelligence (AI) to advance targeted immunotherapeutics of bispecific T-cell engagers (TCEs) and antibody-drug conjugates (ADCs). These partnerships, aimed at advancing the quantification and prognostic prediction of CDH17 expression in tumor tissue and the surrounding tumor immune microenvironment, are expected to accelerate the development of precise companion diagnostics and effective clinical trials for the treatment of advanced cancer patients. Collaboration with BioAI: Development of IHC-Based Quantification Algorithm Arbele enters a strategic alliance with BioAI Health to develop a prototype of an immunohistochemistry (IHC)-based quantification algorithm. Leveraging the PredictX platform to develop AI-based models using Arbele's clinical trial data on colorectal cancer (CRC) biomarker screening, we join force to establish a gold standard companion diagnostic test for anti-CDH17 therapies for patient selection and prediction of clinical outcomes. "By partnering with Arbele, we are excited to apply our novel AI platform and expertise to accelerate the development of innovative treatment options for gastrointestinal cancers," said Thomas Colarusso, CEO of BioAI. "This partnership underscores our commitment to revolutionizing personalized medicine through cutting-edge machine learning." "BioAI's machine learning capabilities offer a transformative approach to biomarker identification and patient stratification through predicting CDH17 expression and its spatial interaction with immune cells in tumor microenvironment," said Dr John Luk, CEO of Arbele. "This collaboration is a critical step in guiding us the uses of the right treatment modalities and/or therapeutic regimens, thereby improving outcomes for patients with high mortality cancers." Collaboration with Chime Biologics: Accelerated CMC Process Development of novel ADC and TCE Arbele has entered a strategic alliance with Chime Biologics to accelerate chemistry, manufacturing and control (CMC) process development of the novel designs of ADCs and TCEs. The partnership supports multiple pipelines of about 10 first-in-class and best-in-class immunotherapeutics, including monoclonal, bispecific/biparatopic and TriAx antibodies within the coming 3 years. The collaboration will ensure Arbele continues to have at least 1-2 new molecular entities (NMEs) successfully filing for investigational new drug (IND) application and entering clinical studies in the next 5 years without any technical and supply-chain interruptions. The first deliverable will be anti-CDH17 ADC (ARB102A), for IND submission in early 2025. "Chime Biologics has partnered Arbele for several years, with our advanced biologics development supporting key milestones such as previous IND filings for multinational clinical trials," said Dr. Jimmy Wei, President of Chime Biologics. "We adopt the Quality-by-Design (QbD) strategy for process development to yield optimal outcomes cost-effectively, delivering innovative immunotherapeutics to enhance the global accessibility of these treatments." About Arbele Arbele founded by accomplished scientists and pharmaceutical executives in 2016 researching on cadherin-17 (CDH17) to develop innovative diagnostic platforms and breakthrough immunotherapeutic solutions; to provide early intervention and treatment for patients with advanced CRC, cholangiocarcinoma, pancreatic adenocarcinoma and subtype of ovarian cancers, for which effective treatment options are scanty with high mortality rates. For more information on ARBELE, please visit About BioAI BioAI is a leading provider of multimodal AI in precision medicine, offering world-leading machine learning technology to develop H&E-based predictive models and digital biomarkers. BioAI works with leading pharmaceutical, biotechnology, clinical laboratories, and academic cancer centers around the world. The company's proprietary PredictX platform enables the generation of advanced AI models using multimodal data. BioAI aims to revolutionize personalized medicine by developing novel AI-based biomarkers to more effectively guide patients to targeted therapies. For more information about BioAI and its innovative machine learning technologies, please visit bioaihealth.com. About the Chime Biologics & Chime Innovation Center Chime Biologics is a global leading CDMO that has introduced the first modular biopharmaceutical plant KUBio in the world to empower its partners' success in biologics in the whole process from cell line development to commercial manufacturing. Built in state-of-the-art technology at Shanghai Innovation Center and Wuhan manufacturing plant, Chime Biologics provides a one-stop CMC solution for biopharmaceutical customers around the world, making biomedicines affordable and accessible to all patients and fulfilling its commitment to human health. For more information, please visit: . For Press Contact: Dr Diana Hay, [email protected] For Corporate Inquires: Ms. Khim Poon, [email protected] SOURCE Arbele WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

免疫疗法

2024-09-30

·PRNewswire

BioAI Announces Strategic Partnership with Arbele Bio to advance Predictive AI-Models in Oncology Clinical Trials

MANCHESTER, N.H., Sept. 30, 2024 /PRNewswire/ -- BioAI, an emerging biotech company applying multimodal artificial intelligence (AI) to novel biomarker discovery, development, and diagnostics, has announced a strategic partnership with Arbele, a biopharmaceutical company dedicated to developing novel immunotherapeutic platforms for gastrointestinal cancers. The collaboration aims to leverage BioAI's PredictX platform to develop AI-based models using Arbele's clinical trial data, with a focus on colorectal cancer (CRC) biomarker screening. The goal is to create a companion diagnostic test for Arbele's drug assets, enhancing patient selection through advanced AI technology. "By joining forces with Arbele, we are excited to apply our novel AI platform and expertise to accelerate the development of innovative treatment options for gastrointestinal cancers," said Thomas Colarusso, CEO of BioAI. "This partnership underscores our commitment to revolutionizing personalized medicine through cutting-edge machine learning." Arbele's CEO & Founder, Dr. John Luk, commented, "BioAI's machine learning capabilities offer a transformative approach to biomarker identification and patient stratification. This collaboration is a critical step in improving outcomes for patients with high mortality cancers." The initial phase of the partnership will focus on developing a prototype machine learning classifier model for quantifying CDH17 expression patterns in CRC samples, using a combination of H&E (hematoxylin and eosin) and IHC (immunohistochemistry) stained images. This initiative aims to standardize and improve the pathologic assessment of treatment response biomarkers to facilitate more effective patient selection for Arbele's specific therapeutic programs. Both companies expect that this collaboration will pave the way for future advances in precision medicine, ultimately benefiting patients with gastrointestinal cancers. About BioAI BioAI is a leading provider of multimodal AI for digital health in precision medicine, offering world-leading machine learning technology to develop digital biomarkers and H&E based predictive models. They partner with leading pharmaceutical, biotechnology, clinical laboratories, and academic cancer centers around the world. With the PredictX Platform, BioAI aims to revolutionize personalized medicine by improving drug efficacy and patient outcomes. For more information about BioAI and its innovative machine learning technologies, visit bioaihealth.com. About Arbele Arbele is a biotech and biopharmaceutical company focused on developing proprietary immunotherapeutic platforms targeting cadherin-17 and other specific tumor targets for gastrointestinal cancers. By inventing "first in class" antibody-based biologics, Arbele aims to address critical unmet needs in cancer treatment. For more information about Arbele, please visit arbelebio.com. SOURCE BioAI Health WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

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ARB-203 ( CD3 x Trop-2 )	胃肠道肿瘤更多	临床1期
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