Delving into the Latest Updates on Università degli Studi di Perugia with Synapse

作者: Altomonte, Iolanda ; Giorgino, Andrea ; Gariglio, Marta ; Barroeta Lajusticia, Ana Cristina ; Castrica, Marta ; Schiavone, Achille ; Profiti, Margherita ; Roccatello, Rosalba ; Forte, Claudio ; Srikanthithasan, Karthika ; Diaz Vicuna, Elena ; Dabbou, Sihem ; Miraglia, Dino ; Fiorilla, Edoardo ; Gasperi, Flavia

Com. processed former foodstuffs (cFF) in broiler diets did not impact carcase traits or meat quality.Inclusion of cFF in broiler diets reduced gizzard yield, especially at 25% inclusion.Inclusion of cFF reduced polyunsaturated fatty acids to saturated fatty acids ratio in chicken meat, while increasing the n-6 to n-3 ratio.Inclusion of cFF did not affect the sensory attributes or overall liking of the final product.

2025-12-31·Journal of Enzyme Inhibition and Medicinal Chemistry

Discovery and development of steroidal enzyme inhibitors as anti-cancer drugs: state-of-the-art and future perspectives

Review

作者: Cerra, Bruno ; Gioiello, Antimo

Steroidal compounds have emerged as effective therapeutic agents in oncology. Beyond natural-occurring and synthetic steroids that act as cytotoxic anti-tumoral agents, steroidal derivatives can be designed to mime the endogenous substrates of key metabolic enzymes in steroidogenesis, thus reducing the circulating levels of relevant oestrogenic and androgenic hormones responsible for cancer survival and proliferation. Therefore, enzyme inhibition represents an intriguing endocrine approach for the treatment of hormone-dependent tumours, such as breast and prostate cancer, with well-known approved drugs and several pre-clinical and clinical candidates under investigation. This review summarises the key advancements over the past decade (2014-2024) in the development of steroidal enzyme inhibitors endowed with anticancer activity, illustrating their mechanisms of action, therapeutic potential, drug design approaches, and current clinical applications. Furthermore, we discuss challenges related to drug resistance, off-target effects, and future strategies to optimise their efficacy in oncology.

2025-12-31·Italian Journal of Animal Science

Native Italian poultry products: the factors influencing consumer perceptions

作者: Zambotto, Valeria ; Castellini, Cesare ; Cerolini, Silvia ; Mota-Gutierrez, Jatziri ; Penasa, Mauro ; Soukand, Renata ; Daniele, Giulia Maria ; Forte, Claudio ; Buccioni, Arianna ; Schiavone, Achille ; Cappone, Eleonora Erika ; Iaffaldano, Nicolaia ; Soglia, Dominga ; Marzoni, Margherita ; Cianciabella, Marta ; Pieroni, Andrea

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