Delving into the Latest Updates on Samsung Biomedical Research Institute with Synapse

Nerve growth factor (NGF), prostaglandin E2 (PGE2)and adenosine triphosphate (ATP) levels in urine were reported to increase in patients with overactive bladder (OAB). Also, administration of the anti-muscarinic agent was reported to decrease urinary NGF and ATP.
The investigators aimed to explore the value of the urinary NGF, PGE2 and ATP as biomarker for predicting the treatment responsiveness and symptom relapse in OAB patients. So, the patients can be categorized into responder or non- responder and relapse or non-relapse groups. Ultimately, they can receive individualized treatments.

开始日期2010-02-01

申办/合作机构

Samsung Medical Center

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项与 Samsung Biomedical Research Institute 相关的文献（医药）

2024-12-01·Asian Journal of Psychiatry

Genome-wide association study and polygenic risk score analysis for schizophrenia in a Korean population

Article

作者: Lee, Kyu Young ; Hong, Kyung Sue ; Kim, Se Joo ; Myung, Woojae ; Ahn, Yong Min ; Joo, Eun-Jeong ; Shim, Injeong ; Ha, Kyooseob ; Kim, Se Hyun ; Won, Hong-Hee ; Rami, Fatima Zahra ; Lee, Heon-Jeong ; Cho, Eun-Young ; Chung, Young-Chul ; Lee, Dongbin ; Jeong, Seunghwa ; Cho, Chamlee ; Lee, Byung Dae ; Kim, Yujin ; Kang, Chae Yeong ; Oh, Hayoung ; Jo, Anna ; Ha, Tae Hyon ; Baek, Ji Hyun ; Huang, Hailiang ; Yu, Hyeona ; Kim, Beomsu ; Kim, Sung-Wan ; Jeon, Sumoa ; Kim, Min Ji

Although large-scale genome-wide association studies (GWASs) have revealed the genetic architecture of schizophrenia, these studies have mainly focused on populations of European ancestry. This study aimed to identify common genetic variants associated with schizophrenia in the Korean population and evaluate the performance of polygenic risk scores (PRSs) derived from large-scale GWASs across ancestries. In the Korean psychiatric GWAS project (KPGP), seven academic institutes and their affiliated hospitals across South Korea recruited a cohort of 1670 patients with DSM-IV-defined schizophrenia and 2271 healthy controls. A total of 6690,822 SNPs were tested for association with schizophrenia. We identified one previously unreported genome-wide significant locus rs2423464 (P = 2.83 × 10^-11; odds ratio = 1.65; 95 % confidence interval = 1.43-1.91, minor allele frequency = 0.126). This variant was also associated with increased lysosomal-associated membrane protein family member 5 (LAMP5) gene expression. The PRS derived from the meta-analysis results of East Asian and European GWASs explained a larger proportion of the phenotypic variance in the Korean schizophrenia sample than the PRS of an East Asian or European GWAS. (R² = 0.073 for meta-analysis; 0.028 for East Asian GWAS; 0.037 for European GWAS). GWASs involving diverse ethnic groups will expand our understanding of the genetic architecture of schizophrenia.

2024-10-15·Journal of Parkinson's Disease

Association Between Body Mass Index Changes and All-Cause Mortality in Parkinson’s Disease

Article

作者: Kim, Chi Kyung ; Kang, Sung Hoon ; Kim, Yong Wook ; Koh, Seong-Beom ; Nam, Ga Eun ; Han, Kyungdo ; Yoon, Seo Yeon ; Choi, Ja Young ; Jung, Jin-Hyung

Background: Whether body weight changes are associated with Parkinson’s disease (PD) mortality remains uncertain. Objective: To investigate the association between changes in body mass index (BMI) and all-cause mortality in patients with PD. Methods: This nationwide cohort study enrolled 20,703 individuals with new-onset PD (ICD-10 code: G20 and a rare intractable disease registration code: V124) who underwent health screening program by the Korean National Health Insurance Service within two years from pre- and post-PD diagnosis. We identified nine BMI change groups based on three BMI status: underweight (BMI < 18.5 kg/m2), normal or overweight (18.5 kg/m2≤BMI < 25 kg/m2), and obese (BMI≥25 kg/m2). Results: Of 20,703 individuals, 3,789 (18.0%) died during the follow-up period. Excessive weight loss to underweight in the obese group (hazard ratio [HR] = 3.36, 95% CI:1.60–7.08), weight loss in the normal to overweight group (HR = 2.04, 95% CI:1.75–2.39), sustained underweight status (HR = 2.05, 95% CI:1.67–2.52), and weight gain from underweight to normal or overweight (HR = 1.52, 95% CI:1.15–2.02) were associated with increased mortality. Sustained obese status (HR = 0.80, 95% CI:0.74–0.87) and weight gain in the normal to overweight group (HR = 0.82, 95% CI:0.71–0.95) were associated with reduced mortality. Conclusions: We found that BMI change at diagnosis was associated with mortality in patients with PD. Specifically, being underweight either before or after diagnosis as well as experiencing weight loss, were associated with increased mortality. These findings provide valuable insights for weight management planning in PD, highlighting the importance of individualized approach that consider pre-diagnosis BMI.

2024-08-15·American Journal of Respiratory and Critical Care Medicine

Risk of Suicide in Individuals with Idiopathic Pulmonary Fibrosis: A Nationwide Cohort Study

Letter