Delving into the Latest Updates on Astra Lakemedel AB with Synapse

概览

疾病领域	数量

血液及淋巴系统疾病	1
感染	1

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

PBPs(细菌青霉素结合蛋白家族)	1
SERT(5-羟色胺转运体)	1

关联

2

项与 Astra Lakemedel AB 相关的药物

Zimelidine

齐美定

靶点

SERT

作用机制

SERT抑制剂

在研机构

Astra Lakemedel AB

原研机构-

在研适应症

抑郁症

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1982-01-01

Bacampicillin Hydrochloride

盐酸巴氨西林

靶点

PBPs

作用机制

PBPs抑制剂

在研机构

Nichi-Iko Pharmaceutical Co., Ltd. [+2]

原研机构

Pfizer Inc.

在研适应症

急性支气管炎 [+27]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1980-12-22

100 项与 Astra Lakemedel AB 相关的临床结果

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0 项与 Astra Lakemedel AB 相关的专利（医药）

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282

项与 Astra Lakemedel AB 相关的文献（医药）

1987-03-15·Biochemical Journal3区 · 生物学

Peroxidase and peroxidase-oxidase activities of isolated human myeloperoxidases

3区 · 生物学

Article

作者: Lindvall, Sven ; Domeij, Kristina ; Svensson, Bjoern E. ; Rydell, Gunilla

Isolated neutrophils from healthy donors were used for the isolation of four highly purified forms of myeloperoxidase as determined by spectral (A430/A280 ratio 0.80-0.87) and enzyme-activity measurements. Although the myeloperoxidases exhibited different elution profiles on cation-exchange chromatography, gel filtration indicated similar relative molecular masses. When these forms were assayed for peroxidase and peroxidase-oxidase activities with several substrates, they all exhibited virtually the same specific activities. These results suggest that possible functional differences between the enzymes may be related to differences in their sites of action rather than to differences in enzyme activity. Myeloperoxidase from a patient with chronic myeloid leukaemia also revealed a similar heterogeneity on cation-exchange chromatography. However, this myeloperoxidase contained in addition one form with a lower and one form with a higher relative molecular mass, as indicated by gel-filtration chromatography.

1986-11-01·Journal of Medicinal Chemistry1区 · 医学

Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action

1区 · 医学

Article

作者: Florvall, Lennart ; Ask, Anna Lena ; Fagervall, Ingrid ; Ross, Svante B.

Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-alpha-methylphenethylamine (5) and 4-amino-2-chloro-alpha-methylphenethylamine (4).

1986-08-01·Journal of Medicinal Chemistry1区 · 医学

Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles

1区 · 医学

Article

作者: Kumar, Yatendra ; Renyi, Lucy ; Ross, Svante B. ; Florvall, Lennart ; Ask, Anna Lena ; Fagervall, Ingrid

Nine 5-(2-aminoethyl)-2,3-dihydroindole derivatives were synthesized and tested as monoamine oxidase (MAO) inhibitors in vitro and in vivo. All compounds were found to be selective MAO-A inhibitors in vitro, the most active ones, 5-[1-(2-aminopropyl)]-2,3-dihydro-4-methylindole acetate (3), 5-[1-(2-aminopropyl)]-4-chloro-2,3-dihydroindole acetate (5), 5-[1-(2-aminopropyl)]-2,3-dihydro-1-ethyl-4-methylindole tartrate (6), 5-[1-(2-aminopropyl)]-2,3-dihydro-1-ethyl-6-methylindole tartrate (7), and 5-[1-(2-aminobutyl)]-4-chloro-2,3-dihydroindole acetate (9) being equipotent with amiflamine, (S)-(+)-4-(dimethylamino)-2, alpha-dimethylphenethylamine. Some of the compounds, 3, 6, 5-[1-(2-aminopropyl)]-2,3-dihydroindole acetate (1), and 5-[1-(2-amino-2-methylpropyl)]-2,3-dihydroindole acetate (8), were found to be very potent inhibitors of MAO in serotonergic and/or noradrenergic nerve terminals in the rat brain in vivo, inhibiting MAO within these neurons at doses 1/10 of those required to inhibit MAO in other neurons or cells. Compound 1 was also a potent and selective inhibitor of MAO within dopaminergic nerve terminals in vivo. This neuron selectivity is due to the uptake of these compounds by the neuronal uptake mechanisms.

100 项与 Astra Lakemedel AB 相关的药物交易

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100 项与 Astra Lakemedel AB 相关的转化医学

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