Delving into the Latest Updates on Vault Nano, Inc. with Synapse

概览

疾病领域	数量

肿瘤	4
神经系统疾病	2
感染	2
内分泌与代谢疾病	1
免疫系统疾病	1

排名前五的药物类型	数量

重组蛋白	6

排名前五的靶点	数量

gp100(黑素细胞蛋白PMEL)	1
IL-17(白细胞介素-17)	1

关联

10

项与 Vault Nano, Inc. 相关的药物

IL17-Vault

靶点

IL-17

作用机制

IL-17激动剂

在研机构

Vault Nano, Inc.

原研机构

University of California, Los Angeles

在研适应症

肺癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

VPI-221

靶点-

作用机制-

在研机构

Vault Nano, Inc.

原研机构

University of California, Los Angeles

在研适应症

流感病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

VPI-201

靶点-

作用机制-

在研机构

Vault Nano, Inc.

原研机构

University of California, Los Angeles

在研适应症

衣原体感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Vault Nano, Inc. 相关的临床结果

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0 项与 Vault Nano, Inc. 相关的专利（医药）

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3

项与 Vault Nano, Inc. 相关的文献（医药）

2020-03-01·Chemosphere2区 · 环境科学与生态学

Vault packaged enzyme mediated degradation of amino-aromatic energetic compounds

2区 · 环境科学与生态学

Article

作者: Kickhoefer, Valerie A ; Wang, Meng ; Lothe, Anjali G ; Mack, Elizabeth Erin ; Kalra, Shashank Singh ; Walecka-Hutchison, Claudia ; Rome, Leonard H ; Mahendra, Shaily

Amino-aromatic compounds, 2-amino-4-nitrotoluene (ANT), and 2,4-diaminotoluene (DAT) are carcinogens and environmentally persistent pollutants. In this study, we investigated their degradation by natural manganese peroxidase (nMnP) derived from Phanerochaete chrysosporium and recombinant manganese peroxidase packaged in vaults (vMnP). Encapsulation of manganese peroxidase (MnP) in ribonucleoprotein nanoparticle cages, called vaults, was achieved by creating recombinant vaults in yeast Pichia pastoris. Vault packaging increased the stability of MnP by locally sequestering multiple copies of the enzyme. Within 96  h, both vMnP and nMnP catalyzed over 72% removal of ANT in-vitro, which indicates that vault packaging did not limit substrate diffusion. It was observed that vMnP was more efficient than nMnP and P. chrysosporium for the catalysis of target contaminants. Only 57% of ANT was degraded by P. chrysosporium even when MnP activity reached about 480 U L^-1 in cultures. At 1.5 U L^-1 initial activity, vMnP achieved 38% of ANT and 51% of DAT degradation, whereas even 2.7 times higher activity of nMnP showed insignificant biodegradation of both compounds. These results imply that due to protection by vault cages, vMnP has lower inactivation rates. Thus, it works effectively at lower dosage for a longer duration compared to nMnP without requiring frequent replenishment. Collectively, these results indicate that fungal enzymes packaged in vault nanoparticles are more stable and active, and they would be effective in biodegradation of energetic compounds in industrial processes, waste treatment, and contaminated environments.

2019-10-01·Journal of Biological Chemistry2区 · 生物学

A new role for vault RNA–TEP1 complexes in mRNA production in trypanosomes

2区 · 生物学

Communications

作者: Kickhoefer, Valerie A

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.

Nature Communications1区 · 综合性期刊

Functional divergence of a bacterial enzyme promotes healthy or acneic skin

1区 · 综合性期刊

ArticleOA

作者: Caldera, J R ; Tsai, Chih-Ming ; Lázaro-Díez, María ; Gonzalez, Cesia ; Choudhury, Biswa ; Kolar, Stacey ; Chatterjee, Avradip ; Liu, George Y ; Katiki, Madhusudhanarao ; Murali, Ramachandran ; Desmond, Trieu ; Li, Huiying ; Paulchakrabarti, Mousumi ; Hajam, Irshad A ; McNally, Randall ; Du, Xin

AbstractAcne is a dermatologic disease with a strong pathologic association with human commensal Cutibacterium acnes. Conspicuously, certain C. acnes phylotypes are associated with acne, whereas others are associated with healthy skin. Here we investigate if the evolution of a C. acnes enzyme contributes to health or acne. Two hyaluronidase variants exclusively expressed by C. acnes strains, HylA and HylB, demonstrate remarkable clinical correlation with acne or health. We show that HylA is strongly pro-inflammatory, and HylB is modestly anti-inflammatory in a murine (female) acne model. Structural and phylogenic studies suggest that the enzymes evolved from a common hyaluronidase that acquired distinct enzymatic activity. Health-associated HylB degrades hyaluronic acid (HA) exclusively to HA disaccharides leading to reduced inflammation, whereas HylA generates large-sized HA fragments that drive robust TLR2-dependent pathology. Replacing an amino acid, Serine to Glycine near the HylA catalytic site enhances the enzymatic activity of HylA and produces an HA degradation pattern intermediate to HylA and HylB. Selective targeting of HylA using peptide vaccine or inhibitors alleviates acne pathology. We suggest that the functional divergence of HylA and HylB is a major driving force behind C. acnes health- and acne- phenotype and propose targeting of HylA as an approach for acne therapy.

100 项与 Vault Nano, Inc. 相关的药物交易

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100 项与 Vault Nano, Inc. 相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

1

5

临床前

其他

4

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当前项目

药物(靶点)	适应症	全球最高研发状态

VPI-221	流感病毒感染更多	临床前
VPI-201	衣原体感染更多	临床前
IL17-Vault ( IL-17 )	肺癌更多	临床前
VPI-121 ( gp100 )	胶质母细胞瘤更多	临床前
VNI-101	胶质母细胞瘤更多	临床前