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项与 Lilly Research Center Ltd. 相关的药物

LSN-2790158

靶点

PDE1

作用机制

PDE1抑制剂

在研机构-

原研机构

Lilly Research Center Ltd.

在研适应症-

非在研适应症

心脏衰竭

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

LY-303496

靶点

thrombin

作用机制

thrombin抑制剂

在研机构-

原研机构

Lilly Research Center Ltd.

在研适应症-

非在研适应症

血栓栓塞

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

LY-288975

靶点

多磷酸肌醇-5-磷酸酶

作用机制

多磷酸肌醇-5-磷酸酶抑制剂

在研机构-

原研机构

Lilly Research Center Ltd.

在研适应症-

非在研适应症

血液疾病 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Lilly Research Center Ltd. 相关的临床结果

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0 项与 Lilly Research Center Ltd. 相关的专利（医药）

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425

项与 Lilly Research Center Ltd. 相关的文献（医药）

2023-02-01·Molecular Psychiatry

Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience

Article

作者: Boerner, Thomas ; Huber, Anna ; Jahans-Price, Thomas ; Sanderson, David J ; Gilmour, Gary ; Walton, Mark E ; Sprengel, Rolf ; Harrison, Paul J ; Bannerman, David M ; Panayi, Marios C

AbstractPsychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic dysfunction and impairments in synaptic plasticity in the etiology of schizophrenia, including deficits associated with the GluA1 AMPAR subunit. GluA1 knockout (Gria1−/−) mice provide a model of impaired synaptic plasticity in schizophrenia and exhibit a selective deficit in a form of short-term memory which underlies short-term habituation. As such, these mice are unable to reduce attention to recently presented stimuli. In this study we used fast-scan cyclic voltammetry to measure phasic dopamine responses in the nucleus accumbens of Gria1−/− mice to determine whether this behavioral phenotype might be a key driver of a hyper-dopaminergic state. There was no effect of GluA1 deletion on electrically-evoked dopamine responses in anaesthetized mice, demonstrating normal endogenous release properties of dopamine neurons in Gria1−/− mice. Furthermore, dopamine signals were initially similar in Gria1−/− mice compared to controls in response to both sucrose rewards and neutral light stimuli. They were also equally sensitive to changes in the magnitude of delivered rewards. In contrast, however, these stimulus-evoked dopamine signals failed to habituate with repeated presentations in Gria1−/− mice, resulting in a task-relevant, hyper-dopaminergic phenotype. Thus, here we show that GluA1 dysfunction, resulting in impaired short-term habituation, is a key driver of enhanced striatal dopamine responses, which may be an important contributor to aberrant salience and psychosis in psychiatric disorders like schizophrenia.

2019-06-03·Current Medical Research and Opinion4区 · 医学

Study description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS)

4区 · 医学

Article

作者: Elsalmawy, Abdulaziz H. ; Brnabic, Alan J.M. ; Ish-Shalom, Sophia ; Yang, Huilin ; Casas, Noemí ; Marin, Fernando ; Al-Ali, Nadia S. ; Altan, Lale ; Cunha-Borges, Joao L. ; Chen, Chung-Hwan ; Burge, Russel T. ; Gurbuz, Sirel ; Moll, Thomas ; Lim, Seung-Jae

OBJECTIVETo describe the study design and baseline patient characteristics of the Asia and Latin America Fracture Observational Study (ALAFOS) to better understand the profile of patients receiving teriparatide during the course of routine clinical practice in Asia, Latin America, the Middle East and Russia.METHODSProspective, observational, non-interventional study in postmenopausal women with osteoporosis who are prescribed teriparatide for up to 24 months, according to local medical standards, with a 12 month post-treatment follow-up.MEASURESDemographics, risk factors for osteoporosis and fractures, history of fracture, prior osteoporosis medications, comorbidities, physical function, back pain and quality of life (QoL).RESULTSIn total 3031 postmenopausal women (mean age 72.5 years) recruited at 152 sites in 20 countries were analyzed; 62.9% had a history of fragility fracture after age 40 (33.0% of patients with spinal, 14.2% with hip fractures). The mean (SD) bone mineral density T-scores at baseline were -3.06 (1.40) and -2.60 (1.05) at the lumbar spine and femoral neck, respectively. At entry, 43.7% of patients were naïve to prior osteoporosis treatments; 40.5% of patients reported ≥1 fall in the past year. The median (Q1; Q3) EuroQoL Visual Analog Scale (EQ-VAS) for perceived overall health status was 60 (50; 80). The mean (SD) worst back pain Numeric Rating Scale in the last 24 hours was 4.6 (3.3).CONCLUSIONSOur data indicates that patients who were prescribed teriparatide in the ALAFOS participant countries had severe osteoporosis, high prevalence of fractures, disabling back pain and poor QoL. The frequency of patients receiving prior osteoporosis medications was lower than in previous observational studies conducted in other locations.

2019-02-01·Healthy Aging – Bone and Joint

Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis: a systematic review and meta-analysis

作者: Marin, F ; Eriksen, EF ; Krege, JH ; Delgado-Rodríguez, M ; Kendler, DL ; Kurth, A

100 项与 Lilly Research Center Ltd. 相关的药物交易

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100 项与 Lilly Research Center Ltd. 相关的转化医学

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当前项目

药物(靶点)	适应症	全球最高研发状态

LY-288975 ( 多磷酸肌醇-5-磷酸酶 )	免疫系统疾病更多	无进展
LY-2033298 ( M4 receptor )	精神分裂症更多	无进展
LSN-2790158 ( PDE1 )	心脏衰竭更多	无进展
LY-303496 ( thrombin )	血栓栓塞更多	无进展