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2

项与 Incara Pharmaceuticals Corp. 相关的药物

Deligoparin sodium

靶点

Heparin

作用机制

肝素激动剂

在研机构-

原研机构

Opocrin SpA

在研适应症-

非在研适应症

溃疡性结肠炎 [+1]

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

TC-002

靶点-

作用机制-

在研机构-

原研机构

Incara Pharmaceuticals Corp.

在研适应症-

非在研适应症

细菌感染

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

1

项与 Incara Pharmaceuticals Corp. 相关的临床试验

NCT00033943 / Completed临床2/3期

A Multi-Center, Placebo-Controlled Evaluation of the Safety and Efficacy of Two Dosage Levels of OP2000 (75 Mg and 125 Mg) Administered Once Daily by Subcutaneous Injection for the Treatment of Active Ulcerative Colitis

This study will evaluate the effectiveness and safety of the experimental compound OP2000 (deligoparin) in patients with active ulcerative colitis. Patients eligible for this study will have received (and will continue to receive) stable doses of aminosalicylates (oral, enema and/or suppository), if tolerated. OP2000 is an ultra low molecular weight heparin with anticoagulant (blood thinning) and anti-inflammatory actions that may be of benefit for the treatment of ulcerative colitis.

开始日期2001-01-01

申办/合作机构

Incara Pharmaceuticals Corp.

100 项与 Incara Pharmaceuticals Corp. 相关的临床结果

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0 项与 Incara Pharmaceuticals Corp. 相关的专利（医药）

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2

项与 Incara Pharmaceuticals Corp. 相关的文献（医药）

1999-08-01·The Journal of Organic Chemistry

Stereospecific Solution- and Solid-Phase Glycosylations. Synthesis of β-Linked Saccharides and Construction of Disaccharide Libraries Using Phenylsulfenyl 2-Deoxy-2-Trifluoroacetamido Glycopyranosides as Glycosyl Donors¹

作者: Wang, Huiming ; Jain, Rakesh K. ; Allanson, Nigel M. ; Sofia, Michael J. ; Silva, Domingos J.

An efficient strategy to construct β-O-2-amino-2-deoxyglycopyranosidic linkages using glycosyl sulfoxides is demonstrated.Phenylsulfenyl 2-deoxy-2-trifluoroacetamido glycopyranosides were found to be reactive glycosyl donors in both solid- and solution-phase glycosylations, affording the corresponding β-glycosides exclusively and in high yield.The trifluoroacetamido group was removed under mild conditions, allowing orthogonal derivatization of multiple protected amino groups on an oligosaccharide or glycoconjugate.On the basis of the results with these glycosyl donors, a solid-phase β-linked disaccharide library was constructed.The scope and flexibility of this approach will be discussed.

Medicinal Chemistry Research

The generation of carbohydrate-based combinatorial libraries for drug discovery

作者: Sofia, Michael J.

A review with 24 referencesThe authors discuss how carbohydrate scaffolds are biol. relevant mol. platforms that can be used to identify unique ligands for a wide variety of biomol. drug targets.The authors have developed solid phase combinatorial chem. strategies using monosaccharide and disaccharide scaffolds for pharmacophore mapping of small-mol. protein interactions and protein-protein interactions.They are exploiting these strategies for identifying novel antibacterial agents, but expect that these libraries will find broad relevance as mol. screening tests.

100 项与 Incara Pharmaceuticals Corp. 相关的药物交易

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100 项与 Incara Pharmaceuticals Corp. 相关的转化医学

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