The investigators have developed an integrated suicide intervention, Brief Suicide and Trauma Therapy (BSTT). BSTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce suicidality-with a trauma therapy component to alleviate the specific impacts of childhood trauma on suicide risk. The aim of this pilot is to test 12-weeks of BSTT to alleviate suicide risk among individuals with a history of childhood trauma and current suicidality.

开始日期2025-04-01

申办/合作机构

Unity Health Toronto

NCT06618807 / Not yet recruiting临床1/2期IIT

A Pilot Study Evaluating the Feasibility, Safety, and Efficacy of the Neuro RX Gamma (Version 2) for the Treatment of Mild Cognitive Impairment (MCI)

Mild cognitive impairment (MCI) is a transitional risk state that occurs between the normal aging process and Alzheimer's dementia (AD). On average 32% of patients with MCI will progress to dementia, 62% will stay stable, and about 6% will return to normal cognition at subsequent visits.
Current treatment for MCI includes cholinesterase inhibitors (donepezil, galantamine and rivastigmine), and NMDA receptor antagonists (memantine) which delay or slow the worsening of symptoms and treat cognitive symptoms (memory loss, confusion, and problems with thinking and reasoning). Despite currently ongoing drug studies and modest clinical benefits of currently approved drug treatments, there continues to remain a need for treatments for long term symptomatic improvement of MCI with fewer and less severe side effects.
Photobiomodulation (PBM) therapy also called low-level laser (or light) therapy (LLLT) is a safe, non-invasive, non-thermal (no significant heat is generated) method of therapy which uses either visible red or near-infrared (NIR) light to stimulate, heal and repair damaged or dying tissue cells. This study proposes to use the Neuro RX Gamma device (version 2) to deliver NIR light energy to particular brain regions which are dysfunctional in MCI participants.

开始日期2025-03-01

申办/合作机构

Unity Health Toronto

[+1]

NCT05713630 / Not yet recruiting临床3期IIT

TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma

Subdural hematoma (SDH) is a common condition experienced after head injury. Blood collects on the surface of the brain, causing headaches which can progress to confusion, weakness, or even coma. While patients with SDH often receive surgery, not all patients require surgery right away to ease pressure on the brain. After surgery, there can be up to 30 percent chance of more bleeding and the need for more surgeries. Given this, a drug capable of lowering the chance of more bleeding and speeding the recovery of the patient is highly desirable. In this study, we will test a commonly used, cheap drug called Tranexamic Acid (TXA). While the body stops unwanted and sometimes dangerous bleeding naturally by forming blood clots, TXA stops these blood clots from breaking down, which helps to keep bleeding spots plugged. Our previous study showed that TXA helped speed up patients' recovery; but a larger number of patients is necessary to evaluate how well TXA works to reduce bleeding and improve patient-reported outcomes. In this study, regardless of the need for surgery, half of the patients will be randomly assigned to take TXA, while the other half will take a placebo, which is a look-alike substance that contains no active drug. We will measure multiple outcomes over time to determine if TXA is working and lowers healthcare and personal costs, while also taking blood and surgical samples, to better understand how this drug works in SDH patients.

开始日期2025-01-31

申办/合作机构

Unity Health Toronto

[+3]

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项与 Unity Health Toronto 相关的文献（医药）

2023-04-01·The American journal of bioethics : AJOB

Ethics Debriefs and Moral Distress: What are we Doing?

Article

作者: Abdool, Steve ; Makkar, Juhee ; Hillman, Sean ; Campbell, Alexandra ; Hassanein, Maram ; Langlois, Dave ; de Bie, A Lee ; Szego, Michael J ; Robertson, Jamie ; Maurice, Rochelle ; Butler, Jeremy

2023-03-01·American journal of respiratory and critical care medicine

Reply to Tobin

Letter

作者: Slutsky, Arthur S. ; Ranieri, V. Marco ; Rubenfeld, Gordon

2021-04-01·Physiotherapy Canada. Physiotherapie Canada4区 · 医学

Updating the Evidence: Suctioning Practices of Physiotherapists in Ontario

4区 · 医学

Article

作者: Brooks, Dina ; Beavers, Lindsay ; Spencer, Abbigale ; Triemstra, Samantha ; Gooder, Megan ; Livings, Nicole ; Miller, Erin ; Liang, Haiyun

Purpose: The purpose of this article is to describe current tracheal suctioning practices of physiotherapists in the province of Ontario and to determine what factors influence these practices. Method: A cross-sectional online survey was conducted. An online survey link and quick response code were mailed to Ontario physiotherapists who were actively providing patient care and were authorized to perform tracheal suctioning as identified by the College of Physiotherapists of Ontario. Results: Ninety physiotherapists participated in the survey (23% response rate). Most (66%) suctioned in an intensive care setting, and many (41%) reported frequently using a closed endotracheal suctioning system. Hyperoxygenation was frequently performed before suctioning by 48% of participants, and only 18% frequently hyperoxygenated after suctioning. Most participants reported infrequently performing saline instillation (52%) and infrequently hyperinflating before suctioning (79%). Clean gloves were reported as the personal protective equipment most frequently worn across all suctioning approaches, and goggles and sterile gloves were least often worn while suctioning. Previous suctioning experience had the most influence on suctioning practices, and limited access to equipment had the least influence. Conclusions: Some of the tracheal suctioning practices of physiotherapists in Ontario vary from evidence-based clinical guidelines.

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2023-10-12

·GlobeNewswire-Health Care

National KOLs converge that data management is the hinge factor for reshaping healthcare in Canada

The first edition of the Canada Healthcare Innovation Summit, organized by Bamberg Health, explored through different roundtables, the challenges ahead while innovating in healthcare, implementing new tools, and the need for coordinated work between stakeholdersTORONTO, Oct. 12, 2023 (GLOBE NEWSWIRE) -- The first edition of the Canada HIS, a hybrid event organized by Bamberg Health, reunited more than 200 key players in the industry to explore the latest advancements and challenges in the field and how they can be integrated into the healthcare systems. “As our healthcare system emerges from the pandemic, the time to innovate and embrace healthcare transformation has never been more important,” declared Cameron Love, President, and CEO at Ottawa Hospital, who was a speaker in the first panel “Innovative Healthcare Management”. The session “A Forward-looking View of Big Data and AI in the New Medicine” pointed out how Canada is leading AI research and the importance of the interpretation of that Data. “Earlier we talked about the transformation needed in Healthcare, to really improve the services, AI has the potential to make a real exponential change. The challenge is to really get things done and to really learn in the process,” stated Nick Milinkovich, Partner of McKinsey & Company. Another key point in this discussion was the need to build trust between players and within the society. “There are doubts regarding implementing new tools, but one thing is for sure: Silo data approaches won't work at any level, no social, no systemical. We understand and respect the privacy concerns, but if we approach it as a competitive product, we will not be able to reach the full potential to change and improve healthcare,” declared Sebnem Kuzulugil, Director of Data Integration and Governance, DSAA at the Unity Health Toronto. The different panelists analyzed the trends and experiences while exploring changes in healthcare. Regardless of their expertise, they all agreed that collaboration among stakeholders is crucial to achieving real change and improving people’s lives as although the tools are developed with a variety of goals, taking advantage of their benefits for healthcare is a cross-responsibility. This event is part of the Healthcare Innovation Series that Bamberg Health hosts around the world looking to connect key decision-makers to achieve a real positive impact on healthcare. Contact information:Camila Demarcocamila@bambergsummits.com

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