更新于：2024-11-01

SIRT5 x NAD+

更新于：2024-11-01

基本信息

关联

项与 SIRT5 x NAD+ 相关的药物

Nicotinamide riboside/Pterostilbene

靶点

NAD+ x SIRT5

作用机制

NAD+调节剂 [+1]

在研机构

Elysium Health, Inc.初创企业

原研机构

Elysium Health, Inc.初创企业

在研适应症

主动脉瘤 [+1]

非在研适应症

肌萎缩侧索硬化 [+1]

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与 SIRT5 x NAD+ 相关的临床试验

CTRI/2024/01/061558 / Not yet recruiting临床4期IIT

A Comparative Study to Assess the Effectiveness of Homoeopathic Medicines Selected on Basis of Totality of Symptoms vis-à-vis Body Language in The Treatment of Chronic Respiratory Diseases - NIL

开始日期2024-01-27

申办/合作机构-

NCT06196398 / RecruitingN/AIIT

Effects of Medical Treatment of Intracranial Atherosclerotic Diseases Based on Magnetic Resonance Fractional Flow Reserve

This multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of ICAS patients divided hemodynamically by Magnetic Resonance Fractional Flow Reserve. PC MRA will be applied for FFR measurement. The primary outcome is the composite of ischemic stroke or death related to the qualifying artery territory for 1 year.

开始日期2023-01-01

申办/合作机构

首都医科大学宣武医院

NCT04841499 / CompletedN/AIIT

Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause

The purpose of this study is to determine whether a short supplementation (7days) with BASIS™ increases the natural production of estradiol, measured in urinary waste. The overall objective is to determine whether through increased estradiol levels, the undesirable menopausal effects, assessed via questionnaires, are mitigated by a short-term supplementation with BASIS™

开始日期2021-04-05

申办/合作机构

University of South Alabama

[+1]

100 项与 SIRT5 x NAD+ 相关的临床结果

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100 项与 SIRT5 x NAD+ 相关的转化医学

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0 项与 SIRT5 x NAD+ 相关的专利（医药）

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项与 SIRT5 x NAD+ 相关的文献（医药）

2024-01-01·Theranostics

Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies

Review

作者: Qin, Zheng ; Fu, Leilei ; Liu, Yuan ; Hu, Yue ; Shen, Hui ; Ma, Wei ; Song, Yaowen

The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on nicotinamide adenine dinucleotide (NAD⁺). Among them, mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) are deacetylases located in mitochondria that regulate the acetylation levels of several key proteins to maintain mitochondrial function and redox homeostasis. Mitochondrial SIRTs are reported to have the Janus role in tumorigenesis, either tumor suppressive or oncogenic functions. Although the multi-faceted roles of mitochondrial SIRTs with tumor-type specificity in tumorigenesis, their critical functions have aroused a rising interest in discovering some small-molecule compounds, including inhibitors and activators for cancer therapy. Herein, we describe the molecular structures of mitochondrial SIRTs, focusing on elucidating their regulatory mechanisms in carcinogenesis, and further discuss the recent advances in developing their targeted small-molecule compounds for cancer therapy. Together, these findings provide a comprehensive understanding of the crucial roles of mitochondrial SIRTs in cancer and potential new therapeutic strategies.

2023-03-09·Cells

Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.

Review

作者: Altucci, Lucia ; Mai, Antonello ; Fabbrizi, Emanuele ; Carafa, Vincenzo ; Fiorentino, Francesco ; Rotili, Dante

Sirtuin 5 (SIRT5) is a predominantly mitochondrial enzyme catalyzing the removal of glutaryl, succinyl, malonyl, and acetyl groups from lysine residues through a NAD⁺-dependent deacylase mechanism. SIRT5 is an important regulator of cellular homeostasis and modulates the activity of proteins involved in different metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle, fatty acid oxidation, electron transport chain, generation of ketone bodies, nitrogenous waste management, and reactive oxygen species (ROS) detoxification. SIRT5 controls a wide range of aspects of myocardial energy metabolism and plays critical roles in heart physiology and stress responses. Moreover, SIRT5 has a protective function in the context of neurodegenerative diseases, while it acts as a context-dependent tumor promoter or suppressor. In addition, current research has demonstrated that SIRT5 is implicated in the SARS-CoV-2 infection, although opposing conclusions have been drawn in different studies. Here, we review the current knowledge on SIRT5 molecular actions under both healthy and diseased settings, as well as its functional effects on metabolic targets. Finally, we revise the potential of SIRT5 as a therapeutic target and provide an overview of the currently reported SIRT5 modulators, which include both activators and inhibitors.

2023-01-01·3 Biotech

Shedding light on structure, function and regulation of human sirtuins: a comprehensive review

Review

作者: Jain, Monika ; Mahur, Pragati ; Muthukumaran, Jayaraman ; Sharma, Abhishek ; Singh, Amit Kumar

Sirtuins play an important role in signalling pathways associated with various metabolic regulations. They possess mono-ADP-ribosyltransferase or deacylase activity like demalonylase, deacetylase, depalmitoylase, demyristoylase and desuccinylase activity. Sirtuins are histone deacetylases which depends upon nicotinamide adenine dinucleotide (NAD) that deacetylate lysine residues. There are a total of seven human sirtuins that have been identified namely, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7. The subcellular location of mammalian sirtuins, SIRT1, SIRT6, and SIRT7 are in the nucleus; SIRT3, SIRT4, and SIRT5 are in mitochondria, and SIRT2 is in cytoplasm. Structurally sirtuins contains a N-terminal, a C-terminal and a Zn⁺ binding domain. The sirtuin family has been found to be crucial for maintaining lipid and glucose homeostasis, and also for regulating insulin secretion and sensitivity, DNA repair pathways, neurogenesis, inflammation, and ageing. Based on the literature, sirtuins are overexpressed and play an important role in tumorigenicity in various types of cancer such as non-small cell lung cancer, colorectal cancer, etc. In this review, we have discussed about the different types of human sirtuins along with their structural and functional features. We have also discussed about the various natural and synthetic regulators of sirtuin activities like resveratrol. Our overall study shows that the correct regulation of sirtuins can be a good target for preventing and treating various diseases for improving the human lifespan. To investigate the true therapeutic potential of sirtuin proteins and their efficacy in a variety of pathological diseases, a better knowledge of the link between the structure and function of sirtuin proteins would be necessary.