别名 GLRA1、Glycine receptor 48 kDa subunit、glycine receptor alpha 1 + [5] |
简介 Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). |
作用机制 ATP2C1 blockers [+2] |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期1992-09-18 |
作用机制 ATP2C1 blockers [+3] |
原研机构 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 日本 |
首次获批日期1990-04-20 |
作用机制 ATP2C1 blockers [+3] |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期1979-12-18 |
开始日期2025-01-01 |
申办/合作机构 University of Zurich [+2] |
开始日期2024-11-04 |
申办/合作机构 |
开始日期2024-11-01 |