别名 Gene associated with retinoic and IFN-induced mortality 12 protein、Gene associated with retinoic and interferon-induced mortality 12 protein、GRIM-12 + [11] |
简介 Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. |
作用机制 GSR inhibitors [+1] |
在研适应症 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 TrxR1抑制剂 |
在研适应症 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2014-08-29 |
申办/合作机构 北京大学 [+1] |
开始日期2014-06-01 |
申办/合作机构 |