更新于：2024-11-01

Bacterial IRS

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 Bacterial IRS 相关的药物

Mupirocin

莫匹罗星

靶点

Bacterial IRS

作用机制

Bacterial IRS抑制剂

在研机构

Glaxosmithkline Australia Pty Ltd. [+4]

原研机构

GSK Plc

在研适应症

脓疱疮 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1987-12-31

SB-205952

靶点

Bacterial IRS

作用机制

Bacterial IRS抑制剂

在研机构-

原研机构

Smithkline Beecham Pharmaceuticals (India) Ltd.

在研适应症-

非在研适应症

细菌感染

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与 Bacterial IRS 相关的临床试验

NCT06541145 / RecruitingN/AIIT

Impact of Bacterial Decolonization on Bacterial Burden Within Maternal-infant Dyads

The goal of this study is to measure bacterial burden, specifically Staph aureus, and how it spreads between mothers and their infants. Researchers will evaluate if the amount of bacteria on their skin remains the same after mothers use a skin antisepsis treatment prior to delivering their infants. The investigators also aim to assess participant interest in and compliance with skin antisepsis treatments. The hypothesis is that increased maternal interest will align with increased treatment compliance.

开始日期2024-08-21

申办/合作机构

Duke University

[+1]

ChiCTR2400085012 / Recruiting早期临床1期IIT

Clinical effects of photodynamic therapy with Ondapench photosensitive antibacterial powder as photosensitiser compared with mupirocin ointment in the treatment of bacterial skin infections

开始日期2024-06-01

申办/合作机构

中南大学湘雅医院

NCT06210594 / Recruiting临床4期IIT

SHIELD (Staph Intervention for Effective Local Defense): An Open-label Randomized Controlled Trial to Assess Efficacy of a Sustained Intervention (Topical Antibiotics and Skin Antisepsis) to Decrease Staphylococcus Aureus Carriage in Adults

Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections. The goal of this clinical trial is to evaluate a community-informed approach to reduce carriage of SA. Participants will be assigned to education and household supplies for prevention of SA with and without a biomedical intervention. Researchers will compare SA carriage in the two groups.

开始日期2024-04-01

申办/合作机构

Johns Hopkins Bloomberg School of Public Health

[+1]

100 项与 Bacterial IRS 相关的临床结果

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100 项与 Bacterial IRS 相关的转化医学

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0 项与 Bacterial IRS 相关的专利（医药）

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项与 Bacterial IRS 相关的文献（医药）

2025-02-01·Bioelectrochemistry

Polynorepinephrine and polydopamine-bacterial laccase coatings for phenolic amperometric biosensors

Article

作者: Morana, Alessandra ; Santos, Romana ; Almeida, Luís C. ; Branco, Clara ; Correia, Jorge P. ; Zeferino, Jorge F. ; Almeida, Luís C ; Ihalainen, Petri ; Sobhana, Liji ; Zeferino, Jorge F ; Viana, Ana S ; Squillaci, Guiseppe ; Correia, Jorge P ; Viana, Ana S.

The successful fabrication of biosensors is greatly limited by the immobilization of their bioreceptor, thus we propose a facile and reproducible two-step method to modify graphite electrodes with a bacterial laccase, relying on a fast and controllable potentiostatic process to coat graphite surfaces with biomolecule-compatible thin films of polynorepinephrine (ePNE) and polydopamine (ePDA). Both polymers, synthesized with a similar thickness, were functionalized with bacterial laccase, displaying distinct electrochemical transducing behaviours at pH 5.0 and 7.0. ePNE layer enables adequate electron transfer of anionic and cationic species in acidic and neutral media, whereas transduction across ePDA strongly depends on pH and redox probe charge. ePNE stands out by improving the amperometric responses of the biosensing interface towards a phenolic acid (gallic acid) and a flavonoid (catechin), in respect to ePDA. The optimal graphite/ePNE/laccase interface outperforms biosensing interfaces based on fungal laccases at neutral pH, displaying detection sensitivities of 104 and 14.4 µA cm^-2 mM^-1for gallic acid and catechin, respectively. The fine synthetic control of the ePNE bio-inspired transduction layer and the use of an alkaliphilic bacterial laccase enabled the construction of an amperometric biosensing interface with extended pH range of polyphenols detection present in food products and agro-industrial waste.

2018-12-01·BMC Medical Genetics4区 · 医学

Expanding the clinical phenotype of IARS2-related mitochondrial disease

4区 · 医学

ArticleOA

作者: Mittag, Falk ; Vona, Barbara ; Bellacchio, Emanuele ; Shahrokhzadeh, Sima ; Diodato, Daria ; Shirzadeh, Ebrahim ; Karimiani, Ehsan Ghayoor ; Taylor, Robert W ; Movaffagh, Jebrail ; Alahmad, Ahmad ; Haaf, Thomas ; Boostani, Reza ; Maroofian, Reza ; Traub, Frank ; Rad, Abolfazl ; Thompson, Kyle ; Ahangari, Najmeh ; Schmidts, Miriam ; Bahena, Paulina ; Doosti, Mohammad ; Najafi, Maryam ; Amiri, Nafise ; He, Langping

BACKGROUNDIARS2 encodes a mitochondrial isoleucyl-tRNA synthetase, a highly conserved nuclear-encoded enzyme required for the charging of tRNAs with their cognate amino acid for translation. Recently, pathogenic IARS2 variants have been identified in a number of patients presenting broad clinical phenotypes with autosomal recessive inheritance. These phenotypes range from Leigh and West syndrome to a new syndrome abbreviated CAGSSS that is characterised by cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia, as well as cataract with no additional anomalies.METHODSGenomic DNA from Iranian probands from two families with consanguineous parental background and overlapping CAGSSS features were subjected to exome sequencing and bioinformatics analysis.RESULTSExome sequencing and data analysis revealed a novel homozygous missense variant (c.2625C > T, p.Pro909Ser, NM_018060.3) within a 14.3 Mb run of homozygosity in proband 1 and a novel homozygous missense variant (c.2282A > G, p.His761Arg) residing in an ~ 8 Mb region of homozygosity in a proband of the second family. Patient-derived fibroblasts from proband 1 showed normal respiratory chain enzyme activity, as well as unchanged oxidative phosphorylation protein subunits and IARS2 levels. Homology modelling of the known and novel amino acid residue substitutions in IARS2 provided insight into the possible consequence of these variants on function and structure of the protein.CONCLUSIONSThis study further expands the phenotypic spectrum of IARS2 pathogenic variants to include two patients (patients 2 and 3) with cataract and skeletal dysplasia and no other features of CAGSSS to the possible presentation of the defects in IARS2. Additionally, this study suggests that adult patients with CAGSSS may manifest central adrenal insufficiency and type II esophageal achalasia and proposes that a variable sensorineural hearing loss onset, proportionate short stature, polyneuropathy, and mild dysmorphic features are possible, as seen in patient 1. Our findings support that even though biallelic IARS2 pathogenic variants can result in a distinctive, clinically recognisable phenotype in humans, it can also show a wide range of clinical presentation from severe pediatric neurological disorders of Leigh and West syndrome to both non-syndromic cataract and cataract accompanied by skeletal dysplasia.

2015-07-01·Journal of Laboratory Physicians

Prevalence of Mupirocin Resistance Among Staphylococci, its Clinical Significance and Relationship to Clinical Use

Article

作者: Navaneeth, Bangalore Viswanath ; Ravi, Giriyapur Siddappa ; Sandhya, Parthasarathi ; Motagi, Aravind ; Rudresh, Manohar Shoorashetty ; Alex, Ann Mary

ABSTRACT Introduction: Mupirocin competitively inhibits bacterial isoleucyl transfer-RNA synthetase and inhibit bacterial protein synthesis. Widespread usage and over the counter availability of the drug has resulted in resistance among Staphylococcus species. Objectives: This study aimed to determine the overall prevalence of mupirocin resistance among staphylococci. Correlate clinical significance of mupirocin resistance and its relationship to clinical use. Methods: Consecutive, nonrepetitive, clinical isolates of Staphylococcus aureus (n = 98), and coagulase-negative staphylococci (CoNS) (n = 45) from skin and soft-tissue infections between January 2014 and June 2014 were studied. Antibiotic susceptibility testing was done according to Clinical and Laboratory Standards Institute guidelines. Low- and high-level mupirocin resistance was screened by using 5 μg and 200 μg discs respectively and confirmed by agar dilution. Annual consumption of mupirocin was studied and correlated with resistance. Results: High-level mupirocin resistance was found in 8.2% S. aureus and 15.6% of CoNS, while low-level mupirocin resistance was found in 17% S. aureus and 8.9% CoNS. High-level mupirocin resistance was more common in methicillin-sensitive S. aureus isolates when compared with methicillin-resistant S. aureus isolates (P < 0.05). Mupirocin resistant S. epidermidis were associated with methicillin resistance and constitutive clindamycin resistance. Conclusion: High prevalence of mupirocin resistance was found in the present study. Increased prevalence of mupirocin resistance among community-acquired staphylococci demands the judicious use of the drug in the community.