A Multicenter, Randomized, Parallel-group, Double-blind, Comparative Trial of the Superiority of Paracetamol 500mg/Fexofenadine 60mg/Phenylephrine 20mg Fixed-dose Combination Versus Placebo in the Symptomatic Treatment of Flu and Cold

A Phase 3, multicenter, Randomized, Double-blind, comparative clinical trial to evaluate the association of paracetamol 500mg + Fexofenadine 60mg + Phenylephrine 20mg in the flu and common cold treatment.
⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is outside brazil).

开始日期2024-11-30

申办/合作机构

Eurofarma Laboratórios SA

CTR20232989 / CompletedN/A

布洛肾素片人体生物等效性研究

主要目的：采用单中心、随机、开放、单剂量、三周期部分重复交叉空腹给药及四周期完全重复交叉餐后给药设计，比较山东新华制药股份有限公司提供的布洛肾素片（规格：布洛芬200mg/盐酸去氧肾上腺素10mg）与GlaxoSmithKline Consumer Healthcare Holdings（US）LLC持证的原研布洛肾素片（商品名：Advil Congestion Relief®，规格：布洛芬200 mg/盐酸去氧肾上腺素10 mg）在健康人群中吸收程度和速度的差异。次要目的：评价空腹及餐后条件下，山东新华制药股份有限公司提供的布洛肾素片（规格：布洛芬200mg/盐酸去氧肾上腺素10 mg）与GlaxoSmithKline Consumer Healthcare Holdings（US）LLC持证的原研布洛肾素片（商品名：Advil Congestion Relief®，规格：布洛芬200 mg/盐酸去氧肾上腺素10 mg）的安全性和耐受性。

开始日期2023-10-25

申办/合作机构

山东新华制药股份有限公司

NCT06539637 / Recruiting早期临床1期IIT

Ketorolac Levels in Vitreous and Aqueous Samples From Patients Undergoing Combined Cataract and Pars Plana Vitrectomy Surgeries With and Without Intracameral Phenylephrine 1.0% / Ketorolac 0.3%

This is a clinical trial evaluating Ketorolac levels in vitreous and aqueous humor samples from patients undergoing combined cataract and pars plana vitrectomy surgeries with and without intracameral phenylephrine 1.0% / ketorolac 0.3% (OMIDRIA). Patients not receiving intracameral OMIDRIA will receive topical ketorolac prior to cataract surgery/pars plana vitrectomy.

开始日期2023-09-01

申办/合作机构-

100 项与 ADRA1 x COX 相关的临床结果

登录后查看更多信息

100 项与 ADRA1 x COX 相关的转化医学

登录后查看更多信息

0 项与 ADRA1 x COX 相关的专利（医药）

登录后查看更多信息

项与 ADRA1 x COX 相关的文献（医药）

2023-04-01·American Journal of Physiology-Heart and Circulatory Physiology

Carotid dysfunction in senescent female mice is mediated by increased α_1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids

Article

作者: Jimenez-Altayó, Francesc ; Gomes, Felipe V. ; Barros, Paula R. ; Costa-Neto, Claudio M. ; Santos-Silva, Thamyris ; Akamine, Eliana H. ; Dantas, Ana Paula ; Hott, Sara Cristina ; Costa, Tiago J. ; Tostes, Rita C. ; Silva-Neto, Júlio A. ; McCarthy, Cameron G. ; Duarte, Diego A.

The present study provides evidence that senescence induces hyperreactivity of α1-adrenoceptor-mediated contraction of the common carotid. Impairment of α1-adrenoceptor responses is linked to increased Ca2+ influx and release of COX-derived vasoconstrictor prostanoids, contributing to carotid dysfunction in the murine model of female senescence (SAMP8). Increased reactivity of the common carotid artery during senescence may lead to morphological and functional changes in arteries of the cerebral microcirculation and contribute to cognitive decline in females. Because the elderly population is growing, elucidating the mechanisms of aging- and sex-associated vascular dysfunction is critical to better direct pharmacological and lifestyle interventions to prevent cardiovascular risk in both sexes.

2022-11-01·Chemistry & Biodiversity

The Mechanism of Crocetin Targeting Cardiovascular Disease Based on Network Pharmacology Constrained by Spectral Experiments

Article

作者: Geng, Zhaoming ; Pan, Lanying ; Zhou, Qingteng ; Guo, Ming

AbstractThe network pharmacology under conditions is a recent development trend. We use network pharmacology methods to analyze the mechanism of crocetin (CRO) that regulates cardiovascular diseases. In this work, the spectral experimental data of CRO‐Protein interaction is first time combined with constraint conditions to solve the problems of targeting redundancy and lack of verification. CRO targets and cardiovascular disease targets were obtained by the target database. The STRING platform was used for PPI analysis. The GO and KEGG pathways of the target were analyzed using the Metascape platform; The core functional targets of CRO were screened by molecular docking techniques and the spectra of CRO and human serum albumin (HSA). Under the collaborative constraint conditions, the core targets of CRO that regulate cardiovascular diseases are ADRA1A, ADRA1B, CHRM1, CHRM2, GABRA1, and PTGS2; This study incorporates spectroscopy and molecular docking as constraints into the network pharmacological analysis, which significantly improves the credibility of network pharmacological analysis compared with unconstrained conditions. This method provides theoretical references for the in‐depth study of the mechanism between active substances and protein targets for other medicines in network pharmacology.

2021-06-04·Evidence-Based Complementary and Alternative Medicine4区 · 医学

Systematic Investigation of the Effect of Powerful Tianma Eucommia Capsule on Ischemic Stroke Using Network Pharmacology

4区 · 医学

ArticleOA

作者: Pei, Jinhong ; Huang, Yan ; Li, Guixia ; Feng, Pengcheng

Background. Ischemic stroke (IS) is a serious disease with a high rate of death and disability, and a growing number of people are becoming victims. Existing drugs not only have limited therapeutic effects but also have obvious side effects. Most importantly, drug resistance due to long-term or improper use of drugs is detrimental to patients. Therefore, it is urgent to find some alternative or supplementary medicines to alleviate the current embarrassment. Powerful Tianma Eucommia Capsule (PTEC) is mainly used to treat IS in China for thousands of years; however, the molecular mechanism is not clear. Methods. Pharmacology ingredients and target genes were filtered and downloaded from websites. A pharmacology ingredient-target gene network was constructed to predict the molecular interactions between ingredients and target genes. Enrichment analysis was performed to explore the possible signal pathways. LeDock was used to simulate the interaction form between proteins and main active ingredients and to deduce key amino acid positions. Results. Two hundred eighty-nine target genes and seventy-four pharmacological ingredients were obtained from public databases. Several key ingredients (quercetin, kaempferol, and stigmasterol) and primary core target genes (PTGS1, NCOA2, and PRSS1) were detected through ingredient-target gene network analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis demonstrated that ingredients affect networks mainly in nuclear receptor activity and G protein-coupled amine receptor activity; besides, fluid shear stress and atherosclerosis, human cytomegalovirus infection, and hepatitis B signaling pathways might be the principal therapy ways. A series of presumed key amino acid sites (189ASP, 190SER, 192GLN, 57HIS, and 99TYE) were calculated in PRSS1. Six of the target genes were differentially expressed between male and female patients. Conclusions. Seven new putative target genes (ACHE, ADRA1A, AR, CHRM3, F7, GABRA1, and PRSS1) were observed in this work. Based on the result of GO and KEGG analysis, this work will be helpful to further demonstrate the molecular mechanism of PTEC treatment of IS.