更新于：2024-11-01

α1B-AR

更新于：2024-11-01

基本信息

别名

ADRA1B、adrenergic, alpha-1B-, receptor、adrenoceptor alpha 1B

+ [3]

简介

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

关联

项与 α1B-AR 相关的药物

Lisdexamfetamine Dimesylate

二甲磺酸赖右苯丙胺

靶点

DAT x α1B-AR

作用机制

DAT拮抗剂 [+1]

在研机构

Takeda Pharmaceutical Co., Ltd. [+3]

原研机构

New River Pharmaceuticals, Inc.

在研适应症

暴食症 [+2]

非在研适应症

安非他明依赖 [+11]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2007-02-23

Norepinephrine Bitartrate

重酒石酸去甲肾上腺素

靶点

α1A-AR x α1B-AR

作用机制

α1A-AR激动剂 [+1]

在研机构

Hospira, Inc. [+7]

原研机构

Hospira, Inc.

在研适应症

休克 [+7]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1950-07-13

Thioproperazine

靶点

D1 receptor x D2 receptor x α1A-AR x α1B-AR

作用机制

D1 receptor拮抗剂 [+3]

在研机构-

原研机构-

在研适应症-

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1800-01-20

505

项与 α1B-AR 相关的临床试验

NCT06158035 / Not yet recruitingN/AIIT

ED90 of Norepinephrine and Phenylephrine Boluses for Treating Postspinal Anesthesia Hypotension Under Intensive Treatment in Preeclamptic Patients During Cesarean Section

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section

开始日期2025-07-01

申办/合作机构

宁夏医科大学总医院

NCT06158009 / Not yet recruitingN/AIIT

ED90 of Norepinephrine and Phenylephrine Boluses for Treating Postspinal Anesthesia Hypotension Under Intensive Treatment During Cesarean Section

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section

开始日期2025-04-01

申办/合作机构

宁夏医科大学总医院

NCT06508359 / Not yet recruitingN/AIIT

Prophylactic vs Rescue Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension on Neonatal Outcomes During Cesarean Section: A Multicenter, Single-blind, Crossover, Factorial Cluster Trial

This study aims to explore the effects of different application modes (prophylactic and rescue strategy) of norepinephrine and norepinephrine on neonate umbilical artery pH undergoing cesarean section.

开始日期2025-03-01

申办/合作机构

宁夏医科大学总医院

100 项与 α1B-AR 相关的临床结果

登录后查看更多信息

100 项与 α1B-AR 相关的转化医学

登录后查看更多信息

0 项与 α1B-AR 相关的专利（医药）

登录后查看更多信息

850

项与 α1B-AR 相关的文献（医药）

2024-11-01·American Journal of Physiology-Endocrinology and Metabolism

Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice

Article

作者: Elmquist, Joel K. ; Mouchiroud, Mathilde ; Beji, Sarra ; Silva, Anisia ; Lavoie, Olivier ; Caron, Alexandre

The sympathetic nervous system plays an important role in regulating hepatic physiology and metabolism. However, the identity of the adrenoceptors involved in these effects is still elusive. Using CRISPR-Cas9, we developed a novel transgenic tool to study the role of liver α-1b adrenoceptor (ADRA1B). We show that ADRA1B plays a key role in mediating the effects of the sympathetic nervous system on hepatic metabolism, particularly in female mice.

2024-10-01·Neuropsychopharmacology

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

Article

作者: Marks, Jesse A ; Page, Grier P ; Han, Shizhong ; Bierut, Laura J ; Won, Hyejung ; Zhou, Linran ; Hyde, Thomas M ; Mandal, Meisha ; Quach, Bryan C ; Carnes, Megan Ulmer ; Jaffe, Andrew E ; Kleinman, Joel E ; Maher, Brion S ; Hancock, Dana B ; Deep-Soboslay, Amy ; Tao, Ran ; Johnson, Eric O

AbstractSmoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWASs) of smoking behaviors have identified hundreds of significant loci. Most GWAS-identified variants are noncoding with unknown neurobiological effects. We used genome-wide genotype, DNA methylation, and RNA sequencing data in postmortem human nucleus accumbens (NAc) to identify cis-methylation/expression quantitative trait loci (meQTLs/eQTLs), investigate variant-by-cigarette smoking interactions across the genome, and overlay QTL evidence at smoking GWAS-identified loci to evaluate their regulatory potential. Active smokers (N = 52) and nonsmokers (N = 171) were defined based on cotinine biomarker levels and next-of-kin reporting. We simultaneously tested variant and variant-by-smoking interaction effects on methylation and expression, separately, adjusting for biological and technical covariates and correcting for multiple testing using a two-stage procedure. We found >2 million significant meQTL variants (padj < 0.05) corresponding to 41,695 unique CpGs. Results were largely driven by main effects, and five meQTLs, mapping to NUDT12, FAM53B, RNF39, and ADRA1B, showed a significant interaction with smoking. We found 57,683 significant eQTL variants for 958 unique eGenes (padj < 0.05) and no smoking interactions. Colocalization analyses identified loci with smoking-associated GWAS variants that overlapped meQTLs/eQTLs, suggesting that these heritable factors may influence smoking behaviors through functional effects on methylation/expression. One locus containing MUSTN1 and ITIH4 colocalized across all data types (GWAS, meQTL, and eQTL). In this first genome-wide meQTL map in the human NAc, the enriched overlap with smoking GWAS-identified genetic loci provides evidence that gene regulation in the brain helps explain the neurobiology of smoking behaviors.

2024-08-01·Life Science Alliance

Chemokine receptor hetero-oligomers regulate monocyte chemotaxis

Article

作者: Gao, Xianlong ; Weche, McWayne ; Majetschak, Matthias ; Enten, Garrett A ; McGee, Michelle Y

It is known that stress influences immune cell function. The underlying molecular mechanisms are unclear. We recently reported that many chemokine receptors (CRs) heteromerize with α1-adrenoceptors (α1-ARs) through which CRs are regulated. Here, we show that arginine vasopressin receptor 1A (AVPR1A) heteromerizes with all human CRs, except chemokine (C-X-C motif) receptor (CXCR)1, in recombinant systems and that such heteromers are detectable in THP-1 cells and human monocytes. We demonstrate that ligand-free AVPR1A differentially regulates the efficacy of CR partners to mediate chemotaxis and that AVPR1A ligands disrupt AVPR1A:CR heteromers, which enhances chemokine (C-C motif) receptor (CCR)1-mediated chemotaxis and inhibits CCR2-, CCR8-, and CXCR4-mediated chemotaxis. Using bioluminescence resonance energy transfer to monitor G protein activation and CRISPR/Cas9 gene-edited THP-1 cells lacking AVPR1A or α1B-AR, we show that CRs that share the propensity to heteromerize with α1B/D-ARs and AVPR1A exist and function within interdependent hetero-oligomeric complexes through which the efficacy of CRs to mediate chemotaxis is controlled. Our findings suggest that hetero-oligomers composed of CRs, α1B/D-ARs, and AVPR1A may enable stress hormones to regulate immune cell trafficking.