A Phase 1 Open-Label, Multicenter Study to Assess the Safety and Efficacy of ANG003 in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis

Randomized, parallel, active-treatment Phase 1 study of a single dose of orally administered ANG003 with a test meal in adult subjects with cystic fibrosis-related exocrine pancreatic insufficiency. The study's overall objectives are to evaluate the safety, tolerability and effect of four dose levels of ANG003.

开始日期2023-08-25

申办/合作机构

Anagram Therapeutics, Inc.

NCT03051490

/ Unknown status临床3期

A Phase 3, Randomized, Open-Label, Assessor-Blind, Non-Inferiority, Active-Comparator Study Evaluating the Efficacy and Safety of Liprotamase in Subjects With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency

Liprotamase powder is a non-porcine, soluble and stable mixture of biotechnology-derived lipase, protease, and amylase digestive enzymes. The purpose of the present study is to to evaluate the non-inferiority of liprotamase compared with porcine-derived, enterically-coated pancreatic enzyme replacement therapy (PERT). The primary efficacy endpoint of the study will be comparative efficacy measured as the change from baseline in the coefficient of fat absorption (CFA) in Cystic Fibrosis patients with exocrine pancreatic insufficiency (EPI).

开始日期2017-04-28

申办/合作机构

Anthera Pharmaceuticals, Inc.

NCT02823964

/ Completed临床4期

An Open-Label Study Evaluating the Efficacy and Safety of Liprotamase in Subjects With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis

Liprotamase consists of 3 soluble, non-porcine digestive enzymes, lipase, protease, and amylase, combined in a fixed ratio. Liprotamase is stable in the stomach and can be formulated without enteric coating for administration either as a capsule or as a dosing solution dissolved in water or juice.

开始日期2016-09-01

申办/合作机构

Anthera Pharmaceuticals, Inc.

100 项与 amylase x Peptidases x Lipase 相关的临床结果

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100 项与 amylase x Peptidases x Lipase 相关的转化医学

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0 项与 amylase x Peptidases x Lipase 相关的专利（医药）

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项与 amylase x Peptidases x Lipase 相关的文献（医药）

2025-07-01·Fish & Shellfish Immunology

Assessing the impact of acidifiers on growth performance, innate immune capacity, response to ammonia nitrogen stress, digestive enzyme activity, intestinal histology, and gene expression of Nile tilapia (Oreochromis niloticus)

Article

作者: Panprommin, Dutrudi ; Nontasan, Supap ; Wangkahart, Eakapol ; Mongkolwit, Keatipong ; Ruenkoed, Supranee ; Pholoeng, Apichet

This study investigated the effects of acidifiers (ACD) supplementation level on the growth, immune response, intestinal histology and gene expression of Nile tilapia (Oreochromis niloticus). The experimental diets included three different levels of ACD concentrations: 0 g/kg (CTRL) as the control, 1 g/kg (ACD1), and 2 g/kg (ACD2). These ACD were sprayed onto the diets and fish were fed to Nile tilapia (7.12 ± 0.47 g) for 56 days. The results indicated that increasing the dietary content of ACD significantly enhanced growth performance, as reflected in higher final body weight, specific growth rate, average daily gain, and feed efficiency. The ACD2 diet showed improved outcomes compared to the CTRL diet. Fish fed ACD diets showed significantly higher antioxidant enzyme activity compared to the CTRL diet and were able to maintain their antioxidant status throughout the experiment. The activity of digestive enzymes, including protease, amylase, and lipase, was significantly increased in fish fed diets supplemented with varying levels of 1 and 2 g/kg diet compared to the CTRL diet (P < 0.05). Additionally, significant increases were observed in the thickness of the intestinal muscularis and the width of the intestinal villi in fish fed ACD at concentrations of 1 and 2 g/kg of the diet, compared to the CTRL diet (P < 0.05). Moreover, dietary supplementation with ACD at concentrations of 2 g/kg of the diet significantly upregulated the expression of immune-related genes (P < 0.05). Overall, the use of ACD in fish diets has shown improvements in growth performance, immune responses, and intestinal histology, indicating their potential as a beneficial feed additive for Nile tilapia aquaculture. To the best of our knowledge, recent evaluations of dietary ACD supplementation in practical diets also highlight the influence of ACD supplementation as a feed additive, which could benefit the aquaculture industry.

2025-05-11·Critical Reviews in Food Science and Nutrition

Recent advances in enzymatic modification techniques to improve the quality of flour-based fried foods

Review

作者: Zhang, Ruojie ; Zhang, Zipei ; McClements, David Julian ; Huang, Guifang ; Lin, Ziqiang ; Jin, Zhengyu ; Chen, Long ; He, Kuang

Flour-based fried foods are among the most commonly consumed foods worldwide. However, the sensory attributes and nutritional value of fried foods are inconsistent and unstable. Therefore, the creation of fried foods with desirable sensory attributes and good nutritional value remains a major challenge for the development of the fried food industry. The quality of flour-based fried foods can sometimes be improved by physical methods and the addition of chemical modifiers. However, enzyme modification is widely accepted by consumers due to its unique advantages of specificity, mild processing conditions and high safety. Therefore, it is important to elucidate the effects of enzyme treatments on the sensory attributes (color, flavor and texture), oil absorption and digestibility of flour-based fried foods. This paper reviews recent research progress in utilizing enzyme modification to improve the quality of flour-based fried foods. This paper begins with the effects of common enzymes on the physicochemical properties (rheological property, retrogradation property and specific volume) of dough. Based on the analysis of the mechanism of formation of sensory attributes and nutritional properties, it focuses on the application of amylase, protease, transglutaminase, and lipase in the regulation of sensory attributes and nutritional properties of flour-based fried foods.

2025-05-01·Tropical Animal Health and Production

Effects of dietary supplementation with Laurus nobilis extract on growth performance, carcass features, blood lipid profile, immunity, antioxidative status, digestive enzymes, and gut microbial load in growing New Zealand white rabbits

Article

作者: Badawy, Mohamed ; Sherasiya, Anjum ; Swelum, Ayman A ; El-Mekkawy, Mohamed M F ; Reda, Fayiz ; Attia, Adel I

This study evaluated the effects of supplementing the diet of growing New Zealand White (NZW) rabbits with Laurus nobilis extract (LNE) on their growth, immune function, digestive enzyme activity, and cecal microbiota. One hundred 5-week-old male New Zealand White rabbits were randomly assigned to five treatment groups (n = 20 per group) in a completely randomized design. The control group received a basal diet, while the other four groups received the basal diet supplemented with LNE at 1, 2, 3, and 4 g/kg, respectively. Results shown that higher LNE supplementation (3-4 g/kg) significantly improved growth parameters, including live body weight (LBW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR). Notably, with 4 g/kg LNE supplementation, there was a marked improvement in carcass characteristics, with reduced abdominal fat (P < 0.043) and increased percentages of dressing, carcass (P < 0.0051), and spleen (P < 0.0198). Furthermore, higher doses of LNE were associated with a reduction in lipid profiles, including decreases in total cholesterol (TC, P < 0.0004), triglycerides (TG, P < .0001), low-density lipoprotein (LDL, P < .0001), and very LDL (VLDL, P < .0001). Immune responses such as immunoglobulins M (IgM), G (IgG), A (IgA), and lysozyme were significantly improved in all LNE groups (P < 0.001). Antioxidant indicators, including superoxide dismutase (SOD, P < 0.0005), total antioxidant capacity (TAC, P < 0.0007), and glutathione peroxidase (GPX, P < .0001), were also enhanced by LEN dietary inclusion. In terms of gut health, pathogenic bacteria such as E-coli, Salmonella spp Coliform and were declined in all LEN supplementation (P < 0.01). Additionally, digestive enzymes including amylase, lipase and protease activities were enhanced by feeding LNE (2, 3 and 4g/kg diet, P < .0001). These findings suggest that LNE supplementation, particularly at 4 g/kg, enhances the growth, health, and metabolic efficiency of NZW rabbits, providing potential benefits for their overall grwoth and well-being.

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