更新于：2024-11-01

FAP x Tubulin

更新于：2024-11-01

基本信息

关联

项与 FAP x Tubulin 相关的药物

OMTX-705

靶点

FAP x Tubulin

作用机制

FAP拮抗剂 [+1]

在研机构

Oncomatryx Biopharma SL [+2]

原研机构

Oncomatryx Biopharma SL

在研适应症

晚期恶性实体瘤 [+3]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期1800-01-20

项与 FAP x Tubulin 相关的临床试验

NCT05547321 / Recruiting临床1期

Phase 1 Dose-escalation Trial of OMTX705, an Anti-fibroblast Activation Protein Antibody-drug Conjugate, as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Open-label, two parallel arm, multicenter, Phase 1 dose-escalation study to evaluate the safety and tolerability of OMTX705, both as monotherapy or in combination with pembrolizumab in the treatment of patients with advanced or metastatic cancer in whom there is no available standard therapeutic option.

开始日期2022-10-20

申办/合作机构

Oncomatryx Biopharma SL

CTIS2024-514746-36-00 / Recruiting

- OMTX705-001

开始日期2022-10-20

申办/合作机构

Oncomatryx Biopharma SL

100 项与 FAP x Tubulin 相关的临床结果

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100 项与 FAP x Tubulin 相关的转化医学

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0 项与 FAP x Tubulin 相关的专利（医药）

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项与 FAP x Tubulin 相关的文献（医药）

2018-01-01·Cell Structure and Function

Flagellar-associated Protein FAP85 Is a Microtubule Inner Protein That Stabilizes Microtubules

Article

作者: Oiwa, Kazuhiro ; Kirima, Junya

Genomics and proteomics studies in Chlamydomonas have revealed that an axoneme is composed of 200-600 types of proteins, including uncharacterized proteins collectively named flagellar-associated proteins (FAPs). Nine FAPs contain the EF-hand motif; however, they have not yet been well characterized. To find components responsible for Chlamydomonas-specific waveform changes coupled with intracellular Ca²⁺ concentrations, we focused on FAP85, an EF-hand motif-containing FAP specific to Chlamydomonas and its relatives. We cloned the cDNA encoding FAP85, expressed it in Escherichia coli cells, and generated a polyclonal antibody against the expressed protein. Immunoblotting showed that FAP85 was present in every axoneme of several flagellar mutants lacking major axonemal components. Immuno-electron microscopy revealed that anti-FAP85 antibodies were found only on the inner wall of A-tubules of the doublets exposed by N-lauroylsarcosine (Sarkosyl) treatment. The zero-length cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) applied to 0.6 M KCl-extracted axonemes generated a 75-kDa complex containing β-tubulin and FAP85. Further characterization of FAP85 and its effects on microtubule dynamics showed that FAP85 binds to tubulin and stabilized microtubules. According to these results, we conclude that FAP85 is a novel member of microtubule-binding proteins, localizing on the inner wall of the A-tubule and stabilizing microtubules.Key words: Chlamydomonas, flagella, doublet microtubule, microtubule inner proteins.

OncoTargets and Therapy4区 · 医学

<p>The Somatic Mutation Landscape and RNA Prognostic Markers in Stomach Adenocarcinoma</p>

4区 · 医学

ArticleOA

作者: Li, Zhen ; Liu, Guangzhi ; Zhang, Xiulei ; Gao, Shanjun ; Zheng, Peiming

PURPOSEStomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer.MATERIALS AND METHODSBy integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA) database, we identified several susceptibility genes and novel molecular markers and validated their potential function by the starBase website. Further, we validated the clinical value of two candidate lncRNAs in collected STAD samples by RT-qPCR.RESULTSWe illustrated the distributions of mutation frequencies and types to get the top 20 high-mutation frequency genes in STAD. We also found 2127 mRNAs, 129 miRNAs, and 170 lncRNAs that were differentially expressed. We identified four lncRNA-miRNA-mRNA ceRNAs (PVT1, MAGI2-AS3, MIR17HG, KCNQ1OT1). Besides, 27 mRNAs (PDE4C, ID1, AQP3, VCAN, FAP, NOX4, ANGPT2, SERPINE1, SPARC, PDGFRB, FN1, MFAP2, CSMD2, INHBA, COL10A1, MATN3, P4HA3, ADAMTS12, DGKI, OLFML2B, TMEM200A, FNDC1, CTHRC1, CHST1, F5, COL5A2, TUBB3) and two lncRNAs (MIR4458HG, LINC01235) showed a significant prognostic value, and their prognostic values were validated by the starBase website. What's more, the clinical values of MIR4458HG and LINC01235 were also demonstrated in collected STAD samples.CONCLUSIONWe constructed the lncRNA ceRNA networks and identified 20 high-mutation frequency genes and 29 prognostic markers (27 mRNAs and two lncRNAs).