A Phase II, Multicenter, Randomized, Double-blind, Placebo controlled Clinical study toevaluate efficacy and safety of PNB-001 as an adjunct to Mesalamine compared toMesalamine alone in Subjects with Inflammatory bowel disease

开始日期2022-10-28

申办/合作机构

PNB Vesper Life Sciences Pvt. Ltd

[+1]

CTRI/2021/09/036411 / Recruiting临床3期

A Phase III, Randomized, Open Label, Multicentric, Clinical Study to Evaluate the Efficacy and Safety of PNB-001 as an Adjunct to Standard of Care Compared to Standard of Care Alone in Treatment of Patients with Moderate COVID-19 Infection

开始日期2021-09-27

申办/合作机构

PNB Vesper Life Sciences Pvt. Ltd

CTRI/2020/10/028423 / Completed临床2期

A Randomized, Open label Clinical Study to Evaluate Efficacy and Safety of PNB-001 in Patients with moderate COVID-19 Infection.

开始日期2020-10-28

申办/合作机构

PNB Vesper Life Sciences Pvt. Ltd

[+1]

100 项与 CCKA x CCKB 相关的临床结果

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100 项与 CCKA x CCKB 相关的转化医学

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0 项与 CCKA x CCKB 相关的专利（医药）

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项与 CCKA x CCKB 相关的文献（医药）

2024-05-01·Reproduction in Domestic Animals

Cholecystokinin‐mediated effect of insulin pathway on the steroidogenic activity of follicular granulosa cells in Camelus bactrianus: In vitro study

Article

作者: Guo, Lusha ; Zhang, Yong

AbstractThe current study aimed to explore the molecular mechanism by which the cholecystokinin (CCK)‐mediated CCKAR and CCKBR, as well as the molecular mechanisms of CCK‐mediated insulin signalling pathway, regulate oestrogen in the granulosa cells. Also, the expression of CCK in ovaries, uterus, hypothalamus and pituitary gland was investigated in Camelus bactrianus. Ovaries, uterus, hypothalamus and pituitary gland were collected from six, three before ovulation (control) and three after ovulation, slaughtered Camelus bactrianus. Ovulation was induced by IM injection of seminal plasma before slaughtering in the ovulated group. The results showed that there were differences in the transcription and protein levels of CCK in various tissues before and after ovulation (p < .05, p < .01). After transfection with p‐IRES2‐EGFP‐CCK, the mRNA and protein levels of CCK, CCKAR, CCKBR and ER in follicular granulosa cells were significantly upregulated (p < .05, p < .01), and the content of E2 was significantly upregulated (p < .01); On the contrary, after transfection with si‐CCK, the mRNA and protein levels of CCK, CCKAR, CCKBR and ER in follicular granulosa cells were significantly downregulated (p < .05, p < .01), and the content of E2 was significantly downregulated (p < .01). Regulating CCK can affect the mRNA levels of INS, INSR, IGF and IGF‐R. In summary, regulating the expression level of CCK can activate insulin‐related signalling pathways by CCKR, thereby regulating the steroidogenic activity of granulosa cells.

2023-01-02·Stress

CCK1R2R ^-/- ameliorates myocardial damage caused by unpredictable stress via altering fatty acid metabolism

Article

作者: Yang, Chen-Teng ; Wang, Song-Jun ; Zhang, Xiao-Jing ; Li, Ya-Ping ; Su, Xiao-Rui ; Cong, Bin ; Zhang, Zhi-Hua

The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism. The cardiac metabolism may be disturbed by stress. Cholecystokinin (CCK), which is a classical peptide hormone, and its receptor (CCKR) are expressed in myocardial cells and affect cardiovascular function. Nevertheless, under stress, the exact role of CCKR on cardiac function and cardiac metabolism is unknown and the mechanism is worth exploring. After unpredictable stress, a common stress-inducing model that induces the development of mood disorders such as anxiety and reduces motivated behavior, we found that the abnormal contraction and diastole of the heart, myocardial injury, oxidative stress and inflammation of mice were aggravated. Cholecystokinin A receptor and cholecystokinin B receptor knockout (CCK1R2R^-/-) significantly reversed these changes. Mechanistically, fatty acid metabolism was found to be altered in CCK1R2R^-/- mice. Differential metabolites, especially L-tryptophan, L-aspartic acid, cholesterol, taurocholic acid, ADP, oxoglutaric acid, arachidonic acid and 17-Hydroxyprogesterone, influenced cardiac function after CCK1R2R knockout and unpredictable stress. We conclude that CCK1R2R^-/- ameliorated myocardial damage caused by unpredictable stress via altering fatty acid metabolism.

2022-07-01·Revista Internacional de Andrología

Priapism – A rare side effect of alpha blockers: Report of 2 cases and literature review

Review

作者: Micoogullari, Uygar ; Unal, Selman ; Okulu, Emrah ; Kayigil, Onder

Priapism is a prolonged unintended erectile state unrelated to sexual stimulation or sexual desire. There is a very rare relationship between the use of alpha blockers and the development of priapism. Here, we describe 2 cases of alpha blocker induced priapism and a literature review. One of these cases is related to the use of silodosin and the other is related to the use of tamsulosin. So far, 18 alpha blocker induced priapism cases have been reported. We are presenting the first case of silodosin induced priapism and the eighth case of priapism secondary to tamsulosin. Despite silodosin having a much greater affinity for the α1-a receptor than the α1-b receptor, as represented in this case it can cause this rare side effect. Before starting alpha blocker treatment, side effects such as priapism, which may be very rare but may cause serious problems, should be kept in mind.