别名 IGF2型受体、300 kDa mannose 6-phosphate receptor、cation-independent mannose-6 phosphate receptor + [19] |
简介 Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). |
靶点 |
作用机制 IGF-2R抑制剂 |
在研机构 |
原研机构 |
在研适应症- |
非在研适应症- |
最高研发阶段药物发现 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 IGF-2R抑制剂 |
在研机构- |
原研机构 |
在研适应症- |
最高研发阶段终止 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 IGF-2R激动剂 |
在研机构- |
在研适应症- |
非在研适应症 |
最高研发阶段无进展 |
首次获批国家/地区- |
首次获批日期1800-01-20 |