African American caregivers of people living with HIV/AIDS (PLWHA) have unique needs because they are more likely to experience stressors related to intersecting sources of stigma, discrimination, and caregiving burdens specifically associated with caregiving for PLWHA. The proposed project will enhance and finalize Phase I app development and evaluate its effectiveness in a randomized controlled trial. The project has high public health significance because of its potential to provide an accessible, easy to use mindfulness-based support tool for African American caregivers that could reduce stress, mitigate the harm of intersecting stigmas, and strengthen the caregiver-care recipient relationship.

开始日期2024-03-01

申办/合作机构

Friends Research Institute, Inc.

NCT06620263 / CompletedN/AIIT

Ensuring Guideline Adherence and Cost Savings in Stress Ulcer Prophylaxis Practices in the Intensive Care Unit: a Pre-Post Education Study

The present study aimed to examine the adherence of proton pump inhibitors (PPIs), commonly recommended for stress ulcer prevention (SUP) in patients in the intensive care unit (ICU), according to an international guideline. The objective of the study was to enhance the adherence of SUP prescriptions to the guideline, therefore preventing potential adverse effects and avoidable financial burden, and, consequently, attaining cost reduction.

开始日期2024-01-01

申办/合作机构-

IRCT20200322046833N3 / Recruiting临床2期IIT

Comparing the effectiveness of injectable pantoprazole, oral pantoprazole and injectable famotidine for stress ulcer prophylaxis in the intensive care unit.

开始日期2023-10-23

申办/合作机构

Tehran University of Medical Sciences

100 项与应激性溃疡相关的临床结果

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100 项与应激性溃疡相关的转化医学

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0 项与应激性溃疡相关的专利（医药）

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项与应激性溃疡相关的文献（医药）

2024-12-01·Journal of Hospital Infection

Hospitalized patients on proton pump inhibitors for stress ulcer prophylaxis have a higher risk of Clostridioides difficile infection compared with those on histamine-2 receptor antagonists

Article

作者: Lin, Swu-Jane ; Cheng, Ching-Lan ; Su, Chien-Chou ; Yang, Y-H K ; Su, C-C ; Liu, Yi-Hsuan ; Wang, J-L ; Wang, Jiun-Ling ; Liu, Y-H ; Cheng, C-L ; Lin, S-J ; Kao Yang, Yea-Huei ; Wu, L-H ; Wu, Lu-Hsuan

BACKGROUNDPrevious studies on Clostridioides difficile infection (CDI) in proton pump inhibitor (PPI) users generally enrolled a heterogeneous population and did not include a control group of histamine H2 receptor antagonists (H2RAs) users or adjust for confounding variables, such as previous antibiotics. It is uncertain whether hospitalized patients using PPIs for stress ulcer prophylaxis (SUP) are at a higher risk of CDI compared with those using H2RAs. This study aimed to compare the association between CDI and the usage of antisecretory drugs (ASDs): PPIs and H2RAs, for SUP among hospitalized patients, and the impact of the duration of their use on CDI.METHODSIn this nationwide population-based cohort study using the Taiwan National Health Insurance Database, hospitalized patients using ASDs for SUP were identified between 2017 and 2018. A total of 63,266 and 69,269 individuals were included in the PPI and H2RA groups, respectively. The primary endpoint was a 90-day monitoring of CDI occurrence.FINDINGSThe incidences of CDI were 1.6/10,000 and 0.5/10,000 person-days in the PPIs and H2RAs groups, respectively. After adjusting for confounding factors, the risk of infection in the PPIs group remained significantly higher than in the H2RAs group (hazard ratio (HR), 2.49; 95% confidence interval (CI), 1.63-3.81). In the subgroup analysis, during hospitalization, the risk of CDI for patients using high-risk antibiotics or admitted to the intensive care unit (ICU), as well as patients with immunodeficiency, using PPIs for SUP, was higher than using H2RAs. Furthermore, the risk of CDI was higher in patients using ASDs for durations >14 days than in those using them for <7 days (adjusted HR, 3.66; 95% CI, 2.34-5.75).CONCLUSIONSThe risk of occurrence CDI for hospitalized patients using PPIs for SUP was higher than using H2RAs. It is recommended not to exceed 14 days of any gastric ASDs for SUP during hospitalization, especially for patients who have used high-risk antibiotics, have been admitted to the ICU, or have immunodeficiency.

2024-11-01·Neurourology and Urodynamics

Effects of using a mobile application on pelvic floor training in women with stress urinary incontinence: A randomized controlled clinical study

Article

作者: Pinto, Rogério de Melo Costa ; Silva, Natasha Morena Bazílio ; Driusso, Patricia ; Vilela, Ingrid da Costa ; Pereira‐Baldon, Vanessa Santos

AbstractIntroductionUrinary incontinence (UI) is defined as any involuntary loss of urine that causes negative impacts on women's lives. Pelvic floor muscle training (PFMT) is considered to be “level A” of scientific evidence in the treatment of UI. Despite its efficacy, it is known that the effect of PFMT may depend on continuous adherence. Therefore, healthcare professionals are looking for alternatives to improve adherence in their patients. Healthcare has been innovating through mobile device apps.ObjectiveThus, the objective of this study was to verify the effects of PFMT with the use of a mobile device app in incontinent women.Trial DesignThis was a controlled, randomized clinical trial that occurred remotely.MethodsA total of 104 women with stress UI and/or mixed incontinence, over 18 years old, literate, with preserved cognitive capacity, with internet access and a mobile device with the Android system, participated in this study. They were randomly divided into two groups: The App group and the Booklet group, which underwent a PFMT protocol guided by a mobile app and a booklet, respectively. Both groups received daily reminders to perform the exercises. Before and after 12 weeks of intervention, it was evaluated using the International Consultation on Incontinence Questionnaire‐Short Form (ICIQ‐SF) and the King's Health Questionnaire (KHQ).ResultsBoth groups showed improvements in the final ICIQ‐SF score. However, superior results were shown for the Booklet group (App: pre: 11.5 [±3.8], post: 9.8 [±4.5]; Booklet: pre: 12.6 [±4.5], post: 7.4 [±4.3]; p = 0.03).ConclusionIt was concluded that PFMT, with the use of a mobile app, is capable of reducing UI and the impact of UI, but it is not superior to training with the use of booklet instructions.

2024-11-01·Clinical Neurology and Neurosurgery

Application value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting stress ulcer after acute cerebral hemorrhage surgery

Article

作者: Liu, Zenghui ; Chen, Yanfei ; Wang, Tingting

OBJECTIVEThe Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) are established biomarkers that are associated with the severity, progression, and fatality of diseases. This study aimed to determine their predictive value for the occurrence of stress ulcers (SU) following surgery for acute cerebral hemorrhage.METHODSRetrospective data from 210 patients with acute cerebral hemorrhage hospitalized between June 2020 and March 2023 were analyzed. Patients were categorized into two groups based on the occurrence of SU post-surgery: the SU group (42 patients) and the non-SU group (168 patients). Clinical characteristics of both groups were compared, and a multivariate logistic regression was conducted to identify independent risk factors for SU. The study evaluated the predictive value of NLR and PLR, individually and in combination, for predicting SU using Receiver Operating Characteristic (ROC) curves.RESULTSWe observed significant differences between the SU and non-SU groups in several parameters, including GCS score, absolute neutrophils, NLR, PLR, postoperative tracheotomy, and intracranial infection (P < 0.05). Our multivariate logistic regression analysis identified four independent risk factors for SU in patients undergoing surgery for acute cerebral hemorrhage: GCS score, NLR, PLR, and fasting blood glucose (P < 0.05). Furthermore, ROC analysis demonstrated that the combination of NLR and PLR exhibited the highest AUC, sensitivity, and specificity in predicting SU following surgery for acute cerebral hemorrhage (P < 0.001), with values of 0.864 (95 % CI: 0.776-0.953), 0.778 (95 % CI: 0.658-0.899), and 0.941 (95 % CI: 0.889-0.993) respectively.CONCLUSIONThis study highlighted the combined application of PLR and NLR as a significant predictor of SU in patients post-acute cerebral hemorrhage surgery.

项与应激性溃疡相关的新闻（医药）

2024-10-30

·摩熵医药

10亿集采大品种，2家药企同日获批！

注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需要得到授权。 10月29日，据NMPA官网最新公示，重庆药友制药和山西普德药业2家药企提交的3类仿制药注射用盐酸罗沙替丁醋酸酯同日获批。至此，该品种已形成14+1家企业的竞争格局，市场竞争愈发白热化。截图来源：NMPA 盐酸罗沙替丁醋酸酯是一款组胺H2受体拮抗剂，主要是治疗与胃酸分泌相关疾病的药物，临床上用于上消化道出血（由消化性溃疡，急性应激性溃疡，出血性胃炎等引起）的低危患者。近年来，注射用盐酸罗沙替丁醋酸酯销售规模持续上涨，据摩熵医药数据库显示，注射用盐酸罗沙替丁醋酸酯在2023年全国院内市场的销售额逼近10亿元。截图来源：摩熵医药（原药融云）全国医院销售数据库此前，国内有12家企业拥有注射用盐酸罗沙替丁醋酸酯生产批文。在仿制药布局方面，注射用盐酸罗沙替丁醋酸酯有国药集团国瑞药业、浙江华海药业、海南倍特药业等17家药企提交了仿制申请，均在审评审批中。截图来源：摩熵医药（原药融云）中国药品审评数据库近期，国家发布了第十批集中采购报量目录，其中包含了注射用盐酸罗沙替丁醋酸酯。截至目前，注射用盐酸罗沙替丁醋酸酯已有包括重庆药友制药、瑞阳制药、扬子江药业集团江苏紫龙药业、四川汇宇制药、山西普德药业等在内的14家国内药企过评，形成了14+1的企业竞争格局，市场竞争态势日趋白热化。截图来源：摩熵医药（原药融云）过评药品汇总数据库 2024年至今，重庆药友制药有阿立哌唑口崩片、利培酮口崩片、甲磺酸仑伐替尼胶囊、盐酸依匹斯汀胶囊、盐酸鲁拉西酮片等21个品种过评，其中盐酸依匹斯汀胶囊为首家过评品种。 END 本文为原创文章，转载请留言获取授权近期热门资源获取后台回复关键词“深度报告”，获取价值18600元，报告大礼包后台回复关键词“2023首仿”，获取2023年首仿药物获批名单后台回复“GLP-1深度报告”，获取完整《GLP-1产业现状与未来发展》PDF版。后台回复“中国 I 类新药”，获取完整《中国 I 类新药靶点》PDF版。后台回复“NAFLD/NASH”，获取完整《NAFLD/NASH报告》PDF版。后台回复“AI+制药”，获取完整《中国AI制药企业白皮书》PDF版。后台回复“XXG”，获取完整《中国心血管系统药物分析报告》PDF版。后台回复“FZZJ”，获取完整《基于剂型改良的复杂注射剂分析》PDF版。后台回复“药品进出口”，获取完整《中国药品进出口白皮书》深度报告-PDF版。联系我们，体验摩熵医药更多专业服务会议合作园区服务数据库咨询定制服务媒体合作点击阅读原文，了解更多品牌升级详情！

申请上市医药出海一致性评价上市批准

2024-09-13

·CPHI制药在线

延胡索化学成分及其药理活性研究进展

关注并星标CPHI制药在线延胡索为罂粟科紫堇属植物延胡索的干燥块茎，又称元胡、玄胡、玄胡索等。唐代《本草拾遗》始名延胡索，其最初产地为辽宁及河北东北部等地。明朝后延胡索产地发生变迁，直至清代开始有产自浙江的记载，逐渐成为浙江道地药材，为传统道地药材“浙八味”之一。目前，延胡索在浙江东阳市、磐安县以及仙居县等地产量较大，其中“磐安元胡”获得了国家地理标志认证商标。延胡索在我国用于治疗疾病已有两千多年的历史，主要有镇痛、活血、理气之功效，现代医学也已经证明延胡索具有显著的镇痛、镇静和催眠作用，对冠心病、心律失常、胃溃疡等多种疾病都具有较好的临床效果。延胡索的化学成分主要包括生物碱类化合物和非生物碱类化合物。延胡索中含有异喹啉生物碱，而根据其连接基团的不同又可见阿朴啡类生物碱、原小檗碱类生物碱、苄基异喹啉、双苄基异喹啉、吗啡类生物碱等九类，其中以阿朴啡类生物碱和原小檗碱类生物碱较多。阿朴啡类生物碱以海罂粟碱（glaucine）骨架为主，因其9个不同的部位连接不同的基团，其化学结构亦不尽相同，有研究表明，现已有约20种此类化合物被鉴定分离，其主要包括脱氢海罂粟碱（D-glaucine）、d-N-甲基樟苍碱（Nmethyllaurotetanine）、d-异波尔定（d-Isoboldine）等。原小檗碱类生物碱则多以小檗碱（berberine）骨架为主，亦因其6个不同的部位连接不同的基团，故其化学结构亦各异，有研究表明，现已有约30多种此类生物碱被鉴定分离，其主要包括延胡索甲素（d-Corydaline）、延胡索乙素（dl-Tetrahydropalmatine），又称 dl-四氢巴马汀、异紫堇球碱（isocorybulbine）及非洲防己胺（columbamine）等。除上述生物碱外，延胡索还含有近10种其他类型的生物碱，主要包括元胡菲碱（coryphenanthrine）、千金藤宁碱、狮足草碱（leonticine）、降氧化北美黄连次碱等生物碱。延胡索中除基本的水分、蛋白质、粘液质及挥发油等非生物碱类化合物外，还含有近10多种非生物碱类的化合物。其中甾体类化合物主要包括豆甾醇（Stigmasterol）、谷甾醇（Sitosterol）和麦角甾-4-烯-3-酮等。现如今可被分离鉴定的有机酸化合物共有11种，主要分为两大类，其中最常用的包括亚油酸（Linoleic Acid）、亚麻酸（α-Linolenic acid,ALA）、延胡索酸（Fumarate）、大黄素（Emodin）和2,3-二羟基丙酸（Glycericacid）等。糖类化合物多以单糖和多糖的形式存在，如多糖（Polysaccharide）、乳糖（Lactose）、D 果糖（Fructose），其中 D果糖则多以呋喃糖和吡喃糖两种形式存在，并为典型的单糖。除上述非生物碱类化合物外，延胡索中还包含核苷类如腺苷（Adenosine）、鸟苷（Guano-sine），以及铜（Cu）、铁（Fe）、锌（Zn）、铬（Cr）、钙（Ca）、镁（Mg）、磷（P）等微量元素成分。中医认为延胡索具有活血化瘀、行气止痛之功效，主要药效物质基础是延胡索总生物碱。药理活性研究表明延胡索具有很好的镇静、镇痛、抗心律失常和降压作用。目前，很多新的研究表明延胡索还有其他广泛的生物活性，如抗氧化、抗肿瘤、抗心肌缺血、抗胃溃疡、抗血栓、保肝等。 01 镇痛作用延胡索辛热温通，既能活血又能行气，气行血活，通则不痛，故历来作为止痛要药，被誉为中草药中的“吗啡”，其多种制剂均具有明显的镇痛作用，尤其以醇制浸膏、醋制浸膏及粉剂作用显著。现代研究表明，延胡索乙素，即消旋四氢帕马丁（dl-tetrahydropalmatine，dl-THP）为主要镇痛物质基础，其左旋体止痛作用较右旋体强，对慢性持续性钝痛效果最佳，其镇痛程度甚至能达到典型镇痛药吗啡的40%。一般认为，dl-THP 能阻扰中枢多巴胺受体，抑制由于背根节神经元（DRG）损伤所致的持续性钠电流而抑制损伤神经元自主放电，从而缓解疼痛。研究发现，延胡索总生物碱能有效抑制中枢和外周疼痛。Dl-THP 具有中枢止痛作用，能治疗因疼痛而引起的失眠。研究表明，dl-THP 能显著解除坐骨神经慢性压迫性损伤所致神经病理性疼痛，延胡索水煎液能缓解慢性炎性疼痛。 02 对心血管系统的作用研究显示延胡索具有扩张冠状动脉，增加冠脉血流量，抑制血小板聚集，抗心律失常，改善心肌供氧，增加心输出量等药理作用。研究表明给家兔静脉注射延胡索乙素具有降低心率和升高 D /S(心脏舒张期 /收缩期) 比值的作用。延胡索总生物碱中高剂量具有缓解异丙肾上腺素所致的心肌缺血大鼠心功能下降的作用。延胡索总生物碱可减轻ISO诱导心肌梗死大鼠的氧化应激，稳定血流动力学参数，保护心功能，减轻心肌损伤和凋亡。此外，研究表明延胡索乙素可通过调节大鼠脑缺血再灌注过程中细胞膜 Na +-K +-ATP 酶的活性和拮抗Ca2+两个方面减轻脑缺血再灌注损伤。 03 对消化系统的作用研究表明，延胡索对大鼠幽门结扎性溃疡、应激性溃疡、阿司匹林溃疡、醋酸溃疡等具有改善作用，但是针对利血平溃疡无显著作用，且延胡索总生物碱具有很强的抗溃疡作用，还能抑制胃酸酸度和胃蛋白酶活性。研究发现延胡索总生物碱对醋酸导致大鼠胃溃疡具有改善作用，并通过代谢组学的方法发现了10种与胃溃疡相关的差异代谢物，而给予延胡索总生物碱后多数代谢物回复至正常水平，提示了延胡索抗溃疡的潜在作用机制。 04 抗肿瘤作用研究表明延胡索生物碱中的延胡索碱、延胡索乙素、小檗碱、黄连碱、去氢紫堇碱、原阿片碱、13-甲基巴马士宾均具有一定的抗肿瘤作用。研究表明延胡索脂溶非酚性生物碱组分对肝肿瘤细胞杀伤活性最强，对 SMMC-7721 的生长抑制活性最高，其IC50约为35 μg /mL。延胡索乙素在体外可抑制恶性胶质瘤细胞U251MG 的增殖，促进其凋亡；在体内可显著抑制恶性胶质瘤组织增长，延长荷瘤小鼠的生存时间。二去氢海罂粟碱可抑制 P-糖蛋白和多药耐药相关蛋白1的表达，降低癌细胞的多药耐药性，提高对癌细胞的化疗效能。此外，研究报道延胡索对乳腺癌 MDA-MB-231 细胞具有很强的抑制作用，其活性受延胡索乙素、小檗碱和去氢紫堇碱三种成分比例影响，当延胡索乙素和小檗碱的摩尔比为2：3 时抗癌活性最强。 05 抗菌消炎及免疫调节作用研究报道，延胡索提取物具有较强的抑菌活性，特别是小檗碱对痢疾杆菌、肺炎球菌、伤寒杆菌等多种细菌均具有显著的抑制作用。研究表明小檗碱能够双向控制TLR2 信号通路的激活和促进抗炎因子的分泌，起到抗菌消炎的作用。从齿瓣延胡索根茎中分离得到的4种异喹啉类生物碱 Pseudocop-tisine、海粟碱(Glaucine)、紫堇碱(Corydaline)和四氢黄连碱(Tetrahydrocoptisine)能够抑制神经氨酸苷酶活性而抑制细菌增殖。 06 其他作用延胡索提取物除具有上述药理作用外还具有镇静催眠、肌肉松弛、延缓衰老、戒毒、保肝、活血利气、抗阿片类药物成瘾、DPPH 自由基清除和抑制络氨酸酶活性、抗糖尿病和糖尿病并发症等诸多药理作用。随着现代分析技术和药理学研究的不断深入，延胡索中化合物的药理活性及其作用机制将更加清晰。参考资料 [1]关秀锋,王锐,曲秀芬,等.延胡索的化学成分与药理作用研究进展[J].化学工程师,2020,34(03):57-60. [2]陈斯.延胡索化学成分和药理作用研究进展[J].中医药信息,2021,38(07):78-82. [3]冯自立,赵正栋,刘建欣.延胡索化学成分及药理活性研究进展[J].天然产物研究与开发,2018,30(11):2000-2008. 作者简介：小米虫，药品质量研究工作者，长期致力于药品质量研究及药品分析方法验证工作，现就职于国内某大型药物研发公司，从事药品检验分析及分析方法验证。 END 【智药研习社直播预告】来源：CPHI制药在线声明：本文仅代表作者观点，并不代表制药在线立场。本网站内容仅出于传递更多信息之目的。如需转载，请务必注明文章来源和作者。投稿邮箱：Kelly.Xiao@imsinoexpo.com ▼更多制药资讯，请关注CPHI制药在线▼ 点击阅读原文，进入智药研习社~

2024-07-05

·复星医药

小暑 | 夏天太热没胃口？两分钟了解两种常见肠胃疾病，让你的健康不“胃”酷暑

小暑明天就是小暑了。小暑是二十四节气中的第十一个节气，民间有“小暑大暑，上蒸下煮”之说。小暑开始进入伏天，所谓“热在三伏”，是一年中气温最高且又潮湿、闷热的时段。夏日炎炎，不知道你有没有过这样的体验——总觉得没胃口，胃里饱饱的，吃不下东西。虽说吃的少点，也能 “减肥”一时，不过这种状态久了，对身体健康而言可不是什么好事，特别是肠胃，胀气、腹痛、便秘通通找上门来，还会引发一些常见常见的肠胃疾病，如十二指肠溃疡、胃溃疡等等。这两种疾病都属于消化性溃疡，但是又有不同。在夏季遇到肠胃不舒服，可不能大意，具体情况具体分析，早识别早发现，今天就让我们跟着兰州大学第一医院主任医师郭庆红来认识十二指肠溃疡和胃溃疡，让你轻松get关于肠胃健康的那些事儿！听了专家的讲解，现在是不是能更好地识别这两种常见的肠胃疾病？如果真的得了疾病该怎么办呢？别着急，第一是尽早发现，到医院寻求专业的医生问诊。除此之外，在药物治疗方面，由复星医药独家商业化的首款国产自主研发的盐酸凯普拉生片（商品名：倍稳®）用于十二指肠溃疡（DU）和反流性食管炎（RE）的治疗。III期研究表明，盐酸凯普拉生片可以迅速起效，且可强效持久抑酸，安全性好。相对于质子泵抑制剂（PPI）类药物，具有抑酸效力更强、更快、更持久、更稳定的特点，首剂即可达到更大抑酸效果。无论是对于夏天的食欲不振，还是对长期食欲不佳带来的“后遗症”，其实与好的生活习惯是分不开的，希望大家在这个夏天都能远离食欲不振的困扰！参考文献： [1] 邹多武. 质子泵抑制剂在酸相关性疾病中的应用新技巧[J]. 中华消化杂志, 2019, 39(3):4. [2] 中华医学会消化病学分会. 2020年中国胃食管反流病专家共识[J]. 中华消化杂志, 2020, 40(10):649-663. [3] 袁耀宗. 消化性溃疡诊断与治疗规范(2016年,西安)[J]. 中华消化杂志, 2016, 36(8):6. [4] 王斌, 李治建, 斯拉甫·艾白,等. 功能性消化不良的研究进展[J]. 中国基层医药, 2011, 18(20):3. [5] 杨龙贵,张新萍,赵祥文.危重症患儿应激性溃疡出血持续时间与预后的关系[J].实用儿科临床杂志,2008,23(18):1446 -1447. [6] Marik P E,Vasu T,Hirani A,et al. Stress ulcer prophylaxis in the new millennium: A systematic review and meta-analysis[J]. Critical Care Medicine, 2010,38. Bardou M,Quenot JP,Barkun A. Stress-related mucosal diseasein the critically ill patient [J]. Nat Rev Gastroenterol Hepatol.2015,12(2): 98 -107. [7] 吴小平. 抑酸深度与酸相关性疾病[J]. 中华消化杂志, 2006, 26(005):354-354. [8] 牛春燕, 罗晓春.钾离子竞争性酸阻滞剂在酸相关疾病中的应用[J].世界华人消化杂志，2021,29(8): 383-388. [9] Andersson K, Carlsson E. Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases. Pharmacol Ther. 2005 Dec;108(3):294-307. [10] Li CY, Su M, Yan YY, et al. KFP-H008 blocks gastric acid secretion through inhibiting H+-K+-ATPase. Eur J Pharmacol. 2017 Sep 5;810:112-119. [11] Sakurai Y, Mori Y, et al. Acid-inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects--a randomised open-label cross-over study. Aliment Pharmacol Ther. 2015 Sep;42(6):719-30. [12] Chen, Songfeng et al. “The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: a phase III, randomised, double-blind multicentre study.” Alimentary pharmacology & therapeutics vol. 55,12 (2022): 1524-1533. doi:10.1111/apt.16959

临床研究