更新于:2024-05-01

Primary Ovarian Insufficiency

原发性卵巢功能不全

基本信息

别名
FMR1 Related Primary Ovarian Insufficiency、FMR1-Related Primary Ovarian Insufficiency、FRAGILE X PREMATURE OVARIAN FAILURE
+ [71]
简介
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.

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