更新于：2024-11-01

Otomycosis

耳真菌病

更新于：2024-11-01

基本信息

别名

Fungal otitis externa、OTOMYCOSIS、Otitis externa fungal

+ [12]

简介

Fungus infection of the external ear, usually by ASPERGILLUS species

关联

项与耳真菌病相关的药物

Dexamethasone

地塞米松

靶点

作用机制

GR激动剂

在研机构

Janssen Research & Development LLC [+33]

原研机构

Merck & Co., Inc.

在研适应症

免疫球蛋白轻链淀粉样变性 [+71]

非在研适应症

急性外耳炎 [+47]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1958-10-30

SVT-15652

靶点-

作用机制-

在研机构

Laboratorios Salvat SA

原研机构

Laboratorios Salvat SA

在研适应症

外耳炎

非在研适应症

耳真菌病

最高研发阶段申请上市

首次获批国家/地区-

首次获批日期1800-01-20

G-238

靶点-

作用机制-

在研机构-

原研机构

Editorial Salvat SL

在研适应症-

非在研适应症

耳真菌病

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与耳真菌病相关的临床试验

NCT06530069 / RecruitingN/AIIT

Exploring the Risk Factors of Otomycosis: A Case-Control Study

The goal of this observational study is to explore the risk factors of fungal otitis externa in the fungal otitis externa patients The main question it aims to answer is:
What behaviors lead to the occurrence of fungal otitis externa? Participants will complete a detailed questionnaire survey. If there is a comparison group: Researchers will compare the healthy group and the disease group to see if there are any differences.

开始日期2024-08-01

申办/合作机构

厦门大学附属中山医院

NCT06431542 / Recruiting临床4期IIT

Comparison of the Efficacy of Patient Self-Application Versus Physician Application of Triamcinolone Acetonide Econazole Cream in the Treatment of Otomycosis

to analyze the clinical characteristics, types of Fungal Infections, and comparison of the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in otomycosis treatment.

开始日期2024-06-01

申办/合作机构

厦门大学附属中山医院

ChiCTR2400084252 / Suspended临床4期IIT

Evaluation of the efficacy of Metobacteriosis (an ear canal spray dressing) in the treatment of fungal otitis externa

开始日期2024-05-20

申办/合作机构-

100 项与耳真菌病相关的临床结果

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100 项与耳真菌病相关的转化医学

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0 项与耳真菌病相关的专利（医药）

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432

项与耳真菌病相关的文献（医药）

2024-12-01·Medical Mycology Case Reports

Invasive fungal otitis media with peripheral facial paralysis

Article

作者: Gao, Hanbing ; Zhang, Jie ; Guan, Ming ; Kang, Wenjie

Invasive fungal otitis media is clinically rare and diagnosis often delayed. We report a 65-year-old female with Aspergillus fumigatus otitis media complicated by mastoiditis and peripheral facial paralysis. Complete mastoidectomy and type II tympanoplasty, with oral administration of voriconazole for more than 3 months resulted in a successful outcome.

2024-10-01·Indian Journal of Otolaryngology and Head & Neck Surgery

Topical Antibiotic-Induced Otomycosis - a Systematic Review of Aetiology and Risk Factors

Article

作者: Tanweer, Faiz ; Sharin, Florida ; Rao, Karthik ; Pereira, Maria ; Rea, Peter ; Mair, Manish

Otomycosis is a chronic or subacute fungal infection of external ear accounting to 5 to 20% of external ear infection worldwide. Literature has suggested multiple local and environmental host factors associated with otomycosis, but their strength of association is not well established. We did this review to analyse otomycosis with respect to it's various common predisposing factors. Human studies reporting ototopical antibiotics with or without steroids as predisposing factors for otomycosis, or pooled data together with other predisposing factors were included. MEDLINE, EMBASE, CINAHL, the ISRCTN register, and Cochrane databases were searched for the data extraction. Critical appraisal was done using the standardized Joanna Briggs Institute's (JBI) Appraisal checklist. Random effects were used to calculate pooled estimate prevalence with 95% Confidence Intervals (CIs). Age varied in different studies with a mean age variation from 7 to 43.19. Most of the studies were conducted in tropical and sub-tropical countries. Aspergillus was the most common species isolated. The use of ototopical antibiotics with or without steroid drops [47% (95% CI, 0.38 - 0.56)] were found to be the commonest predisposing factor for otomycosis, followed by the use of a variety of oils and wax solvents [38% (95% CI,0.26 - 0.51)] and trauma to the External Auditory Canal (EAC) as a result of compulsive cleaning or instrumentation[37% (95% CI, 0.21 - 0.54)]. We suggest the need for caution and vigilance from clinicians treating patients with ototopical drops for ear infections and use of other alternative treatment like 2% acetic acid for mild cases whenever feasible.

2024-10-01·Indian Journal of Otolaryngology and Head & Neck Surgery

Aetiological Profile, Clinical Features and Risk Factors for Otomycosis in Dar Es Salaam, Tanzania: A Cross-Sectional Study

Article

作者: Abraham, Zephania Saitabau

Otomycosis is a commonly encountered otological disorder in otorhinolaryngology practice. It has several predisposing factors such as habitual use of cotton buds, water in the ear, hot humid atmospheric condition or high temperature. Diagnosis of otomycosis frequently relies on the patient's history, otoscopic examination and ascertained clinical features and therefore posing diagnostic and therapeutic challenges. Data on otomycosis in Tanzania are scarce. A hospital based descriptive cross-sectional study was conducted at a private hospital from January to June 2022 in Dar es Salaam, Tanzania. All the clinically diagnosed cases were enrolled in the study with typical symptoms and characteristic fungal debris in the external auditory canal. Data was collected using semi-structured questionnaires and analyzed using Statistical Package for Social Sciences version 23. A total of 250 patients were recruited in this study. Majority were females, 153(81.2%) while males were 97(38.8%). Otomycosis was found to be predominantly unilateral in 203 (81.2%) patients. The commonest presenting complaint was ear itching (94.0%) followed by earache (78.6%), hearing loss (75.6%), ear fullness (74.4%), ear discharge (61.2%) and ringing sensation (14.0%). Based on the type of fungal debris on Otoendoscopy, whitish debris was more predominant in 191 (76.4%) patients followed by yellowish debris, 37 (14.8%), blackish debris, 15 (6.0%) and mixed (whitish-black) debris in 7 (2.8%) patients. The commonest risk factor was earbud use (40.8%) and the least one was comorbid conditions (4.4%). Females were more affected by otomycosis. The commonest otological complaint was ear itching while the least one was ringing sensation. Unilateral presentation of otomycosis predominated and the left ear was more affected. The commonest type of fungal debris was whitish debris and the least one was the mixed type (whitish-black). The commonest risk factor for otomycosis was earbud use and the least was comorbid conditions.