更新于：2024-12-07
Benoxinate Hydrochloride
盐酸奥布卡因
更新于：2024-12-07
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1966-06-07), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C17H29ClN2O3 |
InChIKeyPRGUDWLMFLCODA-UHFFFAOYSA-N |
CAS号5987-82-6 |
关联
9
项与 盐酸奥布卡因 相关的临床试验Preservative-free Topical Anesthetics for the Management of Postoperative Pain Following Photorefractive Keratectomy
Hemodynamic Response Of Premature Brain To Pain During Retinopathy Of Prematurity Screening: A Randomized Controlled Trial
Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening
100 项与 盐酸奥布卡因 相关的临床结果
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100 项与 盐酸奥布卡因 相关的转化医学
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100 项与 盐酸奥布卡因 相关的专利（医药）
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311
项与 盐酸奥布卡因 相关的文献（医药）2024-12-01INTERNATIONAL JOURNAL OF PHARMACEUTICS
Spring and parachute approach for piroxicam dissolution; its phenomenological model on the thermodynamics of irreversible processes
Article
作者: Goto, Satoru ; Tsunoda, Chihiro ; Moritake, Kota ; Tsuchida, Tomohiro ; Kataoka, Hikaru ; Fujita, Momoko
Even though the spring and parachute approach for poorly water-soluble drug candidates effectively improves their dissolution curves with eutectic mixtures, deep eutectic solvents, solid dispersion polymers, and solid solutions, we cannot consider that its enabling factor in these pharmaceutical modifications was enough to be clarified. Based on our previous study that oxybuprocaine acts as a role of parachute generator for piroxicam, the present study explored a small-molecule parachute generator and found that propranolol, a β-adrenergic-blocking drug, has a parachute effect on the supersaturated state of piroxicam. In addition, changing the concentration of tetracaine and dibucaine to 10 mM and 2.5 mM also showed a parachute effect. These parachute generators control piroxicam's dissolved state kinetically by making the supersaturated state of piroxicam a steady state. However, as the piroxicam anhydrous crystals diminished and the piroxicam monohydrate crystals grew due to Ostwald ripening, it led to attenuating the supersaturated state. This finding advances the elucidation of the mechanism of the parachute effect of polymers.
2024-06-15VETERINARY RECORD
Comparing the intraocular pressure values obtained with a rebound tonometer (TONOVET Plus) and an indentation tonometer (IOPvet) in dogs with and without ocular disease
Article
作者: Michaud, Bertrand ; Lesne, Fabien
Abstract:
Background:
This study aimed to compare the intraocular pressure (IOP) values obtained from two groups of dogs using the IOPvet indentation tonometer to those obtained from the same dogs using an established rebound tonometer (TONOVET Plus).
Methods:
Tonometry was performed on 36 dogs with ocular diseases (70 eyes; group A) and 25 healthy dogs (49 eyes; group B). First, the TONOVET Plus rebound tonometer was used. Then, one drop of oxybuprocaine hydrochloride was applied to each eye, and 1 minute later, the IOP was estimated using the IOPvet.
Results:
The IOPvet was safe, well tolerated and easy to use. The instrument had a high specificity (98.5%) for identifying IOPs of 20 mmHg or less. A lack of sensitivity (67.9%) was noted when evaluating eyes with an IOP between 20 and 30 mmHg. The sensitivity (33.3%) for identifying canine eyes with an IOP of greater than 30 mmHg (n = 24) was low.
Limitations:
This study lacks manometric work, which would be hard to justify with client‐owned dogs. Quantitative numerical data were compared with qualitative values and the same investigator obtained readings using both tonometers without being masked.
Conclusions:
The IOPvet is highly sensitive for assessing normal IOPs, but underestimation of higher IOPs can lead to poor diagnostics. Digital tonometers remain the best way to assess IOP in veterinary clinics.
2024-05-01Annals of emergency medicine
Use of Topical Anesthetics in the Management of Patients With Simple Corneal Abrasions: Consensus Guidelines From the American College of Emergency Physicians
Article
作者: Valente, Jonathan H ; Tomaszewski, Christian ; Lo, Bruce ; Milne, Ken ; Green, Steven M
The management of corneal abrasions has largely excluded dispensing topical local anesthetics for home use due to concern for corneal toxicity. We have reviewed and critically appraised the available literature evidence regarding the use of topical anesthetics in patients with simple corneal abrasions. Using sequential Delphi review, we have developed these clinical guidelines. Herein are evidentiary summaries and consensus recommendations for 8 specific relevant questions. Our key observation is that for only simple corneal abrasions, as diagnosed and treated in accordance with the full protocol described herein, it appears safe to prescribe or otherwise provide a commercial topical anesthetic (ie, proparacaine, tetracaine, oxybuprocaine) for use up to every 30 minutes as needed during the first 24 hours after presentation, as long as no more than 1.5 to 2 mL total (an expected 24-hour supply) is dispensed and any remainder is discarded after 24 hours. Importantly, although published findings suggest absent harm for short courses, more rigorous studies with a greater cumulative sample size and ophthalmologic follow-up are needed.
100 项与 盐酸奥布卡因 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 多泪 | 日本 | 1972-12-26 | |
| 麻醉 | 日本 | 1966-06-07 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 憲餘憲遞艱齋壓積顧鹹(製範範積築鑰獵襯製廠) = 鏇鏇鏇齋願遞糧壓選鹽 窪遞糧遞鏇鹹觸獵製夢 (遞廠襯餘襯蓋糧壓廠窪, 簾願鹹構憲膚襯廠鑰觸 ~ 鬱顧膚範窪鏇獵製夢鏇) 更多 | - | 2024-04-23 | ||
N/A | - | 42 | 願夢窪繭鹽顧簾構繭鬱(憲鏇顧鏇選鹽衊簾範淵): P-Value = 0.029 更多 | 积极 | 2021-09-01 | ||
N/A | 50 | Tetracaine/Oxybuprocaine | 選築廠襯範繭襯獵願鏇(遞夢壓遞餘衊鏇繭夢鹹) = 壓製窪齋壓遞鏇繭觸鹹 鹽繭顧積餘鬱鹹獵鹽願 (鑰憲鏇鏇襯觸壓醖憲襯 ) | 积极 | 2006-05-01 | ||
選築廠襯範繭襯獵願鏇(遞夢壓遞餘衊鏇繭夢鹹) = 鹽壓構願夢構醖齋憲齋 鹽繭顧積餘鬱鹹獵鹽願 (鑰憲鏇鏇襯觸壓醖憲襯 ) |
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