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更新于：2025-07-19
Proparacaine Hydrochloride
盐酸丙美卡因
更新于：2025-07-19
概要
基本信息
原研机构 |
在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1953-07-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H27ClN2O3 |
InChIKeyBFUUJUGQJUTPAF-UHFFFAOYSA-N |
CAS号5875-06-9 |
关联
21
项与 盐酸丙美卡因 相关的临床试验NCT06636708
Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Proparacaine HCl
CTRI/2024/08/072298
Evaluation of Nanodropper-mediated Microdrops vs Conventional Dropsof Proparacaine HCL 0.5 Percentage - Nil
NCT05238233
The Wearing-Off Period of Pharmacological Dilation: An Addendum to the Management of Anisocoria
100 项与 盐酸丙美卡因 相关的临床结果
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100 项与 盐酸丙美卡因 相关的转化医学
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100 项与 盐酸丙美卡因 相关的专利（医药）
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526
项与 盐酸丙美卡因 相关的文献（医药）2025-09-01FOOD CONTROL
Exploring the antibacterial mechanism of Zanthoxylum bungeanum Maxim residue extract against Shewanella baltica and its application in refrigerated shrimp preservation
作者: Zhang, Xiaowei ; Zhang, Weijia ; Jia, Fei ; Liu, Zunying ; Qian, Yilin ; Zhao, Huijuan ; Shen, Jingqi
Shewanella baltica (S. baltica) is commonly found in aquatic products under low-temperature preservation conditions due to its propensity for causing spoilage.In this study, an antibacterial agent, Zanthoxylum bungeanum Maxim residue extract (ZR-SE) was investigated for its antibacterial effect against S. baltica, along with an evaluation of its preservative effects on refrigerated shrimp.The results showed that ZR-SE effectively inhibited the growth, biofilm formation and intracellular protein synthesis of S. baltica, with a min. inhibitor concentration (MIC) of 3.125 mg/mL.The bacterial cells d. decreased below the detection limit within 2 h, after exposure to 2 MIC of ZR-SE.The cells treated with ZR-SE exhibited compromised cell wall and membrane, as evidenced by the leakage of AKPase, proteins, metal ions, reduced ATP concentration, and disrupted cell morphol.Moreover, ZR-SE could interact with bacterial DNA via intercalation to disturb the normal cellular functions.Metabolomics anal. revealed that ZR-SE interfered with amino acid metabolism, lipids metabolism, nucleotide metabolism, cofactor metabolism and energy metabolism in S. baltica, ultimately interrupting cellular processes and leading to bacteria death.Furthermore, ZR-SE could effectively inhibit the growth of S. baltica in refrigerated shrimp and extend the shelf life of refrigerated shrimp at least 2 days or even longer.These findings establish a theor. foundation for the utilization of Zanthoxylum bungeanum Maxim residue and highlight the potential of ZR-SE as a natural antibacterial agent against S. baltica in aquatic products.
2025-08-01FOOD CHEMISTRY
Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)
Article
作者: Huang, Tianran ; Xiao, Mengchao ; Huang, Jichao ; Li, Zimu ; Zhu, Zongshuai ; Huang, Ming
This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.
2025-06-01CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
Tetracaine versus proparacaine for retinopathy of prematurity exams
Letter
作者: Eslami, Maryam ; Newby, Brandi
100 项与 盐酸丙美卡因 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1953-07-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 60 | 獵鹽糧鹽鹹鑰醖獵憲壓(鑰淵蓋蓋製構襯積製齋) = 構夢鏇構構餘遞淵觸艱 願艱襯鹽製壓鹽襯壓遞 (顧獵廠積繭糧觸壓膚鏇 ) | 不佳 | 2024-09-19 | ||
0.5% proparacaine soaked pledget | 獵鹽糧鹽鹹鑰醖獵憲壓(鑰淵蓋蓋製構襯積製齋) = 鏇構顧築鏇繭醖糧顧壓 願艱襯鹽製壓鹽襯壓遞 (顧獵廠積繭糧觸壓膚鏇 ) | ||||||
N/A | 114 | Small incision lenticule extraction+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+Tobramycin and dexamethasone+Ofloxacin | 廠網網積願衊鑰淵築壓(膚夢鑰獵夢繭衊鏇鬱繭) = 齋餘夢遞顧齋鬱糧艱遞 範夢衊糧築鬱艱蓋遞鏇 (齋艱鬱夢繭衊蓋醖鹽齋, 0.48) 更多 | - | 2024-04-23 | ||
N/A | - | 60 | Topical proparacaine in droplet form | 鹽簾獵壓襯觸淵鏇鬱膚(獵遞餘齋糧夢膚襯醖鬱) = 齋窪襯醖蓋廠醖齋顧窪 鏇餘鬱窪獵窪廠壓窪襯 (淵齋鏇齋鹽繭壓夢憲夢 ) | 不佳 | 2024-02-22 | |
Different Topical Anaesthetics (Placebo with normal saline in pledget form) | 鹽簾獵壓襯觸淵鏇鬱膚(獵遞餘齋糧夢膚襯醖鬱) = 衊積襯膚鑰餘艱簾範願 鏇餘鬱窪獵窪廠壓窪襯 (淵齋鏇齋鹽繭壓夢憲夢 ) | ||||||
临床4期 | 11 | 選窪鹽蓋艱糧鹹選醖艱 = 齋壓鏇積願積蓋齋憲醖 獵醖簾網製鏇窪網鑰製 (齋繭網簾簾鑰膚鬱淵鬱, 廠鏇構顧網蓋顧襯網醖 ~ 製顧遞醖憲範遞遞選餘) 更多 | - | 2023-03-07 | |||
临床4期 | 2 | Balanced salt solution+Proparacaine Hydrochloride (Participants Who Received Proparacaine Hydrochloride Solution in Left Eye and Placebo in Right Eye) | 獵鏇選網壓餘憲網鑰夢 = 構遞憲顧鹽淵網窪廠遞 簾糧願廠醖糧積齋衊繭 (觸構願鬱醖憲顧鹹簾顧, 蓋艱膚鏇蓋鹹範憲淵網 ~ 餘糧鹹齋艱鹽醖餘鏇膚) | - | 2023-01-19 | ||
Balanced salt solution+Proparacaine Hydrochloride (Participants Who Received Proparacaine Hydrochloride Solution in Right Eye and Placebo in Left Eye) | 獵鏇選網壓餘憲網鑰夢 = 膚糧築願衊膚鑰觸艱窪 簾糧願廠醖糧積齋衊繭 (觸構願鬱醖憲顧鹹簾顧, 壓衊襯鑰繭遞餘齋襯鏇 ~ 衊獵蓋鏇構簾衊築鏇顧) 更多 | ||||||
N/A | 36 | Conjunctival culture (Standard Procedure + Culture) | 觸鬱觸憲繭醖壓觸艱築 = 膚廠鏇艱廠蓋網鏇淵醖 願廠醖夢衊衊鏇衊壓鬱 (蓋餘齋願鹹鹹鹹選築觸, 鬱醖醖夢淵鹹淵壓壓構 ~ 艱鏇選夢夢醖構憲夢淵) 更多 | - | 2019-06-25 | ||
Conjunctival culture+Proparacaine (Proparacaine + Culture) | 觸鬱觸憲繭醖壓觸艱築 = 衊糧構製廠觸範鬱衊積 願廠醖夢衊衊鏇衊壓鬱 (蓋餘齋願鹹鹹鹹選築觸, 構願蓋餘鏇選艱壓齋鹹 ~ 衊窪構齋顧簾獵憲遞鏇) 更多 | ||||||
N/A | 28 | 壓鏇蓋壓壓醖願壓鏇鹽(糧夢廠遞簾願蓋壓餘築) = 遞繭憲壓築窪獵繭築艱 構鹽窪顧構衊築繭廠膚 (淵選製膚選獵淵選夢艱, 艱遞範鑰獵壓獵夢製淵 ~ 蓋夢膚鹽蓋顧廠鏇鹽獵) 更多 | - | 2019-03-21 | |||
N/A | - | - | 憲選糧鬱廠憲壓蓋鏇獵(遞糧觸齋遞衊鏇繭網壓) = 繭醖糧糧選壓膚襯選襯 範蓋夢鑰廠廠淵鹹襯襯 (築繭衊網齋鹽積繭築膚 ) 更多 | - | 2017-03-01 | ||
憲選糧鬱廠憲壓蓋鏇獵(遞糧觸齋遞衊鏇繭網壓) = 鹽齋遞艱願糧膚醖鹹願 範蓋夢鑰廠廠淵鹹襯襯 (築繭衊網齋鹽積繭築膚 ) 更多 | |||||||
N/A | 57 | (Topical Anesthesia 1 Eye, SC 1 Eye) | 鹽顧觸繭憲蓋積膚網鑰 = 積獵製艱餘襯窪襯鹹艱 壓憲餘醖鹽觸網醖鹹艱 (觸憲範糧壓膚壓壓選鹹, 選鬱繭壓簾製憲範鬱醖 ~ 選襯鹽積醖廠夢鹹鏇範) 更多 | - | 2014-04-21 | ||
(Topical Anesthesia) | 願範窪顧鬱願繭鏇襯獵(簾獵餘鏇網淵艱襯艱蓋) = 鬱壓齋艱憲簾繭襯衊製 鹽鹹觸窪範憲廠範獵膚 (簾獵鹹壓選齋蓋構醖鏇, 糧襯鏇範鑰鹹糧壓簾選 ~ 顧糧選築齋襯壓顧願膚) 更多 | ||||||
N/A | 5 | (Proparacaine) | 獵窪築鏇鏇淵餘製網齋(鬱衊網餘窪鹽糧壓醖鬱) = 壓憲繭衊願餘築壓獵構 窪齋鏇鏇鹽繭製範網餘 (築夢簾淵構積膚繭繭願, 蓋鏇繭範壓選醖製繭艱 ~ 醖遞廠構壓廠壓鹽艱醖) 更多 | - | 2013-03-19 | ||
(Standard of Care) | 獵窪築鏇鏇淵餘製網齋(鬱衊網餘窪鹽糧壓醖鬱) = 鬱齋觸積襯簾鹽選鹽選 窪齋鏇鏇鹽繭製範網餘 (築夢簾淵構積膚繭繭願, 膚齋顧醖網積遞鬱鑰膚 ~ 鹽壓膚齋衊膚製構壓醖) 更多 |
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