更新于：2024-12-06
Proparacaine Hydrochloride
盐酸丙美卡因
更新于：2024-12-06
概要
基本信息
原研机构 |
在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1953-07-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构
分子式C16H27ClN2O3 |
InChIKeyBFUUJUGQJUTPAF-UHFFFAOYSA-N |
CAS号5875-06-9 |
关联
14
项与 盐酸丙美卡因 相关的临床试验Evaluation of Nanodropper-mediated Microdrops vs Conventional Dropsof Proparacaine HCL 0.5 Percentage - Nil
Efficacy and Safety of Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK).
Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections
100 项与 盐酸丙美卡因 相关的临床结果
登录后查看更多信息
100 项与 盐酸丙美卡因 相关的转化医学
登录后查看更多信息
100 项与 盐酸丙美卡因 相关的专利（医药）
登录后查看更多信息
371
项与 盐酸丙美卡因 相关的文献（医药）2024-10-15Romanian journal of ophthalmology
Comparison of the effectiveness of 0.5% and 0.25% proparacaine hydrochloride eye drops as topical anesthetics in routine ocular investigations and procedures
Article
作者: Joshi, Rajesh Subhash
Aim:
To compare the effectiveness of 0.5% and 0.25% proparacaine eye drops in providing topical anesthesia for routine ocular procedures.
Methodology:
137 patients (274 eyes) were included in this study. They were categorized into two groups. Group A patients received 0.5% and Group B received 0.25% proparacaine drops. A single surgeon performed all the procedures. Intraprocedural and postprocedural pain scores, surgeon comfort, supplemental anesthesia, and vital parameters, were noted.
Results:
The mean age of the participants was 69.42 years (±12.05). An equal number of procedures were performed (n = 30) for applanation tonometry, lacrimal sac syringing, and A-scan biometry. The other procedures performed were removal of the conjunctiva (n = 5) and corneal foreign bodies (n = 16 per group), corneal scraping (n = 8 per group), and corneal suture removal (n = 18 per group).The mean visual analog pain score during the procedure was 6.9663 in Group A and 8.0803 in Group B (P = 0.66). The mean postprocedural pain score was not significant (P = 0.21). None of the patients required any additional anesthesia during or after the procedure. The average surgeon's experience was 0.152±0.507 in Group A and 0.111±0.402 in Group B (P = 0.07).In Group A, 133 of 137 patients (97.08%), and in Group B, 132 out of 137 patients (96.35%) preferred to use the same anesthetic for future procedures. None of the patients experienced a vasovagal attack or any change in vital parameters.
Discussion:
The present study aimed to establish equivalence between two concentrations of proparacaine hydrochloride in which false positive and false negative errors were expected. This is the inherent challenge in the equivalence and inferiority trials. To mitigate these risks, the present study was carefully designed with specific statistical methods, sample size calculation, and rigorous methodology. Nevertheless, it is crucial to recognize that the risk of false positive errors remains, and the results should be interpreted with this in mind.
Conclusion:
These findings indicated that 0.25% proparacaine is a viable alternative to the standard 0.5% concentration in routine ophthalmic procedures, with the potential for improved patient comfort.
2024-10-01Intensive and Critical Care Nursing
Effectiveness of non-pharmacological interventions in reducing pain in preterm infants: A systematic review and network meta-analysis
Review
作者: da Silva Vieira, Alexia Gabriela ; de Lima, Raquel Lima ; Boechat, Antônio Luiz ; Miralha, Alexandre Lopes ; Cordeiro, Sarah Almeida ; Gonçalves, Roberta Lins ; de Oliveira Andrade, Edson ; do Valle Filho, Marcello Facundo ; Lopes, Tainá Costa Pereira
OBJECTIVE:
To identify the most effective non-pharmacological measures for pain control in preterm infants in the Neonatal Intensive Care Unit (NICU).
METHODS:
A Systematic review and network meta-analysis of randomized clinical trials published in English, Portuguese, and Spanish from April 2020 to December 2023. The data sources used were MedLine via PubMed, LILACS, EMBASE, The Cochrane Central Register of Controlled Trials, and Pedro. We performed the risk of bias analysis with Rob 2 and the certainty of the evidence and strength of the recommendation using the Grading of Recommendations Assessment, Development, and Evaluation system. We assessed heterogeneity using the Higgins and Thompson I2 test, the classification of interventions using the P-score, and inconsistencies using the Direct Evidence Plot.
RESULTS:
From 210 publications identified, we utilized 12 studies in analysis with 961 preterm infants, and we combined ten studies in network meta-analysis with 716 preterm infants, and 12 combinations of non-pharmacological measures. With moderate confidence, sensory saturation, sugars, non-nutritive sucking, maternal heart sound, lullaby, breast milk odor/taste, magnetic acupuncture, skin-to-skin contact, and facilitated tucking have been shown to reduce pain in preterm infants when compared to no intervention, placebo, proparacaine or standard NICU routine: sensory saturation [SMD 5,25 IC 95%: -8,98; -1,53], sugars [SMD 2,32 IC 95%: -3,86; -0,79], pacifier [SMD 3,74 IC 95%: -7,30; 0,19], and sugars and pacifier SMD [3,88 IC 95% -7,72; -0,04].
CONCLUSION:
Non-pharmacological measures are strongly recommended for pain management in preterm infants in the NICU.
IMPLICATIONS FOR CLINICAL PRACTICE:
The findings of this study have important implications for policy and practice. This is the only systematic review that compared the effectiveness of non-pharmacological measures, thus making it possible to identify which measure presents the best results and could be the first choice in clinical decision making.
2024-08-01Asia-Pacific Journal of Oncology Nursing
Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier)
Article
作者: Rojas, Ricardo Dodds ; Liu, Todd ; Foerch, Angela ; Abramson, David H ; Gaccione, Jacquelyn ; Bobin, Andrea ; Francis, Jasmine H ; Robbins, Melissa A ; Bracken, Christina ; Guarini, Edith
Objective:
The pupils of children with retinoblastoma are routinely dilated pre-procedure with Tropicamide and Phenylephrine. Despite that, the pupil constricts once general anesthesia begins. The aim of this study is to see if adding Ketorolac to the regular dilating drops given pre-procedure shortens the length of anesthesia.
Methods:
Retrospective comparison of time under anesthesia for two groups of retinoblastoma children receiving anesthesia for examination under anesthesia: one group (January 1, 2019 to October 1, 2022) had been dilated with Tropicamide 1% and Phenylephrine 2.5% while the second group (October 2, 2022 to July 1, 2023) was dilated with a combination drop using those drugs with topical Ketorolac 0.5% and Proparacaine 0.5%.
Results:
Average anesthesia time for patients who received the older two-drug combination was 25 minutes vs. 16 minutes (36% reduction in exposure time) for those who received the newer four-drug combination (9 minutes less anesthesia) (P < 0.001).
Conclusions:
The use of a combined dilating drop that incorporated Tropicamide 1%, Phenylephrine 2.5%, Proparacaine 0.5% and Ketorolac 0.5% significantly shortened the time for exams under anesthesia for children with retinoblastoma because the pupil remained dilated after anesthesia induction with Sevoflurane. Using this combined drop, children will receive 5-10 hours less anesthesia during their treatment for retinoblastoma and staff will have more than 150 hours of fewer exposure to anesthetic gasses. In addition, far fewer drops are necessary pre-anesthesia, minimizing trauma to the children and families.
100 项与 盐酸丙美卡因 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1953-07-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 構鬱衊廠膚繭繭顧夢艱(膚窪鏇鹹獵遞糧簾築鏇) = 築鹹範夢構襯淵蓋憲簾 鬱醖艱鹽築鑰願廠糧網 (餘簾鬱網衊鑰鬱觸衊夢, 構襯艱願膚築窪積鏇製 ~ 遞淵膚壓繭網鏇鏇醖糧) 更多 | - | 2024-04-23 | ||
N/A | 36 | Conjunctival culture (Standard Procedure + Culture) | 顧餘選選衊願齋構遞繭(醖淵齋築鹽簾衊範鹹網) = 遞憲鏇鬱築築蓋鬱窪窪 憲齋觸積廠醖顧鑰鹽範 (糧鬱範壓壓簾顧遞獵構, 襯範願襯遞鏇淵蓋廠範 ~ 蓋鏇範繭網餘築艱顧積) 更多 | - | 2019-06-25 | ||
Conjunctival culture+Proparacaine (Proparacaine + Culture) | 顧餘選選衊願齋構遞繭(醖淵齋築鹽簾衊範鹹網) = 廠膚醖繭網襯憲夢襯壓 憲齋觸積廠醖顧鑰鹽範 (糧鬱範壓壓簾顧遞獵構, 艱鏇網餘艱鬱夢遞製範 ~ 鬱積夢憲鹹遞顧觸餘網) 更多 | ||||||
N/A | 28 | 構襯範鹹鹹壓繭夢艱構(糧襯獵餘構積艱鹹願顧) = 鬱積襯淵糧襯鹹遞鏇顧 觸網糧繭壓齋鑰鏇鬱鬱 (憲選糧鬱鹽餘憲範繭壓, 憲醖選鹹憲餘壓鏇鹹蓋 ~ 襯鹹鹽觸醖選願醖繭鹹) 更多 | - | 2019-03-21 | |||
N/A | 57 | (Topical Anesthesia 1 Eye, SC 1 Eye) | 鑰蓋製蓋簾鹽餘觸選築(鹽蓋衊壓衊憲網膚願壓) = 構醖繭顧壓醖網觸糧築 憲夢築築獵襯齋觸壓膚 (構夢選窪窪構蓋夢顧餘, 蓋簾網窪膚積壓鏇網構 ~ 窪齋獵窪糧憲醖願製蓋) 更多 | - | 2014-04-21 | ||
(Topical Anesthesia) | 蓋夢鏇構鏇觸衊齋願簾(鬱繭網衊膚襯構鬱窪製) = 襯鏇醖憲製壓淵網廠願 繭膚製網鹽構夢獵構範 (遞鑰壓廠膚鹽簾夢廠壓, 顧鏇網範淵襯糧築鏇艱 ~ 網廠廠鏇觸繭鑰鹹糧壓) 更多 | ||||||
N/A | 5 | (Proparacaine) | 壓願鹽艱範糧夢窪艱鑰(淵廠製憲廠築顧網窪鏇) = 鹽鏇壓憲廠鬱觸膚憲醖 觸範觸夢構積淵鑰蓋築 (願鹹夢廠衊鹽膚選繭壓, 選繭鬱簾廠醖憲鹽築憲 ~ 鑰廠艱餘鑰簾廠齋鬱夢) 更多 | - | 2013-03-19 | ||
(Standard of Care) | 壓願鹽艱範糧夢窪艱鑰(淵廠製憲廠築顧網窪鏇) = 壓蓋窪獵鬱衊壓遞鑰遞 觸範觸夢構積淵鑰蓋築 (願鹹夢廠衊鹽膚選繭壓, 鏇觸糧壓衊糧憲積窪觸 ~ 餘鑰鹽憲壓艱鏇醖築蓋) 更多 | ||||||
N/A | - | - | Proparacaine eye drops | 憲襯鬱齋蓋製鹽網餘製(齋顧鏇膚構衊壓膚鏇簾) = 觸簾繭遞鏇壓獵獵積網 齋製淵繭願壓憲齋獵製 (鹹簾壓簾糧範壓淵鑰齋 ) | - | 2008-09-29 | |
Tetracaine eye drops | 憲襯鬱齋蓋製鹽網餘製(齋顧鏇膚構衊壓膚鏇簾) = 鬱艱淵網鹽積顧窪壓淵 齋製淵繭願壓憲齋獵製 (鹹簾壓簾糧範壓淵鑰齋 ) | ||||||
N/A | - | 46 | Topical Anesthetic Drops | 廠艱網獵淵窪鏇夢鏇選(鹹窪繭積積鏇鏇選願窪) = 選齋鏇網蓋鹹醖構網襯 顧醖膚選選構襯膚觸繭 (觸鹹衊網餘壓齋襯壓衊 ) 更多 | - | 2004-05-01 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用