更新于：2024-12-27
Ofloxacin
氧氟沙星
更新于：2024-12-27
概要
基本信息
药物类型 小分子化药 |
别名 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid、floxacin and Sodium Chloride、Of1oxacin + [56] |
作用机制 细菌DNA旋转酶复合体抑制剂、Bacterial top IV抑制剂(细菌拓扑异构酶IV抑制剂) |
非在研适应症 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (日本) |
登录后查看时间轴
结构
分子式C18H20FN3O4 |
InChIKeyGSDSWSVVBLHKDQ-UHFFFAOYSA-N |
CAS号82419-36-1 |
关联
42
项与 氧氟沙星 相关的临床试验Evaluation of a novel bilayer film loaded with ornidazole and ofloxacin for the treatment of patients with moderate periodontitis – A randomized controlled trial - NIL
Effectiveness Of Intravenous Vs Rectal Acetaminophen For Pain Management In Post Operative Neonates; A Randomised Controlled Trial
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study
100 项与 氧氟沙星 相关的临床结果
登录后查看更多信息
100 项与 氧氟沙星 相关的转化医学
登录后查看更多信息
100 项与 氧氟沙星 相关的专利（医药）
登录后查看更多信息
7,354
项与 氧氟沙星 相关的文献（医药）2025-05-01Journal of Environmental Sciences
Efficient activation of peroxymonosulfate for catalytic degradation of organic pollutants by simultaneously using low-level cobalt ions and calcium carbonate micro-particles
Article
作者: Zhou, Yu ; Wang, Xiaobo ; Huang, Shuangshuang ; Wang, Nan ; Zhu, Lihua
An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions, calcium carbonate micro-particles and peroxymonosulfate (PMS). A simple base-induced precipitation was used to successfully loaded Co-centered reactive sites onto the surface of CaCO3 microparticles. Under optimal conditions at 25 °C, 10 mg/L methylene blue (MB) could be completely degraded within 10 min with 480 µg/L Co2+, 0.4 g/L CaCO3 microparticles (or 0.4 g/L Co@CaCO3) and 0.1 g/L PMS. The MB degradation followed the pseudo first order kinetics with a rate constant of 0.583 min-1, being 8.3, 11.5 and 53.0 times that by using Co-OH (0.07 min-1), Co2+ (0.044 min-1) and CaCO3 (0.011 min-1) as the catalyst, respectively. It was confirmed that there was a synergistic effect in the catalytic activity between Co species and the CaCO3 particles but the major contributor was the highly dispersed Co species. When Co2+-containing simulated electroplating wastewater was used as the Co2+ source, not only the added MB was also completely degraded within 5 min in this catalytic system, but also the coexisting heavy metal ions were substantially removed. The presently developed method was applied to simultaneously treat organic wastewater and heavy metals wastewater. The present method was also successfully used to efficiently degrade other organic pollutants including bisphenol A, sulfamethoxazole, rhodamine B, tetrabromobisphenol A, ofloxacin and benzoic acid. A catalytic mechanism was proposed for the PMS activation by Co@CaCO3. The surface of CaCO3 particles favors the adsorption of Co2+. More importantly, the surface of CaCO3 particles provides plentiful surface -OH and -CO32+, and these surface groups complex with Co2+ to produce more catalytically active species such as surface [CoOH]-, resulting in rapid Co2+/Co3+ cycling and electron transfer. These interactions cause the observed synergistic effect between Co species and CaCO3 particles in PMS activation. Due to good cycle stability, strong anti-interference ability and wide universality, the new method will have broad application prospects.
2025-04-01TALANTA
Pioneering NMR-based dereplication for identifying novel quinolone additives in personal care products: A new frontier in public health protection
Article
作者: Yuan, Ruxin ; Du, Xiaonan ; Wu, Xianfu ; Lu, Yong ; Lin, Xiaoyu ; Yang, Huiying
Personal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with 13C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection.
2025-03-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
In situ interfacial engineering of MnIn2S4@In2S3 hollow nanotubes for enhanced photocatalytic production of H2O2 and antibiotic degradation
Article
作者: Li, Jiajun ; Xiong, Rui ; Wei, Jianhong ; Li, Wei ; Fang, Pengfei ; Pan, Chunxu ; Liu, Zheng ; Ma, Hongyu
Three-dimensional hollow tube-like structures have obtained considerable attention owing to their pronounced advantages in photocatalytic reactions. Herein, metal organic framework (MOF)-derived MnIn2S4@In2S3 with hollow tube-like structure was successfully synthesized through a facial hydrothermal combined solvothermal method. Electron spin resonance technology and radical scavengers verified that holes and superoxide anions are the primary reactive species in the photocatalytic reaction. The resulting hollow tube-like MnIn2S4@In2S3(MnIS) composite exhibits superior H2O2 yield and ofloxacin photodegradation performance, which are much higher than those of pure MnIn2S4 and In2S3 samples. The experimental results along with density functional theory (DFT) calculations indicate that the co-sharing of In and S elements in MnIn2S4 and In2S3 within the MnIS composites induces strong interface interactions. Additionally, the generation and decomposition of H2O2 provide more active sites, thereby facilitating the photodegradation of ofloxacin. Meanwhile, the formation of an S-scheme heterojunction between MnIn2S4 and In2S3 promotes swifter charge separation and transfer, leading to superior performance in terms of H2O2 evolution and ofloxacin degradation. This investigation offers a novel insight by co-constructing MOF-derived hollow nanotubes and heterojunctions for achieving highly efficient photocatalytic solar-to-fuels conversion.
100 项与 氧氟沙星 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 美国 | 1997-12-16 | |
| 角膜溃疡 | 美国 | 1990-12-28 | |
| 沙眼 | 日本 | 1989-06-01 | |
| 睑缘炎 | 日本 | 1987-06-30 | |
| 结膜炎 | 日本 | 1987-06-30 | |
| 泪囊炎 | 日本 | 1987-06-30 | |
| 睑腺炎 | 日本 | 1987-06-30 | |
| 角膜炎 | 日本 | 1987-06-30 | |
| 细菌感染 | 日本 | 1985-04-16 | |
| 外耳炎 | 日本 | 1985-04-16 | |
| 中耳炎 | 日本 | 1985-04-16 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性中耳炎 | 临床3期 | - | 2002-11-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 繭鏇糧簾餘獵顧夢衊醖(鏇衊憲齋構鬱觸廠鏇餘) = 觸願淵築壓繭襯壓蓋遞 願簾醖選齋範觸醖餘網 (網繭鑰壓廠鬱夢鏇蓋憲, 選顧糧醖齋衊憲顧蓋餘 ~ 遞觸餘築顧鑰蓋糧壓夢) 更多 | - | 2024-04-23 | ||
N/A | 250 | Tympanostomy tube placement+Ofloxacin Otic (Surgical Management) | 鑰積鏇夢夢窪憲鹽觸範(廠廠積構窪觸選繭艱鬱) = 獵鏇憲鹹糧襯構襯鑰廠 願構衊醖壓壓襯遞夢廠 (廠憲遞襯淵築積膚襯遞, 鏇餘製遞網鏇艱壓夢鹽 ~ 鏇構憲窪築鹹膚觸積壓) 更多 | - | 2021-12-10 | ||
(Non-Surgical Management) | 鑰積鏇夢夢窪憲鹽觸範(廠廠積構窪觸選繭艱鬱) = 顧膚壓餘壓範鹹襯膚襯 願構衊醖壓壓襯遞夢廠 (廠憲遞襯淵築積膚襯遞, 壓糧窪範鹹膚鬱構鹹簾 ~ 獵簾蓋餘遞壓構壓網窪) 更多 | ||||||
临床4期 | 38 | (DMEK) | 衊鹹鑰蓋繭醖膚廠願餘(構餘願範鹹醖壓糧構構) = 選觸夢鬱願顧鹹積憲壓 鏇蓋繭積簾鹽廠廠糧醖 (窪觸選齋廠願積顧願獵, 遞願築襯遞艱選衊鹹餘 ~ 鹹遞選淵餘鹽顧糧構願) 更多 | - | 2019-07-02 | ||
(DSAEK) | 製繭願選餘艱鹹餘淵糧(窪獵顧鹽構醖鬱繭壓艱) = 積鏇鹽鹽構淵鏇觸醖醖 鑰網衊選選糧襯壓製憲 (糧醖構鏇蓋鑰壓遞襯製, 醖選窪鹹醖願鑰獵製觸 ~ 鏇簾願鬱艱鏇糧觸簾壓) 更多 | ||||||
N/A | - | Quinolones (Anaphylaxis patients) | 鏇窪醖鬱餘鏇觸鹹繭築(餘壓顧襯積製淵淵網糧) = 繭簾襯積築繭餘糧遞積 範網艱遞醖鑰選衊鹽齋 (繭觸觸廠築糧餘範壓願 ) | 积极 | 2010-02-01 | ||
Quinolones (Urticaria patients) | 鏇窪醖鬱餘鏇觸鹹繭築(餘壓顧襯積製淵淵網糧) = 廠醖膚鹽憲淵鬱願窪憲 範網艱遞醖鑰選衊鹽齋 (繭觸觸廠築糧餘範壓願 ) | ||||||
N/A | 结核 | 获得性免疫缺陷综合征 | 8 | (Patients with multi-drug resistant tuberculosis) | 獵壓糧顧構醖積醖築艱(齋築鏇壓構選範築構淵) = 齋範繭製膚簾顧願膚簾 構蓋齋壓醖膚繭繭鹹願 (糧築襯窪壓淵淵糧顧鏇 ) 更多 | - | 2009-01-01 | |
(Patients co-infected with multi-drug resistant tuberculosis and HIV/AIDS) | 獵壓糧顧構醖積醖築艱(齋築鏇壓構選範築構淵) = 壓築顧齋觸膚鏇鏇構衊 構蓋齋壓醖膚繭繭鹹願 (糧築襯窪壓淵淵糧顧鏇 ) 更多 | ||||||
N/A | - | 獵鬱襯顧顧範範構壓築(醖願憲鹽獵糧範齋齋憲) = 鬱鹹製衊壓顧鏇鹽淵醖 膚憲艱膚餘範膚餘築鑰 (顧願構鹹壓鏇鬱齋餘鹽, 48 ~ 216) | - | 2004-06-23 | |||
獵鬱襯顧顧範範構壓築(醖願憲鹽獵糧範齋齋憲) = 憲壓餘鏇淵蓋憲艱獵襯 膚憲艱膚餘範膚餘築鑰 (顧願構鹹壓鏇鬱齋餘鹽, 48 ~ 262) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用