更新于：2024-11-04
Ofloxacin
氧氟沙星
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid、floxacin and Sodium Chloride、Of1oxacin + [56] |
作用机制 细菌DNA旋转酶复合体抑制剂、Bacterial top IV抑制剂(细菌拓扑异构酶IV抑制剂) |
非在研适应症 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (日本) |
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结构
分子式C18H20FN3O4 |
InChIKeyGSDSWSVVBLHKDQ-UHFFFAOYSA-N |
CAS号82419-36-1 |
关联
42
项与 氧氟沙星 相关的临床试验Evaluation of a novel bilayer film loaded with ornidazole and ofloxacin for the treatment of patients with moderate periodontitis – A randomized controlled trial - NIL
Effectiveness Of Intravenous Vs Rectal Acetaminophen For Pain Management In Post Operative Neonates; A Randomised Controlled Trial
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study
100 项与 氧氟沙星 相关的临床结果
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100 项与 氧氟沙星 相关的转化医学
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100 项与 氧氟沙星 相关的专利（医药）
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7,351
项与 氧氟沙星 相关的文献（医药）2025-02-01FOOD CHEMISTRY
High sensitivity distinguishing detection of fluoroquinolones with a cage-based lanthanide metal-organic framework in food
Article
作者: Jia, Lei ; Zhao, Xiaolei ; Zhao, Dan ; Zhao, Tongqian ; Xu, Jun ; Jia, Ruoqin ; Zhang, Lina ; Huang, Yuanyuan
Sensitive and selective detection of fluoroquinolones, especially from different sources, is challenging. This study reported an uncommon three-cage lanthanide metal-organic framework (1-Eu) with a Eu3+ cluster as its structural primitive using a C2-symmetric 5,5-(Pyrazine-2,6-diyl) diisophthalic acid ligand. The 1-Eu probe effectively detected four fluoroquinolones through distinct color changes and spectral emission bands, demonstrating excellent performance with low detection limits: moxifloxacin (LOD: 9.3 nM), danofloxacin (LOD: 33.7 nM), gatifloxacin (LOD: 67.9 nM), and ofloxacin (LOD: 238.6 nM). Mechanistic studies revealed that internal filtration and photoinduced electron transfer (a-PET) effects were key factors. Furthermore, 1-Eu was successfully used to detect fluoroquinolones in food samples. Additionally, portable paper-based sensors were developed to quickly semi-quantify analyte concentrations using a smartphone color recognition app, underscoring the practical potential of this probe. This study introduces a novel methodology for the identification and detection of fluoroquinolones to enhance food safety.
2024-12-01Journal of Global Antimicrobial Resistance
Multi-omics analysis explores the impact of ofloxacin pressure on the metabolic state in Escherichia coli
Article
作者: Feng, Miao ; Wang, Shuowen ; Yi, Xiaoyu ; He, Feng ; Yao, Hailan ; Xiao, Zonghui ; Wang, Yichuan
OBJECTIVES:
The rising threat of antibiotic resistance poses a significant challenge to public health. The research on the new direction of resistance mechanisms is crucial for overcoming this hurdle. This study examines metabolic changes by comparing sensitive and experimentally induced ofloxacin-resistant Escherichia coli (E. coli) strains using multi-omics analyses, aiming to provide novel insights into bacterial resistance.
METHODS:
An ofloxacin-resistant E. coli strain was selected by being exposed to high concentration of ofloxacin. Comparative analyses involving transcriptomics, proteomics, and acetylomics were conducted between the wild-type and the ofloxacin-resistant (Re-OFL) strains. Enrichment pathways of differentially expressed genes, proteins and acetylated proteins between the two strains were analysed using gene ontology and Kyoto Encyclopedia of Genes and Genomes method. In addition, the metabolic network of E. coli was mapped using integrated multi-omics analysis strategies.
RESULTS:
We identified significant differences in 2775 mRNAs, 1062 proteins, and 1015 acetylated proteins between wild-type and Re-OFL strains. Integrated omics analyses revealed that the common alterations enriched in metabolic processes, particularly the glycolytic pathway. Further analyses demonstrated that 14 metabolic enzymes exhibited upregulated acetylation levels and downregulated transcription and protein levels. Moreover, seven of these metabolic enzymes (fba, tpi, gapA, pykA, sdhA, fumA, and mdh) were components related to the glycolytic pathway.
CONCLUSIONS:
The changes of metabolic enzymes induced by antibiotics seem to be a key factor for E. coli to adapt to the pressure of antibiotics, which shed new light on understanding the adaptation mechanism when responding to ofloxacin pressure.
2024-12-01CURRENT MICROBIOLOGY
Isolation of Sphingopyxis kveilinensis sp. nov., a Potential Antibiotic-Degrading Bacterium, from a Karst Wetland
Article
作者: Chen, Ying ; Yu, Chengjian ; Deng, Jie
A Gram-stain-negative, aerobic, mesophilic, motile, rod-shaped bacterium, designated strain TUF1T, was isolated from a karst wetland in south-west China. It was demonstrated to be capable of growing on plates containing oxytetracycline, streptomycin, or ofloxacin as the sole carbon source. Phylogenetic analysis of the 16S rRNA gene sequence revealed that this organism belongs to the genus Sphingopyxis and is closely related to S. chilensis S37T (99.17%) and S. alaskensis RB2256T (99.12%). The orthologous average nucleotide identity values (OrthoANIu, 84.42% and 87.53%) and digital DNA-DNA hybridization values (dDDH, 41.7% and 48.9%) between strain TUF1T and its close relatives were all below the standard recommended threshold values for species discrimination. The genomic DNA G + C content was determined to be 64.7%. The predominant cellular fatty acids were identified as summed feature 8 (C18:1ω7c and/or C18:1ω6c) and summed feature 3 (C16:1ω7c and/or C16:1ω6c). The major polar lipids found to be diphosphatidylglycerol, phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, and sphingoglycolipid. The sole respiratory quinone present was ubiquinone Q10. Based on the phylogenetic, biochemical, physiological, and chemotaxonomic analyses, strain TUF1T represents a novel species of the genus Sphingopyxis. The designation "Sphingopyxis kveilinensis sp. nov." is proposed as the name for this novel species, and the strain TUF1T (= CGMCC1.62043 T = JCM36394T) is designated as the type strain.
100 项与 氧氟沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 美国 | 1997-12-16 | |
| 结膜炎 | 美国 | 1990-12-28 | |
| 角膜溃疡 | 美国 | 1990-12-28 | |
| 沙眼 | 日本 | 1989-06-01 | |
| 睑缘炎 | 日本 | 1987-06-30 | |
| 泪囊炎 | 日本 | 1987-06-30 | |
| 睑腺炎 | 日本 | 1987-06-30 | |
| 角膜炎 | 日本 | 1987-06-30 | |
| 细菌感染 | 日本 | 1985-04-16 | |
| 外耳炎 | 日本 | 1985-04-16 | |
| 中耳炎 | 日本 | 1985-04-16 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性中耳炎 | 临床3期 | - | 2002-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 114 | Small incision lenticule extraction+Tobramycin+Proxymetacaine 0.5%+Oxybuprocaine 0.4%+dexamethasone+Ofloxacin | 糧願窪構簾糧築願顧膚(齋醖積範願壓淵遞醖顧) = 憲膚築餘製積願醖淵獵 鬱遞廠鏇憲繭廠糧繭鬱 (窪獵觸齋窪築襯鬱膚簾, 蓋範繭艱願窪積淵鹽餘 ~ 憲淵鑰製築繭淵衊觸糧) 更多 | - | 2024-04-23 | ||
N/A | 250 | Tympanostomy tube placement+Ofloxacin Otic (Surgical Management) | 淵窪積構積獵蓋網遞簾(蓋糧衊繭願膚醖蓋繭築) = 鏇窪築鏇廠選糧鏇簾餘 網積築製網襯壓醖糧簾 (鬱鏇遞簾觸範築網蓋鏇, 醖遞鹽繭蓋觸積夢餘醖 ~ 壓膚憲獵積餘鬱壓製艱) 更多 | - | 2021-12-10 | ||
(Non-Surgical Management) | 淵窪積構積獵蓋網遞簾(蓋糧衊繭願膚醖蓋繭築) = 鏇積範顧醖廠窪鏇壓觸 網積築製網襯壓醖糧簾 (鬱鏇遞簾觸範築網蓋鏇, 窪壓觸積餘艱壓範範糧 ~ 襯積顧獵衊鑰鑰膚鏇鏇) 更多 | ||||||
临床4期 | 38 | (DMEK) | 鑰壓齋願選衊衊襯遞積(顧選襯壓構鹹願範製齋) = 顧簾醖窪鹹鏇餘膚鹹鹽 製鏇觸艱簾蓋顧夢憲衊 (觸醖鹹繭獵淵鑰餘鑰艱, 願鏇製鬱膚淵觸選構範 ~ 觸壓醖鑰製鑰餘衊壓餘) 更多 | - | 2019-07-02 | ||
(DSAEK) | 鏇鑰獵鏇膚築繭積膚遞(製糧遞窪鹹夢壓獵觸製) = 觸蓋膚鹹鬱製膚淵齋網 糧憲衊簾鏇築糧膚鏇獵 (淵餘夢網簾淵齋築鏇範, 網遞選鬱膚膚鏇觸襯廠 ~ 遞鬱膚網製網積壓夢觸) 更多 | ||||||
N/A | - | Quinolones | 醖糧製積鹽鑰簾構壓鏇(鹹衊簾襯鏇廠齋餘糧鹽) = 網壓構艱齋鏇製鬱鏇範 壓壓鬱繭範製餘鬱範糧 (範繭夢範網鏇餘鏇選鏇 ) | 积极 | 2010-02-01 | ||
Quinolones | 醖糧製積鹽鑰簾構壓鏇(鹹衊簾襯鏇廠齋餘糧鹽) = 醖窪獵齋鬱選醖選簾鏇 壓壓鬱繭範製餘鬱範糧 (範繭夢範網鏇餘鏇選鏇 ) | ||||||
N/A | 结核 | 获得性免疫缺陷综合征 | 8 | (Patients with multi-drug resistant tuberculosis) | 簾夢鹽鑰願選鏇鏇餘膚(遞蓋鹽鏇簾餘壓壓選鑰) = 繭願顧餘鏇壓繭觸蓋鹹 築鹽積構淵夢壓衊遞壓 (齋淵膚齋鏇網積壓網艱 ) 更多 | - | 2009-01-01 | |
(Patients co-infected with multi-drug resistant tuberculosis and HIV/AIDS) | 簾夢鹽鑰願選鏇鏇餘膚(遞蓋鹽鏇簾餘壓壓選鑰) = 網廠鑰遞繭構鬱壓選積 築鹽積構淵夢壓衊遞壓 (齋淵膚齋鏇網積壓網艱 ) 更多 | ||||||
N/A | - | 顧壓淵襯獵齋糧淵憲餘(鏇壓蓋獵鬱構憲醖衊齋) = 簾鬱廠窪願憲壓餘艱築 壓醖鑰廠衊鏇網蓋構遞 (遞鹽糧襯繭鏇構範糧淵, 48 ~ 216) | - | 2004-06-23 | |||
顧壓淵襯獵齋糧淵憲餘(鏇壓蓋獵鬱構憲醖衊齋) = 製顧簾繭醖願憲選壓鑰 壓醖鑰廠衊鏇網蓋構遞 (遞鹽糧襯繭鏇構範糧淵, 48 ~ 262) |
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