利多卡因/肾上腺素(Lidocaine/Adrenaline) - 药物靶点：SCNA_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Lidocaine/Epinephrine、アドレナリン：エピネフリン、アドレナリン：エピレナミン

+ [3]

靶点

SCNA

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

AstraZeneca PLC

在研机构

山德士有限公司

Nipro Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1956-02-01),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构

分子式C9H13NO3

InChIKeyUCTWMZQNUQWSLP-VIFPVBQESA-N

CAS号51-43-4

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关联

26

项与利多卡因/肾上腺素相关的临床试验

NCT06379490 / Recruiting临床3期IIT

Effect of Ultrasound-guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures - A Randomized Controlled Non-inferiority Trial

To investigate the feasibility of the lateral infraclavicular plexus brachialis (LIC) block for acute closed reduction of distal radius fractures, the investigators will compare the pain-relieving and muscle-relaxing properties of the LIC block with short- and long-acting local anesthetics in different concentrations but at the same volume. In addition to motor and sensory blockade during repositioning, feasibility will also be assessed by other patient-related and block-related factors, as well as by factors related to the repositioning and plastering procedure.

开始日期2024-04-23

申办/合作机构-

NCT06381622 / Recruiting临床3期IIT

The Effect of Combining Lidocaine and Ropivacaine on the Duration and Onset Time of an Ultrasound-guided Infraclavicular Brachial Plexus Nerve Block. A Randomized Controlled Trial

The aim of the study is to investigate how the combination of ropivacaine (a slow onset, long duration local anesthetic) with lidocaine (a rapid onset, shorter duration local anesthetic) affects the onset and duration of a lateral infraclavicular plexus brachialis (LIC) block in patients undergoing non-acute hand surgery.

开始日期2024-04-18

申办/合作机构-

NCT05767749 / Completed临床4期IIT

Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. This study will compare a short-acting anesthetic, lidocaine with epinephrine, to one of two long-acting anesthetics (ropivacaine or bupivacaine). This study will also directly compare the duration of actions of ropivacaine and bupivacaine. The investigators hypothesize that the duration of anesthesia of short-acting anesthetics will not differ significantly from long-acting anesthetics at a single site and there will not be a significant difference between the two long-acting anesthetics at a single site.

开始日期2023-03-14

申办/合作机构

Weill Medical College of Cornell University

100 项与利多卡因/肾上腺素相关的临床结果

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100 项与利多卡因/肾上腺素相关的转化医学

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100 项与利多卡因/肾上腺素相关的专利（医药）

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8

项与利多卡因/肾上腺素相关的文献（医药）

2022-02-01·Hand Surgery and Rehabilitation4区 · 医学

Benefits of WALANT in palliative upper limb surgery after nerve injury

4区 · 医学

Article

作者: Dukan, R ; Masmejean, E H ; Gregory, T ; Coudane, H

Wide-Awake Local Anesthesia No Tourniquet (WALANT) may be a satisfactory anesthesia alternative for the management of upper limb peripheral nerve palsy sequelae. The main advantages are the possibility of active patient cooperation through intraoperative active mobilization, comfort and cost reduction. The legislation about WALANT in France remains unclear; the modalities of lidocaine epinephrine injection should be redefined. For palliative upper limb surgery, WALANT allows the surgeon to adjust the tension on the tendon transfer intraoperatively. Level 1 studies are needed to evaluate the effectiveness of WALANT relative to standard anesthesia techniques (regional/general anesthesia).

2021-03-31·Medecine tropicale et sante internationale

[Locoregional Anaesthesia in a Country with Limited Resources: Lidocaine 1.5% Adrenaline, Alternative to Ropivacaine 0.5% for Ultrasound-Guided Axillary Block].

Article

作者: Bah, M L ; Bangoura, A ; Donamou, J

ObjectiveThe aim of this study was to evaluate lidocaine 1.5% adrenaline as an alternative to ropivacaine 0.5% for the echo guided axillary block.MethodeWe conducted a 28-month prospective and randomized study (January 15, 2017 to May 15, 2019) conducted in the anesthesia department of the Ignace Deen National Hospital in Conakry, Guinea.ResultsA total of 38 patients were enrolled: 19 in each group. Their average age was 46 ± 17 years in the lidocaine group compared to 44 ± 20 years in the ropivacaine group. The average time to fix the block in the lidocaine group was 6.8 ± 2.1 minutes compared to 8.3 ± 2.4 minutes in the ropivacaine group (p = 0.04). The average duration of action was 233 ± 57 minutes in the lidocaine group versus 260 ± 74 minutes in the ropivacaine group (p= 0.21). The block efficiency rate was identical in both groups with 89.5% of effective blocks in the lidocaine group and in the ropivacaine group (p =1). The cost of consumables for the lidocaine group was 15 euros compared to 60 euros for the ropivacaine group.Conclusion1.5% adrenaline lidocaine is a good alternative to ropivacaine 0.5% for the production of echoguided axillary blocks in resource-limited countries.

2020-09-24·NeuroRehabilitation4区 · 医学

Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial

4区 · 医学

Article

作者: Salem, Yasser T. ; Hegazy, Fatma A. ; Aboelnasr, Emad A.

BACKGROUND: Gait deviations and spasticity are common impairments seen in children with cerebral palsy (CP) and may interfere with functional performance and effective walking pattern. Lidocaine iontophoresis is effective for reducing muscle spasticity in adults. PURPOSE: To investigate the effect of lidocaine epinephrine iontophoresis combined with exercises on gait and spasticity in children with spastic hemiplegic cerebral palsy (HCP). METHODS: Thirty children with spastic HCP aged 4–6 (5.20±0.32) years were randomly assigned to the experimental group (n = 15) and control group (n = 15). Children in both groups received one hour of exercises, three times a week for three months. Children in the experimental group received 2% lidocaine iontophoresis immediately before the exercises. The lidocaine iontophoresis was delivered for 20 minutes (1mA/min). Spatio-temporal gait parameters were assessed within one week before and after the intervention using 3D motion analysis. Surface electromyography was used to assess muscle tone using H/M ratio of the soleus muscle. ANOVA was used to investigate the differences between experimental and control groups. Statistical significance was set at P value less than 0.05. RESULTS: There was no difference between groups at baseline. Post-intervention, the experimental group showed significant improvements when compared to the control group for gait speed (p = 0.03), stride length (p = 0.04), cadence (p = 0.0001), cycle time (p = 0.0001), and H/M ratio (p = 0.02). CONCLUSION: Lidocaine iontophoresis combined with exercises was effective in improving gait spatiotemporal parameters and reducing spasticity in children with CP.

100 项与利多卡因/肾上腺素相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
麻醉	日本	山德士有限公司	1956-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed	N/A	术后疼痛	40	2% lidocaine with 1:200,000 epinephrine and sodium bicarbonate	構網選選糧淵廠鏇齋鏇(構築夢廠窪廠築壓糧廠) = 廠鑰製顧鬱築積蓋餘艱餘餘膚獵網鑰襯艱願糧 (遞蓋範簾廠積顧簾觸顧, 6.3 ~ 22.5)	-	2023-01-01
NCT04203225 (CTgov)	临床4期	操作性疼痛 \| 撕裂	48	LET Lidocaine (4%), Epinephrine (0.1%),+Tetracaine (0.5%) topical gel (Single LET)	網醖顧築繭簾遞膚窪觸(築醖蓋遞獵遞蓋憲壓網) = 顧廠獵顧淵築夢糧壓廠鹽獵繭選糧顧鹹選壓遞 (簾膚窪觸製獵鹹遞窪鏇, 襯壓淵鏇繭製獵簾製壓 ~ 鹽壓襯鏇餘鏇艱醖鑰鬱) 更多	-	2021-02-18
				LET Lidocaine (4%), Epinephrine (0.1%),+Tetracaine (0.5%) topical gel (Triple LET)	網醖顧築繭簾遞膚窪觸(築醖蓋遞獵遞蓋憲壓網) = 淵鹹積鹽鏇積膚繭艱鹽鹽獵繭選糧顧鹹選壓遞 (簾膚窪觸製獵鹹遞窪鏇, 醖鹹範壓鹹餘鹽壓糧鬱 ~ 觸醖鬱積繭簾膚遞鑰繭) 更多
NCT01981772 (CTgov)	N/A	肿胀	88	4% buffered lidocaine (Buffered Lidocaine)	獵簾襯膚簾築夢淵壓襯(觸獵憲糧積壓衊構願憲) = 選構簾鏇蓋齋壓網簾遞淵觸範壓範蓋鑰鏇鏇築 (醖簾築製糧範範構鏇窪, 餘壓觸顧壓鑰蓋襯選顧 ~ 網蓋製選壓膚獵簾簾繭) 更多	-	2020-10-12
				1:100,000 epinephrine+4% lidocaine (Nonbuffered Lidocaine)	獵簾襯膚簾築夢淵壓襯(觸獵憲糧積壓衊構願憲) = 積範簾襯選壓艱繭積選淵觸範壓範蓋鑰鏇鏇築 (醖簾築製糧範範構鏇窪, 網襯選顧衊選醖糧淵積 ~ 遞鏇顧膚糧鏇鬱獵獵構) 更多
NCT02285634 (CTgov)	N/A	鼻出血	68	Oxymetazoline 0.05% (Oxymetazoline 0.05%)	衊艱構顧窪糧淵築鏇鏇(簾網遞顧積獵選蓋網築) = 蓋觸艱壓壓淵遞繭構鑰廠糧積糧淵鬱鏇積選繭 (鑰範襯醖鹹積齋淵繭壓, 遞襯積遞繭鑰範壓壓壓 ~ 蓋蓋齋憲淵衊醖糧遞夢) 更多	-	2018-10-02
				Phenylephrine 0.25% (Phenylephrine 0.25%)	衊艱構顧窪糧淵築鏇鏇(簾網遞顧積獵選蓋網築) = 壓鏇窪鏇簾齋選襯顧夢廠糧積糧淵鬱鏇積選繭 (鑰範襯醖鹹積齋淵繭壓, 鏇鹽獵獵艱憲顧膚構鹹 ~ 構衊顧遞膚築糧鹽壓衊) 更多
NCT02007434 (CTgov)	临床3期	局部肥胖	84	Cold Compress+Deoxycholic Acid Injection (Paradigm 1 / Deoxycholic Acid Injection)	憲鹽顧窪願糧醖顧蓋範(廠鏇網鬱艱選蓋鹹顧顧) = 鹹蓋憲鬱膚夢簾衊鹹廠願糧餘鏇製蓋膚顧衊觸 (願繭夢餘膚衊簾蓋築製, 獵築遞遞簾蓋齋壓淵積 ~ 網範選糧壓衊製蓋衊網) 更多	-	2015-07-03
				Cold Compress+Lidocaine / Epinephrine+Deoxycholic Acid Injection (Paradigm 2 / Deoxycholic Acid Injection)	憲鹽顧窪願糧醖顧蓋範(廠鏇網鬱艱選蓋鹹顧顧) = 窪繭壓衊鏇顧醖壓願鏇願糧餘鏇製蓋膚顧衊觸 (願繭夢餘膚衊簾蓋築製, 遞糧鑰鑰遞範餘選膚蓋 ~ 製鹽積憲範網願願壓顧) 更多