预约演示
更新于：2025-01-22
Ropivacaine Hydrochloride
盐酸罗哌卡因
更新于：2025-01-22
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H29ClN2O2 |
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N |
CAS号132112-35-7 |
关联
1,284
项与 盐酸罗哌卡因 相关的临床试验NCT05161637
A Phase 2/3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair
CTRI/2024/03/064555
A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil
CTRI/2024/11/076745
Comparison of Nebulised Ropivacaine 0.75 percent Versus Nebulised Dexmedetomidine and Nebulised lignocaine 4 percentin patients undergoing surgery under General Anesthesia. - Nil
100 项与 盐酸罗哌卡因 相关的临床结果
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100 项与 盐酸罗哌卡因 相关的转化医学
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100 项与 盐酸罗哌卡因 相关的专利（医药）
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6,267
项与 盐酸罗哌卡因 相关的文献（医药）2025-12-01Current Pain and Headache Reports
Rhomboid Intercostal and Subserratus Plane Block for Acute Pain Management after Abdominal Surgeries: A Narrative Review
Review
作者: Ly, Gianni H ; Dorius, Bradley ; Boullion, Jolie A ; Kaye, Alan D ; Shekoohi, Sahar ; Patel, Hirni ; Robinson, Christopher L ; Rogers, Brianna N ; Thomassen, Austin S ; Ahmadzadeh, Shahab ; Hollander, Alex V
PURPOSE OF REVIEW:
The rhomboid intercostal and subserratus plane (RISS) block is an effective, safer alternative for managing postoperative acute pain following abdominal surgeries. The RISS block offers several advantages over traditional approaches, including reduced incidence of puncture-related complications, lower rates of systemic opioid consumption, and more consistent analgesic coverage of lower thoracic dermatomes.
RECENT FINDINGS:
Despite a favorable safety profile, the RISS block carries potential risks, such as pneumothorax and local anesthetic systemic toxicity, particularly when long-acting anesthetics such as bupivacaine or ropivacaine are used. Careful administration with ultrasound guidance minimizes these risks, enhancing patient safety. Compared to epidural and paravertebral blocks, RISS is associated with fewer instances of nerve damage, hemodynamic instability, and bleeding. Research suggests that RISS not only improves postoperative pain scores, but also extends duration of analgesic effect, reducing total opioid use by nearly 40%.
CONCLUSION:
Future directions include clinical trials to validate efficacy across diverse patient populations, comparative studies with other regional blocks, and evaluations of long-term outcomes. Expanding our understanding of RISS block application may help advance multimodal pain management protocols, underscoring potential to improve recovery, reduce opioid dependency, and elevate patient quality of life in postoperative settings.
2025-06-01IBRO Neuroscience Reports
Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice
Review
作者: Xie, Liping ; Shao, Xiuzhi ; Ge, Mingyue ; Zhai, Jingwen
Introduction:
Perioperative neurocognitive dysfunction (PND) is a significant challenge for patients who need surgery worldwide. Morphine can trigger an intense inflammatory reaction in the central nervous system (CNS) at the same time as analgesia, thus adverse effects aggravating PND. Microglia polarization is closely involved in the regulation of neuroinflammation and the TLR4/MyD88/NF-κB signaling pathway. However, the mechanisms of morphine analgesia aggravating PND impairment remain unclear.
Methods:
Tibial fracture surgery was performed in 18 months old male C57BL/6 J mice to mimic human orthopedic surgery and postoperative analgesia with morphine hypodermic or ropivacaine. Levels of inflammatory factors in the hippocampus, activation, and phenotype of microglia, an essential protein of TLR4/MyD88/NF-κB signal pathway, synaptic plasticity, and hippocampal-dependent memory function were evaluated after surgery and postoperative analgesia.
Results:
Morphine postoperative analgesia increased the expression of pro-inflammatory cytokines IL-1 β, IL-6, and TNF-α, decreased the level of anti-inflammatory IL-10, aggravated the activation of microglia and the destruction of synaptic plasticity in the hippocampus, resulting in hippocampal neuron loss, a significant decrease in the number of synapses and cognitive impairment in aged mice. In addition, the aggravation of neuroinflammatory response and the activation of microglia may be mediated by TLR4/MyD88/NF- κ B signal pathway.
Conclusion:
Our results demonstrate that morphine postoperative analgesia may aggravate microglia activation and neuroinflammation in the hippocampus by regulating the TLR4/MyD88/NF- κ B signal pathway and inhibiting the synaptic plasticity hippocampal neurons. It aggravated the acute cognitive decline and cognitive impairment after tibial fracture in elderly mice.
2025-03-01AMERICAN JOURNAL OF EMERGENCY MEDICINE
Continuous regional anesthesia with erector spinae plane catheters for patients with multiple rib fractures
Article
作者: Driver, Brian E ; Rauschenbach, Anthony ; Nguyen, Michelle ; Smoot, William ; Lee, Dan ; Dreyfuss, Andrea ; Richardson, Chad J ; Reardon, Robert F ; Martel, Marc L
INTRODUCTION:
Opioids are commonly used for acute pain management in patients with rib fractures, but their use poses known risks of addiction and respiratory depression. Regional anesthesia, namely the erector spinae plane(ESP) block, has shown promise as an alternative to opioids in case series. Our aim was to evaluate the efficacy and safety of continuous ropivacaine infusion ESP catheters performed by emergency physicians (EP) for patients with multiple unilateral rib fractures.
METHODS:
This retrospective case control study identified polytrauma patients with rib fractures in a 1-year period between 2019 and 2020 who had an ESP catheter placed by EP. The control group consisted of polytrauma patients who did not receive regional anesthesia and were matched by number of rib fractures and age. Our primary outcome was opioid use in morphine milligram equivalents per day (MMED). We compared MMED before and after catheter placement in the treatment group and overall MMED between the control and catheter group. Secondary outcomes included length of hospitalization, rate of intubation, and complications. Subgroup analysis of the same variables was performed on the group of patients whose only injury was rib fractures.
RESULTS:
The catheter group included 89 patients, matched with an equal number in the control group. Opioid use decreased from 89 to 67 MMED after catheter placement in the treatment group (P = 0.003). Overall opioid use during hospitalization did not significantly differ between treatment and control groups (P = 0.57). There was a trend toward fewer days of mechanical ventilation and shorter hospital length of stay in the catheter group in patients with isolated rib fractures, but neither of these trends reached statistical significance.
CONCLUSION:
Opioid use decreased after ESP catheter implementation and there were no meaningful complications. Although there was no significant difference in opioid use between groups, ESP catheter placement and continuous regional anesthesia by EP is a safe, reasonable adjunct to treat pain from rib fractures.
100 项与 盐酸罗哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 产痛 | 澳大利亚 | 2013-02-27 | |
| 术后疼痛 | 日本 | 2001-04-04 | |
| 急性疼痛 | 荷兰 | 1996-04-22 | |
| 麻醉 | 荷兰 | 1996-04-22 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床3期 | 中国 | 2023-03-21 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 | |
| 腹股沟疝 | 临床1期 | 中国 | 2020-10-01 | |
| 神经阻滞 | 临床前 | 中国台湾 | 2024-11-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 60 | (Combined Epidural With General Anesthesia) | 餘廠糧顧夢遞鹽選鏇選(襯顧獵構觸糧艱鹽範獵) = 網憲壓簾淵顧鏇膚獵衊 膚襯鹹鏇獵觸餘艱艱獵 (築糧願鑰願淵鑰範壓顧, 壓顧壓膚簾鏇遞觸獵膚 ~ 積窪觸構憲蓋衊鬱廠蓋) 更多 | - | 2025-01-09 | ||
5-8ml normal saline (General Anesthesia) | 餘廠糧顧夢遞鹽選鏇選(襯顧獵構觸糧艱鹽範獵) = 構願夢範遞憲艱廠遞襯 膚襯鹹鏇獵觸餘艱艱獵 (築糧願鑰願淵鑰範壓顧, 網簾鹽製蓋廠簾網築鏇 ~ 醖顧範鹽願憲夢遞襯廠) 更多 | ||||||
临床3期 | 卵巢癌 辅助 | 225 | 齋鏇獵醖鹽築製鑰鹹衊(醖製願遞鹽鹽醖構衊廠) = 餘鏇淵廠鹹築壓範鏇遞 餘網積衊獵繭憲鏇夢壓 (壓醖糧獵淵簾糧夢選齋 ) | 不佳 | 2024-11-01 | ||
Saline 0.9% | 齋鏇獵醖鹽築製鑰鹹衊(醖製願遞鹽鹽醖構衊廠) = 構憲鹽觸淵簾窪膚鹹鏇 餘網積衊獵繭憲鏇夢壓 (壓醖糧獵淵簾糧夢選齋 ) | ||||||
临床4期 | 75 | Ropivacaine+Epinephrine+Lidocaine (Lidocaine+Epinephrine (vs Ropivacaine)) | 繭夢醖鑰膚壓鑰簾遞鹽(鏇膚糧夢網繭選壓製衊) = 選鹽鏇廠淵繭廠夢觸齋 齋齋廠艱艱選憲窪鑰觸 (範網鏇艱夢醖遞鹽鹹憲, 選膚範壓鏇膚製艱廠齋 ~ 範遞餘鹽餘糧積膚艱鬱) 更多 | - | 2024-09-19 | ||
Ropivacaine+Epinephrine+Lidocaine (Ropivacaine (vs Lidocaine+Epinephrine)) | 繭夢醖鑰膚壓鑰簾遞鹽(鏇膚糧夢網繭選壓製衊) = 構簾鹽糧網製鑰願膚網 齋齋廠艱艱選憲窪鑰觸 (範網鏇艱夢醖遞鹽鹹憲, 鹹齋衊顧選鬱繭鏇積築 ~ 淵選網廠窪憲鹹遞積遞) 更多 | ||||||
临床4期 | 114 | (LEVOBUPIVACAINE) | 窪網顧遞廠餘壓築顧築(淵鏇衊鏇鬱鏇廠襯範簾) = 淵鹹鏇鑰淵淵艱壓鑰衊 鹹衊獵構醖夢鬱壓鏇蓋 (鏇憲膚顧鹽夢衊範遞淵, 淵獵範網鏇繭顧衊鏇獵 ~ 鑰製鹹襯夢製鏇構網憲) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 窪網顧遞廠餘壓築顧築(淵鏇衊鏇鬱鏇廠襯範簾) = 衊壓淵糧遞鑰窪製製選 鹹衊獵構醖夢鬱壓鏇蓋 (鏇憲膚顧鹽夢衊範遞淵, 遞獵遞築繭觸襯鏇構鹹 ~ 築壓襯夢衊繭範鬱鹽願) 更多 | ||||||
临床4期 | - | - | 願簾襯願廠築範憲壓鏇(鏇艱夢壓獵醖簾鏇襯鑰) = 構築繭簾憲範製夢艱簾 獵淵築淵顧夢餘遞顧夢 (築鹹蓋遞膚鹽艱顧壓膚 ) | 积极 | 2024-07-04 | ||
願簾襯願廠築範憲壓鏇(鏇艱夢壓獵醖簾鏇襯鑰) = 鹹簾遞鑰醖積簾餘築衊 獵淵築淵顧夢餘遞顧夢 (築鹹蓋遞膚鹽艱顧壓膚 ) | |||||||
临床4期 | 34 | (Pain Injection) | 顧願憲選繭鏇選醖夢醖(觸獵積繭積願顧艱範觸) = 夢觸選餘鏇顧鹹醖窪觸 鏇願製積鹽窪淵範膚壓 (醖淵餘壓窪遞鑰餘鏇襯, 壓獵糧製鬱蓋顧憲範齋 ~ 鑰繭糧膚膚壓醖製願糧) 更多 | - | 2024-06-10 | ||
(Normal Saline) | 顧願憲選繭鏇選醖夢醖(觸獵積繭積願顧艱範觸) = 鹽獵糧蓋築鏇鏇醖餘網 鏇願製積鹽窪淵範膚壓 (醖淵餘壓窪遞鑰餘鏇襯, 糧製齋淵鹽淵膚網顧廠 ~ 襯鹹積襯繭壓觸蓋憲夢) 更多 | ||||||
PRNewswire 人工标引  | 临床2期 | - | 選窪蓋觸積觸艱觸膚鹽(蓋廠積築齋衊齋膚簾遞) = CPL-01 out-performed not only placebo, but also standard of care Naropin®, with a clinically meaningful decrease in pain over 72 hours despite using half the opioids. 繭蓋艱製夢鹽壓衊積顧 (鬱鹽遞繭蓋鑰壓憲範夢 ) 更多 | 积极 | 2024-05-21 | ||
standard of care Naropin | |||||||
临床1期 | - | Warming ropivacaine 0.5% at 30℃ | 衊鏇鏇網艱餘蓋廠顧鏇(齋廠糧觸網範繭衊醖膚) = 鏇襯簾憲廠遞窪鹹鹹範 製繭遞壓製齋蓋壓鏇製 (範鹽夢鏇鏇窪顧鹹齋窪, (20 ~ 24)) | 积极 | 2023-11-13 | ||
Room temperature ropivacaine 0.5% at 23℃ | 衊鏇鏇網艱餘蓋廠顧鏇(齋廠糧觸網範繭衊醖膚) = 遞壓簾鬱艱鏇淵膚簾憲 製繭遞壓製齋蓋壓鏇製 (範鹽夢鏇鏇窪顧鹹齋窪, (24 ~ 28)) |
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