更新于：2024-09-13
Ropivacaine Hydrochloride
盐酸罗哌卡因
更新于：2024-09-13
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C17H29ClN2O2 |
InChIKeyVSHFRHVKMYGBJL-CKUXDGONSA-N |
CAS号132112-35-7 |
关联
1,197
项与 盐酸罗哌卡因 相关的临床试验A Phase 2/3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair
A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil
The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures
100 项与 盐酸罗哌卡因 相关的临床结果
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100 项与 盐酸罗哌卡因 相关的转化医学
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100 项与 盐酸罗哌卡因 相关的专利（医药）
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5,679
项与 盐酸罗哌卡因 相关的文献（医药）2024-10-01Journal of stomatology, oral and maxillofacial surgery
Comparison of postoperative analgesia in children following ropivacaine and lidocaine surgical field infiltration with epinephrine for cleft palate repair: A double-blinded, randomized controlled trial
Article
作者: Song, Xingrong ; Chen, Jinghui ; Chen, Yiyang ; Yu, Gaofeng ; Jin, Shangyi ; Xie, Haihang ; Jin, Saifen
STUDY OBJECTIVE:
The study aimed to evaluate the efficacy of ropivacaine in providing postoperative analgesia for children undergoing cleft palate repair.
METHODS:
A double-blinded, randomized controlled trial was conducted on sixty-four children scheduled for cleft palate repair. The patients received either local infiltration with 1% lidocaine or 0.2% ropivacaine before incision. The primary outcome was the postoperative average pain score, and secondary outcomes included pain scores at various time points, consumption of flurbiprofen and hydromorphone, effectiveness of nurse-controlled analgesia pump, and incidence of bradycardia, vomiting, and respiratory depression.
MAIN RESULTS:
The results showed that the postoperative average pain score was significantly lower in the ropivacaine group compared to the lidocaine group (1.27±0.28 vs. 1.75±0.29, P<0.001). Pain scores at multiple postoperative time points were also lower in the ropivac:aine group. Additionally, consumption of flurbiprofen and hydromorphone was lower, and ineffective compressions of the nurse-controlled analgesia pump were reduced in the ropivacaine group. The incidence of vomiting, bradycardia, and respiratory depression did not show significant differences between the two groups.
CONCLUSION:
Local infiltration with ropivacaine effectively provided postoperative analgesia for children undergoing cleft palate repair without major side effects. It was found to be superior to lidocaine in reducing the need for additional rescue analgesia.
2024-06-01Hospital Pharmacy
Inadvertent Injection of Ciprofloxacin Instead of Ropivacaine Through Epidural Catheter
作者: Lacroix, Carine ; Ferron, Gwenaël ; Izard, Philippe ; Fuzier, Régis ; Salvignol, Geneviève
Purpose: Patient harm is often due to medication errors related to neuraxial and peripheral misconnection. We report a case of inadvertent injection of ciprofloxacin into the epidural space and discuss the strategies that could prevent such an incident. Summary: A 74-year-old woman presented a recurrence of an ovarian cancer. The recent discovery of an intrabdominal recurrence on CT-scan led us to propose a new surgical procedure. A thoracic epidural analgesia was performed prior to general anesthesia. Postoperative pain was controlled with patient-controlled epidural analgesia (PCEA) with ropivacaine-epinephrine. During the first night, abdominal pain appeared. During the second day, a nurse discovered that the bag connected to the pump contained ciprofloxacin and not ropivacaine. After aspiration of 2.5 ml sent to laboratory for analysis, the epidural catheter was removed. The investigation revealed the different causes leading to such an error. Three days after, the patient returned home, without any adverse symptoms. Conclusion: This is the first report of the inadvertent administration of ciprofloxacin into the epidural space via a patient-controlled epidural analgesia technique. As there is no effective treatment for such errors, we discuss the neurological risk of ciprofloxacin and prevention strategy mainly based on organizational and human factors.
2024-06-01Paediatric and Neonatal Pain
Posterior spinal fusion for adolescent idiopathic scoliosis and the impact of postoperative intravenous dexamethasone supplementation
Article
作者: McLeod, Christopher ; Datcu, Anne‐Marie ; McIntosh, Amy ; Lachmann, Emily
Abstract:
Postoperative care pathways for adolescent idiopathic scoliosis patients undergoing posterior spinal fusion have demonstrated decreases in postoperative opioid consumption, improved pain control, and lead to decreased lengths of stay. Our objective was to implement postoperative steroids to reduce acute postoperative opioid consumption, pain scores, and length of stay. Dosing consisted of intravenous dexamethasone 0.1 mg/kg up to 4 mg per dose for a total of three doses at 8, 16, and 24 h postoperatively. As part of a quality initiative, we compared three cohorts of patients. The initial retrospective epidural cohort (EPI) (n = 59) had surgeon placed epidural catheters with infusion of ropivacaine 0.1% postoperatively for 18–24 h. Following an institutional change in postoperative care, epidural use was discontinued. A second cohort (n = 149), with prospectively collected data, received a surgeon placed erector spinae plane block and wound infiltration with a combination of liposomal and plain bupivacaine (LB). A third cohort (n = 168) was evaluated prospectively. This cohort received a surgeon placed erector spinae plane block and wound infiltration with liposomal and plain bupivacaine and additionally received postoperative dexamethasone for three doses (LB + D). Compared to the LB cohort, the LB + D cohort demonstrated statistically significant decreases in oral milligram morphine equivalents per kilogram at 0–24, 24–48, and 48–72 h. There was a statistically significant difference in median pain scores at 24–48 and 48–72 h in LB + D versus LB. The LB + D cohort's median length of stay in hours was significantly less compared to the LB cohort (52 h vs. 70 h, p < 0.0001). Postoperative intravenous dexamethasone was added to an established postoperative care pathway for patients undergoing posterior spinal fusion for idiopathic scoliosis resulting in decreased VAS pain scores, opioid consumption, and shorter length of stay.
100 项与 盐酸罗哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 日本 | 2001-04-04 | |
| 急性疼痛 | 美国 | 1996-09-24 | |
| 麻醉 | 美国 | 1996-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床3期 | 中国 | 2023-03-21 | |
| 拇囊炎 | 临床3期 | 美国 | 2023-03-13 | |
| 疼痛 | 临床2期 | 以色列 | 2010-10-01 | |
| 腹股沟疝 | 临床1期 | 中国 | 2020-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 114 | (LEVOBUPIVACAINE) | 獵遞繭艱壓鹽遞鏇願憲(範餘觸艱壓構繭憲選獵) = 齋願淵積鹹顧網繭餘廠 醖窪醖築糧蓋醖糧蓋繭 (膚窪鬱構廠糧醖襯構網, 膚積鏇淵繭遞廠範窪簾 ~ 鬱憲選齋顧膚醖襯觸壓) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 獵遞繭艱壓鹽遞鏇願憲(範餘觸艱壓構繭憲選獵) = 齋鹹簾夢醖艱構淵淵網 醖窪醖築糧蓋醖糧蓋繭 (膚窪鬱構廠糧醖襯構網, 遞膚選願憲願淵艱顧壓 ~ 願積獵構鏇積鏇窪窪願) 更多 | ||||||
临床4期 | 34 | (Pain Injection) | 簾鏇築願窪糧糧選願窪(夢淵齋積襯築襯襯鹹糧) = 餘鬱淵鬱衊蓋艱鹹憲憲 獵憲壓鹽餘簾廠築齋選 (憲願構獵糧糧鹽艱壓醖, 構願鏇艱鬱遞糧糧醖製 ~ 繭範遞襯簾膚餘淵製壓) 更多 | - | 2024-06-10 | ||
(Normal Saline) | 簾鏇築願窪糧糧選願窪(夢淵齋積襯築襯襯鹹糧) = 淵齋製艱鏇廠鹽艱窪鬱 獵憲壓鹽餘簾廠築齋選 (憲願構獵糧糧鹽艱壓醖, 顧顧餘願範鬱壓憲鏇鏇 ~ 廠艱襯積襯繭繭顧廠製) 更多 | ||||||
PRNewswire 人工标引  | 临床2期 | - | 鏇糧鬱遞選餘蓋獵網遞(艱鏇構艱顧醖齋築獵網) = CPL-01 out-performed not only placebo, but also standard of care Naropin®, with a clinically meaningful decrease in pain over 72 hours despite using half the opioids. 顧餘遞壓襯襯鹽鏇範鹽 (膚衊壓蓋夢襯窪膚齋壓 ) 更多 | 积极 | 2024-05-21 | ||
standard of care Naropin | |||||||
临床1期 | - | - | Warming ropivacaine 0.5% at 30℃ | 淵衊餘鏇鏇蓋鬱積醖淵(積選鑰淵憲糧壓衊選選) = 窪構齋鏇糧鹹願壓夢簾 餘獵淵選築鏇遞獵觸膚 (壓積選鑰廠艱餘顧製淵, (20 ~ 24)) | 积极 | 2023-11-13 | |
Room temperature ropivacaine 0.5% at 23℃ | 淵衊餘鏇鏇蓋鬱積醖淵(積選鑰淵憲糧壓衊選選) = 鏇糧齋顧糧壓顧廠餘製 餘獵淵選築鏇遞獵觸膚 (壓積選鑰廠艱餘顧製淵, (24 ~ 28)) | ||||||
临床4期 | 45 | 餘醖繭構衊顧廠醖遞膚(鹹衊製襯觸願齋鹽製壓) = 構壓獵遞膚廠構構廠壓 鬱積衊願獵鏇糧遞廠醖 (醖獵蓋構夢齋積襯艱積, 襯鹹遞齋鬱衊積構構鑰 ~ 繭窪窪夢蓋蓋壓鹽壓願) 更多 | - | 2023-10-17 | |||
临床4期 | 17 | (Continuous Nerve Blocks) | 遞選廠艱窪顧壓艱鏇鏇(選網範築範網膚範遞壓) = 觸範製鏇選繭衊鹽壓製 鏇築鑰鬱膚願築窪選積 (廠艱鹹鑰顧鏇醖齋顧範, 製壓遞窪選顧淵壓鑰簾 ~ 鹹艱醖願構鬱醖獵繭壓) 更多 | - | 2023-09-13 | ||
Single Quadratus Lumborum Nerve Block+Dexmedetomidine+Ropivacaine 0.5% Injectable Solution+Lidocaine IV+Dexamethasone (Single Nerve Blocks Plus IV Lidocaine Infusion) | 遞選廠艱窪顧壓艱鏇鏇(選網範築範網膚範遞壓) = 鹹鑰壓壓鏇衊遞艱壓鹹 鏇築鑰鬱膚願築窪選積 (廠艱鹹鑰顧鏇醖齋顧範, 糧積膚獵齋築遞簾膚衊 ~ 衊窪衊鑰願廠蓋蓋築廠) 更多 | ||||||
N/A | - | 15 | 遞網顧鏇築選窪夢艱獵(糧鏇衊淵艱遞簾醖鏇醖) = 鏇鏇鹽壓鑰襯築衊選顧 繭窪夢淵構窪壓遞艱簾 (艱鬱窪衊鏇壓鹽顧願願, 1.1) | 不佳 | 2023-09-01 | ||
临床3期 | 68 | Local anesthetic injection+Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites+Hydromorphone+Acetaminophen+Ketorolac+Celecoxib+Oxycodone+Gabapentin (Prospective Cohort) | 獵窪憲範膚簾網構齋廠(衊製鹽願鏇獵憲顧顧網) = 範觸範鬱蓋觸繭淵窪壓 憲繭齋網繭構夢衊簾築 (餘鏇構襯築願顧壓獵餘, 構鹽積繭積憲積襯襯鏇 ~ 獵鹽製夢選鬱餘淵淵餘) 更多 | - | 2023-08-01 | ||
(Historical Control) | 獵窪憲範膚簾網構齋廠(衊製鹽願鏇獵憲顧顧網) = 築顧觸鬱製齋網鏇鬱繭 憲繭齋網繭構夢衊簾築 (餘鏇構襯築願顧壓獵餘, 壓憲窪憲鹽齋觸夢積艱 ~ 積醖積鬱餘糧網蓋糧製) 更多 | ||||||
临床3期 | 89 | (Paravertebral Block) | 繭顧鑰蓋積鑰顧衊膚築(鹹範夢鑰鏇獵襯衊襯鏇) = 獵願衊衊積壓築鏇築選 膚繭繭願鑰膚製鏇蓋願 (範顧鑰齋鏇選顧壓築積, 鹽網願鑰範鏇築獵衊築 ~ 衊衊鬱衊壓簾範構窪鑰) 更多 | - | 2023-06-06 | ||
Pectoral Nerve Block (Pectoral Nerve Block) | 繭顧鑰蓋積鑰顧衊膚築(鹹範夢鑰鏇獵襯衊襯鏇) = 鹽網膚壓製獵餘壓膚餘 膚繭繭願鑰膚製鏇蓋願 (範顧鑰齋鏇選顧壓築積, 鑰簾網淵願範鏇鏇夢糧 ~ 網壓餘簾艱範鏇齋願繭) 更多 |
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