ω-3鱼油脂肪乳(Fish Oil Triglycerides) - 在研适应症：胆汁淤积_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ω-3 Fish Oil Fat Emulsion、精制鱼油/卵磷脂、Omegaven

+ [1]

靶点-

作用机制-

治疗领域

消化系统疾病

在研适应症

胆汁淤积

非在研适应症-

原研机构

Fresenius Kabi AG

在研机构

Fresenius Kabi USA LLC

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2018-07-27),

胆汁淤积

最高研发阶段(中国)-

特殊审评快速通道 (美国)、孤儿药 (美国)

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关联

197

项与 ω-3鱼油脂肪乳相关的临床试验

ChiCTR2400088891 / SuspendedN/AIIT

Fish oil supplementation for mild to moderate rosacea: a randomized, double-blind, cross-over controlled clinical study

开始日期2024-09-01

申办/合作机构-

IRCT20211206053309N1 / CompletedN/AIIT

The effect of topically applying fish oil on pruritus in hemodialysis patients

开始日期2024-08-22

申办/合作机构-

TCTR20240810002 / Recruiting临床3期IIT

Impact of fish oil on efficacy and side effects of low-dose isotretinoin in treatment of moderate to severe acne vulgaris: A Double-blinded Randomized Controlled Trial.

开始日期2024-06-04

申办/合作机构-

100 项与 ω-3鱼油脂肪乳相关的临床结果

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100 项与 ω-3鱼油脂肪乳相关的转化医学

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100 项与 ω-3鱼油脂肪乳相关的专利（医药）

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8,219

项与 ω-3鱼油脂肪乳相关的文献（医药）

2025-02-01·Current pediatric reviews

The Effectiveness of Perinatal Omega-3 Supplements in Neurodevelopment and Physical Growth of 9- and 12-month-old Infants: A Follow-up of a Clinical Trial

Article

作者: Shakouri, Seyed Kazem ; Sarrafi, Somayyeh ; Ostadrahimi, Alireza ; Farshbaf-Khalili, Azizeh ; Pourzeinali, Samira

Background::

Omega-3 fatty acids (FAs) are essential long-chain polyunsaturated fatty acids (LCPUFAs) that are essential for optimal health and development.

Objective::

The present study aimed to evaluate the effectiveness of maternal fish oil (containing omega-3 LCPUFA) intake from 21th week of pregnancy to 30 days postpartum for neurodevelopment and growth of infants at 9 and 12 months.

Methods::

This was a follow-up study of a triple-blinded clinical trial. The study population was 9-- month-old infants. Their mothers were randomly divided into two groups of 75 people with a 1:1 ratio to take one fish oil supplement or a placebo daily. The anthropometric indicators of infants at months 9 and 12 and neurodevelopment at month 12 by the ASQ questionnaire were measured. In the fish oil and placebo groups, respectively, 73 and 71 infants at nine months, as well as 71 and 69 at 12 months, were analyzed.

Results::

No statistically significant impact was observed following consuming omega-3 capsules on the neurodevelopmental domains, growth parameters, and the profile of maternal serum FAs (p > 0.05) except DHA. Neurodevelopmental problems were illustrated in one case in the intervention group and two cases in the placebo group.

Conclusion::

Perinatal relatively low-dose omega-3 LCPUFAs supplements indicated no statistically significant impacts on the growth and neurodevelopment of 9- and 12-month-old infants in a population with low consumption of marine products. Further studies investigating the effect of higher doses of omega-3 LCPUFAs are suggested.

2024-12-31·PHARMACEUTICAL BIOLOGY

Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats

Article

作者: Ahmad, Hafandi ; Titisari, Nurina ; Fauzi, Ahmad ; Abdul Razak, Intan Shameha ; Mohd Noor, Mohd Hezmee ; Samsulrizal, Nurdiana

CONTEXT:

Menhaden fish oil (FO) is widely recognized for inhibiting neuroinflammatory responses and preserving brain function. Nevertheless, the mechanisms of FO influencing brain cognitive function in diabetic states remain unclear.

OBJECTIVE:

This study examines the potential role of FO in suppressing LPS-induced neuroinflammation and cognitive impairment in diabetic animals (DA).

MATERIALS AND METHODS:

Thirty male Wistar rats were divided into 5 groups: i) DA received LPS induction (DA-LPS); ii) DA received LPS induction and 1 g/kg FO (DA-LPS-1FO); iii) DA received LPS induction and 3 g/kg FO (DA-LPS-3FO); iv) animals received normal saline and 3 g/kg FO (NS-3FO) and v) control animals received normal saline (CTRL). Y-maze test was used to measure cognitive performance, while brain samples were collected for inflammatory markers and morphological analysis.

RESULTS:

DA received LPS induction, and 1 or 3 g/kg FO significantly inhibited hyperglycaemia and brain inflammation, as evidenced by lowered levels of pro-inflammatory mediators. Additionally, both DA-LPS-1FO and DA-LPS-3FO groups exhibited a notable reduction in neuronal damage and glial cell migration compared to the other groups. These results were correlated with the increasing number of entries and time spent in the novel arm of the Y-maze test.

DISCUSSION AND CONCLUSION:

This study indicates that supplementation of menhaden FO inhibits the LPS signaling pathway and protects against neuroinflammation, consequently maintaining cognitive performance in diabetic animals. Thus, the current study suggested that fish oil may be effective as a supporting therapy option for diabetes to avoid diabetes-cognitive impairment.

2024-12-31·Journal of psychosomatic obstetrics and gynaecology3区 · 医学

Retracted article: The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

3区 · 医学

Article

作者: Ghaderi, Amir ; Taghizadeh, Mohsen ; Foroozanfard, Fatemeh ; Vahedpoor, Zahra ; Karbassizadeh, Hassan ; Bahmani, Fereshteh ; Amini, Mehrdad ; Asemi, Zatollah

We, the Editor and Publisher of the Journal of Psychosomatic Obstetrics & Gynecology have retracted the following article:Mehrdad Amini, Fereshteh Bahmani, Fatemeh Foroozanfard, Zahra Vahedpoor, Amir Ghaderi, Mohsen Taghizadeh, Hassan Karbassizadeh & Zatollah Asemi (2018), The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Psychosomatic Obstetrics & Gynecology, DOI: 10.1080/0167482X.2018.1508282.Following publication, significant concerns were raised by a third party ¹ about the integrity of the data and the reported findings in the article.When approached for an explanation, the authors and their institution have been cooperative in providing some responses and documents. To verify the reported findings, the article and the documents provided by the authors were further evaluated by the journal editorial team, and also sent for review by an external statistical reviewer.Both the journal editorial team and the external statistical reviewer were unable to confirm the integrity of the trial design and the main outcome of the external review was that the article's results and conclusions are unreliable. Therefore, as the editorial team no longer have confidence in the reported conclusions the decision has been made to retract the article.The authors listed in the publication have been informed. The authors do not agree with the retraction.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.

38

项与 ω-3鱼油脂肪乳相关的新闻（医药）

2024-10-07

·医药地理

【掇菁撷华】ω-3多不饱和脂肪酸甘油酯纳米乳的制备及其在肝损伤治疗中的应用

引用本文韩雯雯, 李耀威, 张馨欣．ω-3 多不饱和脂肪酸甘油酯纳米乳的制备及其在肝损伤治疗中的应用[J]．中国医药工业杂志, 2024, 55(9): 1220-1228．DOI：10.16522/j.cnki.cjph.2024.09.008 Preparation of Omage-3 Polyunsaturated Fatty Acid Glyceride Nanoemulsion and Its Application in the Treatment of Liver Injury ω-3多不饱和脂肪酸甘油酯纳米乳的制备及其在肝损伤治疗中的应用韩雯雯1,2，李耀威1,2，张馨欣2* (1. 南京中医药大学新中药学院，江苏南京 210023；2. 中国科学院上海药物研究所，上海 201203) 摘要采用高速剪切- 高压均质法制备了具有不同含量ω-3 多不饱和脂肪酸甘油酯的纳米乳并考察其在肝损伤治疗中的作用。通过单因素试验筛选出的优化工艺参数组合为：油相和水相以8 000 r/min 的剪切速度，在60 ℃下剪切5 min，然后以60 000 kPa 的均质压力循环6 次。以优化工艺参数制备的纳米乳为白色均匀乳状液，平均粒径约为200 nm，pH 值约为7.4，各项指标均符合质量要求。细胞摄取试验结果显示，所制备的纳米乳可以被人正常肝细胞(LO2 细胞) 有效摄取，且摄取量与ω-3 多不饱和脂肪酸含量呈正相关。在胆汁淤积性肝损伤小鼠模型中，尾静脉注射纳米乳可有效改善小鼠肝损伤，且ω-3多不饱和脂肪酸甘油酯含量高的纳米乳对肝损伤小鼠的治疗作用较好。该研究制备的ω-3 多不饱和脂肪酸甘油酯纳米乳可显著改善肝损伤，具有良好的临床应用潜力，可为注射型甘油酯纳米乳药物的优化设计提供有效参考。关键词 ω-3 多不饱和脂肪酸；甘油酯；纳米乳；质量评价；肝损伤文章节选肝脏具有代谢、排毒、造血和免疫功能，是维持人体生命活动的重要器官之一。肝脏容易受到体内外的刺激而病变。肝脏相关疾病由于发病率高、病因复杂、发病机制不明确，已成为世界性公共卫生问题之一。全世界患有肝脏相关疾病的人数高达13 亿。中国也是“肝病大国”，截至2022 年底，我国各类肝病患者数约为4.47 亿。慢性肝脏疾病如果不能及时干预，就会进一步发展为肝纤维化、肝硬化，甚至肝癌。随着医疗技术的迅速发展，许多治疗肝损伤的药物被开发并应用于临床实践，但大多数药物的治疗作用有限且存在众多不良反应。所以，迫切需要开发安全、有效的药物来预防和治疗肝脏疾病。近年来的研究结果显示，特殊脂肪酸在肝脏疾病的防治中具有高效、安全的特点，在临床预防和治疗肝脏疾病方面发挥了重要作用。在ω-3 多不饱和脂肪酸(polyunsaturated fatty acid，ω-3-PUFA) 的化学结构中，距离末端甲基的3个碳原子处存在1 个双键，是动物脂质代谢的重要组成部分。已有研究表明，ω-3-PUFA 具有抗炎、抗氧化以及辅助改善记忆等药理作用。自20 世纪90 年代以来，基于ω-3-PUFA 甘油酯制备的纳米乳已被广泛用于肠外营养等领域。由于含有丰富的ω-3-PUFA，该类纳米乳在降低促炎因子的释放和对器官损害的保护等方面都比传统脂肪乳剂具有优势。现有的甘油酯纳米乳以肠外营养乳剂为主。德国费森尤斯卡比公司的鱼油甘油三酯乳剂(Omegaven) 是1 种含有ω-3-PUFA 的静脉注射乳剂，在2019 年被美国FDA 批准上市，作为肠外营养相关性胆汁淤积儿童患者的卡路里与脂肪酸补充剂，并在治疗早产儿的肠衰竭相关性肝病(intestinal failure-associated liver disease，IFLDA) 方面有良好的应用前景。但是，Omegaven 采用的鱼油原料中ω-3-PUFA 含量( 约为40％ ) 较低，只作为肠外营养相关性胆汁淤积儿童患者的抢救性治疗药物，对于肝损伤的疗效有限，并未大规模应用。 ω-3-PUFA 含量对其相关制剂在肝损伤治疗中的影响有待进一步探究。本研究选取了具有不同含量ω-3-PUFA 甘油酯的3 种原料——2020TG( 含有约40％ ω-3-PUFA)、3322TG( 含有约55％ ω-3-PUFA)、6015TG( 含有约75％ ω-3-PUFA)，采用高速剪切-高压均质法制备了ω-3-PUFA 甘油酯纳米乳(ω-3 polyunsaturated fatty acid glyceride nanoemulsion，ω-3EM)，表征其形貌、粒径、稳定性，并系统评价ω-3EM 的质量，考察肝细胞对纳米乳的摄取情况。另外，采用α- 异硫氰酸萘酯(α-naphthyl isothiocyanate，ANIT) 建立小鼠胆汁淤积性肝损伤模型，探讨ω-3EM对胆汁淤积性肝损伤的治疗作用。扫描二维码阅读原文/登录官网查看了解更多文章信息作者简介：韩雯雯(1998—)，女，硕士研究生，专业方向：新型脂质制剂。通信作者：张馨欣(1982—)，女，博士生导师，研究员，从事注射用脂质制剂的研究和开发。 E-mail：xinxinzhang@simm.ac.cn 关于转载：原创内容未经允许，不得转载 END 欢迎订阅《中国医药工业杂志》《中国医药工业杂志》是我国医药工业领域中办刊历史最长的医药期刊，是由上海医药工业研究院主管，上海医药工业研究院、中国药学会和中国化学制药工业协会主办的全国性综合医药学术刊物，国内外公开发行。自1970年11月创刊以来，《中国医药工业杂志》始终以报道我国医药工业和科研中的成果和经验为宗旨，刊载了大量反映中国医药工业发展水平的论文和论著，积累了丰富的第一手原始资料；同时密切关注国际上制药技术的发展新动向，刊登有指导意义的综述和专论。期刊订阅详情请登录《中国医药工业杂志》官网（http://www.cjph.com.cn）了解。《中国医药工业杂志》编辑部

临床研究临床结果

2024-09-04

·drugs

Link Between n-3 LCPUFA, Eczema Varies by Maternal COX1 Genotype

WEDNESDAY, Sept. 4, 2024 -- The association of prenatal ω-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) with the risk for childhood atopic dermatitis (AD) varies based on the maternal cyclooxygenase-1 (COX1) genotype, according to a study published online Aug. 28 in JAMA Dermatology . Liang Chen, from Herlev and Gentofte Hospital in Copenhagen, Denmark, and colleagues examined the association of n-3 LCPUFA supplementation during pregnancy with the risk for childhood AD overall and by maternal COX1 genotype. A total of 736 pregnant women at 24 weeks of gestation were randomly assigned to n-3 LCPUFA (fish oil) or placebo (olive oil) until one-week postpartum; 635 children completed clinical follow-up. The researchers observed an association between pregnancy n-3 LCPUFA supplementation and lower urinary thromboxane A2 metabolites at age 1 year (β = −0.46), which was also associated with the COX1 rs1330344 genotype (β per C allele, 0.47). There were no associations for n-3 LCPUFA supplementation or the maternal COX1 genotype with the risk for childhood AD until age 10 years; however, evidence of an interaction between these variables was seen. The risk for AD was lower in the n-3 LCPUFA group versus the placebo group among mothers with the TT genotype, while no association was seen for mothers with the CT genotype. An increased risk was seen for offspring of mothers with the CC genotype. "These findings support use of a personalized prevention strategy for reducing the burden of AD in childhood by only providing n-3 LCPUFA supplementation to pregnant mothers carrying the COX1 rs1330344 TT genotype," the authors write. Several authors disclosed ties to the biopharmaceutical industry.

临床结果

2024-08-14

·drugs

Fish Oil Supplements Counteract Genetic Predisposition to High Cholesterol

WEDNESDAY, Aug. 14, 2024 -- Fish oil seems to counteract genetic predisposition to high cholesterol, according to a study published online July 15 in the American Journal of Clinical Nutrition . Yitang Sun, Ph.D., from the Franklin College of Arts and Sciences at the University of Georgia in Athens, and colleagues examined whether fish oil supplementation modifies the association between genetically predicted and observed concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. The analysis included data from 441,985 participants in the U.K. Biobank. The researchers found that fish oil supplementation attenuates the associations between genetically predicted and observed circulating concentrations of total cholesterol, LDL cholesterol, and triglycerides while accentuating the corresponding association for HDL cholesterol. Findings were consistent across different polygenic score (PGS) calculation methods. Each standard deviation increment in PGS for triglycerides was associated with a 0.254 increase in the observed concentration of participants reporting fish oil usage. A stronger association was seen in nonusers (0.267). Similarly, fish oil significantly attenuates the association between genetically predicted and observed concentrations of triglycerides in participants of African ancestry. "Our study shows that considering lifestyles will improve genetic prediction," coauthor Kaixiong Ye, Ph.D., also from the Franklin College of Arts and Sciences, said in a statement. "Our findings also support that fish oil supplements may counteract the genetic predisposition to high cholesterol." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

临床结果

100 项与 ω-3鱼油脂肪乳相关的药物交易

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外链

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
胆汁淤积	美国	Fresenius Kabi USA LLC	2018-07-27

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02486042 (CTgov)	临床2期	早产儿视网膜病变	48	Standard lipids (primarily omega-6 fatty acids) (Standard of Care (Standard Nutrition))	顧鹹憲鹹醖鑰衊願憲艱(積獵憲淵糧廠鹽製鑰簾) = 範齋構壓膚顧鑰淵襯製獵齋鏇鹹願簾觸衊壓艱 (襯網膚衊襯艱憲簾選艱, 鹹膚範製窪顧夢選淵蓋 ~ 構淵膚繭衊衊醖鏇網構) 更多	-	2022-12-29
				Omegaven (Omegaven)	顧鹹憲鹹醖鑰衊願憲艱(積獵憲淵糧廠鹽製鑰簾) = 膚壓顧淵構選鏇蓋鏇選獵齋鏇鹹願簾觸衊壓艱 (襯網膚衊襯艱憲簾選艱, 餘襯鏇繭窪蓋範壓夢選 ~ 襯製鹹遞壓廠鑰積願齋) 更多
NCT01845116 (CTgov)	临床2期	肠外营养相关的胆汁淤积 \| 肝损伤	11	Omegaven®	蓋壓鹽選淵鬱鬱壓鬱遞(鹽鹽蓋餘鏇顧製鑰夢衊) = 醖餘遞憲願製糧襯網鏇齋衊築鑰壓鬱繭淵壓糧 (範範選築窪獵築蓋範淵, 窪獵選餘廠簾衊顧憲網 ~ 製壓餘艱夢獵繭積襯顧) 更多	-	2022-11-23
NCT04070833 (CTgov)	N/A	脑卒中	290	Vitamin D+Fish oil (Vitamin D + Fish Oil)	選淵衊壓範齋齋醖簾製(淵淵鬱積遞繭襯壓願範) = 膚襯鏇網獵遞艱廠構積壓網艱衊窪獵餘淵鏇餘 (製觸顧衊鏇顧觸顧鑰襯, 範構衊獵觸遞糧繭繭糧 ~ 淵鹹憲鏇鹹壓鏇蓋積鹽) 更多	-	2022-08-15
				Vitamin D (Vitamin D + Fish Oil Placebo)	選淵衊壓範齋齋醖簾製(淵淵鬱積遞繭襯壓願範) = 壓範壓鏇獵糧獵窪製廠壓網艱衊窪獵餘淵鏇餘 (製觸顧衊鏇顧觸顧鑰襯, 蓋壓鏇範範糧淵淵製築 ~ 淵製鹽築網夢鑰觸膚窪) 更多
NCT02271230 (CTgov)	临床3期	心脏衰竭	25,871	Vitamin D3 (Active Vitamin D)	積鹽鬱膚夢蓋鏇醖選醖(淵網願齋觸衊構顧鑰膚) = 齋齋鑰夢遞網廠網鏇願遞蓋襯鑰製願餘膚夢艱 (襯願蓋獵網襯齋襯鑰壓, 遞鹽夢艱夢壓淵構鏇簾 ~ 願糧鬱願願鹽壓範齋積) 更多	-	2022-03-18
				Vitamin D (Vitamin D Placebo)	積鹽鬱膚夢蓋鏇醖選醖(淵網願齋觸衊構顧鑰膚) = 網網顧襯襯網蓋遞齋蓋遞蓋襯鑰製願餘膚夢艱 (襯願蓋獵網襯齋襯鑰壓, 製鹽齋構願積觸鏇積積 ~ 製廠齋餘憲鏇鏇廠淵選) 更多
NCT04697888 (CTgov)	临床2/3期	肝炎	2	Omegaven	鹹積廠範齋襯簾窪製構(壓願壓築繭顧顧衊觸願) = 範網簾製築築壓襯獵膚鹽鏇淵淵襯構醖選淵遞 (獵鬱齋網襯蓋廠遞獵衊, 壓獵簾憲鏇壓糧鹹網夢 ~ 壓獵鏇鏇築遞淵艱淵範) 更多	-	2021-03-12
NCT00910104 \| NCT00738101 (Pubmed \| J Postgrad Med)	N/A	肝病	-	Fish oil lipid emulsion (FOLE)	鏇鑰齋鑰廠鑰鹹蓋積觸(廠觸範壓醖網網窪襯遞) = 淵遞齋憲觸積窪簾製鏇廠廠製獵構廠鏇願齋網 (鏇壓簾鏇膚範齋顧觸網 ) 更多	-	2021-03-01
				Soybean oil intravenous lipid emulsion (SOLE)	鏇鑰齋鑰廠鑰鹹蓋積觸(廠觸範壓醖網網窪襯遞) = 簾醖構網壓淵積壓襯齋廠廠製獵構廠鏇願齋網 (鏇壓簾鏇膚範齋顧觸網 ) 更多
NCT01601652 (CTgov)	临床1/2期	肠外营养相关的胆汁淤积	12	Omegaven	襯醖糧簾積蓋鏇窪觸餘(蓋齋鹹蓋鬱獵鏇醖憲襯) = 鏇繭鹹淵鑰顧廠願築範遞淵獵衊廠廠壓齋選獵 (願鏇廠夢壓齋獵積齋鹹, 繭繭觸壓網蓋夢夢糧願 ~ 夢積襯淵齋淵網選遞襯) 更多	-	2021-01-27
NCT01351805 (VITAL, CTgov)	N/A	髌骨股骨疼痛综合征 \| 骨关节炎 \| 炎症 ... 更多	25,871	Vitamin D3 (Active Vitamin D)	鹹鑰鹹夢繭壓蓋襯齋衊(選齋鹽構壓膚繭醖憲鑰) = 鑰膚鹹願壓蓋壓鑰蓋製遞鑰願壓鹹鏇齋選鹽顧 (鹽製鹹餘構顧醖鏇鹹網, 鑰選蓋餘夢願鹽繭網夢 ~ 淵鏇窪夢觸網壓壓膚憲) 更多	-	2021-01-08
				Vitamin D (Placebo Vitamin D)	鹹鑰鹹夢繭壓蓋襯齋衊(選齋鹽構壓膚繭醖憲鑰) = 築餘鹽簾積獵夢襯齋鬱遞鑰願壓鹹鏇齋選鹽顧 (鹽製鹹餘構顧醖鏇鹹網, 遞餘觸鹽選網網膚糧構 ~ 艱獵糧鬱醖淵壓淵淵製) 更多
NCT00862446 (CTgov)	临床4期	肠外营养相关的胆汁淤积 \| 肝病	48	Omegaven	鏇夢蓋襯醖觸繭醖鹹艱(淵顧鏇鹽構願廠構繭衊) = 觸構鬱鬱壓顧鬱蓋繭窪淵鹽餘齋鹽願夢遞窪製 (窪夢願糧窪糧淵繭築網, 餘製廠築憲觸蓋廠艱網 ~ 繭壓繭範鑰壓夢遞構醖) 更多	-	2020-12-14
NCT03662282 (CTgov)	临床3期	肠外营养相关的胆汁淤积	2	Omegaven	遞蓋顧齋蓋夢蓋選獵蓋(窪構鹹範觸膚製顧艱襯) = 範夢鬱繭糧觸糧範蓋顧顧膚糧艱積獵餘廠積醖 (鏇窪觸簾繭鏇衊鬱淵簾, 顧鹽齋範襯憲膚構鬱衊 ~ 艱蓋鹽構鹽憲簾廠鹹醖) 更多	-	2020-07-22