Colecalciferol

银屑病治疗不再"爬楼梯"！阶梯疗法全解析，精准选择是关键 银屑病（俗称牛皮癣）是一种慢性炎症性皮肤病，虽难根治，但科学治疗可有效控制。传统"阶梯治疗"主张从温和方案逐步升级，但最新研究提出"降阶梯"新思路——治疗选择需因人而异，把握黄金治疗窗更重要！ 传统阶梯疗法：三步精准干预 基础阶梯（轻度患者） 外用药物：糖皮质激素药膏、维生素D3衍生物、煤焦油制剂等，缓解局部皮损 皮肤护理：坚持润肤剂保湿、药浴（如麦麸浴），减少刺激 进阶阶梯（中度患者） 光疗：窄谱UVB、PUVA（光化学疗法），尤其适合顽固斑块 联合治疗：外用药+光疗，增效减毒 强化阶梯（重度/侵袭性患者） 系统性药物：甲氨蝶呤、环孢素、阿维A酸等 生物制剂：TNF-α抑制剂、IL抑制剂等， 有效控制炎症 口服靶向药：JAK抑制剂等新型小分子药物 注：以上数据及图片均来源于原文献[1]Helm M F, Clebak K T, Critchfield L, et al. Psoriasis and Papulosquamous Disorders[J]. Primary Care: Clinics in Office Practice, 2025. [2]Wallace D V. Treatment options for moderate to severe atopic dermatitis[C]//Allergy & Asthma Proceedings. 2022, 43(6). 新趋势："降阶梯"治疗—早用强效 重度患者优先生物制剂：最新指南建议，若皮损广泛或反复发作，可直接启用生物制剂或联合治疗，迅速阻断炎症，再逐步降级维持 优势：3-6个月实现皮损清除效果明显，显著提升生活质量 康复关键：个体化综合管理 精准诊断：通过血液检测识别免疫异常类型 心理支持：60%患者伴焦虑抑郁，认知行为治疗可改善预后 长期随访：即便皮损消退，仍需定期监测防止复发 声明 | 除原创内容及特别说明外，本内容基于提供的学术文献综述编译，其数据及图片均出自引用研究文献，旨在为医疗专业人士提供学术参考及科普前沿进展，仅供学术交流。上述内容药物需严格遵医嘱使用，具体适应症及禁忌症请参考药品说明书或咨询医疗专业人士，不构成任何用药建议，处方药需在医师指导下使用。 —END—

Otsuka Pharmaceutical Co., Ltd. (Otsuka) has women's health as one of its focus areas, including the unique challenges women face throughout different life stages. To support this, we are actively engaged in both research and awareness-raising initiatives. In a recent study published in the Journal of the Japan Society for Menopause and Women's Health, we examined skin changes associated with the menstrual cycle. Our findings categorized these changes by severity and suggested that a jelly drink containing equol, vitamin D, collagen, calcium, and magnesium (the "test food") may help improve skin condition following menstruation. ■ Our Findings Subjective skin evaluations showed that, without the test food, participants experienced improved overall skin conditions from Day 6 to Day 13 of the menstrual cycle. However, these improvements were reduced by the onset of the next cycle. In contrast, when the test food was consumed for six days following menstruation, the skin score from day 6 to day 13 showed a significant enhancement compared to the non-intake period. In addition, the consumption of the test food suppressed the deterioration of skin scores at the beginning of the next menstrual period (Figure 1). Objective assessments further supported this effect, with significant improvements observed in skin smoothness scores from Day 6 to Day 13 (Figure 2). These results indicate that the test food may contribute to better post-menstrual skin condition. Additionally, six days of test food consumption led to an increase in serum 25(OH)D₃, the storage form of vitamin D, which remained elevated for one week after discontinuation. This is the first study to evaluate the effects of a short-term (six-day) intervention using a low dose (20 µg) of vitamin D₃ in Japanese women. Subjective skin evaluations showed that, without the test food, participants experienced improved overall skin conditions from Day 6 to Day 13 of the menstrual cycle. However, these improvements were reduced by the onset of the next cycle. In contrast, when the test food was consumed for six days following menstruation, the skin score from day 6 to day 13 showed a significant enhancement compared to the non-intake period. In addition, the consumption of the test food suppressed the deterioration of skin scores at the beginning of the next menstrual period (Figure 1). Objective assessments further supported this effect, with significant improvements observed in skin smoothness scores from Day 6 to Day 13 (Figure 2). These results indicate that the test food may contribute to better post-menstrual skin condition. Additionally, six days of test food consumption led to an increase in serum 25(OH)D₃, the storage form of vitamin D, which remained elevated for one week after discontinuation. This is the first study to evaluate the effects of a short-term (six-day) intervention using a low dose (20 µg) of vitamin D₃ in Japanese women. ■ Summary: This study investigated the impact of menstrual cycle-related hormonal fluctuations on skin conditions and the potential benefits of foods containing equol, vitamin D, collagen, calcium, and magnesium. A non-blind crossover trial was conducted with 109 premenopausal women who reported experiencing changes in their skin conditions throughout their menstrual cycles. The first day of menstruation was considered Day 1, the participants consumed the test food for 6 consecutive days starting Day 7 during the test food intake period. The skin condition was evaluated subjectively with a self-administered questionnaire and objectively with a physiological assessment. The results demonstrated a significant improvement in the skin condition from Days 6 to 13 during the non-intake period. Conversely, significant deterioration was observed from Day 6 to the beginning of the next menstruation period. During the test food intake period, significant improvements were observed in several areas, including skin roughness. Moreover, these improvements were more pronounced in equol non-producers. This suggests that the consumption of the test food post-menstruation can potentially enhance the skin condition and suppress the deterioration typically experienced at the beginning of the next menstruation cycle. Menopause&Women's Health Jpn 32: 686-698, 2025 Reprint requests: Haruna Miyakawa, Nutraceuticals Research Institute, R&D Headquarters, Nutracenticals Division Otsuka Pharmaceutical Co., Ltd., Reprint requests: Haruna Miyakawa, Nutraceuticals Research Institute, R&D Headquarters, Nutracenticals Division Otsuka Pharmaceutical Co., Ltd., ■ About Equol Equol is a metabolite of soy isoflavone daidzen, which is produced through the action of intestinal bacteria. It is attracting attention for its potential to support women's health and beauty due to its ability to mimic the action of female hormones. However, not everyone can produce equol naturally; studies suggest that only around half of the Japanese population has the gut microbiota necessary to generate it.*1 ■ Otsuka's Initiatives to Promote Women's Health Otsuka has long been committed to addressing the physical and mental changes women experience across different life stages. Our research into menopausal symptoms and premenstrual syndrome (PMS) began in 1996. In 2002, we successfully isolated Lactococcus 20-92, a strain capable of producing equol. Since then, we have conducted extensive domestic and international research on the efficacy and safety of equol derived from fermented soybean sprouts using this strain. In addition to our research, we collaborate with medical professionals to offer seminars and online resources that provide women with accessible, reliable information. Through these efforts, we aim to support women in managing their health and enhancing their quality of life at every stage. Reference：Corporate Website: Women's Health https://www.otsuka.co.jp/en/nutraceutical/about/womens-health/ About Otsuka Otsuka Pharmaceutical Co., Ltd. is a total healthcare company that focuses on each individual's potential to enhance their well-being. Our medical-related business provides treatments and diagnostics for both physical and mental health. Our nutraceutical business supports daily health maintenance and improvement. Otsuka's unique products and services are based on scientific evidence, under the guidance of our corporate philosophy: Otsuka-people creating new products for better health worldwide. For further information, please visit. www.otsuka.co.jp/en/