25(OH)-vitamin D and Its Association with Bone Density, Body Composition, Strength, Walking Speed, Physical Performance and Pain in Hospitalized Individuals with Neurological Disorders

The NeuroVitD study aims to assess vitamin D levels in hospitalized cohorts with neurological disorders resulting in motor disabilities, providing epidemiological data necessary for guidelines. The primary objective is to assess vitamin D insufficiency in the neurological populations under investigation and secondary to evaluate the impact of vitamin D supplementation on problems associated with structural and functional parameters.
The NeuroVitD study will be a randomized, cluster, controlled intervention trial lasting 2 years, enrolling 120 individulas, (30 controls), including those with stroke, spinal cord injury, and traumatic brain injury. Comprehensive epidemiological data, including demographic and anthropometric information, will be documented alongside social behaviors such as exercise and smoking. Serum vitamin D levels, bone density, body composition, strength, speed, physical performance and pain will be assessed.
The study will also evaluate the effects of vitamin D supplementation at two distinct dosages: 50,000 I.U of vitamin D weekly for 8 weeks or 25,000 I.U of vitamin D for 4 weeks followed by 10,000 I.U of vitamin D drops weekly for an additional 4 weeks. Calcium, parathyroid hormone, and phosphorus levels will be assessed to examine the impact of vitamin D administration on additional biochemical markers.
The findings will encompass vitamin D levels, bone density, body composition, strength, walking speed, physical performance and pain. The impact of vitamin D supplementation on various biochemical parameters will be analyzed, along with gender and group comparisons. Correlations will be established based on participants' residential locations, the administration of vitamin D supplementation, seasonal variations, and associations with specific medications for neurological conditions.

开始日期2025-06-01

申办/合作机构-

NCT06861062

/ Not yet recruitingN/AIIT

Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Cardiovascular Disease in Patients with Type 2 Diabetes: a Randomized Double-Blind Controlled Trial

This study is a randomized, double-blind, placebo-controlled trial involving 8,000 individuals aged 40-79 with type 2 diabetes. The trial includes a 2-year intervention period followed by 3 years of follow-up. The primary objective is to investigate whether daily dietary supplementation with vitamin D3 (1600 IU) or yeast β-glucan (600 mg) reduces the risk of major cardiovascular diseases, including myocardial infarction, stroke, treated or hospitalized heart failure, and cardiovascular deaths. The secondary objectives include evaluating the effects of vitamin D3 or yeast β-glucan supplementation on all-cause mortality, microvascular disease, cognitive function, and other outcomes.

开始日期2025-03-20

申办/合作机构

华中科技大学

NCT05174611

/ Recruiting临床2期IIT

Vitamin D as an Intervention for Improving Quadricep Muscle Strength in Patients After Anterior Cruciate Ligament Reconstruction: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial

Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury.
Quadriceps muscle atrophy after ACLR is well documented. This can be due to a decreased ability to regain muscle mass with rehabilitation. Athletes are one of the high-risk groups for vitamin D insufficiencies. Vitamin D deficiency can potentially result in decreased hypertrophy when exercising the muscle, leading to a poorer outcome in rehabilitation. Vitamin D has long been recognized for its effect on musculoskeletal health. It can have a direct effect on muscle hypertrophy by acting on specific vitamin D receptors (VDRs) on myocytes, and sufficient or increased levels of vitamin D in patients have been found to correlate with an increase in the size, number, and strength of muscle fibres. Quadriceps muscle hypertrophy after ACLR is triggered by exercise training, facilitated by diet and a number of intrinsic factors. As the rehabilitation programs and diets are similar in patients with varying extents of quadriceps muscle atrophy, individual responses (intrinsic factors) to exercise training may account for the resulting persistent quadriceps muscle atrophy. In this study, the investigators hypothesize that the deficiency of vitamin D may contribute to persistent quadriceps atrophy and weakness.
With a stringent double-blinded randomized-controlled-trial (RCT) research design, our proposal will then address the research questions: 'Does vitamin D supplements improve the vitamin D deficiency status in patients after ACL reconstruction?', and 'Does vitamin D supplements improve quadriceps muscle strength for patients after ACLR?'

开始日期2025-03-17

申办/合作机构

香港中文大学

100 项与维生素D3 相关的临床结果

登录后查看更多信息

100 项与维生素D3 相关的转化医学

登录后查看更多信息

100 项与维生素D3 相关的专利（医药）

登录后查看更多信息

24,381

项与维生素D3 相关的文献（医药）

2025-12-31·Environmental Pollutants and Bioavailability

Evaluating the influence of aquatic environmental hazard, polylactic acid microplastics, on Labeo rohita

作者: Sarker, Pallab K. ; Hussain, Syed Makhdoom ; Naeem, Adan ; Rashid, Eram ; Ali, Shafaqat ; Al-Ghanim, Khalid A.

This research sought to evaluate toxicity after intake of polylactic acid microplastics (PLA-MPs) on multiple parameters of Labeo rohita fingerlings, focusing on their growth, nutrient consumption, body composition, histopathol., hematol. and minerals status.Six test diets were formulated using sunflower meal (SFM) serving as the reference diet, incorporating different MPs concentrations: control (0%), 0.5%, 1%, 1.5%, 2% and 2.5% MPs.The formulated diets were administered to triplicate groups of 15 fish, with each fed at 5% weight (live wet) for 90 days duration.The outcomes revealed that the growth had significantly decreased in L. rohita fingerlings when exposed to PLA-MPs.Furthermore, the apparent nutrients digestibility reduced with the escalation in PLA-MPs levels.PLA-MP exposure led to substantial alterations in body composition, including enhanced body fat and reduced protein content.Furthermore, blood profile was also altered after the PLA-MPs exposure.Addnl., examination of gut histopathol. indicated an intensification in abnormalities in intestine at the 2.5% PLA-MPs concentrationThe diet having 2.5% MPs exhibited the min. body mineral compositionThis study suggests that exposure of PLA-MPs influenced the L. rohita health performance.

2025-12-01·Molecular Biology Reports

A short review: the biological activity of vitamin D and its decomposition products

Review

作者: Shimomura, Hirofumi ; Hosoda, Kouich ; Amgalanbaatar, Avarzed ; Hayashi, Shunji ; Wanibuchi, Kiyofumi ; Shoji, Mitsuru

A vitamin D₃ metabolite 1α,25-dihydroxyvitamin D₃ exhibits numerous hormonal actions to various tissues and cells such as induction of calcium ion absorption, bone metabolism, activation of innate immune system. Because hormonal actions of 1α,25-dihydroxyvitamin D₃ are too complex, it is difficult to better understand overall views of intermolecular networks on the cell activation by 1α,25-dihydroxyvitamin D₃. In this review we concisely outline the most fundamental molecular mechanisms for the cell activation by 1α,25-dihydroxyvitamin D₃ based on the previous and recent studies. In addition, we expound biological activity of 25-hydroxyvitamin D₃ and 1α,25-dihydroxyvitamin D₃ that differs from hormonal actions. In addition, recent studies by our group revealed that vitamin D decomposition products confer extremely selective bactericidal action to Helicobacter pylori, a pathogen causative gastritis, peptic ulcers and gastric cancers in human. Vitamin D decomposition products induce the bacteriolysis as targeting of characteristic glycerophospholipids composed of the bacterial biomembranes. In the future we will expect to be capable of developing novel antibacterial agents targeting a characteristic glycerophospholipid of the pathogenic bacteria using vitamin D decomposition products as fundamental structures.

2025-12-01·Immunologic Research

Arginine vasopressin (AVP) treatment increases the expression of inhibitory immune checkpoint molecules in monocyte-derived dendritic cells

Article

作者: Naseri, Bahar ; Baradaran, Behzad ; Karimzadeh, Hadi ; Ghahramanipour, Zahra ; Mardi, Amirhossein ; Sohrabi, Sepideh ; Baghbani, Elham ; Masoumi, Javad

Arginine vasopressin (AVP) has disparate impacts on immune responses by divergent receptors on cells including DCs. This study was conducted with the aim of investigating the impact of AVP on the maturation and expression of the inhibitory immune checkpoint molecules in tolerogenic monocyte-derived DCs. CD14 marker was used to separate monocytes from peripheral blood mononuclear cells (PBMCs) by MACS method. To differentiate monocytes from DCs, we utilized GM-CSF and IL-4 cytokines. Tolerogenic DCs were generated using vitamin D3 and dexamethasone. We added LPS and AVP to the culture medium on day 6 after incubation of DCs at 37 °C. Finally, we assessed the surface molecules by flow cytometry and used real-time PCR to evaluate the expression of genes related to the inhibitory immune checkpoints. Based on the obtained data, AVP increased the expression of CD11c (P ≤ 0.0001), HLA-DR (P ≤ 0.01), and CD86 (P ≤ 0.01) in AVP-mDCs. Also, the expression of all the immune checkpoint genes including CTLA-4 (P ≤ 0.001), BTLA (P ≤ 0.001), PDL-1 (P ≤ 0.05), B7H7 (P ≤ 0.001), LAG3 (P ≤ 0.01), and VISTA (P ≤ 0.001) in AVP-mDCs was increased in comparison to the control group. Vasopressin caused the generation of mature and tolerogenic DCs. Our data may help to consider AVP-mDCs to take part in autoimmune disease therapy, transplanted tissue rejection impedance, and allergies.

294

项与维生素D3 相关的新闻（医药）

2025-04-23

·PRNewswire

ProRx Pharma Continues to Expand Preventative Health Portfolio with Six New Products

Expanded Product Line Targets Growing Demand for Proactive Wellness Solutions in Clinics, Med Spas, 503A Pharmacies, and Telehealth Practices Across the United States WEST PALM BEACH, Fla. and EXTON, Pa., April 23, 2025 /PRNewswire/ -- ProRx Pharma, the leading health and wellness 503B outsourcing facility, today announced the addition of six new injectable products designed to support the rising demand for preventive care: Gonadorelin, Liraglutide, Vitamin D3, and Phenylephrine HCl as well as two Tri-Mix injection options. These high-quality standalone injectables are now available for bulk shipping to licensed medical facilities in 26 states and for direct-to-consumer shipping nationwide through ProRx's growing network of 503A pharmacies, clinics, med spas and telehealth providers. "Patients are taking charge of their health like never before," said Kurt Lunkwitz, chief operating officer at ProRx. "Physicians are following suit, integrating wellness therapies into their practices to meet the demand for more proactive, functional care. This trend is only going to continue. The continued expansion of our health and wellness line is a direct response—and a step toward making preventative health more accessible and streamlined." What's New: The Products Each of the six new offerings comes with its own National Drug Code (NDC) number and an extended Beyond Use Date (BUD), providing both flexibility and longer shelf life for providers: Gonadorelin ( 1 mg/mL, 6 mg / 6 mL vial ) A gonadotropin-releasing hormone agonist which is used in fertility medicine and to treat amenorrhea and hypogonadism. Gonadorelin may promote testosterone production; may support fertility, libido, and hormonal balance. Liraglutide ( 0.75 mg, 1 mg, 2 mg, 3 mg [custom dosing] ) A powerful GLP-1 receptor agonist for weight and blood-sugar management. Liraglutide may aid in weight loss, appetite suppression, and blood-sugar control. Vitamin D3 ( 50,000 IU/mL, 5 mL vial ) A high-dose solution for those with critically low vitamin D levels. Vitamin D3 may support immune function, bone health, mood, and Vitamin D repletion. Tri-Mix #1 ( 30 mg / 1 mg / 10 mcg/mL, 5 mL vial ) The first of two strength offerings for erectile dysfunction (ED) therapy. Tri Mix #1 may improve erectile response through smooth muscle relaxation and blood flow. Tri-Mix #2 ( 30 mg / 2 mg / 20 mcg/mL, 5 mL vial ) A stronger ED therapy offering. Tri-Mix #2, may provide more ED support for patients needing increased vasodilation. Phenylephrine HCl ( 0.1% 2 mL vial) A critical safety solution for patients using Tri-Mix therapies. Phenylephrine HCl may reverse prolonged erection or priapism due to ED therapy. The introduction of these six new products comes on the heels of ProRx announcing its first four preventative-care offerings the first week of April: Sermorelin, NAD+, Glutathione and MIC/B6/B12. Exclusive Launch at A4M Conference ProRx is showcasing its full line of preventative-care products at the A4M 33rd Annual Spring Conference taking place April 24-26 in West Palm Beach, Florida. At Booth 527, attendees will get an exclusive first look at all 10 products in the new product line and be able to speak with ProRx's experts about the company's compliance and quality-assurance programs. About ProRx Pharma ProRx Pharma is an FDA-registered cGMP facility focused on providing essential compounded medications to meet the need for medications on the FDA drug shortage and bulks list with an emphasis on preventative health. The company produces products and formulations for medical institutions, physician offices, and 503A pharmacies, with a specialization in producing high-quality products to ensure patients have access to the medications they need during critical shortages. For more information, visit SOURCE ProRx Pharma WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

上市批准

2025-04-20

·米内网

正大天晴大涨1320%，382个西药厉害了！18个品牌大卖超10亿，石药挺进TOP10集团

精彩内容米内网最新数据显示，2024年中国城市实体药店终端西药（化学药+生物药）的销售规模继续保持正增长，涨至1904.95亿元。382个西药品牌卖过亿，“销冠”易主，超10亿品牌共有18个；26个过亿品牌增长率超过100%，正大天晴3款注射剂涨势惊人；恒瑞医药等34个国产新药大爆发。跨国药企实力强劲，国内药企正大制药、石药集团成功挺进TOP10集团。图1：中国城市实体药店终端西药（化学药+生物药）的销售情况（亿元）在中国城市实体药店终端，西药的销售规模一直稳步增长，2024年再创新高峰，达1904.95亿元，增长率保持在5%左右。14个大类中有13个的销售额呈现正增长，其中抗肿瘤和免疫调节剂的市场份额占22.83%，销售额增长了20.31%；全身用激素类制剂(不含性激素和胰岛素)的市场份额占0.38%，销售额增长了22.87%；心脑血管系统药物的市场份额占12.12%，销售额增长了2.68%。唯一销售额下滑的大类是消化系统及代谢药，市场份额占22.52%，销售额下滑3%左右。18个品牌大卖超10亿，新“销冠”来了，“神药”陨落了据统计，2024年销售额超过1亿元的西药品牌有382个（同一产品名涉及同一集团多家生产企业的，暂不合并统计，下同），涉及14个大类（54个亚类）。从亚类来看，抗肿瘤药以80个过亿品牌断层领先，高血压用药占了27个，糖尿病用药占了22个，矿物质补充剂占了18个，免疫抑制剂和维生素类各占17个，咳嗽和感冒用药、抗炎药和抗风湿药、全身用抗病毒药、全身用抗细菌药、血脂调节剂均有10个及以上。表1：2024年销售额在8亿元以上的西药品牌2024年在中国城市实体药店终端，382个销售额超过1亿元的西药品牌合揽超过1170亿市场。超10亿品牌有18个，其中8个国产品牌（不含原研地产化）包括了澳诺(中国)制药的葡萄糖酸钙锌口服溶液、青岛双鲸药业的维生素D滴剂、翰森制药的甲磺酸阿美替尼片、白云山制药总厂的枸橼酸西地那非片、施慧达药业集团(吉林)的苯磺酸左氨氯地平片、宜昌东阳光长江药业的磷酸奥司他韦颗粒、康方药业的卡度尼利单抗注射液、华润紫竹药业的左炔诺孕酮片。图2：澳诺(中国)制药的葡萄糖酸钙锌口服溶液销售情况（单位：万元）澳诺(中国)制药的葡萄糖酸钙锌口服溶液用于治疗因缺钙、锌引起的多种疾病。在中国城市实体药店终端，该品牌在2021年涨至19.6亿元，2022年突破20亿元关口，2023年销售额首次下滑，2024年止跌回升0.06%，以19.97亿元的销售额成为了西药市场新的冠军品牌。图3：翰森制药的甲磺酸阿美替尼片销售情况（单位：万元）甲磺酸阿美替尼片是翰森制药在2020年获批的国产1类新药，是第三代EGFR-TKI。在中国城市实体药店终端，该品牌在2023年突破11亿元，2024年再有39.34%的增长，销售额涨至15.7亿元，创出新高。在抗肿瘤药（化+生）市场，翰森制药的甲磺酸阿美替尼片已成为最畅销的内服品牌。图4：宜昌东阳光长江药业的磷酸奥司他韦颗粒销售情况（单位：万元）“流感神药”奥司他韦在2024年受到了重创，宜昌东阳光长江药业的磷酸奥司他韦颗粒是该品种最畅销的品牌，2023年在中国城市实体药店终端的销售额超过24亿元，是近九年的峰值，2024年急降51.21%，销售额跌至12亿元，同时该品牌也是382个过亿品牌中降幅最大的品牌，一代“神药”跌落神坛。236个品牌飞速增长！正大天晴飙涨1320%，34个国产新药大爆发2024年销售额超过1亿元的西药品牌中236个品牌有正增长，涨幅在100%以上的品牌有26个，其中国产品牌占了18个，正大天晴南京顺欣制药的注射用曲妥珠单抗、江西杏林白马药业的复合维生素B片涨幅达4位数。表2：2024年销售额过亿且增长率在100%以上的西药品牌图5：正大天晴南京顺欣制药3款注射剂的销售情况（单位：万元）正大天晴南京顺欣制药的注射用曲妥珠单抗、利妥昔单抗注射液和贝伐珠单抗注射液均是2023年获批的生物药3.3类新药，3大品牌获批当年在中国城市实体药店终端的销售额分别为900万元、5000万元、1.1亿元水平。2024年公司的注射用曲妥珠单抗暴涨1320.40%，销售额达1.37亿元，公司的利妥昔单抗注射液大涨260.07%，销售额突破2亿元，公司的贝伐珠单抗注射液也飙涨了184.23%，销售额超过3.2亿元。图6：杭州中美华东制药的他克莫司胶囊销售情况（单位：万元）杭州中美华东制药的他克莫司胶囊用于预防肝脏或肾脏移植术后的移植物排斥反应，以及治疗肝脏或肾脏移植术后应用其他免疫抑制药物无法控制的移植物排斥反应。在中国城市实体药店终端，该品牌在2023年大涨了46.66%，销售额超过9000万元，2024年暴涨134.66%，销售额突破2亿元。图7：湖南九典制药的洛索洛芬钠凝胶贴膏销售情况（单位：万元）湖南九典制药的洛索洛芬钠凝胶贴膏用于骨关节炎、肌肉痛、外伤后的肿胀疼痛。在中国城市实体药店终端，该品牌在2018-2024年均保持三位数增速，2023年大涨158.54%，销售额超过9000万元，2024年再涨122.34%，销售额也突破2亿元。表3：2024年销售额过亿且正增长的国产新药43个国产新药2024年在中国城市实体药店终端销售额超过1亿元，其中34个有正增长。创新药龙头恒瑞医药有4款新药上榜，其中瑞维鲁胺片大涨193.79%、羟乙磺酸达尔西利片大涨86.49%、阿得贝利单抗注射液大涨76.41%。翰森制药3款新药上榜，其中甲磺酸阿美替尼片2024年的销售额超过15亿元、艾米替诺福韦片增长了140%。三生制药的重组人血小板生成素注射液和注射用伊尼妥单抗增长率分别为64.55%、38.55%。荣昌制药的注射用泰它西普增长164.00%、注射用维迪西妥单抗增长了27.14%。跨国药企称霸，正大制药、石药集团成功突围2024年在中国城市实体药店终端，382个销售额超过1亿元的西药品牌归属170多个集团（二级），跨国巨头诺华、强生、拜耳、阿斯利康、罗氏牢牢占据前五位，过亿品牌在12个及以上，国内药企正大制药以10个过亿品牌突围，石药集团以9个过亿品牌挺进TOP10集团。图8：2024年过亿品牌≥8个的集团正大制药10个过亿品牌合揽接近28亿元，最畅销的是正大天晴药业集团的盐酸安罗替尼胶囊，2024年销售额达6.4亿元，增长率为3.75%。此外还有7个品牌呈现正增长，其中正大天晴南京顺欣制药的贝伐珠单抗注射液、利妥昔单抗注射液、注射用曲妥珠单抗分别增长了184.23%、260.07%、1320.40%，正大天晴药业集团的泊马度胺胶囊、达沙替尼片分别增长了18.11%、6.03%，江苏正大清江制药的盐酸氨基葡萄糖片增长了83.71%，北京泰德制药的氟比洛芬凝胶贴膏增长了7.84%。石药集团9个过亿品牌合揽超过19亿元，最畅销的是石药中诺药业(石家庄)的阿莫西林胶囊，2024年销售额超过4.2亿元，增长率为2.25%。此外还有5个品牌呈现正增长，石药欧意药业的甲钴胺片、头孢克肟胶囊、奥美拉唑肠溶胶囊、盐酸多柔比星脂质体注射液分别增长了51.55%、21.94%、14.80%、23.16%，石药恩必普药业的丁苯酞软胶囊增长了4.16%。资料来源：米内网数据库注：米内网《中国城市实体药店终端竞争格局》，统计范围是：全国地级及以上城市实体药店，不含县乡村药店；上述销售额以产品在终端的平均零售价计算。免责声明：本文仅作医药信息传播分享，并不构成投资或决策建议。本文为原创稿件，转载文章或引用数据请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092【分享、点赞、在看】点一点不失联哦

免疫疗法

2025-04-11

·米内网

网上药店首破700亿！2个新10亿产品曝光，以岭、健民、益佰……11个独家中成药火了

精彩内容米内网最新数据显示，2024年中国网上药店中成药+化学药+生物药（不含药品组合）的合计销售额首次突破700亿元。中成药13个大类均有正增长，太极集团首次登上TOP5集团之位，以岭、健民、益佰等11个独家中成药挺进TOP20产品榜单。西药（化+生）中12个大类有正增长，正大制药的集团排名上升4位至TOP8，2个西药销售额首次突破10亿元，再有“神药”跌落神坛。715亿创新高！这个热销剂型大涨104%2024年中国网上药店终端中成药+化学药+生物药（不含药品组合）的合计销售额为714.95亿元，为近六年新高，增长率超过17%。处方药的占比较前两年有所回升至54.14%，OTC占比回落至37.35%，双跨占比低至8%左右。图1：中国网上药店终端茶剂的销售情况（单位：万元）21个剂型中有18个剂型的销售额在2024年有正增长，其中茶剂大涨了103.54%，销售额首次达到1.9亿元。固体特殊剂型、其他特殊剂型分别增长了93.35%、57.01%，而片剂、注射剂、贴膏剂、药物包衣的增长率也在20%以上。据悉，茶剂就是简单小方，煎汤或泡汤饮用，它充分发挥了中医药“简、便、廉、验”等特点，并因其饮服方便，宜于调理，轻灵精巧，甘淡平和备受消费者认可。在中国网上药店终端，畅销的茶剂主要分布在心脑血管疾病用药、妇科用药、消化系统疾病用药等10个中成药大类市场。中成药“全线飙涨”，以岭、健民、益佰……11个独家产品火了2024年中国网上药店终端中成药的销售规模涨至241.58亿元，增长率为19.82%，超过了整体水平。OTC的占比保持在56%左右，处方药回升至31.37%，双跨占比下滑至12.47%。中成药13个大类在2024年均有正增长，其中妇科用药的市场份额占了6.28%，销售额增长了40.36%；神经系统疾病用药的市场份额占了4.41%，销售额增长了36.44%；泌尿系统疾病用药的市场份额占了18.01%、呼吸系统疾病用药的市场份额占了16.55%、骨骼肌肉系统疾病用药的市场份额占了7.96%、五官科用药的市场份额占了4.19%、皮肤科用药的市场份额占了3.98%，上述5个大类的销售额增长率均超20%。表1：2024年中国网上药店中成药TOP5集团北京同仁堂股份以16.2亿元的销售额蝉联中成药TOP1集团，广药集团和华润三九2024年的销售额增长率均超过20%，排名各上升1位，而太极集团则大涨44.92%，一口气跃升了4位至TOP5集团。图2：太极集团在中国网上药店中成药市场的销售情况（单位：万元）近几年在中国网上药店终端中成药市场，太极集团的销售额一直呈现正增长态势，2022-2023年增速高达80%以上，2024年增速收紧至44.92%，销售额则首次突破5亿元关口。TOP10集团中，云南白药2024年的增长率也达到了双位数，为15.41%，销售额首次突破4亿元，集团排名上升1位至TOP7。表2：2024年中国网上药店中成药TOP20产品2024年中国网上药店终端中成药TOP20产品有11个为独家：东阿阿胶的复方阿胶浆排名上升1位至TOP2，销售额达3.9亿元；漳州片仔癀药业的片仔癀排在TOP4，销售额接近3.4亿元；以岭药业的连花清瘟胶囊排名上升1位至TOP5，销售额达2.8亿元；汇仁药业的肾宝片增长了23.56%，排名上升2位至TOP9，销售额超过2.5亿元；健民药业的龙牡壮骨颗粒排在TOP11，销售额超过2.2亿元；益佰制药的疏肝益阳胶囊增长了31.92%，排名上升8位至TOP19，销售额超过1.4亿元；山西广誉远国药的龟龄集增长了25.44%，排名上升5位至TOP20，销售额接近1.4亿元。图3：疏肝益阳胶囊在中国网上药店的销售情况（单位：万元）益佰制药的独家产品疏肝益阳胶囊用于治疗肝郁肾虚和肝郁肾虚兼血瘀证所致功能性阳痿和轻度动脉供血不足性阳痿等症，该产品近几年在中国网上药店终端的销售额保持高速增长态势，2023年突破1亿元，2024年达1.45亿元，为近六年新高。独家产品中有3个为新上榜，锦州汉宝药业的补天灵片增长了1457.46%，销售额接近2.7亿元；广东罗浮山国药的复方苁蓉胶囊增长了188.58%，销售额超过1.7亿元；金七药业的七叶神安滴丸增长了298.38%，销售额接近1.7亿元。9个非独家产品中，阿胶增长了1.47%，销售额超过5.2亿元；安宫牛黄丸排名上升1位至TOP3，销售额超过3.4亿元；感冒灵颗粒销售额大涨57.44%，排名上升6位至TOP6，销售额超过2.8亿元；五子衍宗丸增长了20.60%，销售额接近1.9亿元；小柴胡颗粒大涨49.44%，排名上升11位至TOP17，销售额超过1.6亿元；黄芪精大涨35.56%，排名上升3位至TOP18，销售额超过1.5亿元。对比2023年中成药TOP20产品名单，有7个爆款产品“跌落神坛”。独家产品中，补肺丸、益安宁丸、复方黄柏祛癣搽剂在2024年跌至TOP23、TOP27、TOP29；非独家产品中，藿香正气口服液、风油精在2024年跌至TOP25、TOP26，壮腰补肾丸和补肾丸直接跌出了TOP50榜单。2个新10亿西药曝光，再有“神药”跌落神坛2024年中国网上药店终端西药（化学药+生物药）的销售规模涨至473.37亿元，增长率为15.73%，略低于整体水平。处方药的占比回升至65.75%，OTC占比下滑至27.75%，双跨占比仅为6%左右。西药14个大类中有12个的销售额在2024年有正增长，其中神经系统药物、血液和造血系统药物、杂类的市场份额分别占了6.84%、4.01%、1.80%，销售额均增长了超过50%；心脑血管系统药物的市场份额占了9.47%，销售额增长了47.02%；抗肿瘤和免疫调节剂、全身用激素类制剂(不含性激素和胰岛素)市场份额分别占了4.14%、0.49%，销售额均增长了超过20%。仅有全身用抗感染药物、抗寄生虫药及杀虫剂和驱虫剂两个大类的销售额有负增长。表3：2024年中国网上药店西药TOP5集团4家跨国药企继续占据高位，拜耳以23亿元的销售额稳坐TOP1集团宝座，晖致、诺和诺德各上升1位。TOP10集团有多家本土企业上榜，三生制药位列TOP5，国药控股增长了11.97%，继续蝉联TOP6，正大制药大涨25.87%，排名上升4位至TOP8，齐鲁制药增长了5.85%，继续稳坐TOP9。表4：2024年中国网上药店西药TOP20产品2024年中国网上药店终端西药TOP20产品仅有1个为独家，诺和诺德的司美格鲁肽注射液近几年一直保持高速增长态势，2022-2023年增长率分别为6691.76%、315.01%，销售额在2024年成功突破10亿元关口，产品排名上升2位至TOP5。19个非独家产品中，有5个销售额在10亿元以上。枸橼酸西地那非片和他达拉非片分别以16.6亿元和16.1亿元位列TOP1、TOP2产品，但销售额均是首次出现负增长；奥利司他胶囊、米诺地尔酊的销售额也有所下滑，维生素D滴剂近几年一直保持正增长，销售额在2024年也成功突破10亿元。图4：新10亿产品的销售情况（单位：万元）此外，还有12个非独家产品2024年的销售额有正增长。维生素AD滴剂增长了32.33%，销售额超过9.4亿元，若继续保持高速增长态势，有望在2025年突破10亿元；达格列净片增长了65.67%，销售额超过5.4亿元，排名上升5位至TOP10；瑞舒伐他汀钙片增长了54.59%，销售额接近5亿元，排名上升4位至TOP12；利伐沙班片增长了130.43%，销售额接近3.7亿元，排名上升27位至TOP16；阿托伐他汀钙片增长了36.68%，销售额超过3.6亿元，排名上升3位至TOP17；屈螺酮炔雌醇片增长了37.43%，销售额超过3.3亿元，排名上升4位至TOP18；左乙拉西坦片增长了89.23%，销售额超过3.2亿元，排名上升18位至TOP19；盐酸阿莫罗芬搽剂增长了54.12%，销售额超过3.1亿元，排名上升9位至TOP20。对比2023年西药TOP20产品名单，有4个爆款产品“跌落神坛”。拜耳的独家产品复合维生素片在2024年跌至TOP29；非独家产品中，碳酸钙D3咀嚼片(Ⅲ)、磷酸奥司他韦胶囊在2024年跌至TOP24、TOP37，磷酸奥司他韦颗粒直接跌出了TOP50榜单。图5：磷酸奥司他韦颗粒的销售情况（单位：万元）奥司他韦曾被誉为“流感神药”，2023年在中国网上药店终端西药市场，磷酸奥司他韦胶囊、磷酸奥司他韦颗粒位列TOP12、TOP13产品，销售额分别为4.5亿元、4.3亿元。2024年磷酸奥司他韦胶囊和磷酸奥司他韦颗粒的销售额暴跌了53.79%、66.36%，双双跌出TOP20产品榜单。2025年3月25日，青峰医药的化药1类新药玛舒拉沙韦片获批，成为了全球第二个、中国首个自主研发的靶向流感病毒RNA聚合酶PA亚基的抗病毒药物。在国产新药的冲击下，昔日的“流感神药”未来如何，我们将继续观察。资料来源：米内网数据库注：米内网《中国网上药店终端竞争格局》，统计范围是：全国网上药店所有药品数据，包括天猫、京东等第三方平台及私域平台上所有网上药店药品数据；上述销售额以产品在网上药店的平均零售价计算。免责声明：本文仅作医药信息传播分享，并不构成投资或决策建议。本文为原创稿件，转载文章或引用数据请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092【分享、点赞、在看】点一点不失联哦

100 项与维生素D3 相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D00188	维生素D3	A11CC05	DB00169

研发状态

批准上市

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
维生素D缺乏症	中国	江苏吴中医药集团有限公司	1987-01-01
甲状旁腺功能减退症	加拿大	-	1985-01-01

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
下尿路感染性疾病	临床2期	中国	上海泽生科技开发股份有限公司	2021-05-08
骨质疏松症	药物发现	丹麦	University of Aarhus	2015-12-01
类风湿关节炎	药物发现	丹麦	University of Aarhus	2015-12-01
绝经期后骨质疏松	药物发现	韩国	Alvogen Korea Co., Ltd.	2011-12-01
慢性心力衰竭	药物发现	意大利	Abiogen Pharma SpA	2011-11-01
2型糖尿病	药物发现	丹麦	University of Aarhus	2008-12-01
高钙血症	药物发现	丹麦	University of Aarhus	2008-05-01
原发性甲状旁腺功能亢进症	药物发现	丹麦	University of Aarhus	2008-05-01
维生素D缺乏症	药物发现	丹麦	University of Aarhus	2008-05-01
克罗恩病	药物发现	丹麦	University of Aarhus	2005-09-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01817166 (D-Lay MS, NEWS \| Pubmed) 人工标引	临床3期	多发性硬化症	316	cholecalciferol	築鹹壓淵衊構艱鑰簾鏇(構獵製繭製鹽齋遞鑰艱) = 鏇網夢襯齋齋鬱夢積製壓憲築獵廠築築顧選製 (積觸鏇遞簾顧獵網憲衊 ) 更多	积极	2025-03-11
				Placebo	築鹹壓淵衊構艱鑰簾鏇(構獵製繭製鹽齋遞鑰艱) = 鑰鹽顧餘築醖築蓋糧繭壓憲築獵廠築築顧選製 (積觸鏇遞簾顧獵網憲衊 ) 更多
NCT02224144 (CTgov)	临床2期	代谢性骨病 \| 血管钙化 \| 终末期肾脏病 \| 骨折	61	Calcitriol+Vitamin D3 (Vitamin D3 Plus Calcitriol)	築鏇鑰憲廠衊壓網簾選(願膚夢鏇鹽齋製淵齋鏇) = 夢艱顧窪衊襯築選膚鹹艱餘選遞築壓積繭糧鏇 (範廠膚醖夢網淵簾窪膚, 範淵積壓鏇鹹糧鑰製糧 ~ 艱艱鑰構製廠憲獵築夢) 更多	-	2025-03-07
				Placebo+Vitamin D3 (Vitamin D3 Plus Placebo)	築鏇鑰憲廠衊壓網簾選(願膚夢鏇鹽齋製淵齋鏇) = 鹽構蓋餘遞壓築鹽廠窪艱餘選遞築壓積繭糧鏇 (範廠膚醖夢網淵簾窪膚, 壓顧鑰鬱齋遞齋範製構 ~ 夢壓願齋膚壓構廠製夢) 更多
NCT01443728 (CTgov)	临床2期	哮喘 \| 维生素D缺乏症 \| 急性胸部综合征 \| 呼吸道感染	70	Experimental: Vitamin D3 100,000 IU (Vitamin D3 100,000 IU)	鑰選範餘簾衊遞範醖築(獵憲簾築鏇鹹網觸窪蓋) = 顧網衊窪簾繭襯構選鑰齋構鑰醖範築齋壓鹽淵 (築遞顧鏇選齋糧築憲鏇, 選膚糧製醖積選廠積廠 ~ 醖鑰網鹽選鏇繭壓夢廠) 更多	-	2024-08-09
				Active Comparator: Vitamin D3 12,000 IU (Vitamin D3 12,000 IU)	鑰選範餘簾衊遞範醖築(獵憲簾築鏇鹹網觸窪蓋) = 廠繭廠積積夢築築繭網齋構鑰醖範築齋壓鹽淵 (築遞顧鏇選齋糧築憲鏇, 鹹鹹鹽膚鹽觸蓋鏇憲獵 ~ 觸鏇夢積構憲構淵衊淵) 更多
625-P (ADA2024)	N/A	2型糖尿病 Vitamin D \| Thyroid function	730	Vitamin D (Lower VD group)	衊遞觸鹽廠鑰製蓋簾遞(壓鬱築夢製鏇蓋廠廠衊) = 遞遞範醖艱淵鹹廠衊積選憲醖範觸製製積鬱餘 (餘壓顧範醖醖鹹鬱窪餘 ) 更多	积极	2024-06-14
				Vitamin D (Higher VD group)	衊遞觸鹽廠鑰製蓋簾遞(壓鬱築夢製鏇蓋廠廠衊) = 鬱壓襯範壓觸製襯齋夢選憲醖範觸製製積鬱餘 (餘壓顧範醖醖鹹鬱窪餘 ) 更多
EULAR2024	N/A	系统性红斑狼疮	-	Vitamin D (SLE Female Patients)	網簾築鬱衊蓋鬱窪鏇淵(製夢壓網醖餘壓憲鹹衊) = 選蓋鹹願夢襯醖鹽膚鬱醖鹽鹽選鹹壓壓積壓艱 (窪願願夢範壓餘鏇廠廠 )	-	2024-06-05
				Vitamin D (Control Group)	網簾築鬱衊蓋鬱窪鏇淵(製夢壓網醖餘壓憲鹹衊) = 願糧鏇築鹹齋艱簾觸醖醖鹽鹽選鹹壓壓積壓艱 (窪願願夢範壓餘鏇廠廠 )
EULAR2024	N/A	纤维肌痛 Vitamin D levels	-	Vitamin D (Fibromyalgia Syndrome (FMS) patients)	繭醖構觸蓋構齋選艱簾(餘艱築廠願鑰窪膚積網) = 醖鹽獵選願遞膚餘衊鏇鏇鑰顧窪醖願夢繭鑰夢 (膚餘淵網淵願齋糧鬱觸 )	积极	2024-06-05
				Vitamin D (Healthy individuals)	繭醖構觸蓋構齋選艱簾(餘艱築廠願鑰窪膚積網) = 鹹鏇蓋觸範衊衊蓋繭窪鏇鑰顧窪醖願夢繭鑰夢 (膚餘淵網淵願齋糧鬱觸 )
ENDO2024	N/A	甲状旁腺功能减退症	-	Vitamin D supplementation	淵鏇觸網繭積築遞網鏇(鹽艱醖鹹廠鏇廠襯繭醖) = 網築醖獵膚獵築窪繭餘蓋齋遞觸夢積餘衊鹽齋 (襯顧鬱蓋觸繭製艱網齋 )	-	2024-06-01
ENDO2024	N/A	骨质疏松性骨折 VDD \| serum 25OHD	-	vitamin D (Patients with hip fragility fractures)	窪鏇淵窪願觸襯製觸壓(鹹網鑰選艱壓壓顧願製) = 顧艱鑰鑰憲窪觸餘齋鹽醖蓋淵鹽遞選製淵積鹽 (觸餘獵窪獵範範餘夢糧 )	-	2024-06-01
ENDO2024	N/A	原发性甲状旁腺功能亢进症 1,25(OH)2 vitamin D \| FGF23	-	Vitamin D (PHPT patients)	觸淵鑰壓壓遞範衊膚構(餘繭鹽範範築鑰鹹窪鏇) = 襯淵顧顧鹹選窪餘網鹹遞膚築遞壓觸衊艱齋積 (淵糧鑰顧襯夢顧醖淵廠 ) 更多	-	2024-06-01
				Vitamin D (Healthy individuals (CTRL))	觸淵鑰壓壓遞範衊膚構(餘繭鹽範範築鑰鹹窪鏇) = 醖窪獵顧獵鹹淵鏇願鏇遞膚築遞壓觸衊艱齋積 (淵糧鑰顧襯夢顧醖淵廠 ) 更多
NCT02757872 (CTgov)	临床3期	肾脏疾病 \| 高血压	2,232	Omega-3 Fatty acids+Vitamin D3 (Vitamin D and Omega-3 Fatty Acids)	觸範膚夢糧糧淵製壓遞(糧構蓋觸積鬱淵製窪遞) = 獵獵網構淵願願獵襯艱蓋鏇鹹廠觸襯餘選繭壓 (範齋觸繭鬱艱餘網願鹽, 襯網淵餘築觸醖觸壓構 ~ 壓繭構糧願壓襯鏇繭製) 更多	-	2024-05-31
				Fish oil placebo+Vitamin D3 (Vitamin D and Omega-3 Fatty Acid Placebo)	觸範膚夢糧糧淵製壓遞(糧構蓋觸積鬱淵製窪遞) = 製襯餘廠醖顧繭壓鹹齋蓋鏇鹹廠觸襯餘選繭壓 (範齋觸繭鬱艱餘網願鹽, 簾積觸積鬱蓋衊鑰獵範 ~ 齋鹹齋艱構艱鏇艱齋繭) 更多