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更新于：2026-07-15
Diclofenac Diethylamine
双氯芬酸二乙胺
更新于：2026-07-15
概要
基本信息
原研机构- |
在研机构- |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C18H22Cl2N2O2 |
InChIKeyZQVZPANTCLRASL-UHFFFAOYSA-N |
CAS号78213-16-8 |
关联
55
项与 双氯芬酸二乙胺 相关的临床试验CTIS2025-524764-38-00
Study of diclofenac skin reservoir formation and emptying after Voltaren Emulgel 2.32% application in healthy participants
CTR20261799
双氯芬酸二乙胺乳胶剂在健康人群中的生物等效性试验
CTR20260209
双氯芬酸二乙胺乳胶剂在中国健康成年研究参与者中随机、开放、单剂量、四周期、完全重复交叉、空腹状态下的生物等效性试验
100 项与 双氯芬酸二乙胺 相关的临床结果
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100 项与 双氯芬酸二乙胺 相关的转化医学
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100 项与 双氯芬酸二乙胺 相关的专利（医药）
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173
项与 双氯芬酸二乙胺 相关的文献（医药）2025-12-01Current Research in Translational Medicine
Green solvent-based synthesis of diclofenac diethylamine-loaded PCL nanoparticles for sustained drug delivery
Article
作者: Ajji, Zaki Ali ; Al-Laham, Antoun ; Soliman, Soolafa Al
BACKGROUND:
Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumor properties; however, its clinical application is limited by systemic toxicity. Encapsulation in biodegradable polymeric nanoparticles offers a strategy to enhance therapeutic efficacy while minimizing adverse effects. Nevertheless, the use of toxic organic solvents in nanoparticle fabrication remains a significant challenge.
OBJECTIVE:
This study aimed to develop and characterize diclofenac diethylamine-loaded polycaprolactone (PCL) nanoparticles using green solvents and to compare two preparation methods-emulsification solvent evaporation/extraction and spontaneous emulsification solvent diffusion-for producing diclofenac-loaded nanoparticles with potential applications in tumor therapy.
METHODS:
Diclofenac diethylamine-loaded PCL nanoparticles were prepared using both methods, employing a novel green solvent system. The nanoparticles were characterized in terms of size, polydispersity index (PDI), zeta potential, morphology, and encapsulation efficiency. In vitro drug release profiles were evaluated and fitted to kinetic models.
RESULTS:
The developed diclofenac diethylamine-loaded PCL nanoparticles exhibited a mean diameter below 200 nm, a monodisperse population, and a negative surface charge. Both preparation methods achieved high encapsulation efficiency and prolonged, diffusion-controlled drug release. The spontaneous solvent diffusion method provided slightly better control over particle size.
CONCLUSION:
These nanoparticles are well-suited for cancer therapy, offering sustained drug release, enhanced safety due to the use of green solvents, and robust physicochemical stability. The findings support their potential as an innovative, effective, and safe delivery system for antitumoral applications.
2025-09-12Zhongguo zhen jiu = Chinese acupuncture & moxibustion
[Electroacupuncture at neuro-arterial stimulation points for post-stroke shoulder-hand syndrome: a randomized controlled trial].
Article
作者: Zhao, Meidan ; Wu, Jiazhu ; Liu, Zhixin ; Yin, Xiumei ; Xu, Zhifang ; DU, Yuanhao ; Zhang, Man
Objective:
To compare the clinical efficacy of electroacupuncture (EA) at neuro-arterial stimulation points with topical western medication in treating post-stroke shoulder-hand syndrome (SHS).
Methods:
A total of 72 patients with post-stroke SHS were randomly assigned to an observation group (n=36, 2 cases dropped out) and a control group (n=36, 3 cases dropped out). Both groups received standard neurological treatment, comprehensive rehabilitation, and physical therapy. The observation group received EA at neuro-arterial stimulation points, including the ipsilateral stellate ganglion point, vagus nerve trunk and auricular branch (left side), and stimulation points of the radial and ulnar arteries, radial nerve, ulnar nerve, and median nerve, once daily for 4 weeks. The control group was treated with topical diclofenac diethylamine emulgel, and mucopolysaccharide polysulfate cream was added for patients with pronounced early-stage edema, twice a day for 4 weeks. The VAS pain score and hand edema volume were recorded before treatment, at 2 and 4 weeks during treatment, and 2 weeks after treatment completion (follow-up). Musculoskeletal ultrasound was used to measure the thickness of the dorsal hand and middle finger skin on the affected side before and after 4 weeks of treatment.
Results:
Compared before treatment, the VAS pain scores and edema volume of the affected hand in both groups were decreased at week 2, week 4, and follow-up (P<0.05). At week 4, both groups showed lower VAS pain scores and edema volume than those at week 2 (P<0.05); during follow-up, both VAS pain scores and edema volume were further reduced compared to those at week 4 (P<0.05). At week 2, week 4, and follow-up, the VAS scores and edema volume of the affected hand in the observation group were lower than those in the control group (P<0.05). Compared before treatment, the dorsal hand skin thickness and middle finger skin thickness on the affected side were decreased in both groups after 4 weeks of treatment (P<0.05). Compared with the control group, the observation group showed thinner dorsal hand and middle finger skin thickness after 4 weeks of treatment (P<0.05).
Conclusion:
EA at neuro-arterial stimulation points effectively alleviates pain and edema in patients with post-stroke SHS, and demonstrates superior efficacy compared to topical western medication.
2025-06-01MICROCHEMICAL JOURNAL
Transformation model to green HPLC methods for lipophilic acidic compounds based on isoeluotropic series of elution solvents
作者: Brezovska, Katerina ; Lazova, Jelena ; Dimitrovska, Aneta ; Antovska, Packa ; Atanasova, Ana ; Nakov, Natalija ; Trifunovska, Bojana Vulovska
The transition from conventional to environmentally friendly liquid chromatog. (LC) methods is impeded by the lack of isoeluotropic series between ethanol (EtOH), a sustainable eluent, and the commonly used conventional eluents methanol (MeOH) and acetonitrile (ACN).Providing empirical data on the elution strength of EtOH compared to the MeOH and ACN would significantly facilitate the transformation to green LC methods.The aim of this study was to evaluate the elution strength of EtOH in comparison to MeOH and ACN, establish isoeluotropic series among these solvents, and propose a practical guide for transformation from conventional to green LC methods.The elution strength of EtOH was evaluated using different retention models on four stationary phases based on octadecyl silica, using ten lipophilic acidic active pharmaceutical ingredients (APIs) as model compoundsThe isoeluotropic series between EtOH, MeOH and ACN were established using the adsorption (log-log) retention model.It was found that the elution strength of MeOH corresponds to 1.46 times that of EtOH (φ MeOH = 1.46 φ EtOH), while ACN′s elution strength is 1.03 times that of EtOH (φ ACN = 1.03 φ EtOH).The proposed model shows the required volume fraction (φ (%)) of EtOH needed to replace MeOH or ACN used as eluents in conventional HPLC methods, while keeping all other chromatog. conditions the same.The applicability of the proposed transformation model was demonstrated by successfully converting two conventional reversed-phase LC methods (for cefpodoxime and aceclofenac) into EtOH-based green chromatog. methods.The findings provide valuable guidance for more efficient optimization and facilitating the transformation of conventional into "green" LC methods in the pharmaceutical industry.
100 项与 双氯芬酸二乙胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 炎症 | 中国 | - | 1999-01-01 |
| 疼痛 | 中国 | - | 1999-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 关节痛 | 临床3期 | 中国 | 2019-10-24 | |
| 关节痛 | 临床3期 | 中国 | 2019-10-24 | |
| 挫伤 | 临床3期 | 中国 | 2019-10-24 | |
| 挫伤 | 临床3期 | 中国 | 2019-10-24 | |
| 骨关节炎 | 临床3期 | 中国 | 2019-10-24 | |
| 骨关节炎 | 临床3期 | 中国 | 2019-10-24 | |
| 膝关节炎 | 临床3期 | 德国 | 2013-10-01 | |
| 踝损伤 | 临床3期 | 德国 | 2009-07-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | 302 | 膚壓觸網膚蓋築糧網醖(繭願鹹構淵衊齋壓鹽壓): mean difference = 1.11, P-Value = 0.595 更多 | 积极 | 2022-12-24 | ||
临床3期 | 313 | 積鏇窪獵壓範顧鹽遞廠(遞壓獵鏇顧繭壓壓鑰淵) = 鹽範遞繭觸觸鹹淵範艱 製顧願願製繭鏇繭糧觸 (鹹網壓築鏇齋選艱齋艱, 1.45) 更多 | - | 2022-04-12 | |||
临床1期 | 47 | Diclofenac Diethylamine (DDEA) (Diclofenac Diethylamine (DDEA) Gel) | 艱憲築獵繭獵範鏇顧齋(餘築膚鹹製醖窪廠壓糧) = 襯網鏇鹹願願觸鬱網網 網壓製願觸襯壓憲壓憲 (衊觸淵鑰網遞獵選範窪, 襯積艱觸鑰襯鹽膚範範 ~ 艱鬱窪淵積膚鏇壓糧積) 更多 | - | 2020-02-24 | ||
Placebo (Placebo Gel) | 艱憲築獵繭獵範鏇顧齋(餘築膚鹹製醖窪廠壓糧) = 觸鬱簾願膚糧鬱鏇壓夢 網壓製願觸襯壓憲壓憲 (衊觸淵鑰網遞獵選範窪, 範鑰壓鑰鏇艱築製衊淵 ~ 鏇鬱觸壓積糧廠窪憲鏇) 更多 | ||||||
临床3期 | 304 | (Diclofenac Diethylamine, DDEA 2.32% Gel) | 餘鏇鑰艱製觸簾淵齋齋(選廠壓構窪鹹範夢繭壓) = 蓋積願範願獵壓顧構醖 膚衊鹽餘壓顧積蓋遞選 (簾鬱鬱鹽鑰積齋糧襯築, 23.8) 更多 | - | 2015-06-03 | ||
Placebo (Placebo) | 餘鏇鑰艱製觸簾淵齋齋(選廠壓構窪鹹範夢繭壓) = 壓繭膚鑰壓鬱蓋網鑰蓋 膚衊鹽餘壓顧積蓋遞選 (簾鬱鬱鹽鑰積齋糧襯築, 23.5) 更多 | ||||||
临床4期 | 72 | 艱觸觸齋餘範鹽醖膚艱(顧選鏇壓淵鏇艱獵鏇遞) = 鹽齋糧糧簾顧觸齋鬱鏇 窪製鹽範築鹹憲顧淵窪 (齋憲壓廠鏇窪鏇顧壓餘 ) 更多 | 积极 | 2013-08-21 | |||
Placebo gel | 艱觸觸齋餘範鹽醖膚艱(顧選鏇壓淵鏇艱獵鏇遞) = 壓鏇積餘壓顧鬱構膚醖 窪製鹽範築鹹憲顧淵窪 (齋憲壓廠鏇窪鏇顧壓餘 ) 更多 | ||||||
临床4期 | 72 | (Diclofenac Diethylamine 1.16% Gel) | 鏇糧窪顧獵糧製願夢廠(衊憲遞簾壓衊遞糧餘憲) = 齋願鑰鹹糧餘醖構構齋 淵遞鏇選築積範夢夢蓋 (構獵醖鑰獵淵積範廠餘, 12.9) 更多 | - | 2012-07-18 | ||
Placebo gel (Placebo Gel) | 鏇糧窪顧獵糧製願夢廠(衊憲遞簾壓衊遞糧餘憲) = 鑰築糧範製窪鹽餘鹽鏇 淵遞鏇選築積範夢夢蓋 (構獵醖鑰獵淵積範廠餘, 16.1) 更多 | ||||||
临床3期 | 242 | (Diclofenac Diethylamine Gel 2.32% Gel. Applied 2 Times a Day) | 簾鏇構糧齋網窪衊積壓(獵網築艱廠構積觸糧選) = 糧鏇簾憲範鏇鹹遞糧餘 遞獵網願糧蓋窪鬱餘餘 (糧鬱鬱繭淵鏇膚願鏇夢, 19.3) 更多 | - | 2011-01-26 | ||
(Diclofenac Diethylamine Gel 2.32% Gel. Applied 3 Times a Day) | 簾鏇構糧齋網窪衊積壓(獵網築艱廠構積觸糧選) = 淵憲淵憲觸築鬱鑰繭廠 遞獵網願糧蓋窪鬱餘餘 (糧鬱鬱繭淵鏇膚願鏇夢, 21.5) 更多 |
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