VXM-01

BELLEVUE, Wash., Nov. 21, 2025 /PRNewswire/ -- OSR Holdings, Inc. (NASDAQ: OSRH), today announced that Vaximm AG, an OSR Company, has entered into a non-binding term sheet with BCM Europe AG ("BCME"), a Swiss-based life sciences investment group and OSRH's largest shareholder, to explore a potential exclusive global licensing agreement for VXM01, Vaximm's first-in-class oral cancer immunotherapy platform. The term sheet establishes a six-month exclusivity period during which Vaximm and BCME intend to negotiate and finalize a definitive licensing agreement, subject to customary due diligence and Board approvals. Under the contemplated terms (which remain subject to final negotiation and execution of definitive agreements): Vaximm would receive a $20 million upfront payment Up to $815 million in clinical, regulatory, and commercial milestone payments, and a pass-through of commercial royalties that BCME may receive from any future pharmaceutical partner after BCME recovers any milestone differential under a defined delta-recovery mechanism. The proposed structure positions BCME as a strategic financial intermediary, funding the partnering and development activities required to secure a global out-license with a major pharmaceutical company. The model mirrors the structured financing approaches used by Royalty Pharma, Blackstone Life Sciences, and RTW Investments, which provide capital to biotech innovators in exchange for future royalties or milestone-based returns. "This term sheet marks an important step forward for Vaximm and our VXM01 oral T-cell immunotherapy platform," said Andreas Niethammer, incoming CEO of Vaximm AG. "The contemplated collaboration with BCME would accelerate development and global commercialization of VXM01, while allowing us to retain full ownership of our intellectual property and continue our mission to deliver innovative immunotherapies to patients worldwide." "Vaximm's oral T-cell platform represents a truly innovative approach in oncology, with the potential to transform cancer treatment," said Tim Smith, Head of IR, OSR Holdings. "Entering this exclusivity period with BCME reflects our shared commitment to maximizing the global opportunity for VXM01, and we are excited to work towards a definitive agreement that positions the asset for a major pharmaceutical partnership." The term sheet also outlines an optional blockchain-based royalty participation mechanism, using "TAC" tokens as an on-chain representation of the future royalty revenue stream. If Vaximm elects to draw development capital from the BCM Royalty Fund, a portion of VXM01 commercial royalties could be allocated to TAC token holders. If not, royalties flow solely through the BCME pass-through structure. During the exclusivity period, BCME and Vaximm will collaborate to complete confirmatory diligence, prepare partnering materials, and finalize the structure and documentation of the proposed definitive license. Vaximm retains full ownership of all VXM01 intellectual property, while BCME would receive exclusive global rights only upon execution of a definitive agreement. About OSR Holdings, Inc. OSR Holdings, Inc. (NASDAQ: OSRH) is a global healthcare holding company dedicated to advancing biomedical innovations in healthcare and wellness. Through its subsidiaries, OSRH engages in immuno-oncology, regenerative biologics, and medical device technologies to improve global health outcomes. Learn more at . About Vaximm AG Vaximm AG is a privately held Swiss-German biotechnology company and a wholly owned subsidiary of OSR Holdings, Inc. (NASDAQ: OSRH). Vaximm's proprietary oral T-cell vaccination platform harnesses live, attenuated bacterial vectors to deliver tumor-associated antigens, inducing robust cellular immune responses. Lead candidate VXM01, targeting VEGFR-2, has demonstrated clinical activity and safety in multiple cancer indications. About BCM Europe AG BCM Europe AG is a Switzerland-based life sciences investment entity and the largest shareholder of OSR Holdings. Forward-Looking Statements This press release contains forward-looking statements regarding the potential licensing agreement between Vaximm AG and BCM Europe AG, the development and commercialization of VXM01, and the expected benefits of the collaboration. Actual results may differ materially due to risks and uncertainties, including the possibility that a definitive agreement may not be reached or anticipated milestones may not be achieved. OSR Holdings, Vaximm, and BCM Europe AG do not assume any obligation to update these statements except as required by law. Media & Investor Contact OSR Holdings, Inc. Investor Relations [email protected] SOURCE OSR Holdings 21% more press release views with Request a Demo

LOS ANGELES, Sept. 23, 2025 (GLOBE NEWSWIRE) -- Innovate GBM, a 501(c)(3) nonprofit dedicated to transforming the landscape of brain tumor research, investment, and treatment, has released its 2025 Year-to-Date Impact Report, showcasing a bold new approach to solving some of oncology’s most stubborn and underfunded problems: glioblastoma multiforme (GBM) and other brain tumors. Built in memory of Sanam Thukral, DVM, a young veterinarian who passed away in 2024 following a 30-month battle with GBM, Innovate GBM has grown from a grassroots support group into a globally connected movement accelerating momentum in one of oncology’s most neglected fields. Rather than relying on traditional philanthropy or government grants, the organization is executing a capital markets driven playbook to fuel progress in a field long ignored by mainstream funders. Brain cancer research has too often been slowed by disconnected systems and isolated efforts, while other diseases have moved forward through clearer, more structured pipelines. Through an independent, investor-driven Ecosystem, Innovate GBM is channeling private capital, supporting public-company pathways, and engaging in high-level policy work to provide more clear treatment pathways. Most importantly, Innovate GBM is bringing physicians, researchers, advocates, regulators, investors, and companies into one coordinated network that works side by side to build a stronger path toward progress. Despite GBM’s lethality, accounting for just 1.5% of cancers but over 3.4% of cancer deaths, federal funding for brain tumor research has declined in recent years. “This isn’t just about the funding sources,” said Kush Thukral, Co-Executive Director of Innovate GBM. “it’s about changing the architecture of how investment, innovation, and urgency come together in the brain tumor space.” The Ecosystem is growing stronger. Since January 2025, Innovate GBM and its Community have achieved milestones such as: NASDAQ Closing Bell Ceremony: On June 12, 2025, Innovate GBM rang the NASDAQ Closing Bell in Times Square in honor of GBM patients and the broader brain tumor community, signaling a new era of urgency and visibility for the field.40+ Community Members with Zero Dollar Fundraising: The organization remains entirely bootstrapped, driven not by donations, but by a committed internal operations team and a coalition of over 40 top tier Community Members spanning clinical, academic, venture, and advocacy sectors.Catalyzing Investment: Helped drive $170M+ in committed capital across 9+ companies in the brain tumor pipeline: Paxalisib, SurVaxM, VXM01, NEO100, TTX-MC138, VAL-083, CHI3L1, CeCava, and DCVax–L.Joined a brain tumor investment syndicate in collaboration with leading partners including the Brain Tumor Investment Fund, Sontag Foundation, White Lion GBM Innovation Fund, BrightEdge, Alliance for Cancer Gene Therapy, MEDA Angels, Lindonlight, Pathway Bioventures, and DeepWork Capital. Policy and Legislative Advocacy: Advanced support for the BRAIN Act (S.4739) alongside the National Brain Tumor Society, spotlighting bipartisan federal action to improve care and innovation pathways for brain cancer patients.Ecosystem Partnerships: Strengthened working relationships with members from top institutions including the National Brain Tumor Society, Global Coalition for Adaptive Research, GBM Agile, OSR Holdings, UCLA, Brown University, USC, StacheStrong, Glioblastoma Research Organization, Landmark Bioventures, Spanios Lab, Valkyrie Clinical Trials, Penn Medicine, and Northwestern University. Every breakthrough in brain cancer is the result of one more shot on goal. Innovate GBM’s playbook doesn’t just create hope, it helps expand the chances for patients and families to see better options in their lifetime. We are not the first and we will not be the last, but we are proud to stand shoulder to shoulder with every patient, family, researcher, and advocate fighting this disease. Co-Executive Director Yash Thukral, JD, reflected, “We are building more than a market, we are building momentum. Every dollar, every investment, and every partnership adds up to a new architecture where cures are no longer impossible, but inevitable.” To support Innovate GBM’s efforts to drive progress across the brain tumor Ecosystem, please consider making a donation at: https://innovategbm.org/donate/ About Innovate GBMInnovate GBM is a 501(c)(3) nonprofit organization that is curating an ecosystem for innovation amongst researchers, physicians, and investors to speed up treatment for Glioblastoma. By uniting key nodes of the healthcare ecosystem - physicians, researchers, companies, regulators, investors, and advocates - Innovate GBM builds the platforms and partnerships needed to accelerate progress in glioblastoma and related brain cancers. Our Community members span across a variety of organizations, such as the National Brain Tumor Society, the Brain Tumor Investment Fund, the Global Coalition for Adaptive Research, OSR Holdings, Inc, University of California Los Angeles, Brown University, University of Southern California, Spanios Labs, Penn Medicine, and Northwestern University. Media Contact: Katelyn Laufer, Head of Marketing operations@innovategbm.org www.innovategbm.org Community Contact: Harrison Seidner, PhD WaterSeid Partners, Inc. harrison@waterseid.com