预约演示
更新于：2025-05-16
Vonoprazan Acetate
醋酸沃诺拉赞
更新于：2025-05-16
概要
基本信息
原研机构 |
非在研机构- |
权益机构- |
最高研发阶段申请上市 |
首次获批日期- |
最高研发阶段(中国)申请上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C19H20FN3O4S |
InChIKeyNVOIBVBRUBFZQC-UHFFFAOYSA-N |
CAS号1957202-37-7 |
关联
24
项与 醋酸沃诺拉赞 相关的临床试验CTR20233570
多中心、随机、双盲、阳性药平行对照的Ⅲ期临床研究评价H009注射液用于急性胃和/或十二指肠溃疡引起的上消化道出血经内镜治疗后降低再出血风险的有效性和安全性
CTRI/2023/02/050047
A Phase III, Multi-Center, Randomized, Double Blind, Active-controlled, Parallelgroup study to evaluate the Efficacy and Safety of Vonoprazan 20mg tablets compared to Pantoprazole 40mg tablets in Patients with Gastroesophageal Reflux Disease (GERD)
NCT05728424
ONE WEEK VS. TWO WEEKS VONOPRAZAN CONTAINING TRIPLE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI:
100 项与 醋酸沃诺拉赞 相关的临床结果
登录后查看更多信息
100 项与 醋酸沃诺拉赞 相关的转化医学
登录后查看更多信息
100 项与 醋酸沃诺拉赞 相关的专利（医药）
登录后查看更多信息
433
项与 醋酸沃诺拉赞 相关的文献（医药）2025-07-01JOURNAL OF MOLECULAR STRUCTURE
Quercetin capped Au-Ag bimetallic nanoparticles for the detection of calcium dobesilate monohydrate in biological and environmental samples
作者: Asrar, Shaz ; Qayoom, Amtul ; Hussain, Dilshad ; Ali, Saeeda Nadir
The study details the synthesis of quercetin-capped Au-Ag bimetallic nanoparticles (Qct-AuAg BMNps) in an aqueous environment.UV visible spectra showed absorbance peak of gold and bimetallic nanoparticles at 524 nm and 403 nm, resp.The SEM anal. of Qct-AuAg BMNps showed an average particle size of 67.5 nm with good uniformity (PdI: 0.386).FTIR confirmed the presence of resp. functional groups in Qct-AuAg BMNps.The Qct-AuAg BMNps were used as a colorimetric sensor for detecting calcium dobesilate monohydrate (CDM) in aqueous solutions, showing a linear spectrophotometric relationship with CDM concentration ranging from 0.000001 mM to 10 mM (R2 = 0.9984).The detection and quantification limits were 1.66 x 10-6 and 2.71 x 10-5 mM, resp.The binding constant (Ka) was 9.8 x 104 M-1, with a 1:1 stoichiometry confirmed by Job's plot.The Qct-AuAg BMNps were successfully used to detect CDM in tap water and serum samples.The synthesis process was optimized using Box Behnken Design, with the optimal conditions found at 50°C, 2 mM quercetin, and a 5:1 silver-to-gold ratio.Therefore, the synthesized quercetin capped gold silver bimetallic nanoparticles were proved effective for the detection of CDM in liquid samples.
2025-04-28Journal of Chemical Information and Modeling
DirectMultiStep: Direct Route Generation for Multistep Retrosynthesis
Article
作者: Morgunov, Anton ; Shee, Yu ; Batista, Victor S. ; Li, Haote
Traditional computer-aided synthesis planning (CASP) methods rely on iterative single-step predictions, leading to exponential search space growth that limits efficiency and scalability. We introduce a series of transformer-based models that leverage a mixture of experts approach to directly generate multistep synthetic routes as a single string, conditionally predicting each transformation based on all preceding ones. Our DMS Explorer XL model, which requires only target compounds as input, outperforms state-of-the-art methods on the PaRoutes dataset with 1.9x and 3.1x improvements in Top-1 accuracy on the n1 and n5 test sets, respectively. Providing additional information, such as the desired number of steps and starting materials, enables both a reduction in model size and an increase in accuracy, highlighting the benefits of incorporating more constraints into the prediction process. The top-performing DMS-Flex (Duo) model scores 25-50% higher on Top-1 and Top-10 accuracies for both n1 and n5 sets. Additionally, our models successfully predict routes for the FDA-approved drugs not included in the training data, demonstrating strong generalization capabilities. While the limited diversity of the training set may affect performance on less common reaction types, our multistep-first approach presents a promising direction toward fully automated retrosynthetic planning.
2025-03-07JOURNAL OF ORGANIC CHEMISTRY
Development of a Synthetic Route to Vonoprazan via Atom Transfer Radical Cyclization
Article
作者: Komori, Tatsuya ; Nishiguchi, Shigenobu ; Doi, Nobuyoshi ; Ojima, Ken-ichi ; Nishikawa, Toru ; Imaizumi, Ryoya
In this Note, a new synthetic route to vonoprazan via atom transfer radical cyclization (ATRC) is described. The pivotal 1,3,5-trisubstituted pyrrole ring of vonoprazan has been accomplished by ATRC, the subsequent aromatization which simultaneously occurred with the introduction of N-methylamine moiety into the cyclic imine, and the sulfonylation at the 1-position of pyrrole. Furthermore, our approach enabled the synthesis of vonoprazan on a 0.7 kg scale without the isolation of intermediates throughout the process.
100 项与 醋酸沃诺拉赞 相关的药物交易
登录后查看更多信息
外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 消化性溃疡出血 | 申请上市 | 中国 | 2025-03-19 | |
| 十二指肠溃疡 | 临床2期 | 中国 | 2022-07-22 | |
| 十二指肠溃疡 | 临床2期 | 中国 | 2022-07-22 | |
| 出血 | 临床2期 | 中国 | 2022-07-22 | |
| 出血 | 临床2期 | 中国 | 2022-07-22 | |
| 上消化道出血 | 临床2期 | 中国 | 2022-07-22 | |
| 上消化道出血 | 临床2期 | 中国 | 2022-07-22 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用