1) 评价注射用D(-)磺苄西林钠在健康受试者中单次和多次给药的安全性、耐受性和药代动力学特征，为II期临床试验给药方案提供安全剂量范围，为制定合理的临床方案提供依据。 2）比较注射用D(-)磺苄西林钠和含有相同D(-)磺苄西林钠剂量的注射用磺苄西林钠在健康受试者中单次给药的药代动力学特征和尿药排泄情况。

开始日期-

申办/合作机构

湖南三清药业有限公司

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100 项与磺苄西林钠相关的临床结果

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100 项与磺苄西林钠相关的转化医学

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100 项与磺苄西林钠相关的专利（医药）

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154

项与磺苄西林钠相关的文献（医药）

2022-02-01·Journal of Pharmaceutical and Biomedical Analysis3区 · 医学

Analysis of polymerized impurities in mezlocillin sodium and sulbenicillin sodium using two chromatographic separation mechanisms coupled to tandem mass spectrometry

3区 · 医学

Article

作者: Zhou, Ping ; Tang, Kaixian ; Ren, Xiaojuan ; Wang, Jian

To effectively control the polymerized impurities in mezlocillin sodium and sulbenicillin sodium, a HPSEC method with TSK-gel G2000SWxl column and a RP-HPLC method with C18 analytical column were established to replace the classical gel filtration chromatography with Sephadex G-10 gel as stationary phase. By studying the chromatographic behavior of polymerized impurities in both methods with different chromatographic separation mechanisms, the polymerized impurities in mezlocillin sodium and sulbenicillin sodium were separated and detected effectively. The column switching two-dimension liquid chromatography ion trap/time-of-flight mass spectrometry was applied to characterize the structures of polymerized impurities eluted from the HPSEC method and RP-HPLC method for both drugs. The structures of the polymerized impurities in mezlocillin sodium and sulbenicillin sodium were deduced based on the MSⁿ data. The results showed that the polymerized impurities detected by HPSEC method and RP-HPLC method were completely different. Therefore, two methods should be used meanwhile to control the polymerized impurities in mezlocillin sodium and sulbenicillin sodium.

2020-12-01·Microbiology4区 · 生物学

MexXY RND pump of Pseudomonas aeruginosa PA7 effluxes bi-anionic β-lactams carbenicillin and sulbenicillin when it partners with the outer membrane factor OprA but not with OprM

4区 · 生物学

Article

作者: Singh, Manu ; Sykes, Ellen M. E. ; Li, Yanqi ; Kumar, Ayush

Antibiotic resistance in

Pseudomonas aeruginosa

is a serious concern in healthcare systems. Among the determinants of antibiotic resistance in

P. aeruginosa

, efflux pumps belonging to the resistance–nodulation–division (RND) family confer resistance to a broad range of antibacterial compounds. The MexXY efflux system is widely overexpressed in

P. aeruginosa

isolates from cystic fibrosis (CF) patients. MexXY can form functional complexes with two different outer membrane factors (OMFs), OprA and OprM. In this study, using state-of-the-art genetic tools, the substrate specificities of MexXY–OprA and MexXY–OprM complexes were determined. Our results show, for the first time, that the substrate profile of the MexXY system from

P. aeruginosa

PA7 can vary depending on which OM factor (OprM or OprA) it complexes with. While both MexXY–OprA and MexXY–OprM complexes are capable of effluxing aminoglycosides, the bi-anionic β-lactam molecules carbenicillin and sulbenicillin were found to only be the substrate of MexXY–OprA. Our study therefore shows that by partnering with different OMF proteins MexY can expand its substrate profile.

2017-10-01·Medicine4区 · 医学

Amputation of the first metatarsophalangeal joint due to a giant gouty tophi

4区 · 医学

ArticleOA

作者: Zhou, Chenchen ; Wang, Wutao ; Xue, Cheng ; Wang, Yi ; Xu, Yanqiu ; Huang, Fang ; Yang, Bo

RATIONALEThe first metatarsophalangeal joint (MTP1) is the most frequent site of gouty tophi. We report an unusual case with a giant skin-perforating tophi. This is the first case of gouty tophi at MTP1 which accepts surgical debulking and amputation.PATIENT CONCERNSA 42-year-old man presented with a seven-year history of gout and a giant tophi at MTP1. The patient was referred to hospital due to persistent pain and ulcerations on the surface of the left MTP1. This rounded, giant, swelling, tophaceous tophi severely interfered with his normal walking.DIAGNOSESThe patient was diagnosed with gouty arthritis seven years ago, and did not receive regular anti-gout treatments.OUTCOMESBiochemical examination showed he had raised serum uric acid (SUA, 11.92 mg/dl) and creatinine (258 μmol/l). There was a severe joint destruction of MTP1 by X-ray examination. We controlled the skin infection by sulbenicillin. He was given febuxostat to reduce SUA. After 3 months of treatment, SUA fell to 6.8 mg/dl. Then we performed surgical debulking of MTP1 and amputation of hallux. Surgical operations obviously relieved the pain, and improved the function of his left foot. The visual closure after amputation was good.CONCLUSIONSurgical amputation of the gout lesion at MTP1 maximized the function, and reduced the pain of this patient. In the case of giant tophi with severe gouty arthritis or skin infections, surgical decisions need to weigh gains and losses carefully.

100 项与磺苄西林钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01489	磺苄西林钠	J01CA16	DB13693

研发状态

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适应症	国家/地区	公司	日期
复杂的皮肤和软组织感染	中国	湖南尔康制药股份有限公司	1985-01-01
肺炎	中国	湖南尔康制药股份有限公司	1985-01-01
脓毒症	中国	湖南尔康制药股份有限公司	1985-01-01
泌尿道感染	中国	湖南尔康制药股份有限公司	1985-01-01
细菌感染	日本	Takeda Pharmaceutical Co., Ltd.	1972-08-10

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适应症	最高研发状态	国家/地区	公司	日期
软组织感染	临床2期	中国	湖南三清药业有限公司	2019-07-17
软组织感染	临床2期	中国	长沙市华美医药科技有限公司	2019-07-17