Program of ipragliflozin for endothelial dysfunction in chronic kidney disease and type 2 diabetes: a multicenter, randomized-controlled, open-label trial - PROCEED

开始日期2020-03-26

申办/合作机构-

JPRN-jRCTs031190022

/ Completed临床4期IIT

Switching sitagliptin to ipragliflozin in obese patients with type 2 diabetes mellitus who have inadequate glycemic control with sitagliptin - IPRA-SWITCH

开始日期2019-06-24

申办/合作机构-

JPRN-UMIN000035555

/ RecruitingN/AIIT

Efficacy and Safety of SGLT2 Inhibitor Ipragliflozin in with Type 1 Diabetes patients using FGM - Efficacy and Safety of SGLT2 Inhibitor Ipragliflozin in with Type 1 Diabetes patients using FGM

开始日期2019-02-01

申办/合作机构-

100 项与伊格列净L-脯氨酸盐相关的临床结果

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100 项与伊格列净L-脯氨酸盐相关的转化医学

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100 项与伊格列净L-脯氨酸盐相关的专利（医药）

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303

项与伊格列净L-脯氨酸盐相关的文献（医药）

2025-11-01·AACE endocrinology and diabetes

Evaluating the Comparative Effectiveness of Sodium-Glucose Transporter 2 Inhibitors (SGLT-2i) on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease: A Comprehensive Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials

Review

作者: Khalil, Ibrahim ; Hossain, Md Imran ; Akter, Mahmuda

Objective:

This study aimed to conduct the first network meta-analysis (NMA) comparing the effectiveness of sodium-glucose transporter 2 (SGLT-2) inhibitors-dapagliflozin, empagliflozin, and ipragliflozin-in improving liver-related and metabolic outcomes in patients with nonalcoholic fatty liver disease (NAFLD), utilizing a robust Bayesian NMA framework.

Methods:

We conducted a systematic review and Bayesian NMA of randomized controlled trials (RCTs) up to December 31, 2024, following Preferred Reporting Items for Systematic Reviews and Network Meta-Analyses guidelines. Databases (PubMed, Cochrane Library, Scopus, Embase) were searched for RCTs involving NAFLD patients (with or without type 2 diabetes) treated with SGLT-2 inhibitors versus placebo/standard treatments. Outcomes included alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, fibrosis-4 score, body weight, and fasting plasma glucose. A random-effects Bayesian NMA was performed using a Markov Chain Monte Carlo method, with treatments ranked via Surface Under the Cumulative Ranking Curve (SUCRA) scores.

Results:

Eleven RCTs (805 patients) were included. Dapagliflozin led in alanine aminotransferase (mean difference [MD]: -11.35 IU/L, 95% CrI: -18.39 to -4.19, SUCRA: 84.87%), aspartate aminotransferase (MD: -7.96 IU/L, 95% CrI: -15.69 to -0.18, SUCRA: 81.70%), and body weight reduction (MD: -3.60 kg, 95% CrI: -5.92 to -1.64, SUCRA: 88.88%). Ipragliflozin excelled in gamma-glutamyl transferase (MD: -15.19 IU/L, 95% CrI: -31.25 to -2.11, SUCRA: 81.35%) and fasting plasma glucose reduction (MD: -2.20 mmol/L, 95% CrI: -9.88 to 5.30, SUCRA: 59.79%). Empagliflozin topped fibrosis-4 score reduction (MD: -0.12, 95% CrI: -0.42 to 0.13, SUCRA: 73.27%).

Conclusion:

SGLT-2 inhibitors significantly improve liver and metabolic outcomes in NAFLD, with dapagliflozin, ipragliflozin, and empagliflozin offering distinct benefits, supporting personalized treatment strategies.

2025-11-01·CURRENT TOPICS IN MEDICINAL CHEMISTRY

Exploring SGLT2 Inhibitors' Activity in Breast Cancer: An Overview

Review

作者: Gurav, Shailendra S. ; Maldhure, Gayatri S ; Labhade, Sonali D. ; Bhole, Ritesh P. ; Kapare, Harshad

Sodium‒glucose cotransporter 2 (SGLT2) inhibitors have become viable therapeutic options for treating breast cancer. Diabetes is the primary source of these medications. This research examines how SGLT2 blockers can induce apoptosis, decrease the amount of glucose taken up by cancer cells, and modify key signaling pathways, such as the PI3K/AKT/mTOR and MAPK pathways. The effects of four different SGLT2 inhibitors on breast cancer cells were investigated in this study via both in vitro and in vivo testing: dapagliflozin, ipragliflozin, canagliflozin, and empagliflozin. The potential synergistic effects of these inhibitors with conventional chemotherapy medications were also examined. This review explores the complex relationship between SGLT2 inhibitors and breast cancer, examining how drugs interact with this disease at various stages of its development. Additionally, this study highlights how SGLT2 inhibitors may be used in conjunction with precision medicine techniques to treat breast cancer. Although encouraging outcomes have been noted, this review highlights the necessity of additional clinical studies to evaluate the safety and effectiveness of SGLT2 blockers in patients with breast cancer, in addition to ongoing research into the molecular mechanisms underlying the anticancer effects of these drugs.

2025-08-01·DIABETES OBESITY & METABOLISM

Comparative efficacy and safety of oral hypoglycaemic drugs as adjunctive therapy in the management of type 1 diabetes mellitus: A systematic review and meta‐analysis

Review

作者: Luo, Xia ; Wu, Dong ; Wang, Xiaowu ; Liu, Qiao

Abstract:

Aims:

To evaluate the efficacy and safety of oral hypoglycaemic drugs (OHDs) as an adjunct to insulin therapy in patients with type 1 diabetes mellitus (T1DM), addressing the need for optimized glycaemic control and reduced insulin dependency.

Materials and Methods:

A systematic literature search was conducted across PubMed, Embase and the Cochrane Library to identify randomized clinical trials (RCTs) published up to October 31, 2024. Primary outcomes included changes in glycated haemoglobin (HbA1c) and hypoglycaemia risk. Secondary endpoints assessed six efficacy and seven safety measures using meta‐analysis. Treatment effects were quantified using weighted mean difference (WMD) and risk ratios (RRs) with 95% confidence intervals (CIs). Subgroup and indirect comparisons were performed to explore variations across patient demographics and drug classes.

Results:

The meta‐analysis included 51 RCTs with 8664 participants. Overall, compared with placebo, OHDs demonstrated significant reductions in HbA1c (WMD −0.32%, p < 0.001), fasting plasma glucose (WMD −0.91 mmol/L, p < 0.001), postprandial plasma glucose (WMD −2.08 mmol/L, p < 0.001), daily insulin dosage(WMD −4.88 IU/day, p < 0.001) and body weight (WMD −1.89 kg, p < 0.001), while improving the percentage time in the target glucose range of 3.9–10.0 mmol/L (WMD 6.04%, p = 0.04). However, no significant change was observed in BMI (WMD −0.18 kg/m 2 , p = 0.08). Compared with placebo, OHDs did not increase the risk of hypoglycaemia (RR 1.01, p = 0.08), severe hypoglycaemia (RR 0.95, p = 0.73) or nocturnal hypoglycaemia (RR 0.97, p = 0.24), but were associated with elevated risks of serious adverse events (RR 1.30, p = 0.005), discontinuation due to adverse events (RR 1.88, p < 0.001), genital tract infection (RR 3.30, p < 0.001), gastrointestinal side effects (RR 1.98, p < 0.001) and ketoacidosis (RR 3.14, p < 0.001). Indirect comparisons favoured alpha glucosidase inhibitor (AGI) over thiazolidinediones for HbA1c reduction (mean difference −0.46%, p < 0.001). Subgroup analysis revealed greater fasting glucose reduction in adults compared to children/adolescents (WMD −1.15 mmol/L vs. −0.26 mmol/L, p of group difference = 0.02).

Conclusions:

OHDs as adjunctive therapy in T1DM significantly improve glycaemic control and reduce insulin requirements. However, their use is associated with notable safety concerns, particularly ketoacidosis and other adverse events. Clinicians must conduct thorough risk assessments and tailor treatment plans to individual patient profiles to balance efficacy and safety. Future research should focus on long‐term outcomes and strategies to mitigate adverse effects.

项与伊格列净L-脯氨酸盐相关的新闻（医药）

2026-04-11

·CVDAILY

全球糖尿病速递（第101期）｜T2DM房颤消融、农民工与当地居民的缺血性卒中、温度和湿度对糖尿病患者舌色影响分析

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至04月11日15点59分，近期共有 526 本期刊发布了 1043 篇文章，其中糖尿病相关的文章共 331 篇，覆盖 36 个领域的内容。中国专家参与发表的文章有 84 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。今日头条 Headlines 01 Irish journal of medical science IF: 01.600 2型糖尿病患者心房颤动消融：心房快速性心律失常复发及不良心血管事件的长期随访研究 Ardıç, Mustafa Lütfullah, Cetin, Abdullah Eren, Ozdemir, Hasan Burak, Koca, Fadime, Sumbul, Hilmi Erdem, Koc, Mevlut, etc. 一项最新发表的研究显示，2型糖尿病（T2DM）是接受冷冻球囊消融（CBA）治疗心房颤动（AF）患者心房快速性心律失常复发及不良心血管事件的重要独立危险因素。研究回顾性分析了2013年至2023年间接受CBA治疗的748例阵发性AF患者，其中26%患有T2DM。结果显示，T2DM组患者心房快速性心律失常复发率（24% vs. 15%，P=0.004）和心血管事件发生率（33% vs. 9%，P=0.045）均显著高于非T2DM组。多因素分析发现，左心房直径（LAd）和T2DM独立预测心房快速性心律失常复发，而男性性别、T2DM、CHA₂DS₂-VASc评分及尿酸水平则独立预测心血管事件。研究结论指出，T2DM是影响CBA治疗AF长期效果的关键因素，综合管理T2DM对改善CBA治疗结局至关重要。该研究由Mustafa Lütfullah Ardıç等学者完成，为糖尿病患者AF治疗提供了新的风险管控方向。本文由韩玉莲编辑扫描二维码查看源文 Irish journal of medical science | Ahead of Print. 10.1007/s11845-026-04380-5 02 Neuroepidemiology IF: 04.000 中国舟山群岛农民工与当地居民缺血性卒中的流行病学模式：一项横断面研究 Li, Ling, Xu, Yiwei, Liu, Jingjing, Dong, Jiaoxuan, He, Songbin, Dai, Fangyu, etc. 在线发表的中国舟山群岛横断面研究，分析了农民工与当地居民缺血性卒中的流行病学模式及临床特征差异。舟山群岛作为城市化群岛，农民工群体心血管疾病风险受关注，本研究旨在明确其缺血性卒中特点。研究纳入1006例缺血性卒中患者，其中452例为农民工，554例为当地居民。团队收集临床及影像学数据，采用t检验/非参数检验、卡方检验、二元logistic回归等方法对比两组患者特征，统计显著性设定为P<0.05。结果显示，与当地居民相比，农民工患者体重指数更高，超重/肥胖比例显著升高；糖尿病和房颤发病率更低。实验室指标中，农民工淋巴细胞、尿酸、叶酸及维生素B12水平更低。影像学方面，两组病因分类无差异，但农民工基底节梗死发生率更高（P<0.05）。结论指出，农民工缺血性卒中临床特征与当地居民不同，表现为更高BMI、超重/肥胖比例及基底节梗死发生率，更低糖尿病和房颤发病率。提示城市化群岛环境中需针对农民工开展针对性预防性医疗干预。本文由韩玉莲编辑扫描二维码查看源文 Neuroepidemiology | Ahead of Print. 10.1159/000551939 03 Frontiers in endocrinology IF: 04.600 温度和湿度对糖尿病患者舌色的依赖型交互作用：定量分析及中医视角 Zhang, Bingnan, Zhang, Naijin, Ren, Huixia, Li, Yonghui, Du, Haiyan, Ren, Tingjing, etc. 本研究通过对1711名糖尿病患者的多中心回顾性研究，首次量化验证了温度和相对湿度（以11月-次年4月为冷季、5-10月为热季）对舌色的影响。研究将参与者分为无糖尿病、单纯糖尿病、糖尿病合并高血压、糖尿病合并冠心病、糖尿病合并高血压和冠心病五组，采用TFDA-1舌诊仪采集舌色RGB数据（5个部位×3色，共30个指标），并通过多元线性回归分析发现：糖尿病患者舌色与温湿度存在显著交互作用，其中糖尿病合并高血压和冠心病的患者在高温高湿季节（7-8月）舌色显著变红（P<0.0001），而无糖尿病组全年舌色稳定。进一步主成分分析显示，舌体中部R值对温湿度最敏感，且与并发症数量呈剂量反应关系（P<0.05）。这些结果为中医“天人相应”理论提供了现代科学支持，提示舌色可作为高温高湿环境下糖尿病心血管代谢风险的动态生物标志物。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in endocrinology | Volume 17, Issue 10.3389/fendo.2026.1772207 中国发表（84） China Chin J Integr Med IF: 02.500Ahead of Print.No.01Mechanisms of Tianma Gouteng Yin in Treating Hypertension-Associated Vascular Cognitive Impairment: Insights from Experiments, Network Pharmacology, and Molecular Docking天麻钩藤饮治疗高血压相关血管性认知障碍的机制：实验、网络药理学和分子对接的见解DOI: 10.1007/s11655-026-4039-6 Placenta IF: 02.500Ahead of Print.No.02The dynamic interplay between insulin resistance and autophagy: Exploring the coordinated regulation of multiple pathways in the pathogenesis of miscarriage胰岛素抵抗与自噬的动态相互作用：探索流产发病机制中多条通路的协同调控DOI: 10.1016/j.placenta.2026.03.015 IF: 03.700Ahead of Print.No.03Perilipin 5 enhances glycogen storage and mitigates excessive fatty acid oxidation in skeletal muscle to alleviate mitochondrial impairment脂滴包被蛋白5增强骨骼肌糖原储存并减轻过度脂肪酸氧化以缓解线粒体损伤DOI: 10.1016/j.bbamcr.2026.120146 Tissue & cell IF: 02.500Ahead of Print.No.04Antagonism of GPR75 inhibits gestational diabetes mellitus-induced placental tissue injury by preventing activation of the NLRP3 inflammasomeGPR75拮抗剂通过抑制NLRP3炎性小体激活减轻妊娠期糖尿病诱导的胎盘组织损伤DOI: 10.1016/j.tice.2026.103515 Stem cell research & therapy IF: 07.300Ahead of Print.No.05Apoptotic BMSCs reduce grafted islets apoptosis through the holo-Lcn2/Slc22a17/Fe(3+) axis凋亡骨髓间充质干细胞通过holo-Lcn2/Slc22a17/Fe(3+)轴减少移植胰岛的凋亡DOI: 10.1186/s13287-026-05001-9 Diabetes & metabolism IF: 04.700Ahead of Print.No.06BMD: Toward mechanistically-informed and fracture-specific treatment thresholds in diabetic bone disease骨密度：糖尿病性骨病中基于机制和特定骨折类型的治疗阈值DOI: 10.1016/j.diabet.2026.101759 Mol Cell Endocrinol IF: 03.600Ahead of Print.No.07Glucose deprivation impairs lipid tolerance related to mitophagy disorder in cardiomyocytes葡萄糖剥夺损害与心肌细胞线粒体自噬紊乱相关的脂质耐受性DOI: 10.1016/j.mce.2026.112804 Int J Biol Macromol IF: 08.500Ahead of Print.No.08Preparation and performance regulations of ionic cellulose-based glucose semipermeable membranes离子纤维素基葡萄糖半透膜的制备及性能调控DOI: 10.1016/j.ijbiomac.2026.151926 Free radical biology & medicine IF: 08.200Ahead of Print.No.09Echinacoside Improves Antioxidant Responses and Angiogenesis Through Parkin-MFN2-Mediated Mitophagy to Promote Diabetic Wound Healing松果菊苷通过Parkin-MFN2介导的线粒体自噬改善抗氧化反应和血管生成以促进糖尿病创面愈合DOI: 10.1016/j.freeradbiomed.2026.04.012 Brain research bulletin IF: 03.700Ahead of Print.No.10Plasma Exosomal Proteomics: Unveiling Novel Biomarkers for Ischemic Stroke in the Context of Diabetes血浆外泌体蛋白质组学：在糖尿病背景下揭示缺血性卒中的新生物标志物DOI: 10.1016/j.brainresbull.2026.111884 Biomedical materials IF: 03.700Ahead of Print.No.11Multifunctional eutectogel for co-delivery of baicalein and metformin to promote diabetic wound healing多功能共晶凝胶用于黄芩素和二甲双胍的共递送以促进糖尿病伤口愈合DOI: 10.1088/1748-605X/ae5e13 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.12Role of the NF-κB signaling pathway in vascular endothelial cell injury associated with metabolic dysfunction-associated steatotic liver disease under hypoxia缺氧条件下代谢功能障碍相关脂肪性肝病（MASLD）中NF-κB信号通路在血管内皮细胞损伤中的作用DOI: 10.1016/j.bbrc.2026.153710 BMC ophthalmology IF: 01.700Ahead of Print.No.13Effects of anti-VEGF therapy on choroidal thickness in eyes with diabetic macular edema抗VEGF治疗对糖尿病黄斑水肿患者眼脉络膜厚度的影响DOI: 10.1186/s12886-026-04811-y J Ocul Pharmacol Ther IF: 02.100Ahead of Print.No.14SDF-1 Inhibition Attenuates VEGF-Driven Retinal Leukostasis and Neovascularization in Ischemic RetinopathySDF-1抑制减轻缺血性视网膜病变中VEGF驱动的视网膜白细胞滞留和新生血管形成DOI: 10.1177/10807683261441054 Acta pharmaceutica IF: 01.400Ahead of Print.No.15Pelargonidin protects retinal ganglion cells in a streptozotocin-induced diabetic rat model by reducing intraocular pressure, suppressing TGF-β and activating JAK2/STAT3 signalling pathway天竺葵素通过降低眼内压、抑制TGF-β并激活JAK2/STAT3信号通路在链脲佐菌素诱导的糖尿病大鼠模型中保护视网膜神经节细胞DOI: 10.2478/acph-2026-0010 Lipids in health and disease IF: 04.200Ahead of Print.No.16Comparative effects of central adiposity and BMI trajectories on cardiometabolic diseases in Chinese adults: a longitudinal cohort study中国成年人中心性肥胖与BMI轨迹对心血管代谢疾病的比较影响：一项纵向队列研究DOI: 10.1186/s12944-026-02948-9 Lipids in health and disease IF: 04.200Ahead of Print.No.17Assessment of BMI percentages of obesity thresholds and cardiometabolic risk factors in children and adolescents: a retrospective cross-sectional study in Beijing北京儿童青少年肥胖阈值BMI百分比及心血管代谢危险因素评估：一项回顾性横断面研究DOI: 10.1186/s12944-026-02940-3 BMC pediatrics IF: 02.000Ahead of Print.No.18Association between low-carbohydrate diet score and childhood obesity: a national population-based study低碳水化合物饮食评分与儿童肥胖的关联：一项全国性人群研究DOI: 10.1186/s12887-026-06835-1 BMC geriatrics IF: 03.800Ahead of Print.No.19Sarcopenic obesity definitions and their association with cardiovascular disease and mortality肌少症肥胖的定义及其与心血管疾病和死亡率的关联DOI: 10.1186/s12877-026-07433-7 Nature communications IF: 15.700Ahead of Print.No.20Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice亮氨酸分解代谢酶AUH通过PPARγ的HMG化修饰和RNA结合功能调控雄性小鼠棕色脂肪组织产热DOI: 10.1038/s41467-026-71581-y Int J Oral Sci IF: 12.200Volume 18, Issue 1No.21The structure and function of taste G protein-coupled receptors and their implications in diseases味觉G蛋白偶联受体的结构、功能及其在疾病中的意义DOI: 10.1038/s41368-026-00436-5 J Int Med Res IF: 01.500Volume 54, Issue 4No.22Association between cardiometabolic index and high-sensitivity C-reactive protein: A cross-sectional study from National Health and Nutrition Examination Survey 2015 to 2018心脏代谢指数与高敏C反应蛋白的关联：基于2015-2018年美国国家健康与营养检查调查的横断面研究DOI: 10.1177/03000605261436654 Environmental pollution IF: 07.300Ahead of Print.No.23Gender-Specific Association between Household Cooking Oil Fume exposure and Small Airway Dysfunction in China: a national cross-sectional study中国家庭烹饪油烟暴露与小气道功能障碍的性别特异性关联：一项全国性横断面研究DOI: 10.1016/j.envpol.2026.128094 IF: 03.700Ahead of Print.No.24FTO-mediated m6A demethylation inhibits bladder cancer progression via decreasing EMG1 and reducing ribosome biosynthesisFTO介导的m6A去甲基化通过降低EMG1和减少核糖体生物合成抑制膀胱癌进展DOI: 10.1016/j.bbamcr.2026.120147 JCTS IF: 01.500Ahead of Print.No.25de Winter-like anterior electrocardiographic changes coexisting with inferior ST-elevation myocardial infarction: a case report and literature insight类似De Winter型前壁心电图改变并存下壁ST段抬高型心肌梗死：病例报告及文献解读DOI: 10.1186/s13019-026-04031-x BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.26Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review孕妇甲状腺功能与孕妇及后代不良结局的关联：来自总览综述的证据DOI: 10.1186/s12884-026-09024-1 Phytomedicine IF: 08.300Ahead of Print.No.27Amygdalin alleviates MAFLD via inhibiting cytoplasmic calcium ion overload-induced liver sinusoidal endothelial cell defenestration苦杏仁苷通过抑制细胞质钙离子超载诱导的肝血窦内皮细胞窗孔缺失来缓解代谢功能障碍相关脂肪性肝病DOI: 10.1016/j.phymed.2026.158135 Food chemistry IF: 09.800Ahead of Print.No.28Deciphering the molecular mechanism of DPP-IV inhibition by quinoa-derived peptides: Insights from kinetics, spectroscopy, and in silico perspectives破译藜麦来源肽对DPP-IV抑制的分子机制：来自动力学、光谱学和计算机模拟视角的见解DOI: 10.1016/j.foodchem.2026.149169 Phytomedicine IF: 08.300Ahead of Print.No.29Integrated analysis of network pharmacology and multi-omics reveals the mechanisms of Zuogui Jiangtang Qinggan formula ameliorates MASLD via fatty acid metabolic reprogramming网络药理学与多组学整合分析揭示左归丸降糖清肝方通过脂肪酸代谢重编程改善代谢功能障碍相关脂肪性肝病的机制DOI: 10.1016/j.phymed.2026.158128 Medicine IF: 01.400Volume 105, Issue 15No.30Visceral adipose tissue and risk of kidney stones: Evidence from NHANES 2011-2018 and Mendelian randomization analysis内脏脂肪组织与肾结石风险：来自NHANES 2011-2018的数据及孟德尔随机化分析的证据DOI: 10.1097/MD.0000000000048216 Medicine IF: 01.400Volume 105, Issue 15No.31Body fat percentage and hypertension risk: A population-based observational and Mendelian randomization study体脂率与高血压风险：一项基于人群的观察性及孟德尔随机化研究DOI: 10.1097/MD.0000000000048262 Medicine IF: 01.400Volume 105, Issue 15No.32The potential of 8 insulin resistance indicators as biomarkers for predicting gallstone risk in American adults: A cross-sectional NHANES study8种胰岛素抵抗指标作为美国成年人胆结石风险预测生物标志物的潜力：一项横断面NHANES研究DOI: 10.1097/MD.0000000000048229 Medicine IF: 01.400Volume 105, Issue 15No.33Celiac disease increases the risk of pulmonary arterial hypertension: A multivariable Mendelian randomization and mediation analysis乳糜泻增加肺动脉高压风险：一项多变量孟德尔随机化与中介分析DOI: 10.1097/MD.0000000000048334 Medicine IF: 01.400Volume 105, Issue 15No.34Association between urinary cadmium exposure and metabolic syndrome and the mediating role of thyroid dysfunction: NHANES 2007 to 2012尿镉暴露与代谢综合征的关联及甲状腺功能障碍的中介作用：2007-2012年NHANES研究DOI: 10.1097/MD.0000000000048230 Medicine IF: 01.400Volume 105, Issue 15No.35Diabetes, obesity, hyperlipidemia, and sudden sensorineural hearing loss: A bidirectional and multivariable Mendelian randomization study糖尿病、肥胖、高脂血症与突发性感音神经性听力损失：一项双向多变量孟德尔随机化研究DOI: 10.1097/MD.0000000000048255 Medicine IF: 01.400Volume 105, Issue 15No.36Nicotine metabolite ratio and clinically significant depressive symptoms in U.S. adults: A smoker-specific association美国成年人的尼古丁代谢物比率与具有临床意义的抑郁症状：吸烟者特异性关联研究DOI: 10.1097/MD.0000000000048186 Medicine IF: 01.400Volume 105, Issue 15No.37Urinary bladder obstruction caused by fungal balls: Unusual computed tomography findings - a case report真菌球导致的膀胱梗阻：不寻常的CT表现——病例报告DOI: 10.1097/MD.0000000000048244 Medicine IF: 01.400Volume 105, Issue 15No.38Association between serum dehydroepiandrosterone sulfate and type 2 diabetes in US adults with adiposity as a mediator血清脱氢表雄酮硫酸盐与美国成年人2型糖尿病的关联（以肥胖为中介）DOI: 10.1097/MD.0000000000048280 Medicine IF: 01.400Volume 105, Issue 15No.39Association between the endothelial activation and stress index and cardiometabolic multimorbidity: Results from the NHANES 2003 to 2020内皮激活和应激指数与心脏代谢共病的关联：来自美国国家健康与营养检查调查2003-2020的结果DOI: 10.1097/MD.0000000000048226 Journal of robotic surgery IF: 03.000Volume 20, Issue 1No.40Robotic versus laparoscopic surgery for rectal cancer in overweight and obese patients: pathological outcomes, complications, and trial sequential analysis超重和肥胖患者直肠癌的机器人手术与腹腔镜手术：病理结果、并发症及试验序贯分析DOI: 10.1007/s11701-026-03394-6 Singapore Medical Journal IF: 01.900Ahead of Print.No.41Metabolic dysfunction-associated steatotic liver disease in Asia: implications on management亚洲代谢功能障碍相关脂肪性肝病：对管理的影响DOI: 10.4103/singaporemedj.SMJ-2025-167 J Mol Neurosci IF: 02.700Volume 76, Issue 2No.42Clinical Study on the Combined Use of Tadalafil and Epalrestat in the Treatment of Diabetic Neurovascular Erectile Dysfunction他达拉非与依帕司他联合使用治疗糖尿病神经血管性勃起功能障碍的临床研究DOI: 10.1007/s12031-026-02504-1 The FASEB journal : IF: 04.200Volume 40, Issue 8No.43BGP-15 Mitigates Oxidative Stress and Mitochondrial Dysfunction in In Vitro Matured Oocytes From Type 1 Diabetic MiceBGP-15缓解1型糖尿病小鼠体外成熟卵母细胞中的氧化应激和线粒体功能障碍DOI: 10.1096/fj.202505013RR Ophthalmology and therapy IF: 03.200Ahead of Print.No.44Efficacy, Durability, and Safety of Faricimab for Diabetic Macular Edema: 1-Year Results from the China RHINE SubpopulationFaricimab治疗糖尿病黄斑水肿的有效性、持久性及安全性：中国RHINE亚组的1年结果DOI: 10.1007/s40123-026-01378-1 J Bioenerg Biomembr IF: 03.000Volume 58, Issue 1No.45USF1 transcriptionally activates TRIM55 to promote diabetic cardiomyopathy progression by enhancing HSPB1 protein degradationUSF1通过转录激活TRIM55促进糖尿病心肌病进展（增强HSPB1蛋白降解）DOI: 10.1007/s10863-026-10107-z The FASEB journal : IF: 04.200Volume 40, Issue 8No.46CTNNB1 Genetic Variation and Its Interaction With DLK1 in Type 2 Diabetes MellitusCTNNB1基因变异及其与DLK1在2型糖尿病中的相互作用DOI: 10.1096/fj.202600107R Renal failure IF: 03.000Volume 48, Issue 1No.47Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis白藜芦醇通过降低氧化应激、炎症和凋亡抑制糖尿病肾缺血再灌注损伤DOI: 10.1080/0886022X.2026.2652103 JCBFM IF: 04.500Ahead of Print.No.48Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population普通人群中脑小血管病负担通过淀粉样蛋白清除受损与认知衰退相关DOI: 10.1177/0271678X261437577 Frontiers in public health IF: 03.400Volume 14, Issue No.49High rate of marginal vitamin A deficiency in children aged 0-6 years in Quanzhou, China: a cross-sectional study中国泉州0-6岁儿童维生素A边缘性缺乏高患病率：一项横断面研究DOI: 10.3389/fpubh.2026.1727761 Frontiers in nutrition IF: 05.100Volume 13, Issue No.50CT-assessed abdominal visceral adiposity and MASLD: a sex-stratified cross-sectional analysis性别分层及非线性分析：腹部脂肪分布与代谢功能障碍相关脂肪性肝病（MASLD）的关联DOI: 10.3389/fnut.2026.1750470 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51The impact of bariatric surgery on male sexual function: a systematic review and meta-analysis减重手术对男性性功能的影响：一项系统综述与荟萃分析DOI: 10.3389/fendo.2026.1798050 Renal failure IF: 03.000Volume 48, Issue 1No.52Emerging roles of ATP citrate lyase in kidney diseases: from pathogenic driver to therapeutic target三磷酸腺苷柠檬酸裂合酶在肾脏疾病中的新兴作用：从致病驱动因素到治疗靶点DOI: 10.1080/0886022X.2026.2652826 J Health Popul Nutr IF: 02.800Ahead of Print.No.53Obesity, physical activity, and gene-environment interactions: a natural experiment framework肥胖、体力活动与基因-环境相互作用：一种自然实验框架DOI: 10.1186/s41043-026-01312-y Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations between lipid-derived indices and cardiovascular-kidney-metabolic syndrome progression among Chinese middle-aged and elderly adults: a longitudinal study脂质衍生指标与心血管-肾脏-代谢综合征患者心血管疾病风险的关系：一项回顾性队列研究DOI: 10.3389/fnut.2026.1742974 Frontiers in pediatrics IF: 02.000Volume 14, Issue No.55Risk factors for necrotizing enterocolitis in preterm infants: a 1:1 matched case-control study早产儿坏死性小肠结肠炎的危险因素：一项回顾性队列研究DOI: 10.3389/fped.2026.1807022 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.56The effect of continuous glucose monitoring on neonatal outcomes in pregnant women with diabetes合并糖尿病的妊娠中持续葡萄糖监测：随机对照试验的系统综述与荟萃分析DOI: 10.3389/fendo.2026.1815133 China CDC weekly IF: 02.900Volume 8, Issue 10No.57Association Between Longitudinal Serum Ferritin and Gestational Diabetes Mellitus - Beijing, Shanxi, and Shandong PLADs, China, 2021-2024中国人群中孕早期和孕中期血清铁蛋白与妊娠糖尿病的关联：一项多中心前瞻性队列研究DOI: 10.46234/ccdcw2026.044 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.58Association of mid-pregnancy remnant cholesterol levels with adverse pregnancy outcomes in women with gestational diabetes mellitus妊娠期糖尿病女性妊娠中期残余胆固醇水平与不良妊娠结局的关联DOI: 10.1186/s12884-026-09031-2 Journal of pregnancy IF: 02.200Volume 2026, Issue 1No.59A Qualitative Study on TPB-Based Factors for Breastfeeding Cessation in Women With Gestational Diabetes Mellitus in the Early Postpartum Period一项基于计划行为理论（TPB）的妊娠期糖尿病女性产后早期母乳喂养中断因素的定性研究DOI: 10.1155/jp/5369691 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60ChatGPT-5 versus other mainstream large language models in core diabetic retinopathy patient queries五种主流大语言模型在糖尿病视网膜病变健康教育和患者分诊中的比较分析DOI: 10.3389/fcell.2026.1754221 Materials today bio IF: 10.200Volume 38, Issue No.61Glucose modulates macrophage polarization via glycating adsorbed albumin on titanium葡萄糖通过钛表面糖化吸附白蛋白调节巨噬细胞极化DOI: 10.1016/j.mtbio.2026.103047 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.62The influence of tranexamic acid on intraoperative blood transfusion in short-segment PLIF and analysis of influencing factors of the transfusion: a retrospective case study氨甲环酸减少短节段腰椎椎间孔融合术中失血和输血：一项回顾性研究DOI: 10.3389/fphar.2026.1736382 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.63Helicobacter pylori infection is independently associated with triglyceride levels: a propensity score-matched cross-sectional study幽门螺杆菌感染与甘油三酯水平独立相关：一项倾向评分匹配的横断面研究DOI: 10.3389/fendo.2026.1792530 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.64Prevalence, risk factors, and early prediction of cognitive impairment in patients with diabetes mellitus: a systematic review and meta-analysis糖尿病患者认知障碍的系统综述与荟萃分析DOI: 10.3389/fendo.2026.1757367 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Temperature and humidity-dependent interaction effects on tongue color in diabetic patients: a quantitative analysis and TCM perspective温度和湿度对糖尿病患者舌色的依赖型交互作用：定量分析及中医视角DOI: 10.3389/fendo.2026.1772207 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Efficacy and safety of different anti-VEGF agents combined with pars plana vitrectomy in proliferative diabetic retinopathy: a systematic review and network meta-analysis of randomized controlled trials抗血管内皮生长因子药物联合经扁平部玻璃体切割术治疗增殖性糖尿病视网膜病变的有效性和安全性：一项网络荟萃分析DOI: 10.3389/fendo.2026.1772351 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Cross-sectional analysis of the association between physical activity and metabolic syndrome in the elderly社区居住老年人中体力活动与代谢综合征的关联：一项横断面研究DOI: 10.3389/fendo.2026.1799367 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.68Real-world performance of open-source large language models in diabetes diagnosis临床糖尿病诊断中的开源大语言模型：亚分型、并发症及提示策略的综合评估DOI: 10.3389/fendo.2026.1747468 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.69Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis增殖性糖尿病视网膜病变亚型（旺炽型vs纤维增生型）表观遗传特征的差异甲基化模式DOI: 10.3389/fendo.2026.1664104 Front Bioeng Biotechnol IF: 04.800Volume 14, Issue No.70Hydroxypropyl methylcellulose stearoxy ether hydrogel loaded with aloe vera peel-derived extracellular vesicle mimetics promotes wound healing in diabetic mice芦荟皮来源细胞外囊泡模拟物通过Sangeose 60L水凝胶递送促进糖尿病伤口愈合DOI: 10.3389/fbioe.2026.1768930 Ophthalmology science IF: 04.600Volume 6, Issue 5No.71Using OCT Angiography to Predict Diabetic Retinopathy Progression and Vision Decline in a Multiethnic CohortOCT血管造影预测糖尿病视网膜病变进展及视力下降的多中心研究DOI: 10.1016/j.xops.2026.101111 Frontiers in immunology IF: 05.900Volume 17, Issue No.72Recent advances in the positive role of Clostridium in autoimmune diseases: as a crucial regulator of restoring immune-metabolic equilibrium有益梭菌及其代谢物在自身免疫性疾病中的作用：综合综述DOI: 10.3389/fimmu.2026.1730351 Frontiers in medicine IF: 03.000Volume 13, Issue No.73Longitudinal associations between treatment adherence patterns and blood pressure control among rural hypertensive patients in Central China: a real-world retrospective cohort study现实世界基层医疗环境中血压控制的时间趋势及预测因素：一项纵向队列研究DOI: 10.3389/fmed.2026.1791265 Chemistry & biodiversity IF: 02.500Volume 23, Issue 4No.74Rapid Identification of Chemical Components and Prediction of Medicinal Value for Blachia Siamensis Leaves暹罗黑面神叶的化学成分快速鉴定及药用价值预测DOI: 10.1002/cbdv.202503300 Zhonghua Wei Zhong Bing Ji Jiu Yi XueVolume 38, Issue 3No.75[Predictive value of the modified Nutrition Risk in Critically Ill Score for intensive care unit mortality risk in septic patients]改良型重症患者营养风险评分（mNUTRIC）对脓毒症患者ICU死亡率风险的预测价值DOI: 10.3760/cma.j.cn121430-20250716-00390 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.76MicroRNA, MicroRNA-lncRNA and MicroRNA-Circular RNA axes, and exosomal MicroRNAs: driving exercise-induced cardioprotection in heart failure运动诱导心脏保护中的非编码RNA：机制、生物标志物及治疗潜力DOI: 10.3389/fcell.2026.1767057 Current opinion in physiology IF: 01.900Volume 46, Issue No.77Caveolin in extracellular vesicles: orchestrating interorgan communication in diabetes-associated cardiovascular disease(☆)窝蛋白在小细胞囊泡中：调控糖尿病相关心血管疾病中的器官间通讯DOI: 10.1016/j.cophys.2025.100862 Journal of oral microbiology IF: 05.500Volume 18, Issue 1No.78Association between oral microbial shifts and polycystic ovary syndrome: a systematic review多囊卵巢综合征中的口腔微生物群失调：系统综述与荟萃分析DOI: 10.1080/20002297.2026.2650921 Frontiers in immunology IF: 05.900Volume 17, Issue No.79Role of Treg cells in diabetes mellitus and association with traditional Chinese medicine: a literature review调节性T细胞（Tregs）在糖尿病及其并发症中的作用：综述DOI: 10.3389/fimmu.2026.1763798 J Cell Mol Med IF: 04.200Volume 30, Issue 7No.80Exploration of the Potential Mechanism of Metal Ion Transport-Related Genes in Myocardial Infarction Based on Transcriptomics基于转录组学探索心肌梗死中金属离子转运相关基因的潜在机制DOI: 10.1111/jcmm.71134 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81The diagnostic value of immune-inflammatory markers for diabetic kidney disease in type 2 diabetic patients: a meta-analysis2型糖尿病患者免疫炎症标志物对糖尿病肾病的诊断价值：一项荟萃分析DOI: 10.3389/fendo.2026.1811189 Zhonghua Wei Zhong Bing Ji Jiu Yi XueVolume 38, Issue 3No.82[Risk factors for critical illness-related corticosteroid insufficiency in sepsis and construction of nomogram prediction model]脓毒症中危重病相关皮质类固醇功能不全的危险因素及列线图预测模型的构建DOI: 10.3760/cma.j.cn121430-20250616-00587 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83Clinical efficacy of combining fenofibrate with statins in patients with diabetes and hyperlipidemia: a meta-analysis非诺贝特与他汀类药物联合治疗糖尿病合并高脂血症患者的Meta分析DOI: 10.3389/fendo.2026.1694928 Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.84Effectiveness of Wearable Devices for Diabetes Management: An Overview of Systematic Reviews and Meta-Analyses可穿戴设备用于糖尿病管理的有效性：系统综述和荟萃分析概述DOI: 10.1155/jdr/1464982 其他发布内容（245） More Published Articles Scientific reports IF: 03.900Ahead of Print.No.01Metformin treatment impairs the adenine nucleotide translocator activity and energy metabolism in human clear cell renal carcinoma cells二甲双胍治疗损害人透明细胞肾癌细胞中的腺嘌呤核苷酸转位酶活性和能量代谢DOI: 10.1038/s41598-026-48200-3 BMC medical imaging IF: 03.200Ahead of Print.No.02Automated MRI-based brain volumetric analysis in women with polycystic ovary syndrome多囊卵巢综合征女性的基于MRI的大脑体积自动分析DOI: 10.1186/s12880-026-02336-w Cell death and disease IF: 09.600Ahead of Print.No.03Fatty acid synthesis supports tumor progression through facilitating the activity of TORC1 signaling脂肪酸合成通过促进TORC1信号通路活性支持肿瘤进展DOI: 10.1038/s41419-026-08738-6 J Nutr Biochem IF: 04.900Ahead of Print.No.04Small litter size attenuates adverse hepatic effects induced by a high-sucrose diet小窝产仔数减少可减轻高蔗糖饮食诱导的肝脏不良影响DOI: 10.1016/j.jnutbio.2026.110372 Metabolism IF: 11.900Ahead of Print.No.05Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation二甲双胍通过抑制蛋白质翻译在ER应激下抑制β细胞凋亡DOI: 10.1016/j.metabol.2026.156607 Chemico-biological interactions IF: 05.400Ahead of Print.No.06Glutathione-deficiency promotes basal hyperinsulinemia in the insulin secreting cell line INS-1 (832/13)谷胱甘肽缺乏促进胰岛素分泌细胞系INS-1 (832/13)的基础高胰岛素血症DOI: 10.1016/j.cbi.2026.112080 BMC chemistry IF: 04.600Ahead of Print.No.07Identification of α-glucosidase inhibitory phytochemicals from Erythrina crista-galli using combined experimental and computational methods采用实验与计算相结合的方法从刺桐（Erythrina crista-galli）中鉴定α-葡萄糖苷酶抑制性植物化学物质DOI: 10.1186/s13065-026-01785-2 JCTS IF: 01.500Ahead of Print.No.08Factors influencing Major lower extremity amputations in Johannesburg影响约翰内斯堡主要下肢截肢的因素DOI: 10.1186/s13019-026-03896-2 Diabetic medicine IF: 03.400Ahead of Print.No.09Acute kidney injury in hospitalised patients with type 2 diabetes: Associations with continuous glucose monitoring-based glucose levels, mortality, and ICU admission住院2型糖尿病患者急性肾损伤：与持续葡萄糖监测血糖水平、死亡率及ICU入院的关联DOI: 10.1111/dme.70321 Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.10Cardiovascular risk prediction in women with gestational diabetes using risk assessment tools: a scoping review妊娠糖尿病女性心血管风险预测：使用风险评估工具的范围综述DOI: 10.1186/s13098-026-02154-8 BMC endocrine disorders IF: 03.300Ahead of Print.No.11Advanced glycation end-products and sclerostin are elevated across diabetes phenotypes and associated with vertebral fractures in type 2 diabetes晚期糖基化终产物和硬骨素在糖尿病表型中升高并与2型糖尿病的椎体骨折相关DOI: 10.1186/s12902-026-02254-6 BMC medicine IF: 08.300Volume 24, Issue 1No.12Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions干预措施预防和治疗生命全程中的多种长期疾病及其后果：概念和定义DOI: 10.1186/s12916-026-04838-4 BMC nephrology IF: 02.400Ahead of Print.No.13Single-kidney transplantation with discarded partner kidney vs. Dual kidney transplantation: results from a national cohort study单肾移植（使用弃用伴侣肾）与双肾移植：一项全国队列研究结果DOI: 10.1186/s12882-026-04945-7 BMC geriatrics IF: 03.800Ahead of Print.No.14Effectiveness and safety of SGLT2 inhibitors in aged patients (≥ 75 Years) with diabetes: a multi-center retrospective cohort studySGLT2抑制剂在≥75岁老年糖尿病患者中的有效性和安全性：一项多中心回顾性队列研究DOI: 10.1186/s12877-026-07446-2 Int J Emerg Med IF: 02.000Ahead of Print.No.15Mortality among patients diagnosed with stroke presenting to remote emergency department in Bhutan - a retrospective study不丹偏远急诊部门就诊的卒中患者死亡率回顾性研究DOI: 10.1186/s12245-026-01227-9 Pediatric nephrology IF: 02.600Ahead of Print.No.16Anthropometric characteristics at birth and growth outcome in patients with X-linked hypophosphatemia treated with oral phosphate and active vitamin DX连锁低磷血症患者口服磷酸盐和活性维生素D治疗的出生人体测量特征及生长结局DOI: 10.1007/s00467-026-07271-0 J Expo Sci Environ Epidemiol IF: 04.700Ahead of Print.No.17Bisphenol S and female reproductive toxicity: a scoping review of human studies双酚S与女性生殖毒性：人类研究的范围综述DOI: 10.1038/s41370-026-00868-5 Pediatric research IF: 03.100Ahead of Print.No.18Antibodies to mannose-binding lectin and factor XI Inhibit Shiga toxin-induced kidney injury additively in a murine model针对甘露聚糖结合凝集素和XI因子的抗体在小鼠模型中对志贺毒素诱导的肾损伤具有叠加抑制作用DOI: 10.1038/s41390-025-04535-7 Scientific reports IF: 03.900Ahead of Print.No.19Comparison of biochemical oxidative stress markers of glucose tolerance tests performed for葡萄糖耐量试验的生化氧化应激标志物比较DOI: 10.1038/s41598-026-45946-8 Nature communications IF: 15.700Ahead of Print.No.20Pervasive non-triplet alternative splicing drives functional isoform diversity普遍的非三联体选择性剪接驱动功能性异构体多样性DOI: 10.1038/s41467-026-71615-5 Nature communications IF: 15.700Volume 17, Issue 1No.21Exposome-wide patterns predict brain health in aging全暴露组模式预测衰老中的大脑健康DOI: 10.1038/s41467-026-71271-9 Cell death and disease IF: 09.600Ahead of Print.No.22EpCAM supports exit from pluripotency of embryonic stem cells via EomesEpCAM通过Eomes支持胚胎干细胞退出多能性DOI: 10.1038/s41419-026-08734-w The Journal of arthroplasty IF: 03.800Ahead of Print.No.23Outcomes Following Supplementary Oral Methylprednisolone Pack After Outpatient Total Knee Arthroplasty: A Matched Cohort Study门诊全膝关节置换术后补充口服甲基泼尼松龙包的预后：一项匹配队列研究DOI: 10.1016/j.arth.2026.03.033 Primary care diabetes IF: 02.300Ahead of Print.No.24Impact of automatic e-consults on use of SGLT2i and GLP-1 RA in rural veterans with type 2 diabetes and chronic kidney disease自动电子咨询对农村退伍军人中2型糖尿病合并慢性肾脏病患者使用SGLT2i和GLP-1 RA的影响DOI: 10.1016/j.pcd.2026.04.004 Can J Ophthalmol IF: 02.800Ahead of Print.No.25Lipemia retinalis: a case study of a rare finding in pediatric retina secondary to diabetes视网膜脂血症：糖尿病继发儿童视网膜罕见表现的病例研究DOI: 10.1016/j.jcjo.2026.03.023 Bone IF: 03.600Ahead of Print.No.26The effect of prior osteoporosis treatment on bone mineral density response to romosozumab既往骨质疏松治疗对罗莫索单抗骨密度反应的影响DOI: 10.1016/j.bone.2026.117892 Int J Biol Macromol IF: 08.500Ahead of Print.No.27Chitosan-starch biodegradable hydrogels incorporating core-shell copper nanoparticles for complex wound healing壳聚糖-淀粉可生物降解水凝胶结合核壳铜纳米颗粒用于复杂伤口愈合DOI: 10.1016/j.ijbiomac.2026.151922 Indian J Med Microbiol IF: 01.300Ahead of Print.No.28Acute post-operative panophthalmitis by Nocardia otitidiscaviarum: A rare presentation耳道诺卡菌引起的急性术后全眼球炎：一种罕见表现DOI: 10.1016/j.ijmmb.2026.101113 Clin Microbiol Infect IF: 08.500Ahead of Print.No.29Pharmacokinetic and Pharmacodynamic Evaluations of Oral Moxifloxacin for Enterococcus faecalis Endocarditis口服莫西沙星对粪肠球菌心内膜炎的药代动力学和药效学评估DOI: 10.1016/j.cmi.2026.04.001 Metabolism IF: 11.900Ahead of Print.No.30When the proteome meets the metabolome observational and Mendelian randomization analyses蛋白质组与代谢组相遇：观察性与孟德尔随机化分析DOI: 10.1016/j.metabol.2026.156602 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.31ADAMDEC1 is not a driver of intestinal fibrosis but a marker of the inflammation-stromal niche in Crohn's diseaseADAMDEC1不是肠道纤维化的驱动因素，而是克罗恩病中炎症-基质微环境的标志物DOI: 10.1016/j.bbrc.2026.153749 Pilot and feasibility studies IF: 01.600Ahead of Print.No.32Conversation cards for pregnancy: a protocol for a multi-method study孕期对话卡片：一项多方法研究方案DOI: 10.1186/s40814-026-01793-y BMC medicine IF: 08.300Ahead of Print.No.33Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses孕产妇大量营养素摄入与妊娠糖尿病：前瞻性观察研究及剂量反应荟萃分析的系统综述DOI: 10.1186/s12916-026-04748-5 BMC medicine IF: 08.300Ahead of Print.No.34Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis全球、区域和国家层面中心性肥胖导致的结直肠癌负担：人群归因分数分析DOI: 10.1186/s12916-026-04858-0 BMC medicine IF: 08.300Volume 24, Issue 1No.35Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes高胰岛素血症为何不利于减肥：来自1型糖尿病的见解DOI: 10.1186/s12916-026-04849-1 Diabetic medicine IF: 03.400Ahead of Print.No.36Receipt of postpartum diabetes screening after gestational diabetes mellitus in the United States, 2016-20222016-2022年美国妊娠糖尿病后产后糖尿病筛查接受情况DOI: 10.1111/dme.70327 J Laparoendosc Adv Surg Tech A IF: 01.100Ahead of Print.No.37Hiatal Hernia Following a Sleeve Gastrectomy袖状胃切除术后的食管裂孔疝DOI: 10.1177/10926429261420529 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.38International expert consensus on definitions and management of weight recurrence and suboptimal response after metabolic and bariatric surgery: a Delphi study国际专家共识：代谢与减重手术后体重复发及反应不佳的定义与管理——一项德尔菲研究DOI: 10.1016/j.soard.2026.03.006 Sleep health IF: 03.400Ahead of Print.No.39Objective prediction of siesta based on machine learning and association with obesity基于机器学习的午睡客观预测及其与肥胖的关联DOI: 10.1016/j.sleh.2026.02.007 Advances in wound care IF: 05.600Ahead of Print.No.40Metabolic Effects on Wound Healing代谢对伤口愈合的影响DOI: 10.1177/21621918261438987 BMJ case reports IF: 00.500Volume 19, Issue 4No.41Awake video laryngoscopy and tracheal intubation in a super morbidly obese critically ill patient with a physiologically difficult airway清醒视频喉镜检查与气管插管在超级病态肥胖重症患者（伴生理困难气道）中的应用DOI: 10.1136/bcr-2025-269211 Am J Clin Nutr IF: 06.900Ahead of Print.No.42Corrigendum to Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society [Am J Clin Nutr 2025; 122: 344-367]关于支持肥胖GLP-1疗法的营养优先事项的勘误：美国生活方式医学学院、美国营养学会、肥胖医学协会及肥胖学会联合咨询[美国临床营养学杂志 2025; 122: 344-367]DOI: 10.1016/j.ajcnut.2026.101303 Journal of nutrition IF: 03.800Ahead of Print.No.43Quadruple burden of young child malnutrition in the Children's Healthy Living program, US Affiliated Pacific美国附属太平洋地区儿童健康生活计划中幼儿营养不良的四重负担DOI: 10.1016/j.tjnut.2026.101527 Neuroscience letters IF: 02.000Ahead of Print.No.44The exposure to the air pollutant fine particulate matter (PM(2.5)) slightly enhances high-fat diet-induced anxiety-like behavior and impairs brain redox balance in female rats空气污染物细颗粒物(PM2.5)暴露略微增强高脂饮食诱导的雌性大鼠焦虑样行为并损害脑氧化还原平衡DOI: 10.1016/j.neulet.2026.138599 J Am Pharm Assoc (2003)Ahead of Print.No.45Real-world weight impact upon tirzepatide discontinuation at a single-center endocrinology clinic in patients with overweight or obesity单中心内分泌诊所中超重或肥胖患者停用替尔泊肽后的真实体重影响DOI: 10.1016/j.japh.2026.103112 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.46Indirect relationship between alexithymia and binge eating disorder in the context of obesity肥胖背景下述情障碍与暴饮暴食障碍的间接关系DOI: 10.1016/j.clnesp.2026.103274 Brain research bulletin IF: 03.700Ahead of Print.No.47Exposure to a High-Fat Diet Compromises Gut Health, Behavior, and HPA Axis Function, with Partial Reversal When Limited to Adolescence暴露于高脂饮食会损害肠道健康、行为和HPA轴功能，青春期限制暴露后部分逆转DOI: 10.1016/j.brainresbull.2026.111883 The American journal of surgery IF: 02.700Ahead of Print.No.48Patient perspectives on access to bariatric surgical care in the Deep South: A qualitative study美国南部地区患者获取减重手术护理的观点：一项定性研究DOI: 10.1016/j.amjsurg.2026.116973 Nutrition IF: 03.000Ahead of Print.No.49The effect of ultra-processed food reduction in an attempt to control abdominal pain after Roux-Y gastric bypass: A retrospective cohort study减少超加工食品以控制Roux-Y胃旁路术后腹痛的效果：一项回顾性队列研究DOI: 10.1016/j.nut.2026.113182 Atención primaria IF: 01.600Ahead of Print.No.50[Anti-obesity drugs and potential changes in the epidemiology of this condition and in cardiovascular risk factors]抗肥胖药物及该疾病流行病学和心血管危险因素的潜在变化DOI: 10.1016/j.aprim.2026.103496 Chemosphere IF: 08.100Ahead of Print.No.51Exposure to lead on children's intellectual functioning: A target trial with multimedia biomarkers in Mexico City儿童智力功能的铅暴露：墨西哥城采用多介质生物标志物的目标试验DOI: 10.1016/j.chemosphere.2026.144932 BMJ case reports IF: 00.500Volume 19, Issue 4No.52Leydig cell ovarian tumour: a rare cause of hyperandrogenism卵巢间质细胞瘤：高雄激素血症的罕见原因DOI: 10.1136/bcr-2025-268251 Clin Exp Nephrol IF: 01.700Ahead of Print.No.53Effects of individual sodium-glucose cotransporter-2 inhibitors on all-cause mortality in patients with diabetic kidney disease个体化钠-葡萄糖协同转运蛋白2抑制剂对糖尿病肾病患者全因死亡率的影响DOI: 10.1007/s10157-026-02865-2 Pancreatology IF: 02.700Ahead of Print.No.54Identifying risk factors for pancreatic cancer in a large Japanese cohort using an insurance and health check-up database利用保险和健康检查数据库识别日本大型队列中胰腺癌的风险因素DOI: 10.1016/j.pan.2026.04.012 Heart IF: 04.400Ahead of Print.No.55Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study主动脉瓣狭窄的危险因素概况与血流动力学进展：一项回顾性人群研究DOI: 10.1136/heartjnl-2025-327243 Endocrine practice IF: 04.600Ahead of Print.No.56Cardiovascular Effects of Alogliptin, Linagliptin, Saxagliptin, and Sitagliptin: A Target Trial Emulation of a Comparative Effectiveness Study阿格列汀、利格列汀、沙格列汀和西格列汀的心血管影响：一项比较有效性研究的目标试验模拟DOI: 10.1016/j.eprac.2026.04.004 Contemporary clinical trials IF: 01.900Volume 164, Issue No.57Promoting sustained behavior change and nutrition security in medicaid-enrolled individuals with stage 2 cardiovascular kidney metabolic syndrome (CKMS): Protocol of the SUSTAIN study促进获得医疗补助的患有2期心血管-肾脏-代谢综合征（CKMS）个体的持续行为改变和营养安全：SUSTAIN研究方案DOI: 10.1016/j.cct.2026.108285 Hypertension Research IF: 04.600Ahead of Print.No.58The effects of glucagon-like peptide-1 receptor agonists on sympathetic neuron activity胰高血糖素样肽-1受体激动剂对交感神经元活动的影响DOI: 10.1038/s41440-026-02633-5 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.59The Impact of Malnutrition and Probable Sarcopenia on Mortality in Older Patients with Type 2 Diabetes营养不良和可能的肌少症对老年2型糖尿病患者死亡率的影响DOI: 10.1016/j.clnesp.2026.103273 Scientific reports IF: 03.900Ahead of Print.No.60Metabolic determinants of torque teno virus load across the diabetes spectrum: insights from a cross-sectional analysis跨糖尿病谱的转矩骨病毒载量的代谢决定因素：来自横断面分析的见解DOI: 10.1038/s41598-026-47810-1 Obes Res Clin Pract IF: 02.300Ahead of Print.No.61Bariatric surgery reverses blunted blood pressure reactivity to cold-induced stress in patients with severe obesity减重手术逆转严重肥胖患者对冷诱导应激的血压反应迟钝DOI: 10.1016/j.orcp.2026.03.005 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.62TRIGLYCERIDE-RELATED LIPID CHANGES IN ADULTS WITH CYSTIC FIBROSIS TREATED WITH ELEXACAFTOR/TEZACAFTOR/IVACAFTOR: A REAL-WORLD CROSS-SECTIONAL STUDY使用依伐卡托/泰泽卡托/依伐卡托治疗的囊性纤维化成人患者的甘油三酯相关脂质变化：一项真实世界横断面研究DOI: 10.1016/j.clnesp.2026.103275 Arch Gerontol Geriatr IF: 03.800Ahead of Print.No.63Efficacy of telephone-based health counseling with wearable device-Smartphone monitoring in older adults with metabolic syndrome: A randomized controlled trial基于可穿戴设备（智能手机监测）的电话健康咨询对代谢综合征老年患者的有效性：一项随机对照试验DOI: 10.1016/j.archger.2026.106232 Pediatric neurology IF: 02.100Ahead of Print.No.64Caring for Gender Diverse Youth With Duchenne Muscular Dystrophy: A Multisite Case Series关怀性别多样化杜氏肌营养不良症青年：多中心病例系列研究DOI: 10.1016/j.pediatrneurol.2026.03.018 EClinicalMedicine IF: 10.000Ahead of Print.No.65Weight trajectories and obesity onset between 17 and 60 years of age, and cause-specific mortality: the Obesity and Disease Development Sweden (ODDS) pooled cohort study成年男性和女性的体重增加轨迹与死亡率：ODDS队列研究DOI: 10.1016/j.eclinm.2026.103870 Int Arch Allergy Immunol IF: 01.800Ahead of Print.No.66Bioinformatics Analysis and Animal Experiments Revealed the Potential Role of IGFBP3 in Allergic Rhinitis生物信息学分析和动物实验揭示IGFBP3在过敏性鼻炎中的潜在作用DOI: 10.1159/000551921 Journal of medicinal food IF: 02.000Ahead of Print.No.67Coffee Berry Pulp Extract Improves Hepatic Lipid Metabolism and Reduces Triglyceride Levels in High-Fat, High-Fructose Diet-Fed Mice咖啡浆果提取物改善高脂高果糖饮食喂养小鼠的肝脏脂质代谢并降低甘油三酯水平DOI: 10.1177/1096620X261441411 Dermatology IF: 02.700Ahead of Print.No.68Efficacy of Gabapentin Combined with Standard-dose Antihistamines versus Antihistamine Monotherapy in Prurigo Nodularis: A Prospective Monocentric Real-world Observational Study加巴喷丁联合标准剂量抗组胺药与抗组胺药单药治疗结节性痒疹的有效性：一项前瞻性单中心真实世界观察性研究DOI: 10.1159/000551865 PloS one IF: 02.600Volume 21, Issue 4No.69Examining the mediating effects of metabolic syndrome components on the relationship between dairy product consumption and nonalcoholic fatty liver disease in Korean adults韩国成年人中代谢综合征组分对乳制品摄入与非酒精性脂肪肝关系的中介作用研究DOI: 10.1371/journal.pone.0346774 J Neurosurg Pediatr IF: 02.100Ahead of Print.No.70Endoscopic disconnection of hypothalamic hamartoma: an already outdated story?内镜下下丘脑错构瘤切断术：是否已过时？DOI: 10.3171/2025.11.PEDS25377 Wiadomo?ci LekarskieVolume 79, Issue 3No.71The gut-brain axis and its role in obesity-induced homeostatic dysregulation肠脑轴及其在肥胖诱导的体内平衡失调中的作用DOI: 10.36740/WLek/218289 Wiadomo?ci LekarskieVolume 79, Issue 3No.72Body mass index as a determinant of surgical outcomes in total hip arthroplasty体重指数作为全髋关节置换术手术结果的决定因素DOI: 10.36740/WLek/218174 Hepatology : IF: 15.800Ahead of Print.No.73Genetic risk of steatotic liver disease: Pathogenesis, prognosis, and implications for treatment脂肪性肝病的遗传风险：发病机制、预后及治疗意义DOI: 10.1097/HEP.0000000000001758 JMIR formative research IF: 02.100Volume 10, Issue No.74Evaluating an Incentive-Based mHealth App for Physical Activity Promotion Using the Obesity-Related Behavioral Intervention Trial Model: Small Cohort Study基于激励的移动健康应用促进体力活动：使用与肥胖相关的行为干预试验模型的小队列研究DOI: 10.2196/85484 J Paediatr Child Health IF: 01.400Ahead of Print.No.75Effects of Probiotic and Synbiotic Supplementation on Metabolic and Hepatic Outcomes in Children and Adolescents With Obesity, Including Those With Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis益生菌和益生元补充剂对患有肥胖症（包括患有与肥胖相关的代谢功能障碍相关脂肪性肝病的儿童和青少年）的代谢和肝脏结局的影响：一项系统综述和荟萃分析DOI: 10.1111/jpc.70344 PloS one IF: 02.600Volume 21, Issue 4No.76Association of visceral fat and plasmacytoid dendritic cell-derived interferon alpha with SARS-CoV-2 infection内脏脂肪与浆细胞样树突状细胞衍生的干扰素α和SARS-CoV-2感染的关联DOI: 10.1371/journal.pone.0344870 PLOS global public health IF: 02.500Volume 6, Issue 4No.77Prevalence and factors associated with obesity in Rwanda: Evidence from the 2022 NCD STEPS Survey卢旺达肥胖患病率及相关因素：来自2022年非传染性疾病阶梯式调查的证据DOI: 10.1371/journal.pgph.0004736 Respiration IF: 03.800Ahead of Print.No.78Sex comparison in clinical presentation, response, and remission in severe type-2 asthma patients treated with biologics: a real-world analysis from the "Southern Italy Network on Severe Asthma Therapy"生物制剂治疗重度2型哮喘患者的临床表型、反应和缓解情况的性别差异：来自“意大利南部重度哮喘治疗网络”的真实世界分析DOI: 10.1159/000550911 Respiration IF: 03.800Ahead of Print.No.79Paediatric long-term home respiratory support: Recommendations of the Swiss Society of Paediatric Pulmonology儿科长期家庭呼吸支持：瑞士儿科肺科学会的建议DOI: 10.1159/000550985 American journal of nephrology IF: 03.200Ahead of Print.No.80Potentially modifiable factors associated with longitudinal health-related quality of life in the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort国家统一肾脏转化研究企业慢性肾脏病（NURTuRE-CKD）队列中与纵向健康相关生活质量相关的潜在可调节因素DOI: 10.1159/000551177 Medicina IF: 00.600Volume 86, Issue 2No.81[REMI-ICAR: Argentine multicenter registry of hospitalization due to heart failure in medical clinic services]REMI-ICAR：阿根廷内科门诊心力衰竭住院患者多中心登记研究https://pubmed.ncbi.nlm.nih.gov/41961598 Journal of neurosurgery. Spine IF: 03.100Ahead of Print.No.82Diabetes as a significant risk factor for postoperative dysphagia following cervical spine surgery糖尿病是颈椎手术后吞咽困难的重要危险因素DOI: 10.3171/2025.11.SPINE25838 Wiadomo?ci LekarskieVolume 79, Issue 3No.83Obesity as an interdisciplinary medical and social problem: Therapeutic opportunities肥胖作为一个跨学科的医学和社会问题：治疗机会DOI: 10.36740/WLek/218280 Wiadomo?ci LekarskieVolume 79, Issue 3No.84Lifestyle, diet, and physical activity in the prevention and rehabilitation of chronic diseases: A review生活方式、饮食和体力活动在慢性病预防与康复中的作用：综述DOI: 10.36740/WLek/217892 Wiadomo?ci LekarskieVolume 79, Issue 3No.85Clinico-epidemiological spectrum of constipation patients at a tertiary care center in Ajman, UAE - a descriptive 5 year data analysis阿联酋阿治曼某三级医疗中心便秘患者的临床流行病学特征——一项为期5年的描述性数据分析DOI: 10.36740/WLek/218273 Wiadomo?ci LekarskieVolume 79, Issue 3No.86Clinico-epidemiological spectrum of chronic liver disease patients at a tertiary care center in Ajman, UAE - a descriptive 5 year data analysis阿联酋阿治曼一家三级医疗机构慢性肝病患者的临床流行病学特征——5年描述性数据分析DOI: 10.36740/WLek/218412 Swiss Med WklyVolume 156, Issue No.87Effect of implementing measures to reduce resource utilisation in medical wards (CopAIN project): a single-centre interrupted time-series analysis实施减少医疗病房资源利用措施（CopAIN项目）的效果：一项单中心中断时间序列分析DOI: 10.57187/4539 Plast Reconstr Surg IF: 03.400Ahead of Print.No.88Mini Free Flaps for Diabetic Foot Reconstruction用于糖尿病足重建的小型游离皮瓣DOI: 10.1097/PRS.0000000000012628 The Journal of urology IF: 06.800Ahead of Print.No.89Generalized Sensory Sensitivity in Patients with Urinary Urgency - a LURN II Urinary Urgency Phenotyping Study尿急迫患者的广义感觉敏感性——LURN II尿急迫表型研究DOI: 10.1097/JU.0000000000005061 JBJS case connectorVolume 16, Issue 2No.90Differentiating Infective Bursitis and Prosthetic Joint Infection in a Patient With Medial Knee Pain After Total Knee Arthroplasty: A Case Report全膝关节置换术后内侧膝痛患者感染性滑囊炎与假体关节感染的鉴别：一例报告DOI: e25.00515 Science advances IF: 12.500Volume 12, Issue 15No.91Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity组成型AMPK激活通过抑制HNF4α活性预防肝细胞癌发展DOI: 10.1126/sciadv.aea8017 Crit Rev Clin Lab Sci IF: 05.500Ahead of Print.No.92Glycation and disease: a systematic review of the analytical methods and applications of advanced glycation end products (AGEs) as biomarkers of disease糖基化与疾病：晚期糖基化终产物（AGEs）作为疾病生物标志物的分析方法与应用系统综述DOI: 10.1080/10408363.2026.2651310 PloS one IF: 02.600Volume 21, Issue 4No.93Predicted meta-omics: A potential solution to multi-omics data scarcity in microbiome studies预测元组学：解决微生物组研究中多组学数据稀缺的潜在方案DOI: 10.1371/journal.pone.0345919 PloS one IF: 02.600Volume 21, Issue 4No.94Exploring barriers and enablers to diabetes self-care practice in Ethiopia, 2025: A qualitative systematic review埃塞俄比亚2025年糖尿病自我护理实践的障碍与促进因素：一项定性系统综述DOI: 10.1371/journal.pone.0346867 PloS one IF: 02.600Volume 21, Issue 4No.95WHO five moments for medication safety among diabetic patients in Saudi Arabia沙特阿拉伯糖尿病患者用药安全的WHO五时刻模型DOI: 10.1371/journal.pone.0346935 PloS one IF: 02.600Volume 21, Issue 4No.96Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial妊娠期间及孕前短期内接种戊型肝炎疫苗后自发性流产的危险因素：来自整群随机试验的进一步分析DOI: 10.1371/journal.pone.0345974 Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.97New Anticomplement Drugs in Nephrology - Mechanism and Indication肾脏病学中的新型抗补体药物——作用机制与适应症DOI: 10.1159/000551965 European thyroid journal IF: 04.300Ahead of Print.No.98Thyroid hormone therapy in a population cohort over two decades indicates persistent overtreatment二十年间人群队列中的甲状腺激素治疗表明持续过度治疗DOI: 10.1530/ETJ-25-0259 ESC Heart Failure IF: 03.700Ahead of Print.No.99An integrated Biobank in the Swedish Heart Failure Registry - clinomics, proteomics, transcriptomics and genomics瑞典心力衰竭登记处（SwedeHF）中的综合生物库——临床组学、蛋白质组学、转录组学和基因组学DOI: 10.1093/eschf/xvag092 Medicina IF: 00.600Volume 86, Issue 2No.100[Pulmonary cryptococcosis in a non-HIV patient]非HIV患者的肺隐球菌病https://pubmed.ncbi.nlm.nih.gov/41961617 EJHF IF: 10.800Ahead of Print.No.101Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF射血分数降低的心力衰竭患者的肾衰竭风险方程及肾脏和心血管结局风险：来自PARADIGM-HF研究的见解DOI: 10.1093/ejhf/xuag079 IEEE J Biomed Health Inform IF: 06.800Ahead of Print.No.102Lesion Learning Network with Relation Aware Transformer for Diabetic Retinopathy Grading带有关系感知Transformer的病变学习网络用于糖尿病视网膜病变分级DOI: 10.1109/JBHI.2026.3682783 Journal of neurosurgery IF: 03.600Ahead of Print.No.103Glucagon-like peptide-1 receptor agonists in patients with moyamoya disease and type 2 diabetes mellitus胰高血糖素样肽-1受体激动剂在烟雾病合并2型糖尿病患者中的应用DOI: 10.3171/2025.12.JNS251072 Reproduction & fertility IF: 03.400Ahead of Print.No.104Interconnection between Polycystic Ovary Syndrome, Immune Disorders, and Reproductive Outcomes多囊卵巢综合征、免疫失调与生殖结局的相互联系DOI: 10.1530/RAF-25-0186 The Lancet Digital Health IF: 24.100Ahead of Print.No.105ChatGPT for obesity management: a review of evidence, potential challenges, and clinical implicationsChatGPT在肥胖管理中的应用、挑战与未来方向综述DOI: 10.1016/j.landig.2026.100980 Fish physiology and biochemistry IF: 02.500Volume 52, Issue 2No.106Low temperatures impact on the expression of growth genes and miRNAs in Nile tilapia (Oreochromis niloticus)低温对尼罗罗非鱼生长基因和微小RNA表达的影响DOI: 10.1007/s10695-026-01679-z Clin Hemorheol MicrocircAhead of Print.No.107A comprehensive review of GLP-1 and aerobic training in cardiovascular disease managementGLP-1和有氧运动在心血管疾病管理中的综合综述DOI: 10.1177/13860291251414840 International endodontic journal IF: 07.100Ahead of Print.No.108Foetal Development and Placental Health in Response to Apical Periodontitis Induced in Pregnant Wistar Rats妊娠Wistar大鼠诱导根尖周炎后胎儿发育及胎盘健康DOI: 10.1111/iej.70155 Sports medicine IF: 09.400Ahead of Print.No.109Instrumented Mouthguards in Women's Rugby League: Quantifying the Incidence and Probability of Head Acceleration Events at Group and Individual Levels女子橄榄球联盟中仪器化护齿套：量化群体和个体层面的头部加速事件发生率与概率DOI: 10.1007/s40279-026-02420-9 Molecular diversity IF: 03.800Ahead of Print.No.110Transdermal self-assembled Xanthine/hybrid needle nanofibers for management of abdominal obesity via phosphodiesterase 4B suppression经皮自组装黄嘌呤/杂化针状纳米纤维通过抑制磷酸二酯酶4B用于管理腹型肥胖DOI: 10.1007/s11030-026-11512-7 European journal of nutrition IF: 04.300Volume 65, Issue 3No.111The swift study: dietary profiles of night shift workers characterised by overweight and obesity快速研究：以超重和肥胖为特征的夜班工作者饮食特征DOI: 10.1007/s00394-026-03917-9 Indian journal of pediatrics IF: 02.000Ahead of Print.No.112Smartphone Applications-Based Intervention to Reduce Body Mass Index and Improve Health-Related Behavior Among Children with Overweight/Obesity: A Pilot Clinical Trial - Authors' Reply基于智能手机应用的干预措施降低超重/肥胖儿童体重指数并改善健康相关行为：一项试点临床试验——作者回复DOI: 10.1007/s12098-026-06117-9 Journal of robotic surgery IF: 03.000Volume 20, Issue 1No.113Trends and comparative study of robotic-assisted benign hysterectomy among morbidly obese patients in united States美国病态肥胖患者中机器人辅助良性子宫切除术的趋势与比较研究DOI: 10.1007/s11701-025-02991-1 Nutrición hospitalaria IF: 01.100Ahead of Print.No.114Longitudinal analysis of weight regain after Roux-en-Y gastric bypass ‒ The role of the MTCH2 gene polymorphism and dietary factorsRoux-en-Y减重手术后体重反弹的纵向分析——MTCH2基因多态性与饮食因素的作用DOI: 10.20960/nh.06238 Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.115Influence of maternal body mass index on the accuracy of clinical and sonographic fetal weight estimation母体体重指数对临床和超声胎儿体重估计准确性的影响DOI: 10.1002/ijgo.71012 ANZ journal of surgery IF: 01.600Ahead of Print.No.116Re: How to Do an Emergency Robotic Hartmann's Procedure in a Morbidly Obese Patient如何在病态肥胖患者中进行紧急机器人哈特曼手术DOI: 10.1111/ans.70681 JAMA IF: 55.000Ahead of Print.No.117Triple Agonist Reduces Hemoglobin A1C and Weight in Patients With Type 2 Diabetes三重激动剂可降低2型糖尿病患者的糖化血红蛋白和体重DOI: 10.1001/jama.2026.2107 Mol Cell Pediatr IF: 03.400Volume 13, Issue 1No.118The conundrum in diagnosing Maturity-Onset Diabetes of the Young (MODY) in a large German pedigree with early-onset diabetes and a novel HNF1A variant在具有早发性糖尿病的大型德国家系中诊断年轻发病的成人型糖尿病（MODY）的难题及新型HNF1A变异DOI: 10.1186/s40348-026-00229-0 Current diabetes report IF: 06.400Volume 26, Issue 1No.119Correction: Glucagon-Like Peptide-1 and Dual Incretin Agonists in Type 2 Diabetes with Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Vascular, Cardiovascular, Metabolic, and Mortality Outcomes修正：胰高血糖素样肽-1和双重肠促胰素激动剂在合并外周动脉疾病的2型糖尿病中的应用：血管、心血管、代谢和死亡率结局的系统综述与荟萃分析DOI: 10.1007/s11892-026-01622-9 Acta diabetologica IF: 02.900Ahead of Print.No.120Diabetes mellitus and risk of endometrial cancer: an updated systematic review and meta-analysis糖尿病与子宫内膜癌风险：更新的系统综述与荟萃分析DOI: 10.1007/s00592-026-02681-w Osteoporosis international IF: 05.400Ahead of Print.No.121Romosozumab versus teriparatide and risk of all-cause mortality in patients with osteoporosis: a real-world propensity score-matched cohort study罗莫佐单抗与特立帕肽在骨质疏松症患者中的全因死亡率风险比较：一项真实世界倾向评分匹配队列研究DOI: 10.1007/s00198-026-07968-w Osteoporosis international IF: 05.400Ahead of Print.No.122Adjusting fracture probability according to duration of diabetes: the Manitoba BMD Registry根据糖尿病病程调整骨折概率：曼尼托巴骨密度登记处DOI: 10.1007/s00198-026-08001-w Endocrine connections IF: 02.800Ahead of Print.No.123Mapping Transition of Care for Rare Endocrine Conditions: Findings from a Cross-Sectional Survey by the Endo-ERN ToC Working Group罕见内分泌疾病的护理过渡映射：Endo-ERN护理过渡工作组横断面调查结果DOI: 10.1530/EC-25-0798 Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 4No.124Age-Specific Increases in the Prevalence and Treatment Burden of Neovascular Age-Related Macular Degeneration in a Super-Aged Society超老龄化社会中新生血管性年龄相关性黄斑变性的患病率和治疗负担的年龄特异性增加DOI: 10.1167/iovs.67.4.19 Int J Low Extrem Wounds IF: 01.500Ahead of Print.No.125Assessment of the Comprehensive Score for Financial Toxicity (COST) among People with Diabetic Foot Ulcers at a Tertiary Care Centre in South India南印度三级医疗中心糖尿病足溃疡患者财务毒性综合评分（COST）评估DOI: 10.1177/15347346261441107 J Am Coll Surg IF: 03.400Ahead of Print.No.126Increasing Use of Wearable Devices for Health or Activity Tracking Among Adults with Chronic Diseases in the US美国慢性病成年人群中用于健康或活动追踪的可穿戴设备使用量增加DOI: 10.1097/XCS.0000000000001746 Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.127Polycystic ovarian syndrome and perinatal outcomes: A population-based pooled cross-sectional study多囊卵巢综合征与围产期结局：一项基于人群的汇总横断面研究DOI: 10.1002/ijgo.71006 Curr Opin Endocrinol Diabetes Obes IF: 02.700Ahead of Print.No.128Parathyroid hormone assays in 2026: second versus third generation, standardization, and clinical interpretation2026年甲状旁腺激素检测：第二代与第三代、标准化及临床解读DOI: 10.1097/MED.0000000000000960 Diabetes therapy IF: 02.600Ahead of Print.No.129Tirzepatide as an Add-on for Participants with Inadequate Glycemic Control Using Basal Insulin: Pooled Subgroup Analysis of SURPASS-5 and -6替尔泊肽作为基础胰岛素治疗血糖控制不佳参与者的附加治疗：SURPASS-5和-6研究的合并亚组分析DOI: 10.1007/s13300-026-01859-3 European journal of pain IF: 03.400Volume 30, Issue 4No.130Postoperative Pain Management After Lumbar Discectomy. A Systematic Review With Meta-Analyses and Trial Sequential Analyses腰椎间盘切除术后的术后疼痛管理：一项系统综述、荟萃分析及试验序贯分析DOI: 10.1002/ejp.70261 BioMed research international IF: 02.300Volume 2026, Issue 1No.131Bacteria Associated With Urinary Tract Infections, Antimicrobial Resistance Profiles, and Associated Factors Among Diabetes Mellitus Patients at Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia埃塞俄比亚西北部德布雷塔布尔综合专科医院糖尿病患者尿路感染相关细菌、抗菌药物耐药谱及相关因素DOI: 10.1155/bmri/6664132 Eur J Ophthalmol IF: 01.400Ahead of Print.No.132The impact of polycystic ovarian syndrome on ocular health多囊卵巢综合征对眼部健康的影响DOI: 10.1177/11206721261436102 Nutrición hospitalaria IF: 01.100Ahead of Print.No.133Effects of betaine-containing nutrients on homocysteine levels and glucose-lipid metabolism in overweight and obese patients with hyperhomocysteinemia甜菜碱类营养物质对伴有高同型半胱氨酸血症的超重和肥胖患者的同型半胱氨酸水平及糖脂代谢的影响DOI: 10.20960/nh.05892 Nutrición hospitalaria IF: 01.100Ahead of Print.No.134[Triglycerides glucose index in Madrid university students]马德里大学生甘油三酯葡萄糖指数DOI: 10.20960/nh.06225 Med Lett Drugs Ther IF: 01.400Volume 68, Issue 1752No.135In brief: Rybelsus R2 rebranded as Ozempic简要介绍：Rybelsus R2重命名为OzempicDOI: 10.58347/tml.2026.1752f Am J Phys Med Rehabil IF: 02.400Ahead of Print.No.136Semaglutide-Associated Sequential Unilateral Transient Osteoporosis of The Hip: A Case Report司美格鲁肽相关序贯单侧髋部暂时性骨质疏松症：一例报告DOI: 10.1097/PHM.0000000000003003 Diabetes therapy IF: 02.600Ahead of Print.No.137Fixed-Dose Combination Therapy as a Strategy to Improve Antidiabetic Medication Adherence in People with Type 2 Diabetes: A Narrative Review固定剂量联合疗法作为提高2型糖尿病患者抗糖尿病药物依从性的策略：一项叙述性综述DOI: 10.1007/s13300-026-01863-7 Infectious diseases and therapy IF: 05.300Ahead of Print.No.138Burden of Respiratory Syncytial Virus in Older ADults in Nagasaki, Japan (Nagasaki ROAD): Preliminary Results (April 2024-March 2025) of a Prospective, Multicenter, Epidemiological Study日本长崎地区老年人群呼吸道合胞病毒（RSV）负担（Nagasaki ROAD研究）：2024年4月-2025年3月前瞻性多中心流行病学研究初步结果DOI: 10.1007/s40121-026-01312-9 Journal of obesity IF: 03.900Volume 2026, Issue 1No.139Expression Analysis of Selected microRNAs in Diabetes Mellitus Visceral Fat Tissues糖尿病内脏脂肪组织中选定微小RNA的表达分析DOI: 10.1155/jobe/3230015 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.140Expanding Evidence for Glucagon-Like Peptide-1 Receptor Agonists in Those with Diabetes and Kidney Disease胰高血糖素样肽-1受体激动剂在糖尿病和肾病患者中的证据扩展DOI: 10.2215/CJN.0000001072 JAMA Network Open IF: 09.700Volume 9, Issue 4No.141Risk Prediction Model for Taxane-Induced Peripheral Neuropathy in Early-Stage Cancer早期癌症中紫杉醇诱导的周围神经病变风险预测模型DOI: 10.1001/jamanetworkopen.2026.4901 Eur J Appl Physiol IF: 02.700Ahead of Print.No.142Hyperlactatemia and pulmonary gas exchange at rest and during exercise: lessons from patients on metformin高乳酸血症与静息及运动时的肺气体交换：二甲双胍治疗患者的启示DOI: 10.1007/s00421-026-06213-w JAMA IF: 55.000Ahead of Print.No.143PCSK9 Inhibitors in Diabetes, Tirzepatide's Cardiorenal Effects, Shingles Vaccine, and More From ACC糖尿病中的PCSK9抑制剂、替尔泊肽的心脏肾脏影响、带状疱疹疫苗及ACC其他相关内容DOI: 10.1001/jama.2026.2399 Acta diabetologica IF: 02.900Ahead of Print.No.144The silent side effect of metformin: understanding Vitamin B12 deficiency in Type 2 Diabetes二甲双胍的隐性副作用：认识2型糖尿病中的维生素B12缺乏症DOI: 10.1007/s00592-026-02684-7 J Interv Cardiol IF: 01.700Volume 2026, Issue 1, Page 5898802-5898802No.145Gentamicin–Collagen Sponge Use in the Implant Pocket for the Prevention of Cardiac Implantable Electronic Device Infections庆大霉素-胶原海绵用于植入袋预防心脏植入式电子设备感染DOI: 10.1155/joic/9922994 Int J Hepatol IF: 01.400Volume 2026, Issue No.146Natriuretic Effect of Dapagliflozin in Cirrhosis With Ascites: A Randomized, Placebo-Controlled Crossover Trial达格列净对肝硬化腹水患者尿钠排泄及临床结局的影响：一项随机、双盲、安慰剂对照交叉试验DOI: 10.1155/ijh/9503323 Public health nursing IF: 01.300Ahead of Print.No.147Enhancing Community-Based Nursing Decision Support: Machine Learning Models for Diabetes Risk Prediction Using Home Health Nursing Notes增强基于社区的护理决策支持：利用家庭健康护理记录进行糖尿病风险预测的机器学习模型DOI: 10.1111/phn.70122 Bioinformation IF: 01.900Volume 22, Issue 1No.148Obesity and periodontal diseases: A review肥胖与牙周疾病：综述DOI: 10.6026/973206300220392 Bioinformation IF: 01.900Volume 22, Issue 1No.149Smoking and its impact on eating behavior: A review吸烟及其对进食行为的影响：综述DOI: 10.6026/973206300220132 J Health Dispar Res PractVolume 10, Issue 2No.150Investigation of the Cultural Context of Sugars Consumption Behavior in Low-Income Mexican-American Women美国墨西哥裔美国母亲的食品采购、制备及呈现行为与糖消费研究：焦点小组研究https://pubmed.ncbi.nlm.nih.gov/41960351 Research squareVolume 2026, Issue No.151Metabolic Adaptations to Caloric Restriction: Time- and Group-Dependent Metabolomic Signatures from the CALERIE™ Trial热量限制调节健康成年人的血浆代谢组：来自CALERIE试验的纵向代谢组学分析DOI: 10.21203/rs.3.rs-9237764/v1 J Coll Med S AfrVolume 4, Issue 1No.152A unique case report of bilateral spontaneous cerebrospinal fluid leak from bilateral sphenoid sinus skull base defects双侧蝶窦颅底缺损致双侧自发性脑脊液漏的独特病例报告DOI: 10.4102/jcmsa.v4i1.271 Frontiers in pediatrics IF: 02.000Volume 14, Issue No.153Impact of pediatric obesity on abdominal surgery outcome: a narrative review儿童肥胖与腹部手术：围手术期并发症及管理策略的叙事性综述DOI: 10.3389/fped.2026.1780811 Curēus IF: 01.300Volume 18, Issue 3No.154Impact of Pre-pregnancy BMI and Gestational Weight Gain on Fetomaternal Outcomes: A Cross-Sectional Analytical Study孕前体重指数和孕期增重对母婴结局的影响DOI: 10.7759/cureus.104941 Osteoarthr Cartil Open IF: 02.800Volume 8, Issue 2No.155Implementing a guideline-based model of care for hip and knee osteoarthritis in Finland (FIN-OA): Protocol for a benchmarking-controlled trial芬兰国家骨关节炎实施（FIN-OA）试验：基层医疗中基于指南的髋膝关节骨关节炎护理模式的混合3型基准对照试验方案DOI: 10.1016/j.ocarto.2026.100782 Surgery in practice and science IF: 00.600Volume 25, Issue No.156Comment on "Associations between obesity and lymph node metastasis and early recurrence in pancreatic head cancer: A single-center retrospective cohort study"对“胰头癌中肥胖与淋巴结转移及早期复发的关联：单中心回顾性队列研究”的评论DOI: 10.1016/j.sipas.2026.100342 bioRxivVolume 2026, Issue No.157Cognitive reappraisal of food and emotion cues involves common and unique neural contributions参考文献列表DOI: 10.64898/2026.03.09.710570 bioRxivVolume 2026, Issue No.158Adrβ2 in skeletal muscle cells is required for exercise-induced Pgc1α but not for metabolic benefits of exercise on diet-induced obesity骨骼肌中的Adrβ2对于运动在饮食诱导肥胖中的代谢益处并非必需DOI: 10.64898/2026.03.27.714812 bioRxivVolume 2026, Issue No.159Hypothalamus amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats下丘脑淀粉样蛋白水平与TgF344-AD大鼠早期能量稳态的性别依赖性改变相关DOI: 10.64898/2026.03.08.710398 bioRxivVolume 2026, Issue No.160Diet quality shapes development and feeding circuits in poison frog tadpoles饮食质量影响箭毒蛙蝌蚪的发育与摄食回路DOI: 10.64898/2026.03.28.714959 bioRxivVolume 2026, Issue No.161Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model自发性孕前肥胖在非人灵长类模型中重塑胎儿免疫发育DOI: 10.64898/2026.03.27.714880 J Indian Assoc Pediatr SurgVolume 31, Issue 2No.162Chemoport Placement in Children Who are Overweight or Obese: A Practical Approach儿童超重或肥胖时的Chemoport放置：一种实用方法DOI: 10.4103/jiaps.jiaps_379_25 J Hum Reprod Sci IF: 01.100Volume 19, Issue 1No.163Psychological Morbidity (Stress, Anxiety and Depression) and Fertility Quality of Life amongst Infertile Women with and without Polycystic Ovary Syndrome (PCOS): A Cross-sectional Study多囊卵巢综合征（PCOS）有无的不孕女性心理疾病（压力、焦虑和抑郁）与生育生活质量：一项横断面研究DOI: 10.4103/jhrs.jhrs_241_25 Frontiers in medicine IF: 03.000Volume 13, Issue No.164The effect of iron treatment on fetal fraction according to gestational weeks in maternal anemia非侵入性产前检测中母体血液学参数和铁补充对胎儿分数的影响：一项队列研究DOI: 10.3389/fmed.2026.1772334 HSS journal : IF: 01.300Ahead of Print.No.165Preoperative GLP-1 Receptor Agonist Use Is Not Associated With Complications in Non-Obese Patients Undergoing Total Shoulder Arthroplasty: A Propensity Score Matched Large Database Analysis围手术期使用胰高血糖素样肽-1受体激动剂与非肥胖患者全肩关节置换术后并发症增加无关DOI: 10.1177/15563316261439127 Addiction IF: 05.300Ahead of Print.No.166A genetically informed cross-lagged twin study of the longitudinal association between addiction-related behaviors and obesity基于遗传学的交叉滞后双胞胎研究：成瘾相关行为与肥胖的纵向关联DOI: 10.1111/add.70407 Obesity reviews IF: 07.400Ahead of Print.No.167How Does the Ultra-Processed Food Industry Drive Consumption Through Product Design and Marketing? Mapping a Complex Commercial System According to Expert Mental Models and Evidence Review超加工食品行业如何通过产品设计和营销推动消费？基于专家心智模型与证据综述的复杂商业系统解析DOI: 10.1111/obr.70135 Diabetes & metabolism journal IF: 08.500Ahead of Print.No.168Obesity Transitions by Age, Period, and Cohort: A Population-Based Application of the Lancet Commission Framework in the United States and Korea不同年龄、时期和队列的肥胖转变：美国和韩国基于人群的《柳叶刀》委员会框架应用DOI: 10.4093/dmj.2025.0918 International journal of cancer IF: 04.700Ahead of Print.No.169At what age should people with obesity start colorectal cancer screening?肥胖人群应从什么年龄开始结直肠癌筛查？DOI: 10.1002/ijc.70448 Annals of African medicine IF: 00.600Ahead of Print.No.170The Impact of Competency-based Medical Education-mandated Yoga Training on First-Year Medical Students: A Quasi-experimental Study基于能力的医学教育要求的瑜伽训练对一年级医学生的影响：一项类实验研究DOI: 10.4103/aam.aam_869_25 J Integr Complement Med IF: 01.700Ahead of Print.No.171Osteopathic Visceral Manipulation on Functional Constipation in Obese Adults: A Randomized Controlled Clinical Trial整骨内脏手法对肥胖成人功能性便秘的随机对照临床试验DOI: 10.1177/27683605261427696 Lipids in health and disease IF: 04.200Ahead of Print.No.172Serum metabolite patterns of adipose tissue distribution and body composition subphenotypes血清代谢物模式与脂肪组织分布及身体成分亚型DOI: 10.1186/s12944-026-02944-z Int J Behav Nutr Phys Act IF: 05.500Ahead of Print.No.173Socioeconomic inequalities in exposure to neighbourhood environments for physical activity: a systematic review体力活动相关社区环境暴露的社会经济不平等：一项系统综述DOI: 10.1186/s12966-026-01912-1 bioRxivVolume 2026, Issue No.174Empagliflozin preserves cardiac function and modulates metabolism in a mouse model of Duchenne muscular dystrophy恩格列净在杜氏肌营养不良症小鼠模型中维持心脏功能并调节代谢DOI: 10.64898/2026.03.11.710889 Curēus IF: 01.300Volume 18, Issue 3No.175Lacunar Pontine Infarct Presenting as Ipsilateral Lower Motor Neuron Facial Palsy: A Case Report腔隙性脑桥梗死表现为同侧下运动神经元面瘫：一例报告DOI: 10.7759/cureus.104930 Shoulder & elbow IF: 01.100Ahead of Print.No.176Perioperative testosterone therapy linked to higher 5-year risk of periprosthetic joint infection without increased 90-day major complications or revision rates in total shoulder arthroplasty围手术期睾酮治疗与初次肩关节置换术后5年假体周围关节感染风险增加相关但90天并发症无增加DOI: 10.1177/17585732261437972 Mol Nutr Food Res IF: 04.200Volume 70, Issue 7No.177Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach to Enhance Therapeutic Potential in Nonalcoholic Steatohepatitis鞣花酸减轻菊粉的不良反应：联合方法增强非酒精性脂肪性肝炎的治疗潜力DOI: 10.1002/mnfr.70456 Journal of medicine and lifeVolume 19, Issue 2No.178Epigenetic alterations in preeclampsia: a systematic review of current mechanisms and biomarker potential子痫前期中的表观遗传失调：2022-2025年分子与临床特征的系统综述与荟萃分析DOI: 10.25122/jml-2026-0009 Acta Obstet Gynecol Scand IF: 03.100Ahead of Print.No.179Perinatal and long-term implications of diagnosing gestational diabetes mellitus using only fasting and one-hour post-load glucose concentrations: Secondary analysis of the GEMS trial and its five-year follow-up仅用空腹和1小时负荷后血糖诊断妊娠糖尿病的围产期及长期影响：GEMS试验及其五年随访的二次分析DOI: 10.1111/aogs.70191 Bioinformation IF: 01.900Volume 22, Issue 1No.180A case of takayasu arteritis presenting with multiple cerebral infarcts: Diagnostic and therapeutic challenges一例以多发脑梗死为表现的Takayasu动脉炎：诊断与治疗挑战DOI: 10.6026/973206300220071 Bioinformation IF: 01.900Volume 22, Issue 1No.181The impact of obesity, smoking and diabetes on the susceptibility to postoperative spinal infections: A risk-based approach肥胖、吸烟和糖尿病对术后脊柱感染风险的影响DOI: 10.6026/973206300220409 Bioinformation IF: 01.900Volume 22, Issue 1No.182Clinicopathological and microbiological profile of osteomyelitis at a teaching hospital in India: A retrospective study印度某教学医院骨髓炎的临床病理和微生物学特征回顾性研究DOI: 10.6026/973206300220443 Bioinformation IF: 01.900Volume 22, Issue 1No.183Fitness assessment to promote exercise for diabetes and hypertension用于促进糖尿病和高血压患者运动的体质评估DOI: 10.6026/973206300220142 Bioinformation IF: 01.900Volume 22, Issue 1No.184Sarcopenia with postoperative outcomes in patients undergoing pancreaticoduodenectomy胰十二指肠切除术后患者的肌少症及其术后结局DOI: 10.6026/973206300220066 Bioinformation IF: 01.900Volume 22, Issue 1No.185Early thiamine therapy in Rogers syndrome: Systematic review of hematologic, auditory and glycemic outcomes罗杰斯综合征早期硫胺素治疗：血液学、听觉和血糖结局的系统综述DOI: 10.6026/973206300220026 Bioinformation IF: 01.900Volume 22, Issue 1No.186Periodontal severity and metabolic syndrome: A cross-sectional study from a tertiary care hospital in India印度一家三级医疗机构牙周炎严重程度与代谢综合征的横断面研究DOI: 10.6026/973206300220477 Bioinformation IF: 01.900Volume 22, Issue 1No.187Treatment outcomes and clinical characteristics in diabetic versus non-diabetic sinonasal tuberculosis糖尿病与非糖尿病患者鼻窦结核的治疗结局及临床特征对比DOI: 10.6026/973206300220206 Frontiers in public health IF: 03.400Volume 14, Issue No.188Impact of a brief diabetes education on teachers' diabetes-related knowledge, attitude, and confidence: a nonrandomized school-based intervention study标准化糖尿病教育课程对教师1型糖尿病管理知识态度和信心的短期影响DOI: 10.3389/fpubh.2026.1747185 Research squareVolume 2026, Issue No.189Abdominal Waist Circumference and Subcutaneous Adipose Tissue Thickness Predicts Development of Post-Transplant Diabetes Mellitus肾移植后糖尿病风险预测中腹部皮下脂肪厚度和腰围的应用：一项回顾性队列研究DOI: 10.21203/rs.3.rs-8543193/v1 Research squareVolume 2026, Issue No.190Risk Factors for Hepatocellular Carcinoma: Findings from a Case-Control Study in Vietnam越南人群肝细胞癌的风险因素DOI: 10.21203/rs.3.rs-8383243/v1 Research squareVolume 2026, Issue No.191Epidemiological and Multi-Omics Investigation of Phytosterol Intake and Type 2 Diabetes Risk植物甾醇摄入与2型糖尿病风险的流行病学及多组学研究DOI: 10.21203/rs.3.rs-9222420/v1 South Afr J HIV Med IF: 02.300Volume 27, Issue 1No.192Cardiovascular risk profiles in people living with HIV taking antiretroviral therapy in rural Lesotho: Findings from the PRECARIF study莱索托农村地区接受抗逆转录病毒治疗的HIV感染者心血管疾病风险特征：PRECARIF研究结果DOI: 10.4102/sajhivmed.v27i1.1779 Case Rep Obstet Gynecol IF: 00.600Volume 2026, Issue No.193Intrauterine Tampon Identified on CT as an Intrauterine Foreign Body Associated With Bilateral Leg Edema: A Case ReportCT显示宫内棉条为宫内异物并伴双侧腿部水肿：一例报告DOI: 10.1155/crog/1505612 Bioimpacts IF: 02.200Volume 16, Issue No.194Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review3D打印技术在糖尿病伤口愈合中的应用进展：综合综述DOI: 10.34172/bi.32751 Curēus IF: 01.300Volume 18, Issue 3No.195Incidence of Sepsis After Transrectal Ultrasound-Guided Prostate Biopsy in Dubai Tertiary Care Hospitals: A Multicenter Cohort Study迪拜三家三级医院经直肠超声引导前列腺穿刺活检术后脓毒症发生率：一项多中心队列研究DOI: 10.7759/cureus.104933 Curēus IF: 01.300Volume 18, Issue 3No.196Health-Seeking Behavior for Noncommunicable Diseases in Rural and Urban Areas of Ernakulam District, Kerala: A Cross-Sectional Study喀拉拉邦厄纳库拉姆地区城乡居民非传染性疾病就医行为比较研究DOI: 10.7759/cureus.104899 Int J Breast Cancer IF: 03.000Volume 2026, Issue No.197Modifiable and Nonmodifiable Risk Factors for Breast Cancer: A Comprehensive Scoping Review乳腺癌风险因素：综合综述DOI: 10.1155/ijbc/8689986 Case reports in endocrinology IF: 00.900Volume 2026, Issue No.198A Rare Primary Adrenal Malignancy Manifesting as a Hemorrhagic Mass: Case Report and Literature Review罕见原发性肾上腺恶性肿瘤表现为出血性肿块：病例报告及文献综述DOI: 10.1155/crie/1260707 Curēus IF: 01.300Volume 18, Issue 4No.199Assessing Functional Outcomes and Complications After Turndown Flap With Flexor Hallucis Longus Augmentation in Chronic Achilles Tendon Ruptures腓肠肌下翻瓣联合拇长屈肌增强治疗慢性跟腱断裂的回顾性病例系列研究DOI: 10.7759/cureus.106610 ACG case reports journal IF: 00.500Volume 13, Issue 4No.200Semaglutide-Induced Symptomatic Remission in Ulcerative Colitis司美格鲁肽诱导溃疡性结肠炎的症状缓解DOI: 10.14309/crj.0000000000002070 bioRxivVolume 2026, Issue No.201Deletion of endothelial KLF4 as a model for preeclampsia内皮KLF4缺失诱导小鼠子痫前期DOI: 10.64898/2026.03.30.715448 bioRxivVolume 2026, Issue No.202Synthetic Immunological Niche Reveals Early Immune Dysregulation and Stratifies Therapeutic Response in Type 1 Diabetes工程化免疫微环境揭示1型糖尿病中阶段特异性免疫失调及预测治疗效果DOI: 10.64898/2026.03.06.710219 bioRxivVolume 2026, Issue No.203Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank体力活动与脑成像：英国生物样本库中功能连接性和灰质体积的综合分析DOI: 10.64898/2026.03.10.710798 bioRxivVolume 2026, Issue No.204Serum proteomics reveals distinct phenotypic signatures to IL-6 blockade between two immunotherapies血清蛋白质组学揭示两种免疫疗法在IL-6阻断时的不同表型特征DOI: 10.64898/2026.03.27.712461 bioRxivVolume 2026, Issue No.205Aberrant immune regulation and enrichment of stem-like CD8 (+) T cells in the pancreatic lymph node during type 1 diabetes development1型糖尿病发展过程中胰腺淋巴结中异常免疫调节及类干细胞样CD8(+)T细胞的富集DOI: 10.1101/2025.05.23.655848 Kidney international reports IF: 05.700Volume 11, Issue 5No.206Response to the Letter to the Editor Entitled "Beyond Access: How Homelessness Shapes Kidney Trajectories in Diabetes"对题为‘超越获取：无家可归如何影响糖尿病患者肾脏轨迹’的信件的回应DOI: 10.1016/j.ekir.2026.106381 Imaging Neurosci (Camb)Volume 4, Issue No.207Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter视网膜神经纤维层厚度反映大脑灰白质特征DOI: 10.1162/IMAG.a.1174 JMA journal IF: 01.800Volume 9, Issue 2No.208Melioidosis Presenting as Parapharyngeal Abscess类鼻疽表现为咽旁脓肿DOI: 10.31662/jmaj.2025-0546 Frontiers in medicine IF: 03.000Volume 13, Issue No.209Acupuncture in the treatment of inflammation-related ocular degenerations: a systematic review针灸治疗炎症相关眼部退行性病变：一项系统综述DOI: 10.3389/fmed.2026.1749297 HSS journal : IF: 01.300Ahead of Print.No.210The Outpatient Surge in Total Hip Arthroplasty: National Trends in Volume Migration, Demographic Disparities, and Comorbidity Profiles (2019-2022)全髋关节置换术在住院与门诊环境中的比例：全国趋势、人口统计学和合并症（2019-2022）DOI: 10.1177/15563316261431234 Journal of medicine and lifeVolume 19, Issue 2No.211Correlations between Psoriasis Area and Severity Index (PASI), body mass index (BMI), smoking, and alcohol consumption in patients with psoriasis - a Romanian study银屑病患者中银屑病面积和严重程度指数（PASI）、体重指数（BMI）、吸烟和饮酒之间的相关性——一项罗马尼亚研究DOI: 10.25122/jml-2026-0013 Journal of materials chemistry IF: 05.700Ahead of Print.No.212H(2)O(2) responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis对H₂O₂响应的若丹明基探针用于早期糖尿病诊断监测DOI: 10.1039/d5tb02687c Nuclear medicine communications IF: 01.300Ahead of Print.No.213Pilot feasibility study investigating 68Ga-NODAGA-RGD PET-computed tomography molecular angiogenesis imaging in patients with peripheral arterial diseases: can it be of potential clinical value?初步可行性研究：68Ga-NODAGA-RGD PET-CT分子血管生成成像在外周动脉疾病患者中的潜在临床价值探讨DOI: 10.1097/MNM.0000000000002160 British journal of nutrition IF: 03.000Ahead of Print.No.214Cardiometabolic health effects of dietary counselling on a high-quality, fibre-rich diet in adults with type 2 diabetes: A randomised controlled trial饮食咨询对成年2型糖尿病患者高质量高纤维饮食的心脏代谢健康影响：一项随机对照试验DOI: 10.1017/S0007114526107041 Stroke IF: 08.900Ahead of Print.No.215Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes美国2型糖尿病成年人减少院前延误与一级卒中预防的成本效益比较DOI: 10.1161/STROKEAHA.126.055187 Prim Health Care Res Dev IF: 01.700Volume 27, Issue No.216From silos to synergy: assessing tuberculosis basic management units readiness for integrated diabetes mellitus care across different districts of Pakistan从孤立到协同：评估巴基斯坦不同地区结核病基层管理单位开展糖尿病综合管理的准备情况DOI: 10.1017/S146342362610111X Public health nutrition IF: 03.000Ahead of Print.No.217Dietary Knowledge and Perceptions in UK Pakistani/Bangladeshi Communities: A Survey on Low-Carbohydrate and Intermittent Fasting diets for Diabetes Prevention and Management英国巴基斯坦/孟加拉裔社区的饮食知识与认知：关于低碳水化合物和间歇性禁食饮食对糖尿病预防和管理的调查DOI: 10.1017/S136898002610250X Chemistry & biodiversity IF: 02.500Volume 23, Issue 4No.218Capparis Spinosa and Glutamine Reduce Oxidative Stress via Nrf2/Ho-1 Pathway in Diabetic Wound Healing刺山柑与谷氨酰胺通过Nrf2/HO-1通路减轻糖尿病创面愈合中的氧化应激DOI: 10.1002/cbdv.71196 Sci Diabetes Self Manag Care IF: 02.200Ahead of Print.No.219Transition to Virtual Diabetes Self-Management Education Delivery in the Setting of Health Care Disruption for Adults With Diabetes and Their Support Persons医疗保健中断背景下，成年糖尿病患者及其支持者向虚拟糖尿病自我管理教育交付的转变DOI: 10.1177/26350106261432172 Annals of African medicine IF: 00.600Ahead of Print.No.220Role of Renal Doppler and Shearwave Elastography in Diabetic Nephropathy肾多普勒超声和剪切波弹性成像在糖尿病肾病中的作用DOI: 10.4103/aam.aam_877_25 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.221Biological Context and Endpoint Alignment Are Critical for Interpreting Population-Based Validation of Cluster-Based MASLD Subtypes生物学背景和终点对齐对解释基于人群的聚类代谢相关脂肪性肝病（MASLD）亚型验证至关重要DOI: 10.1111/dom.70627 Ethnicity & health IF: 02.000Ahead of Print.No.222Overcoming barriers to blood glucose monitoring: the mediating role of social cognitive theory components in black/African American men with type 2 diabetes克服血糖监测障碍：社会认知理论组成部分在黑人/非裔美国2型糖尿病男性中的中介作用DOI: 10.1080/13557858.2026.2655624 Am J Surg Pathol IF: 04.200Ahead of Print.No.223Segmental Atrophy of the Liver: An Increasingly Recognized Pseudotumor With Distinct Clinicopathologic and Imaging Features肝脏节段性萎缩：一种日益被认识的具有独特临床病理和影像学特征的假瘤DOI: 10.1097/PAS.0000000000002543 Curēus IF: 01.300Volume 18, Issue 3No.224Human Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) and p16 Expression in Squamous Cell Carcinoma of the Head and Neck人乳头瘤病毒(HPV)状态及p16INK4a、IMP3在头颈部鳞状细胞癌(HNSCC)中的表达DOI: 10.7759/cureus.104895 Genes & diseases IF: 09.400Volume 13, Issue 4No.225FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasisFOXA2在胰腺胰岛生物学中的作用：调控发育、功能与疾病DOI: 10.1016/j.gendis.2025.101972 Pediatric diabetes IF: 05.600Volume 2026, Issue No.226Achieving Glycemic Targets in and out-of-School: Real-World Data From 1341 Italian Children Using the MiniMed 780G System During Auto Mode意大利1341名儿童使用MiniMed 780G自动模式系统在学校内外实现血糖目标的真实世界数据DOI: 10.1155/pedi/1653728 bioRxivVolume 2026, Issue No.227Desynchrony between events triggers a compensatory delay during C. elegans development秀丽隐杆线虫发育过程中事件不同步触发补偿性延迟DOI: 10.1101/2024.03.31.587169 bioRxivVolume 2026, Issue No.228Profiling Peripheral Blood with an Optimized, Multiplexed, Single-cell Multiome Approach Supports an Insulin-driven Asthma Subtype采用优化的多重单细胞多组学方法分析外周血支持胰岛素驱动的哮喘亚型DOI: 10.64898/2026.03.27.714744 bioRxivVolume 2026, Issue No.229Sex and breeding stage differences in neurogenomic profiles reflect hormone signaling in a socially polyandrous shorebird社会性一妻多夫制滨鸟中神经基因组谱的性别和繁殖阶段差异反映激素信号DOI: 10.64898/2026.03.10.710941 bioRxivVolume 2026, Issue No.230A high-resolution mass spectrometry-based method for quantifying insulin-stimulated glucose uptake in mice following an intraperitoneal injection of tracer腹腔注射示踪剂后基于高分辨率质谱的小鼠胰岛素刺激葡萄糖摄取定量方法DOI: 10.64898/2026.03.31.714892 bioRxivVolume 2026, Issue No.231Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets生物传感器细胞阵列揭示胰岛GABA分泌的时间动态DOI: 10.64898/2026.03.31.715660 bioRxivVolume 2026, Issue No.232Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk胰腺β细胞应激反应的单细胞多组学分析鉴定2型糖尿病风险机制DOI: 10.64898/2026.03.30.715154 bioRxivVolume 2026, Issue No.233Sleeve gastrectomy protects lean mice from future obesity减重手术减轻高脂饮食诱导小鼠的代谢恶化DOI: 10.64898/2026.03.09.710623 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.234Correction: Intrinsic, pro-apoptotic effects of IGFBP-3 on breast cancer cells are reversible: involvement of PKA, Rho, and ceramide更正：IGFBP-3对乳腺癌细胞的内在促凋亡作用具有可逆性：涉及PKA、Rho和神经酰胺DOI: 10.3389/fendo.2026.1810747 Annals of African medicine IF: 00.600Ahead of Print.No.235Association of Serum Leptin with Insulin Resistance in Obese and Nonobese Patients with Type 2 Diabetes Mellitus: A Case-control Study from Eastern India血清瘦素与肥胖和非肥胖2型糖尿病患者胰岛素抵抗的关联：来自印度东部的病例-对照研究DOI: 10.4103/aam.aam_65_26 Bioinformation IF: 01.900Volume 22, Issue 1No.236Linking diabetic retinopathy with lipid abnormalities糖尿病视网膜病变与脂质异常的关联DOI: 10.6026/973206300220128 Bioinformation IF: 01.900Volume 22, Issue 1No.237The prevalence of anemia among type 2 diabetes mellitus with respect to renal function at a tertiary care hospital: A case-control study三级护理医院中2型糖尿病患者贫血患病率与肾功能的关系：一项病例对照研究DOI: 10.6026/973206300220353 Mayo Clinic proceedings. Digital healthVolume 4, Issue 2No.238Patients' Perspectives on Telemedicine for Type 2 Diabetes in Primary Care: Systematic Review and Thematic Synthesis2型糖尿病患者在基层医疗中使用远程医疗的观点：系统综述与主题综合分析DOI: 10.1016/j.mcpdig.2025.100333 bioRxivVolume 2026, Issue No.239Pharmacologic DPP-4 inhibition promotes CD8⁺ T cell metabolic fitness to enhance anti-tumor activity药理DPP-4抑制促进CD8⁺ T细胞代谢适应性以增强抗肿瘤活性DOI: 10.64898/2026.03.31.715681 BMC public health IF: 03.600Ahead of Print.No.240Incidence and predictors of diabetic ketoacidosis among adults with type 1 diabetes in Northwest, Ethiopia, 2023: a retrospective cohort study2023年埃塞俄比亚西北部1型糖尿病成人患者糖尿病酮症酸中毒的发病率及预测因素：一项回顾性队列研究DOI: 10.1186/s12889-026-27281-9 Bioimpacts IF: 02.200Volume 16, Issue No.241Moroccan virgin olive oil triterpenes: HPLC-DAD-ELSD profiling and computational investigation of anti-diabetic potential摩洛哥初榨橄榄油三萜类化合物：HPLC-DAD-ELSD分析及抗糖尿病潜力的计算研究DOI: 10.34172/bi.31007 Curēus IF: 01.300Volume 18, Issue 3No.242Successful Pregnancy Post-Kidney Transplant: A Case Report肾移植术后成功妊娠病例报告DOI: 10.7759/cureus.104884 J Chin Med Assoc IF: 02.400Ahead of Print.No.243Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine超越疾病治疗与预防：从衰老科学与分子特征到衰老治疗与精准衰老医学DOI: 10.1097/JCMA.0000000000001374 Trials IF: 02.000Ahead of Print.No.244Applying a hypothetical strategy to the intercurrent event of non-adherence with the parametric g-formula: a post hoc secondary analysis of the MET-PREVENT randomised controlled trial应用参数化g公式处理不依从偶发事件的假设性策略：对MET-PREVENT随机对照试验的事后二次分析DOI: 10.1186/s13063-026-09708-1 Cardiology in the Young IF: 00.900Ahead of Print.No.245Obesity prevalence and risk factors in surgically repaired CHD手术修复的先天性心脏病患儿肥胖患病率及危险因素DOI: 10.1017/S1047951126111718 213 Diabetes Mellitus(DM) 糖尿病 118 Obesity 肥胖症 49 Insulin 胰岛素 20 Type 2 diabetes mellitus(T2DM) 2型糖尿病 15 Metabolic Syndrome 代谢综合征 14 Diabetic Retinopathy 糖尿病视网膜病 13 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 9 Metformin 二甲双胍 6 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 6 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 5 Diabetic Foot 糖尿病足 3 Hypoglycemic Agents 降糖药 3 Semaglutide 司美格鲁肽 3 Tirzepatide 替尔泊肽 2 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 2 Sitagliptin 西他列汀 2 Type 1 diabetes mellitus(T1DM) 1型糖尿病 2 Diabetic acidosis 糖尿病性酸中毒 2 Diabetic Cardiomyopathies 糖尿病心肌病 2 Dapagliflozin 达格列净 2 Empagliflozin 恩格列净 2 Gabapentin 加巴喷丁 1 Pregabalin 普瑞巴林 1 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 1 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 1 Ipragliflozin 依格列净 1 Luseogliflozin 鲁格列净 1 Tofogliflozin 托格列净 1 Diabetes Complications 糖尿病并发症 1 Saxagliptin 沙格列汀 1 Linagliptin 利格列汀 1 Alogliptin 阿格列汀 1 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 1 Canagliflozin 卡格列净 1 Exenatide 艾塞那肽 1 Liraglutide 利拉鲁肽编辑：韩玉莲审校：韩玉莲

2026-03-11

·商业新知

恩格列净从降糖到心肾共治，重构SGLT-2抑制剂百亿美金市场

纵观全球创新药发展史，First-in-Class（首创药物）往往享有极高的市场先发优势。然而，在SGLT-2抑制剂这一拥挤的百亿美金赛道中，欧唐静（英文通用名：empagliflozin，恩格列净）却生动演绎了一场“后发先至”的经典商业反超战。2013年12月31日，恩格列净率先于哥伦比亚获批，随后在2014年相继拿下欧盟与美国的上市许可。截至2024年，作为后来者的恩格列净，其全球年销售额已强势突破131.5亿美元，正式跻身全球标志性重磅炸弹药物的超级俱乐部。恩格列净是如何打破达格列净与卡格列净的先发壁垒的？其底层逻辑又为当下的创新药立项与生命周期管理带来了哪些启示？我们需要从人类对抗糖尿病的漫长历史中去寻找答案。一、靶点溯源：从“甜尿”到代谢科学的演进糖尿病，这一以长期高血糖为显著特征的代谢性疾病，其典型临床表现为“三多一少”（多食、多饮、多尿及体重下降）。在病理学分类上，主要分为因自身免疫导致胰岛B细胞受损、胰岛素绝对缺乏的1型糖尿病（胰岛素依赖型），以及因胰岛素抵抗或分泌进行性不足引发的2型糖尿病。根据国际糖尿病联盟（IDF）的统计，2021年全球20-79岁成年糖尿病患者已达5.37亿，其中2型糖尿病占比高达90%，且预计到2045年全球患者规模将攀升至7.83亿。人类对这一疾病的认知历经了数千年的探索：•上古时期的症状观察：早在公元前1550年的古埃及莎草纸文献中，便记录了一种具有“多尿”特征的贵族疾病，这是人类迄今发现最早的糖尿病史料。•中外古典医学的共识：公元前400年，中国《黄帝内经》详述了“消渴”病的症状；古印度医学（公元5-6世纪）与中国隋唐时期的甄立言（《古今录验方》）则不约而同地发现了患者尿液“甜如蜜”的核心病征。•现代病理学的曙光：17世纪，英国医生Thomas Willis首次使用拉丁文“mellitus”（极甜）来描述该病；1815年，法国化学家确证尿液中的甜味物质为葡萄糖。•胰岛素时代的开启：1869年Paul Langerhans发现胰岛，直至1920年Banting与Macleod成功提取胰岛素，人类终于掌握了干预糖尿病的利器，两人因此荣获1923年诺贝尔奖。然而，面对占据绝对主力的2型糖尿病患者，单纯的胰岛素补充疗法因“胰岛素抵抗”机制的存在而显得捉襟见。肘寻找口服降糖新靶点，成为了现代制药工业的百年命题。二、药物迭代：2型糖尿病治疗药物的百年变迁在SGLT-2抑制剂大放异彩之前，2型糖尿病的临床治疗经历了多次重要的靶点迭代，每一次都伴随着偶然的发现与艰难的机制探索：双胍类（二甲双胍）：源自天然牧草山羊豆中的山羊豆碱。1957年首次应用于临床后，二甲双胍曾因同类药物（苯乙双胍等）引发的致死性乳酸性酸中毒风波而一度被冷落。直至历时30年的具有里程碑意义的UKPDS（英国糖尿病前瞻性研究）证实了其在降糖的同时兼具心血管保护作用，FDA才于1995年批准其上市，奠定了其一线用药的霸主地位。磺酰脲类：发现源自二战期间磺胺类抗菌药（2254PR化合物）导致的低血糖副作用。经历第一代的高不良反应后，发展至第三代（如1995年上市的格列美脲），具备了刺激胰岛素分泌与增敏的双重机制。噻唑烷二酮类（TZDs）：日本三共制药基于抗氧化理念研发的曲格列酮（1995年）开启了PPARγ激动剂时代。但该类药物饱受安全性困扰，曲格列酮因肝毒性退市，罗格列酮被FDA黑框警告提示心衰风险，吡格列酮则因隐瞒膀胱癌风险致使礼来遭到巨额罚单。肠促胰素类（GLP-1与DPP-4）：科学家发现口服葡萄糖比静脉注射能引发更强烈的胰岛素分泌（肠促胰素效应）。人体Langerhans细胞分泌的GLP-1能稳定血糖，但半衰期极短。由此诞生了抑制GLP-1降解的DPP-4抑制剂（如2006年获批的西格列汀）和直接补充作用的GLP-1受体激动剂。正是在不断追求更优效、更安全的降糖机制的驱动下，科学家的目光转向了人体的排泄器官——肾脏。三、SGLT-2抑制剂的结构破局：从根皮苷到恩格列净肾脏近端肾小球的钠葡萄糖转运蛋白-2（SGLT-2）负责了人体约90%的葡萄糖重吸收。阻断这一通道，就能让过量的葡萄糖随尿液直接排出，这是一种完全独立于胰岛素的降糖路径。1. 先导化合物的发现与困境SGLT-2抑制剂的灵感源泉，是1835年法国化学家从苹果树皮中提取的根皮苷。1886年其降糖作用被发现，但根皮苷作为药物存在两大致命缺陷：第一，选择性差。它不仅抑制肾脏的SGLT-2，还会抑制小肠内负责吸收葡萄糖的SGLT1，从而引发严重的胃肠道不良反应；第二，极度不稳定。其分子结构中的O-糖苷键在肠道中极易被水解酶切断，降解为无活性的根皮素和葡萄糖。根皮苷化学结构2. 构效关系（SAR）的突破与First-in-Class的诞生早期的结构改造中，田边三菱制药尝试合成的T-1095因未能克服O-糖苷不稳定性而在临床二期折戟。百时美施贵宝（BMS）随后提出缩短连接基的策略，成功解决了高选择性问题。最终的破局之法，是将易水解的O-苷键巧妙替换为极其稳定的C-C键（C-苷）。基于这一底层逻辑，两款具有开创意义的SGLT-2抑制剂率先完成了临床转化并相继问世：达格列净（Dapagliflozin/Farxiga）：由BMS与阿斯利康联合开发。它在A环上引入了氯原子，R基团设定为甲氧基。作为全球首个获批（2012年于澳大利亚和欧盟）的SGLT-2抑制剂，达格列净率先推开了这一全新降糖机制的大门。达格列净化学结构卡格列净（Canagliflozin/Invokana）：由田边三菱与强生公司联合开发。采用了A环为苯环、B环为苯基噻吩的母核结构，并引入了甲基与氟苯基。它于2013年3月成为首个登陆美国FDA的SGLT-2抑制剂，2016年达销售峰值14.13亿美元，一度在北美市场独领风骚。卡格列净化学结构3. 恩格列净的精妙设计勃林格殷格翰（BI）在此基础上进行了更深入的结构优化。恩格列净的分子设计在保留核心骨架的同时，精细调节了基团，赋予了其极佳的药代动力学特征。2009年9月，恩格列净正式步入临床试验阶段，2011年1月，勃林格殷格翰与礼来强强联手，共同推进恩格列净的全球研发进程。恩格列净化学结构四、核心临床数据解构：坚实的降糖基本盘恩格列净的上市基石，建立在三项严谨且大规模的关键3期临床试验之上（Trial 1245.20、1245.23、1245.19），不仅验证了其单药疗效，更确立了其作为联用方案的黄金地位。恩格列净三项关键性3期临床试验核心数据对比分析上述数据充分证明，恩格列净不仅能够独立或协同其他经典降糖药物产生强效的降糖作用，还能凭借其独特的渗透性利尿机制与能量排泄机制，额外带来减轻体重、降低血压的“溢出红利”。然而，这仅仅是它问鼎王座的序曲。FDA于2014年8月1日正式批准欧唐静用于2型糖尿病患者的血糖控制。五、循证医学重塑市场格局：跨越圈层的“三大战役”如果仅作为一款降糖药，恩格列净由于上市时间晚于达格列净和卡格列净，在早期市场争夺中处于绝对劣势。恩格列净的真正突围，源自其在心血管与肾脏适应证上的前瞻性战略布局，彻底改变了SGLT-2抑制剂的用药格局。战役一：EMPA-REG OUTCOME —— 降糖药跨界心血管的“历史性拐点”长期以来，学术界普遍悲观地认为“单纯降糖无法改善糖尿病患者的大血管预后”。•试验设计：EMPA-REG OUTCOME研究历时多年，纳入7064例确诊心血管疾病的2型糖尿病患者，中位随访时间长达3.1年。•震撼结果：恩格列净组心血管死亡相对风险大幅降低38%，任何原因死亡风险降低32%，因心衰住院发生率降低35%。•商业意义：2016年12月，FDA依据此结果批准其用于降低心血管死亡风险。这是全球医学史上极具划时代意义的突破，凭借这一关键适应证，恩格列净销量在2017年迅速实现对卡格列净与达格列净的反超，确立了绝对的领先优势。而同期，卡格列净因被FDA标注下肢截肢的黑框警告，遭遇重创，逐渐淡出核心竞争圈。战役二：EMPEROR 项目 —— 攻克心力衰竭的“不治之症”心力衰竭分为射血分数降低（HFrEF）和射血分数保留（HFpEF）两种类型，后者长期处于无特效药的学术荒漠地带。•EMPEROR-Reduced（针对HFrEF）：纳入3730例患者，证实恩格列净可显著降低心血管死亡或心衰恶化住院的复合终点发生率（19.4% vs 安慰剂组24.7%），且无论患者是否伴有糖尿病。•EMPEROR-Preserved（针对HFpEF）：纳入5988例患者。该试验更是成为了业界首个在HFpEF领域取得阳性结果的大型临床试验，具备极其重要的里程碑意义。•基于此，FDA分别于2021年8月及2022年2月，全线批准恩格列净用于两型心力衰竭患者。这直接推动了其百亿美元销售额的第二增长曲线。战役三：EMPA-KIDNEY —— 筑牢慢性肾病（CKD）防线•试验概况：纳入6609名慢性肾脏病患者，恩格列净组肾脏疾病进展或心血管死亡的复合终点发生率为13.1%，显著优于安慰剂组的16.9%。•适应证获批：2023年9月21日，FDA批准其用于降低CKD成人患者的eGFR持续下降及终末期肾病等风险。•至此，恩格列净完美构筑了“糖-心-肾”共治的超宽护城河。恩格列净研发现状图源：摩熵医药数据库六、商业权谋与王座加冕：后来居上的市场逻辑医药市场的较量从来都不是纸面数据的单纯比拼，而是临床证据、监管决策、处方习惯与市场推广的多维综合博弈。恩格列净的逆袭，教科书般地展示了“First-in-disease（最佳疾病获益）”如何从战略层面击溃“First-in-class（同类首创）”。截至2025年，全球SGLT-2抑制剂市场规模估值已达178亿美元，并预计在未来十年持续扩张。在这片蓝海中，各方势力的沉浮令人唏嘘。1. 竞争对手的滑铁卢：卡格列净的黑框之痛曾在美国市场风头无两的卡格列净（Invokana），因安全性问题惨遭滑铁卢。FDA在评估CANVAS-R试验时发现，该药会导致下肢截肢（主要为脚趾和中足）的风险显著增加（发生率7.5/1000，远超安慰剂组的4.2/1000）。2017年5月，FDA对其发出了极其严厉的“黑框警告”。尽管强生等后续补充了心肾保护数据，并于2020年促使FDA撤销警告，但医学界的处方信心已然溃败，其全球销售额从2016年的巅峰断崖式下跌，彻底退出第一梯队。卡格列净全球销售额图源：摩熵医药数据库2. 双雄对决：恩格列净与达格列净的交锋分化卡格列净退场后，市场演变为恩格列净（Jardiance）与达格列净（Farxiga）的双雄争霸。恩格列净背靠礼来与勃林格殷格翰，凭借核心适应证的时间差优势步步为营：它于2016年率先斩获“降低心血管死亡风险”适应证，比达格列净早了整整三年；在攻克射血分数保留型心衰（HFpEF）的战役中，恩格列净于2022年2月率先获批，再次领先达格列净一年多。此外，真实世界处方分化显示，达格列净在降低心房颤动风险上受部分电生理医生青睐，但恩格列净在降低心血管死亡硬终点和改善心脏泵血效能上表现更佳，斩获了更广泛的内分泌与心肾专家的处方转化。3. 财务底座与远景扩张强大的临床护城河带来了巨额回报。恩格列净2024年全球销售额突破131.5亿美元。恩格列净历年销售图源：摩熵医药数据库在2025年总规模约178亿美元的SGLT-2抑制剂全球市场中，恩格列净凭借广泛的处方信任，以高达55.3%的市占率稳居霸主地位。业绩方面，2025年上半年勃林格殷格翰端恩格列净销售额达43亿欧元，礼来亦在25年第一季度因其获得3.7亿美元一次性收益。得益于完善的专利布局以及新适应症的拓展，预计恩格列净在未来数年内将继续维持其市场主导地位。七、SGLT-2抑制剂的最新进展根据摩熵医药数据库最新统计，截至2026年3月初，全球SGLT-2抑制剂赛道依然保持极高的研发热度。全球范围内处于研发或上市阶段的SGLT-2抑制剂共计99款。其中，已获批上市达42款，NDA申请阶段1款，处于三期临床的有19款，一二期临床共计28款，临床前研究8款。全球在研的SGLT-2抑制剂阶段分布恩格列净获批之后，全球相继涌现了多款创新型SGLT-2抑制剂，包括日本的伊格列净、鲁格列净；美国的艾托格列净、索格列净；以及中国恒瑞医药的脯氨酸恒格列净（2022年1月上市）和四环医药的加格列净（2024年1月上市）等。这标志着该领域的竞争已步入微创新的差异化时代。八、结语欧唐静的成功，是医药产业战略与执行力完美结合的典范：① 疗效与安全性是永恒的底色：卡格列净虽顶着美国First-in-Class的光环，却因截肢黑框警告折戟沉沙，这警示产业界：分子特性的底层安全性决定了药物的最终生命周期上限。② 顶层试验设计的“降维打击”：恩格列净虽上市较晚，但在关键的适应证拓展上（尤其是心血管预后及HFpEF），凭借极具魄力和前瞻性的大型随机双盲临床试验设计，实现了差异化占位。赢得首批上市只是第一步，依靠坚实的循证医学数据不断重塑疾病治疗指南，才是Best-in-Class加冕销售王座的核心密码。正如这段长达千年的医学探索史所昭示的：科学的突破永远属于那些不满足于现状、勇于在未知领域寻找更高确定性的探路者。恩格列净百亿美金突围密码的背后，是一部精准医疗战略指导下的大型临床循证史诗。

2026-03-11

·雪球

131亿美金！从降糖到心肾共治，恩格列净重构SGLT-2 抑制剂赛道格局

纵观全球创新药发展史，First-in-Class（首创药物）往往享有极高的市场先发优势。然而，在SGLT-2抑制剂这一拥挤的百亿美金赛道中，欧唐静（英文通用名：empagliflozin，恩格列净）却生动演绎了一场“后发先至”的经典商业反超战。2013年12月31日，恩格列净率先于哥伦比亚获批，随后在2014年相继拿下欧盟与美国的上市许可。截至2024年，作为后来者的恩格列净，其全球年销售额已强势突破131.5亿美元，正式跻身全球标志性重磅炸弹药物的超级俱乐部。恩格列净是如何打破达格列净与卡格列净的先发壁垒的？其底层逻辑又为当下的创新药立项与生命周期管理带来了哪些启示？我们需要从人类对抗糖尿病的漫长历史中去寻找答案。一、靶点溯源：从“甜尿”到代谢科学的演进糖尿病，这一以长期高血糖为显著特征的代谢性疾病，其典型临床表现为“三多一少”（多食、多饮、多尿及体重下降）。在病理学分类上，主要分为因自身免疫导致胰岛B细胞受损、胰岛素绝对缺乏的1型糖尿病（胰岛素依赖型），以及因胰岛素抵抗或分泌进行性不足引发的2型糖尿病。根据国际糖尿病联盟（IDF）的统计，2021年全球20-79岁成年糖尿病患者已达5.37亿，其中2型糖尿病占比高达90%，且预计到2045年全球患者规模将攀升至7.83亿。人类对这一疾病的认知历经了数千年的探索：•上古时期的症状观察：早在公元前1550年的古埃及莎草纸文献中，便记录了一种具有“多尿”特征的贵族疾病，这是人类迄今发现最早的糖尿病史料。•中外古典医学的共识：公元前400年，中国《黄帝内经》详述了“消渴”病的症状；古印度医学（公元5-6世纪）与中国隋唐时期的甄立言（《古今录验方》）则不约而同地发现了患者尿液“甜如蜜”的核心病征。•现代病理学的曙光：17世纪，英国医生ThomasWillis首次使用拉丁文“mellitus”（极甜）来描述该病；1815年，法国化学家确证尿液中的甜味物质为葡萄糖。•胰岛素时代的开启：1869年PaulLangerhans发现胰岛，直至1920年Banting与Macleod成功提取胰岛素，人类终于掌握了干预糖尿病的利器，两人因此荣获1923年诺贝尔奖。然而，面对占据绝对主力的2型糖尿病患者，单纯的胰岛素补充疗法因“胰岛素抵抗”机制的存在而显得捉襟见。肘寻找口服降糖新靶点，成为了现代制药工业的百年命题。二、药物迭代：2型糖尿病治疗药物的百年变迁在SGLT-2抑制剂大放异彩之前，2型糖尿病的临床治疗经历了多次重要的靶点迭代，每一次都伴随着偶然的发现与艰难的机制探索：双胍类（二甲双胍）：源自天然牧草山羊豆中的山羊豆碱。1957年首次应用于临床后，二甲双胍曾因同类药物（苯乙双胍等）引发的致死性乳酸性酸中毒风波而一度被冷落。直至历时30年的具有里程碑意义的UKPDS（英国糖尿病前瞻性研究）证实了其在降糖的同时兼具心血管保护作用，FDA才于1995年批准其上市，奠定了其一线用药的霸主地位。磺酰脲类：发现源自二战期间磺胺类抗菌药（2254PR化合物）导致的低血糖副作用。经历第一代的高不良反应后，发展至第三代（如1995年上市的格列美脲），具备了刺激胰岛素分泌与增敏的双重机制。噻唑烷二酮类（TZDs）：日本三共制药基于抗氧化理念研发的曲格列酮（1995年）开启了PPARγ激动剂时代。但该类药物饱受安全性困扰，曲格列酮因肝毒性退市，罗格列酮被FDA黑框警告提示心衰风险，吡格列酮则因隐瞒膀胱癌风险致使礼来遭到巨额罚单。肠促胰素类（GLP-1与DPP-4）：科学家发现口服葡萄糖比静脉注射能引发更强烈的胰岛素分泌（肠促胰素效应）。人体Langerhans细胞分泌的GLP-1能稳定血糖，但半衰期极短。由此诞生了抑制GLP-1降解的DPP-4抑制剂（如2006年获批的西格列汀）和直接补充作用的GLP-1受体激动剂。正是在不断追求更优效、更安全的降糖机制的驱动下，科学家的目光转向了人体的排泄器官——肾脏。三、SGLT-2抑制剂的结构破局：从根皮苷到恩格列净肾脏近端肾小球的钠葡萄糖转运蛋白-2（SGLT-2）负责了人体约90%的葡萄糖重吸收。阻断这一通道，就能让过量的葡萄糖随尿液直接排出，这是一种完全独立于胰岛素的降糖路径。1.先导化合物的发现与困境SGLT-2抑制剂的灵感源泉，是1835年法国化学家从苹果树皮中提取的根皮苷。1886年其降糖作用被发现，但根皮苷作为药物存在两大致命缺陷：第一，选择性差。它不仅抑制肾脏的SGLT-2，还会抑制小肠内负责吸收葡萄糖的SGLT1，从而引发严重的胃肠道不良反应；第二，极度不稳定。其分子结构中的O-糖苷键在肠道中极易被水解酶切断，降解为无活性的根皮素和葡萄糖。根皮苷化学结构2.构效关系（SAR）的突破与First-in-Class的诞生早期的结构改造中，田边三菱制药尝试合成的T-1095因未能克服O-糖苷不稳定性而在临床二期折戟。百时美施贵宝（BMS）随后提出缩短连接基的策略，成功解决了高选择性问题。最终的破局之法，是将易水解的O-苷键巧妙替换为极其稳定的C-C键（C-苷）。基于这一底层逻辑，两款具有开创意义的SGLT-2抑制剂率先完成了临床转化并相继问世：达格列净（Dapagliflozin/Farxiga）：由BMS与阿斯利康联合开发。它在A环上引入了氯原子，R基团设定为甲氧基。作为全球首个获批（2012年于澳大利亚和欧盟）的SGLT-2抑制剂，达格列净率先推开了这一全新降糖机制的大门。达格列净化学结构卡格列净（Canagliflozin/Invokana）：由田边三菱与强生公司联合开发。采用了A环为苯环、B环为苯基噻吩的母核结构，并引入了甲基与氟苯基。它于2013年3月成为首个登陆美国FDA的SGLT-2抑制剂，2016年达销售峰值14.13亿美元，一度在北美市场独领风骚。卡格列净化学结构3.恩格列净的精妙设计勃林格殷格翰（BI）在此基础上进行了更深入的结构优化。恩格列净的分子设计在保留核心骨架的同时，精细调节了基团，赋予了其极佳的药代动力学特征。2009年9月，恩格列净正式步入临床试验阶段，2011年1月，勃林格殷格翰与礼来强强联手，共同推进恩格列净的全球研发进程。恩格列净化学结构四、核心临床数据解构：坚实的降糖基本盘恩格列净的上市基石，建立在三项严谨且大规模的关键3期临床试验之上（Trial1245.20、1245.23、1245.19），不仅验证了其单药疗效，更确立了其作为联用方案的黄金地位。恩格列净三项关键性3期临床试验核心数据对比分析上述数据充分证明，恩格列净不仅能够独立或协同其他经典降糖药物产生强效的降糖作用，还能凭借其独特的渗透性利尿机制与能量排泄机制，额外带来减轻体重、降低血压的“溢出红利”。然而，这仅仅是它问鼎王座的序曲。FDA于2014年8月1日正式批准欧唐静用于2型糖尿病患者的血糖控制。五、循证医学重塑市场格局：跨越圈层的“三大战役”如果仅作为一款降糖药，恩格列净由于上市时间晚于达格列净和卡格列净，在早期市场争夺中处于绝对劣势。恩格列净的真正突围，源自其在心血管与肾脏适应证上的前瞻性战略布局，彻底改变了SGLT-2抑制剂的用药格局。战役一：EMPA-REGOUTCOME——降糖药跨界心血管的“历史性拐点”长期以来，学术界普遍悲观地认为“单纯降糖无法改善糖尿病患者的大血管预后”。•试验设计：EMPA-REGOUTCOME研究历时多年，纳入7064例确诊心血管疾病的2型糖尿病患者，中位随访时间长达3.1年。•震撼结果：恩格列净组心血管死亡相对风险大幅降低38%，任何原因死亡风险降低32%，因心衰住院发生率降低35%。•商业意义：2016年12月，FDA依据此结果批准其用于降低心血管死亡风险。这是全球医学史上极具划时代意义的突破，凭借这一关键适应证，恩格列净销量在2017年迅速实现对卡格列净与达格列净的反超，确立了绝对的领先优势。而同期，卡格列净因被FDA标注下肢截肢的黑框警告，遭遇重创，逐渐淡出核心竞争圈。战役二：EMPEROR项目——攻克心力衰竭的“不治之症”心力衰竭分为射血分数降低（HFrEF）和射血分数保留（HFpEF）两种类型，后者长期处于无特效药的学术荒漠地带。•EMPEROR-Reduced（针对HFrEF）：纳入3730例患者，证实恩格列净可显著降低心血管死亡或心衰恶化住院的复合终点发生率（19.4%vs安慰剂组24.7%），且无论患者是否伴有糖尿病。•EMPEROR-Preserved（针对HFpEF）：纳入5988例患者。该试验更是成为了业界首个在HFpEF领域取得阳性结果的大型临床试验，具备极其重要的里程碑意义。•基于此，FDA分别于2021年8月及2022年2月，全线批准恩格列净用于两型心力衰竭患者。这直接推动了其百亿美元销售额的第二增长曲线。战役三：EMPA-KIDNEY——筑牢慢性肾病（CKD）防线•试验概况：纳入6609名慢性肾脏病患者，恩格列净组肾脏疾病进展或心血管死亡的复合终点发生率为13.1%，显著优于安慰剂组的16.9%。•适应证获批：2023年9月21日，FDA批准其用于降低CKD成人患者的eGFR持续下降及终末期肾病等风险。•至此，恩格列净完美构筑了“糖-心-肾”共治的超宽护城河。恩格列净研发现状图源：摩熵医药数据库六、商业权谋与王座加冕：后来居上的市场逻辑医药市场的较量从来都不是纸面数据的单纯比拼，而是临床证据、监管决策、处方习惯与市场推广的多维综合博弈。恩格列净的逆袭，教科书般地展示了“First-in-disease（最佳疾病获益）”如何从战略层面击溃“First-in-class（同类首创）”。截至2025年，全球SGLT-2抑制剂市场规模估值已达178亿美元，并预计在未来十年持续扩张。在这片蓝海中，各方势力的沉浮令人唏嘘。1.竞争对手的滑铁卢：卡格列净的黑框之痛曾在美国市场风头无两的卡格列净（Invokana），因安全性问题惨遭滑铁卢。FDA在评估CANVAS-R试验时发现，该药会导致下肢截肢（主要为脚趾和中足）的风险显著增加（发生率7.5/1000，远超安慰剂组的4.2/1000）。2017年5月，FDA对其发出了极其严厉的“黑框警告”。尽管强生等后续补充了心肾保护数据，并于2020年促使FDA撤销警告，但医学界的处方信心已然溃败，其全球销售额从2016年的巅峰断崖式下跌，彻底退出第一梯队。卡格列净全球销售额图源：摩熵医药数据库2.双雄对决：恩格列净与达格列净的交锋分化卡格列净退场后，市场演变为恩格列净（Jardiance）与达格列净（Farxiga）的双雄争霸。恩格列净背靠礼来与勃林格殷格翰，凭借核心适应证的时间差优势步步为营：它于2016年率先斩获“降低心血管死亡风险”适应证，比达格列净早了整整三年；在攻克射血分数保留型心衰（HFpEF）的战役中，恩格列净于2022年2月率先获批，再次领先达格列净一年多。此外，真实世界处方分化显示，达格列净在降低心房颤动风险上受部分电生理医生青睐，但恩格列净在降低心血管死亡硬终点和改善心脏泵血效能上表现更佳，斩获了更广泛的内分泌与心肾专家的处方转化。3.财务底座与远景扩张强大的临床护城河带来了巨额回报。恩格列净2024年全球销售额突破131.5亿美元。恩格列净历年销售图源：摩熵医药数据库在2025年总规模约178亿美元的SGLT-2抑制剂全球市场中，恩格列净凭借广泛的处方信任，以高达55.3%的市占率稳居霸主地位。业绩方面，2025年上半年勃林格殷格翰端恩格列净销售额达43亿欧元，$礼来(LLY)$亦在25年第一季度因其获得3.7亿美元一次性收益。得益于完善的专利布局以及新适应症的拓展，预计恩格列净在未来数年内将继续维持其市场主导地位。七、SGLT-2抑制剂的最新进展根据摩熵医药数据库最新统计，截至2026年3月初，全球SGLT-2抑制剂赛道依然保持极高的研发热度。全球范围内处于研发或上市阶段的SGLT-2抑制剂共计99款。其中，已获批上市达42款，NDA申请阶段1款，处于三期临床的有19款，一二期临床共计28款，临床前研究8款。全球在研的SGLT-2抑制剂阶段分布恩格列净获批之后，全球相继涌现了多款创新型SGLT-2抑制剂，包括日本的伊格列净、鲁格列净；美国的艾托格列净、索格列净；以及中国$恒瑞医药(SH600276)$的脯氨酸恒格列净（2022年1月上市）和$四环医药(00460)$的加格列净（2024年1月上市）等。这标志着该领域的竞争已步入微创新的差异化时代。八、结语欧唐静的成功，是医药产业战略与执行力完美结合的典范：①疗效与安全性是永恒的底色：卡格列净虽顶着美国First-in-Class的光环，却因截肢黑框警告折戟沉沙，这警示产业界：分子特性的底层安全性决定了药物的最终生命周期上限。②顶层试验设计的“降维打击”：恩格列净虽上市较晚，但在关键的适应证拓展上（尤其是心血管预后及HFpEF），凭借极具魄力和前瞻性的大型随机双盲临床试验设计，实现了差异化占位。赢得首批上市只是第一步，依靠坚实的循证医学数据不断重塑疾病治疗指南，才是Best-in-Class加冕销售王座的核心密码。正如这段长达千年的医学探索史所昭示的：科学的突破永远属于那些不满足于现状、勇于在未知领域寻找更高确定性的探路者。恩格列净百亿美金突围密码的背后，是一部精准医疗战略指导下的大型临床循证史诗。

上市批准临床研究

100 项与伊格列净L-脯氨酸盐相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10200	伊格列净L-脯氨酸盐	A10BK05	DB11698

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
1型糖尿病	日本	-	2014-01-17
2型糖尿病	日本	-	2014-01-17

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肝功能不全	临床1期	美国	Astellas Pharma, Inc.	2010-05-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


JPRN-UMIN000015170 (EASD2022)	N/A	HbA1c \| BMI \| visceral fat area ... 更多	103	Ipragliflozin 50 mg	壓鏇積網鑰構憲獵構選(鑰夢積鬱觸繭繭廠鏇鏇) = 製選衊鹹夢餘糧衊餘糧艱簾鬱艱鏇鹽鬱壓鹹膚 (鏇願願廠繭顧窪廠願淵 )	积极	2022-09-20
				Metformin 1000 mg	壓鏇積網鑰構憲獵構選(鑰夢積鬱觸繭繭廠鏇鏇) = 淵願願糧鹹鹹築醖範繭艱簾鬱艱鏇鹽鬱壓鹹膚 (鏇願願廠繭顧窪廠願淵 )
NCT02479399 (STELLA-LONG TERM, Pubmed \| Diabetol Int)	N/A	2型糖尿病一线	11,412	ipragliflozin (Treatment-naïve patients)	範製範顧網繭願範觸築(衊觸壓鏇糧鏇繭範積壓) = 壓憲獵衊壓鏇願襯醖觸廠襯顧蓋艱鹽積構壓鬱 (構夢觸築鏇艱遞繭積積 ) 更多	-	2021-10-01
				ipragliflozin (Non-naïve patients)	範製範顧網繭願範觸築(衊觸壓鏇糧鏇繭範積壓) = 醖夢憲糧鹹構壓鹹糧蓋廠襯顧蓋艱鹽積構壓鬱 (構夢觸築鏇艱遞繭積積 ) 更多
NCT02577003 \| NCT02564211 (Pubmed \| Diabetes Obes Metab)	临床3期	2型糖尿病	-	Ipragliflozin 50 mg	壓鹹糧獵窪繭夢艱願鹽(廠糧鑰醖艱窪製鑰餘衊) = 積構網繭醖艱選鏇簾鹽鹹艱製願窪鏇鑰鹽廠憲 (餘齋衊糧壓繭襯築構壓 )	-	2021-05-25
NCT02479399 (STELLA-LONG TERM, Pubmed \| Diabetes Ther)	N/A	2型糖尿病	11,412	Ipragliflozin in patients aged <65 years	積鹽鑰蓋糧積願鏇遞壓(壓淵憲鏇觸構積鏇艱艱) = 構構製獵鹽簾膚衊網獵簾齋衊齋鏇遞鹽壓鹽獵 (獵鏇齋糧襯蓋繭醖積壓 ) 更多	-	2021-03-17
				Ipragliflozin in patients aged ≥65 years	積鹽鑰蓋糧積願鏇遞壓(壓淵憲鏇觸構積鏇艱艱) = 窪憲憲製鹽鹹淵衊築廠簾齋衊齋鏇遞鹽壓鹽獵 (獵鏇齋糧襯蓋繭醖積壓 ) 更多
JPRN-jRCTs031180205 (ADA2020)	临床4期	2型糖尿病二线	-	Ipragliflozin	簾夢獵網襯壓齋網壓構(憲簾廠齋醖艱壓顧簾膚) = 鑰築觸顧鏇齋膚淵壓憲積鹹餘壓膚製顧鹹夢襯 (鹹艱製繭觸壓蓋範獵製 ) 更多	-	2020-06-01
				Sitagliptin	簾夢獵網襯壓齋網壓構(憲簾廠齋醖艱壓顧簾膚) = 鹹鹹憲淵網憲製獵膚製積鹹餘壓膚製顧鹹夢襯 (鹹艱製繭觸壓蓋範獵製 ) 更多
NCT01225081 \| NCT01071850 \| NCT01117584 \| NCT00621868 \| NCT01057628 \| NCT01316094 \| NCT01135433 \| NCT02452632 \| NCT02175784 \| NCT01242215 \| NCT01505426 \| NCT02794792 (Pubmed \| Diabetes Ther)	N/A	2型糖尿病	-	Ipragliflozin 50 mg	範遞積衊範廠淵壓糧鹹(鬱衊壓淵夢窪糧窪願製) = 鏇膚積遞繭顧餘鏇齋廠鏇齋醖憲淵繭壓築築廠 (鹽鹹繭壓餘顧鏇鏇壓構 ) 更多	-	2019-12-01
				Placebo	範遞積衊範廠淵壓糧鹹(鬱衊壓淵夢窪糧窪願製) = 夢醖膚膚襯積網鬱壓憲鏇齋醖憲淵繭壓築築廠 (鹽鹹繭壓餘顧鏇鏇壓構 ) 更多
NCT02479399 (STELLA-LONG TERM, Pubmed \| Curr Med Res Opin)	N/A	2型糖尿病	11,412	ipragliflozin (Non-elderly patients)	觸壓獵憲衊憲壓構選憲(鏇遞鏇網醖鹹顧遞衊構) = 膚淵鏇遞蓋繭選壓觸積顧範願夢鹹鏇蓋襯壓網 (製選壓齋構範範製餘膚 ) 更多	-	2019-11-01
				ipragliflozin (Elderly patients)	觸壓獵憲衊憲壓構選憲(鏇遞鏇網醖鹹顧遞衊構) = 糧醖範壓鏇鬱憲淵構憲顧範願夢鹹鏇蓋襯壓網 (製選壓齋構範範製餘膚 ) 更多
NCT02897219 (Pubmed) 人工标引	临床3期	1型糖尿病	175	insulin+ipragliflozin	膚簾遞衊簾淵鏇窪襯廠(製鏇淵鑰獵構餘鏇簾鹹): difference = -3.8 (95% CI, -6.2 ~ -1.5) 更多	积极	2019-10-01
				insulin+Placebo
JPRN-UMIN000015170 (EASD2019)	N/A	insulin \| α1microglobulin (α1MG) \| glutamic pyruvic transaminase (GPT)	103	Ipragliflozin	鏇簾餘觸鹽顧膚糧醖簾(餘顧鑰醖願顧鑰鹽築鏇) = 鹽憲壓顧壓艱鑰齋淵製鏇艱觸鹽蓋選鬱鹽壓鏇 (憲遞繭簾鏇鹽餘憲遞廠 ) 更多	积极	2019-09-17
				Metformin	鏇簾餘觸鹽顧膚糧醖簾(餘顧鑰醖願顧鑰鹽築鏇) = 窪繭積觸餘構選鑰膚窪鏇艱觸鹽蓋選鬱鹽壓鏇 (憲遞繭簾鏇鹽餘憲遞廠 ) 更多
JPRN-UMIN000015170 (EASD2018)	N/A	2型糖尿病一线 visceral fat area \| bone-specific alkaline phosphatase (BAP) \| tartrate-resistant acid phosphatase-5b (TRACP-5b)	103	Ipragliflozin 50 mg/day	製醖廠積鏇醖醖網積艱(獵廠積鏇觸憲網構蓋築) = 製選壓蓋廠鑰淵窪遞簾壓築選願繭壓築觸構鹽 (鏇鬱構鹹積壓夢糧淵願 ) 更多	不佳	2018-10-05
				Metformin 1000-1500 mg/day	製醖廠積鏇醖醖網積艱(獵廠積鏇觸憲網構蓋築) = 蓋襯醖繭願鏇鬱遞築鏇壓築選願繭壓築觸構鹽 (鏇鬱構鹹積壓夢糧淵願 ) 更多